Motif ID: HNF4A_NR2F1,2.p2

Z-value: 3.941


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR2F1chr5_+_929205920.485.9e-02Click!
NR2F2chr5_+_929205920.485.9e-02Click!
HNF4Achr20_+_430298650.448.5e-02Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_27370155 14.541 PIPOX
pipecolic acid oxidase
chr14_-_94855120 12.439 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_31623668 10.456 NM_019101
APOM
apolipoprotein M
chr12_+_53497273 10.428 NM_003578
SOAT2
sterol O-acyltransferase 2
chr1_-_169555710 10.353 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr1_-_230849847 10.199 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr6_+_31623688 10.115 APOM
apolipoprotein M
chr12_+_53497287 9.731 SOAT2
sterol O-acyltransferase 2
chr1_-_230849863 9.453 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_21266893 9.278 APOB
apolipoprotein B (including Ag(x) antigen)
chr1_-_169555624 9.095 F5
coagulation factor V (proaccelerin, labile factor)
chr6_+_31982538 9.031 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr5_-_42811959 8.433 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr1_-_161193190 8.040 APOA2
apolipoprotein A-II
chr10_+_102732285 7.759 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr17_+_27369917 7.743 NM_016518
PIPOX
pipecolic acid oxidase
chr11_-_116708334 7.634 NM_000039
APOA1
apolipoprotein A-I
chr11_+_46740769 7.585 F2
coagulation factor II (thrombin)
chr11_+_46740736 7.573 NM_000506
F2
coagulation factor II (thrombin)
chr14_-_24777184 7.511 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_24777153 7.449 CIDEB
cell death-inducing DFFA-like effector b
chr17_-_34329083 7.376 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr3_-_52479042 7.311 NM_020163
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr2_-_21225640 7.139 APOB
apolipoprotein B (including Ag(x) antigen)
chr6_+_31913763 7.105 CFB
complement factor B
chr14_-_24777160 7.048 CIDEB
cell death-inducing DFFA-like effector b
chr1_-_230850335 6.965 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr17_+_19437140 6.897 NM_018242
SLC47A1
solute carrier family 47, member 1
chr13_+_113777112 6.852 NM_000504
F10
coagulation factor X
chr1_-_173886464 6.712 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr6_+_31913852 6.429 CFB
complement factor B
chr14_-_94854910 6.338 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr1_-_173886401 6.244 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr1_-_161193375 6.192 NM_001643
APOA2
apolipoprotein A-II
chr19_+_35629727 6.189 NM_021902
FXYD1
FXYD domain containing ion transport regulator 1
chr10_+_114133838 6.074 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_-_7082654 6.002 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr19_-_6720585 5.924 NM_000064
C3
complement component 3
chr2_-_238499317 5.812 RAB17
RAB17, member RAS oncogene family
chr6_+_31949800 5.720 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr6_-_29527477 5.718 UBD
ubiquitin D
chr2_+_219646448 5.460 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr2_+_219283809 5.363 NM_007127
VIL1
villin 1
chr10_+_114133775 5.215 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_238499713 5.171 NM_022449
RAB17
RAB17, member RAS oncogene family
chr3_-_50340979 5.041 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr4_+_100495972 4.953 MTTP
microsomal triglyceride transfer protein
chr17_-_7018049 4.881 NM_001181
NM_001201352
NM_080912
NM_080913
ASGR2



asialoglycoprotein receptor 2



chrX_-_105282714 4.819 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr3_-_194072004 4.789 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr3_+_186330711 4.705 AHSG
alpha-2-HS-glycoprotein
chr17_+_4675175 4.550 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr6_+_31913708 4.508 NM_001710
CFB
complement factor B
chr20_+_56136136 4.502 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr2_-_88427535 4.472 NM_001443
FABP1
fatty acid binding protein 1, liver
chr19_+_5823817 4.413 NM_004558
NRTN
neurturin
chr22_+_25003610 4.405 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr17_-_7017971 4.345 ASGR2
asialoglycoprotein receptor 2
chr4_+_69962191 4.324 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr17_-_26697224 4.322 VTN
vitronectin
chr19_-_41196419 4.278 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr11_+_73358593 4.225 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_-_110306525 4.187 NM_024526
NM_133181
NM_139053
EPS8L3


EPS8-like 3


chr6_+_31895401 4.176 C2
complement component 2
chr2_-_21266809 4.151 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_41006094 4.137 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr4_-_69886112 4.048 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr19_+_18496966 3.997 NM_004864
GDF15
growth differentiation factor 15
chr14_-_24777064 3.942


chr16_-_87970107 3.933 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr17_-_34328607 3.931 CCL14-CCL15
CCL14-CCL15 readthrough
chr17_+_1646290 3.907 NM_001165920
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr16_-_55867016 3.849 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr17_+_1646129 3.699 NM_000934
NM_001165921
SERPINF2

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

chr13_+_113760101 3.691 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr8_+_21916858 3.680 EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr6_+_31895201 3.679 NM_000063
NM_001145903
C2

complement component 2

chr12_+_7169192 3.649


chr2_-_21266915 3.641 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr17_+_41052813 3.538 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr16_-_55866972 3.536 CES1
carboxylesterase 1
chr12_-_110939877 3.534 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr14_-_65409445 3.458 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr2_+_241544819 3.449 NM_001195381
NM_001195382
GPR35

G protein-coupled receptor 35

chr10_+_101542554 3.407 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr19_-_51869632 3.402 NM_001985
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr2_+_11674241 3.397 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr17_-_34328530 3.374 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr10_+_101542460 3.282 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr8_-_17743062 3.262 FGL1
fibrinogen-like 1
chr17_+_72439187 3.257 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr16_-_16317290 3.248 NM_001079528
NM_001171
ABCC6

ATP-binding cassette, sub-family C (CFTR/MRP), member 6

chr12_-_122296619 3.197 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr12_-_8043743 3.164 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr6_-_29527701 3.151 NM_006398
UBD
ubiquitin D
chr16_+_8768403 3.112 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr19_+_925984 3.110 NM_005224
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr4_-_10023094 3.088 NM_020041
SLC2A9
solute carrier family 2 (facilitated glucose transporter), member 9
chr17_+_1665342 3.084 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr4_+_140587086 3.038 MGST2
microsomal glutathione S-transferase 2
chrX_+_115567746 2.977 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr4_+_140586921 2.936 NM_001204366
NM_001204367
NM_001204368
NM_002413
MGST2



microsomal glutathione S-transferase 2



chr16_+_29471206 2.936 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr7_+_137761177 2.910 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr12_+_100897137 2.894 NM_001206992
NM_001206993
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr14_+_39735500 2.888 NM_001247988
NM_203356
CTAGE5

CTAGE family, member 5

chr3_-_120400957 2.886 HGD
homogentisate 1,2-dioxygenase
chr17_-_26697293 2.867 VTN
vitronectin
chr14_+_74003817 2.837 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr6_+_30130982 2.799 NM_033229
TRIM15
tripartite motif containing 15
chr3_-_58522873 2.795 NM_003500
ACOX2
acyl-CoA oxidase 2, branched chain
chr2_+_42396392 2.785 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr19_-_51869579 2.779 ETFB
electron-transfer-flavoprotein, beta polypeptide
chr1_+_155100304 2.745 NM_004428
NM_182685
EFNA1

ephrin-A1

chr19_-_4540078 2.708 LRG1
leucine-rich alpha-2-glycoprotein 1
chr9_-_99329092 2.701 NM_001077181
CDC14B
CDC14 cell division cycle 14 homolog B (S. cerevisiae)
chr16_-_30124829 2.684 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr14_+_21156922 2.674 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr8_+_21916685 2.640 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr22_+_21128378 2.624 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr3_+_133464883 2.589 NM_001063
TF
transferrin
chr15_-_79237353 2.568 NM_004390
CTSH
cathepsin H
chr19_-_41255827 2.568 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr16_+_29690464 2.560 QPRT
quinolinate phosphoribosyltransferase
chr19_-_633526 2.560 POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr1_+_44064509 2.555 PTPRF
protein tyrosine phosphatase, receptor type, F
chr1_+_145727665 2.539 NM_001201325
NM_001201326
NM_002614
PDZK1


PDZ domain containing 1


chr16_+_30210548 2.533 NM_001017390
NM_177552
SULT1A4
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr3_+_52812438 2.467 NM_001166434
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr17_-_26697310 2.376 VTN
vitronectin
chr9_-_130712866 2.355 NM_203305
FAM102A
family with sequence similarity 102, member A
chr17_+_53344966 2.341 HLF
hepatic leukemia factor
chr16_+_3115312 2.289 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr1_+_145727712 2.275 PDZK1
PDZ domain containing 1
chr18_-_21166440 2.274 NM_000271
NPC1
Niemann-Pick disease, type C1
chr18_-_21166378 2.239 NPC1
Niemann-Pick disease, type C1
chr17_+_41003184 2.235 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr11_-_71781091 2.182 NUMA1
nuclear mitotic apparatus protein 1
chr12_-_57009361 2.178 BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr2_+_159313407 2.177 PKP4
plakophilin 4
chr19_+_45449228 2.170 NM_000483
APOC2
apolipoprotein C-II
chr19_-_55720812 2.150 NM_001161440
NM_002842
PTPRH

protein tyrosine phosphatase, receptor type, H

chrX_-_130423199 2.146 IGSF1
immunoglobulin superfamily, member 1
chr1_+_28696056 2.127 NM_001048183
PHACTR4
phosphatase and actin regulator 4
chr1_-_15911461 2.111 NM_024758
AGMAT
agmatine ureohydrolase (agmatinase)
chr17_+_1665306 2.109 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_-_9921933 2.095 NM_001199551
NM_001199552
CIDEC

cell death-inducing DFFA-like effector c

chr16_-_28621279 2.063 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr17_+_1665281 2.058 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_-_36304200 2.050 NM_021232
PRODH2
proline dehydrogenase (oxidase) 2
chr1_+_65613211 1.995 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr17_+_72427535 1.989 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_+_37896219 1.987 NM_001242443
GRB7
growth factor receptor-bound protein 7
chr10_+_102729249 1.973 SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr11_+_61102035 1.955 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr20_-_3149070 1.951 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr16_+_29690328 1.921 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr22_-_37975937 1.896 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr3_-_49459870 1.896 AMT
aminomethyltransferase
chr17_+_37894212 1.884 GRB7
growth factor receptor-bound protein 7
chr20_+_35973083 1.864 NM_005417
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr2_+_219575507 1.861 NM_014640
TTLL4
tubulin tyrosine ligase-like family, member 4
chr2_+_27719702 1.859 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr11_-_2170792 1.857 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr7_+_149571029 1.844 ATP6V0E2
ATPase, H+ transporting V0 subunit e2
chr19_-_4342718 1.838 STAP2
signal transducing adaptor family member 2
chr3_+_142315205 1.832 NM_001145319
PLS1
plastin 1
chr3_+_38495778 1.827 NM_001106
ACVR2B
activin A receptor, type IIB
chr20_-_22566092 1.817 NM_153675
FOXA2
forkhead box A2
chr11_+_121461070 1.813 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr19_-_36303766 1.811 PRODH2
proline dehydrogenase (oxidase) 2
chr19_+_45445494 1.796 NM_001646
APOC4-APOC2
APOC4
APOC4-APOC2 readthrough
apolipoprotein C-IV
chr2_+_47596286 1.796 NM_002354
EPCAM
epithelial cell adhesion molecule
chr16_+_29912146 1.793 NM_181718
ASPHD1
aspartate beta-hydroxylase domain containing 1
chrX_+_38420690 1.789 NM_004615
TSPAN7
tetraspanin 7
chr19_+_50016490 1.788 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr9_-_95896498 1.786 NM_004148
NINJ1
ninjurin 1
chr11_-_2160199 1.769 NM_000612
IGF2
insulin-like growth factor 2 (somatomedin A)
chr2_+_211421322 1.766 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr19_+_50016500 1.739 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr2_+_228678556 1.734 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr3_-_8693723 1.725 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr3_+_186330859 1.724 AHSG
alpha-2-HS-glycoprotein
chr4_-_69817478 1.707 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr19_-_633563 1.705 NM_005035
POLRMT
polymerase (RNA) mitochondrial (DNA directed)
chr7_-_100882100 1.692 NM_001185080
CLDN15
claudin 15
chr3_-_9920471 1.691 NM_001199623
CIDEC
cell death-inducing DFFA-like effector c
chr7_-_95025622 1.688 NM_000940
PON3
paraoxonase 3
chr20_+_31367637 1.685 NM_175850
DNMT3B
DNA (cytosine-5-)-methyltransferase 3 beta
chr19_+_50016606 1.678 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr16_+_72088507 1.675 NM_001126102
NM_005143
HP

haptoglobin

chr17_+_37894161 1.670 NM_005310
GRB7
growth factor receptor-bound protein 7
chr3_-_120401401 1.658 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr8_+_22224758 1.656 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr12_-_48398284 1.648 NM_001844
NM_033150
COL2A1

collagen, type II, alpha 1

chr3_+_186330844 1.645 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr6_-_47254143 1.639 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_+_211458078 1.635 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr12_-_51419923 1.633 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr2_+_219646704 1.632 CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.30 1.76e-07 GO:0006082 organic acid metabolic process
2.91 4.02e-07 GO:0006629 lipid metabolic process
2.00 2.11e-06 GO:0042221 response to chemical stimulus
3.10 5.10e-06 GO:0019752 carboxylic acid metabolic process
3.10 5.10e-06 GO:0043436 oxoacid metabolic process
3.03 9.08e-06 GO:0042180 cellular ketone metabolic process
9.76 1.65e-05 GO:0055088 lipid homeostasis
16.46 2.00e-05 GO:0071825 protein-lipid complex subunit organization
16.46 2.00e-05 GO:0071827 plasma lipoprotein particle organization
12.18 4.62e-05 GO:0030301 cholesterol transport
25.71 5.77e-05 GO:0034377 plasma lipoprotein particle assembly
25.71 5.77e-05 GO:0065005 protein-lipid complex assembly
11.87 5.91e-05 GO:0015918 sterol transport
3.61 7.29e-05 GO:0071702 organic substance transport
6.16 7.99e-05 GO:0051346 negative regulation of hydrolase activity
18.00 8.15e-05 GO:0033344 cholesterol efflux
5.15 1.16e-04 GO:0052548 regulation of endopeptidase activity
17.14 1.20e-04 GO:0034367 macromolecular complex remodeling
17.14 1.20e-04 GO:0034368 protein-lipid complex remodeling
17.14 1.20e-04 GO:0034369 plasma lipoprotein particle remodeling
4.93 2.11e-04 GO:0052547 regulation of peptidase activity
3.91 2.74e-04 GO:0032787 monocarboxylic acid metabolic process
12.10 2.89e-04 GO:0097006 regulation of plasma lipoprotein particle levels
1.88 3.47e-04 GO:0065008 regulation of biological quality
1.99 3.99e-04 GO:0044281 small molecule metabolic process
8.04 5.24e-04 GO:0006638 neutral lipid metabolic process
8.04 5.24e-04 GO:0006639 acylglycerol metabolic process
4.19 9.07e-04 GO:0008202 steroid metabolic process
6.66 9.74e-04 GO:0010466 negative regulation of peptidase activity
16.24 1.51e-03 GO:0034381 plasma lipoprotein particle clearance
8.27 1.58e-03 GO:0010951 negative regulation of endopeptidase activity
5.61 1.97e-03 GO:0030162 regulation of proteolysis
9.57 1.99e-03 GO:0042632 cholesterol homeostasis
9.57 1.99e-03 GO:0055092 sterol homeostasis
5.11 2.12e-03 GO:0006869 lipid transport
34.28 2.75e-03 GO:0034384 high-density lipoprotein particle clearance
6.43 4.34e-03 GO:0006662 glycerol ether metabolic process
3.92 4.59e-03 GO:0032101 regulation of response to external stimulus
6.35 4.87e-03 GO:0018904 organic ether metabolic process
4.68 5.69e-03 GO:0010876 lipid localization
29.38 6.31e-03 GO:0010873 positive regulation of cholesterol esterification
6.61 1.07e-02 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
1.56 1.23e-02 GO:0051179 localization
25.71 1.24e-02 GO:0010872 regulation of cholesterol esterification
6.43 1.36e-02 GO:0002250 adaptive immune response
15.13 1.85e-02 GO:0043691 reverse cholesterol transport
2.85 2.17e-02 GO:0006066 alcohol metabolic process
22.86 2.20e-02 GO:0033700 phospholipid efflux
2.76 2.23e-02 GO:0009308 amine metabolic process
2.53 2.55e-02 GO:0048878 chemical homeostasis
6.86 2.64e-02 GO:0006641 triglyceride metabolic process
6.86 2.64e-02 GO:0072376 protein activation cascade
1.36 2.79e-02 GO:0050896 response to stimulus
2.24 2.88e-02 GO:0042592 homeostatic process
6.53 3.79e-02 GO:0002449 lymphocyte mediated immunity
38.57 3.88e-02 GO:0010901 regulation of very-low-density lipoprotein particle remodeling
7.66 4.23e-02 GO:0061041 regulation of wound healing
7.50 4.87e-02 GO:0033993 response to lipid

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.10 2.78e-08 GO:0005615 extracellular space
2.58 2.20e-06 GO:0044421 extracellular region part
20.00 5.13e-06 GO:0034361 very-low-density lipoprotein particle
20.00 5.13e-06 GO:0034385 triglyceride-rich lipoprotein particle
2.10 5.36e-06 GO:0005576 extracellular region
12.86 2.57e-05 GO:0032994 protein-lipid complex
12.86 2.57e-05 GO:0034358 plasma lipoprotein particle
14.03 5.86e-04 GO:0034364 high-density lipoprotein particle
25.71 1.84e-03 GO:0034366 spherical high-density lipoprotein particle
18.70 8.30e-03 GO:0034362 low-density lipoprotein particle
18.70 8.30e-03 GO:0042627 chylomicron

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
7.74 1.68e-08 GO:0004866 endopeptidase inhibitor activity
7.60 2.24e-08 GO:0030414 peptidase inhibitor activity
7.41 3.40e-08 GO:0061135 endopeptidase regulator activity
5.10 1.06e-07 GO:0004857 enzyme inhibitor activity
6.12 7.22e-07 GO:0061134 peptidase regulator activity
7.47 8.52e-04 GO:0004867 serine-type endopeptidase inhibitor activity
7.22 3.98e-03 GO:0005319 lipid transporter activity
7.20 1.42e-02 GO:0033293 monocarboxylic acid binding
17.14 1.84e-02 GO:0015248 sterol transporter activity
30.85 2.12e-02 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
4.73 3.60e-02 GO:0008201 heparin binding