Motif ID: GLI1..3.p2

Z-value: 0.810


Transcription factors associated with GLI1..3.p2:

Gene SymbolEntrez IDGene Name
GLI1 2735 glioma-associated oncogene homolog 1 (zinc finger protein)
GLI2 2736 GLI-Kruppel family member GLI2
GLI3 2737 GLI-Kruppel family member GLI3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GLI2chr2_+_121554866-0.214.4e-01Click!
GLI1chr12_+_578539170.097.5e-01Click!
GLI3chr7_-_42276617-0.078.1e-01Click!


Activity profile for motif GLI1..3.p2.

activity profile for motif GLI1..3.p2


Sorted Z-values histogram for motif GLI1..3.p2

Sorted Z-values for motif GLI1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_45418063 1.324 APOC1
apolipoprotein C-I
chr4_+_166299942 1.106 NM_001873
CPE
carboxypeptidase E
chr2_-_20212408 1.071 MATN3
matrilin 3
chr17_-_7017971 1.040 ASGR2
asialoglycoprotein receptor 2
chr17_+_80192774 1.025 NM_001206951
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr17_+_80193649 1.004 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr11_-_66115016 0.958 NM_006876
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr6_+_7541863 0.945 NM_001008844
NM_004415
DSP

desmoplakin

chr21_+_18885104 0.904 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr19_+_45417576 0.899 APOC1
apolipoprotein C-I
chr17_-_7018049 0.892 NM_001181
NM_001201352
NM_080912
NM_080913
ASGR2



asialoglycoprotein receptor 2



chr21_+_18885296 0.873 CXADR
coxsackie virus and adenovirus receptor
chr2_-_20212448 0.859 NM_002381
MATN3
matrilin 3
chr8_+_21916685 0.854 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr8_-_17555158 0.790 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr3_-_32023237 0.775 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chrX_+_152954965 0.767 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr8_+_21916858 0.758 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr6_+_31913708 0.755 NM_001710
CFB
complement factor B
chr7_+_94292737 0.743 PEG10
paternally expressed 10
chr15_-_90358057 0.734 NM_001150
ANPEP
alanyl (membrane) aminopeptidase
chr7_-_94285426 0.732 SGCE
sarcoglycan, epsilon
chr20_-_22564893 0.727 FOXA2
forkhead box A2
chr13_+_113760101 0.724 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr7_+_94292816 0.719 PEG10
paternally expressed 10
chr1_+_44064509 0.718 PTPRF
protein tyrosine phosphatase, receptor type, F
chr5_+_150400132 0.706 GPX3
glutathione peroxidase 3 (plasma)
chr17_-_42200957 0.701 HDAC5
histone deacetylase 5
chrX_-_51812249 0.689 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr6_-_3752245 0.687 NM_183373
PXDC1
PX domain containing 1
chr19_+_45312294 0.671 NM_001013257
NM_005581
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr17_-_53499055 0.660 NM_012329
MMD
monocyte to macrophage differentiation-associated
chr7_-_94285372 0.648 SGCE
sarcoglycan, epsilon
chrX_+_51927918 0.643 NM_001098800
NM_001242362
NM_030801
NM_177535
NM_177537
MAGED4
MAGED4B



melanoma antigen family D, 4
melanoma antigen family D, 4B



chr1_-_55352881 0.629 DHCR24
24-dehydrocholesterol reductase
chr5_+_92920592 0.622 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr17_-_7017558 0.619 NM_080914
ASGR2
asialoglycoprotein receptor 2
chr1_-_55352893 0.601 DHCR24
24-dehydrocholesterol reductase
chr9_-_6645564 0.598 NM_000170
GLDC
glycine dehydrogenase (decarboxylating)
chr9_+_35673852 0.584 NM_001216
CA9
carbonic anhydrase IX
chr16_-_16317290 0.580 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr5_+_176516550 0.576 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr5_-_121412805 0.565 NM_001178102
LOX
lysyl oxidase
chr15_-_90349819 0.549 ANPEP
alanyl (membrane) aminopeptidase
chr22_+_38201232 0.536 H1F0
H1 histone family, member 0
chr11_+_68079999 0.527 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr8_-_101322180 0.525 RNF19A
ring finger protein 19A
chr13_-_41240607 0.513 NM_002015
FOXO1
forkhead box O1
chr6_+_7541892 0.507 DSP
desmoplakin
chr7_+_100770378 0.502 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chrX_+_115567746 0.499 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr7_+_94285620 0.499 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr20_+_35974458 0.498 NM_198291
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chrX_+_70443055 0.496 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr10_+_124134093 0.491 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr19_-_41196419 0.489 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr10_+_124134206 0.487 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_+_19734821 0.486 NM_001244963
NM_145117
NM_182964
NAV2


neuron navigator 2


chr19_-_33793429 0.479 NM_004364
CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chr9_-_99329092 0.476 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr14_-_94856926 0.474 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr6_+_31913763 0.467 CFB
complement factor B
chr3_+_50306578 0.465 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr1_-_12677347 0.463 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr11_-_35441099 0.457 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr1_-_11986455 0.446 NM_138346
KIAA2013
KIAA2013
chr4_-_84030995 0.438 NM_001130716
PLAC8
placenta-specific 8
chr8_-_134584012 0.435 NM_003033
NM_173344
ST3GAL1

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

chr1_-_55352818 0.433 DHCR24
24-dehydrocholesterol reductase
chr12_-_125348346 0.433 SCARB1
scavenger receptor class B, member 1
chr6_-_138428477 0.423 NM_022121
PERP
PERP, TP53 apoptosis effector
chr13_+_113741668 0.415 MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_55352920 0.415 NM_014762
DHCR24
24-dehydrocholesterol reductase
chr6_+_7541837 0.415 DSP
desmoplakin
chr4_+_8200918 0.411 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr2_-_242447449 0.409 STK25
serine/threonine kinase 25
chr4_-_186697065 0.408 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr3_-_49726081 0.407 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr14_-_38064440 0.406 NM_004496
FOXA1
forkhead box A1
chr3_+_50306305 0.401 SEMA3B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chrY_+_16634487 0.401 NM_001206850
NLGN4Y
neuroligin 4, Y-linked
chr7_+_138144847 0.400 NM_003852
NM_015905
TRIM24

tripartite motif containing 24

chrX_-_108976453 0.400 ACSL4
acyl-CoA synthetase long-chain family member 4
chr12_-_26985922 0.397 NM_002223
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2
chr17_-_42201009 0.390 NM_001015053
NM_005474
HDAC5

histone deacetylase 5

chr8_+_97506478 0.389 SDC2
syndecan 2
chr1_+_64058891 0.389 NM_002633
PGM1
phosphoglucomutase 1
chr11_+_62104882 0.385 ASRGL1
asparaginase like 1
chr3_-_79068542 0.382 NM_001145845
NM_133631
ROBO1

roundabout, axon guidance receptor, homolog 1 (Drosophila)

chr4_+_4861371 0.381 NM_002448
MSX1
msh homeobox 1
chr17_+_1648262 0.381 SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr12_+_56473944 0.375 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr17_-_41623652 0.372 NM_001079675
ETV4
ets variant 4
chr11_-_116708334 0.369 NM_000039
APOA1
apolipoprotein A-I
chr20_-_60942300 0.361 NM_005560
LAMA5
laminin, alpha 5
chr16_+_28834407 0.360 NM_007245
NM_145714
NM_148414
NM_148415
NM_148416
ATXN2L




ataxin 2-like




chr3_-_32022734 0.358 OSBPL10
oxysterol binding protein-like 10
chr2_+_235860616 0.353 NM_014521
SH3BP4
SH3-domain binding protein 4
chr20_+_306205 0.353 NM_006943
SOX12
SRY (sex determining region Y)-box 12
chr12_-_125348422 0.352 NM_001082959
NM_005505
SCARB1

scavenger receptor class B, member 1

chr18_+_55862577 0.352 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_-_93651242 0.352 NM_022151
MOAP1
modulator of apoptosis 1
chr1_+_13521962 0.352 NM_001100114
PRAMEF21
PRAME family member 21
chr1_-_110306525 0.346 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr10_+_81073763 0.343 ZMIZ1
zinc finger, MIZ-type containing 1
chr10_-_118764559 0.342 KIAA1598
KIAA1598
chr19_-_39466290 0.341 NM_024907
FBXO17
F-box protein 17
chr17_+_41003184 0.341 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr12_-_6798619 0.340 NM_001039920
NM_001135734
ZNF384

zinc finger protein 384

chr19_-_58874078 0.336 NM_001207009
NM_198458
ZNF497

zinc finger protein 497

chr17_-_80041166 0.334 FASN
fatty acid synthase
chr2_-_242448000 0.331 NM_006374
STK25
serine/threonine kinase 25
chr8_+_136470108 0.330 KHDRBS3
KH domain containing, RNA binding, signal transduction associated 3
chr22_+_20008633 0.328 C22orf25
chromosome 22 open reading frame 25
chr12_-_46766563 0.326 NM_018976
SLC38A2
solute carrier family 38, member 2
chr4_+_38665587 0.326 NM_016531
KLF3
Kruppel-like factor 3 (basic)
chr14_+_24899139 0.325 NM_015299
KHNYN
KH and NYN domain containing
chr12_-_46766019 0.324 SLC38A2
solute carrier family 38, member 2
chr14_-_93651182 0.324 MOAP1
modulator of apoptosis 1
chr19_-_33793441 0.323 CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chr14_+_24584321 0.322 DCAF11
DDB1 and CUL4 associated factor 11
chr22_-_19166276 0.320 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr12_+_112204690 0.320 NM_000690
NM_001204889
ALDH2

aldehyde dehydrogenase 2 family (mitochondrial)

chr19_+_35550794 0.319 HPN
hepsin
chr7_+_130131921 0.317 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr2_-_242447919 0.313 STK25
serine/threonine kinase 25
chr14_+_24584009 0.313 DCAF11
DDB1 and CUL4 associated factor 11
chr14_-_94759360 0.309 NM_016186
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr1_+_43766565 0.308 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr14_-_94759556 0.306 SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_35099296 0.306 NM_021249
NM_152233
SNX6

sorting nexin 6

chrX_-_108976509 0.304 NM_004458
NM_022977
ACSL4

acyl-CoA synthetase long-chain family member 4

chr17_+_19437140 0.303 NM_018242
SLC47A1
solute carrier family 47, member 1
chr12_+_56473808 0.302 NM_001982
NM_001005915
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chr2_-_86850935 0.302 RNF103
ring finger protein 103
chr17_-_26697293 0.301 VTN
vitronectin
chr20_-_50384899 0.298 NM_006045
ATP9A
ATPase, class II, type 9A
chr7_-_27170351 0.298 NM_002141
HOXA4
homeobox A4
chr16_+_28834565 0.297 ATXN2L
ataxin 2-like
chr2_+_97481977 0.296 NM_017623
NM_199078
CNNM3

cyclin M3

chr15_-_75017710 0.295 NM_000499
CYP1A1
cytochrome P450, family 1, subfamily A, polypeptide 1
chr8_+_123793988 0.294 ZHX2
zinc fingers and homeoboxes 2
chr1_+_32042122 0.294 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr19_-_49176263 0.291 NM_145807
NTN5
netrin 5
chr22_-_19166296 0.290 NM_005984
SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr2_-_26205327 0.290 KIF3C
kinesin family member 3C
chr7_-_24797031 0.289 DFNA5
deafness, autosomal dominant 5
chr7_-_94285477 0.286 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr22_-_19166133 0.286 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr1_+_32042125 0.282 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_+_178257488 0.281 AGPS
alkylglycerone phosphate synthase
chr12_+_102271349 0.281 DRAM1
DNA-damage regulated autophagy modulator 1
chr17_+_40118696 0.281 NM_033133
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr16_+_57702156 0.280 NM_170776
GPR97
G protein-coupled receptor 97
chr1_+_32042085 0.279 NM_001204414
NM_022164
TINAGL1

tubulointerstitial nephritis antigen-like 1

chr3_-_15468981 0.279 NM_152396
METTL6
methyltransferase like 6
chr2_-_86850959 0.276 NM_001198951
NM_001198952
NM_005667
RNF103


ring finger protein 103


chr22_-_19165872 0.273 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr9_+_71736179 0.273 NM_001170414
TJP2
tight junction protein 2 (zona occludens 2)
chr6_+_142622797 0.269 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr14_+_24583979 0.269 NM_025230
DCAF11
DDB1 and CUL4 associated factor 11
chr3_+_153839136 0.268 NM_001251963
NM_015595
ARHGEF26

Rho guanine nucleotide exchange factor (GEF) 26

chr10_+_102729249 0.267 SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr11_-_35441501 0.266 NM_001195728
NM_001252652
SLC1A2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

chr3_-_50340979 0.266 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chrX_-_119603136 0.265 LAMP2
lysosomal-associated membrane protein 2
chr20_+_57466509 0.265 GNAS
GNAS complex locus
chrX_-_119603068 0.263 LAMP2
lysosomal-associated membrane protein 2
chr14_+_24583905 0.262 NM_001163484
DCAF11
DDB1 and CUL4 associated factor 11
chr20_+_3451615 0.258 NM_001207047
NM_139321
NM_139322
ATRN


attractin


chr5_-_168271852 0.258


chr5_+_52776408 0.257 FST
follistatin
chr16_+_3115641 0.256 NM_001012632
NM_001012636
IL32

interleukin 32

chr7_+_94285676 0.256 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr18_+_7567313 0.256 NM_001105244
NM_002845
PTPRM

protein tyrosine phosphatase, receptor type, M

chr14_-_39572414 0.255 NM_006364
SEC23A
Sec23 homolog A (S. cerevisiae)
chr16_+_89686999 0.254 NM_004413
DPEP1
dipeptidase 1 (renal)
chr20_-_3154169 0.253 ProSAPiP1
ProSAPiP1 protein
chr12_-_122018858 0.252 NM_032590
KDM2B
lysine (K)-specific demethylase 2B
chr19_+_45417920 0.250 NM_001645
APOC1
apolipoprotein C-I
chr7_-_100425035 0.250 NM_004444
EPHB4
EPH receptor B4
chr6_-_16761600 0.247 NM_000332
NM_001128164
ATXN1

ataxin 1

chr7_+_45927958 0.247 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr6_+_43738757 0.245 VEGFA
vascular endothelial growth factor A
chr2_+_102508333 0.244 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr2_+_178257371 0.243 NM_003659
AGPS
alkylglycerone phosphate synthase
chr2_+_219646448 0.243 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr20_+_57466721 0.243 GNAS
GNAS complex locus
chr1_+_11994710 0.242 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr2_+_24272627 0.242 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr10_-_95360959 0.241 NM_006744
RBP4
retinol binding protein 4, plasma
chr7_+_130131172 0.241 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr6_+_31913852 0.240 CFB
complement factor B
chr1_+_28696056 0.240 NM_001048183
PHACTR4
phosphatase and actin regulator 4
chr10_+_120863558 0.240 FAM45A
family with sequence similarity 45, member A
chr12_-_6798528 0.240 NM_133476
ZNF384
zinc finger protein 384
chr12_+_125549924 0.238 NM_023928
AACS
acetoacetyl-CoA synthetase
chr12_-_112819755 0.237 NM_001109662
C12orf51
chromosome 12 open reading frame 51
chr17_-_8534008 0.236 NM_005964
MYH10
myosin, heavy chain 10, non-muscle
chr2_+_219646704 0.235 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.