Motif ID: NKX3-2.p2

Z-value: 1.456


Transcription factors associated with NKX3-2.p2:

Gene SymbolEntrez IDGene Name
NKX3-2 579 NK3 homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-2chr4_-_135460370.146.0e-01Click!


Activity profile for motif NKX3-2.p2.

activity profile for motif NKX3-2.p2


Sorted Z-values histogram for motif NKX3-2.p2

Sorted Z-values for motif NKX3-2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_32497925 2.575 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr14_-_107179043 2.374 IGHA1
immunoglobulin heavy constant alpha 1
chr5_-_149792370 2.336 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr17_-_38721701 2.058 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr14_-_106471439 1.844 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr5_+_118604504 1.825 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_118604417 1.653 NM_001077654
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr10_-_98031154 1.651 NM_001114094
NM_013314
BLNK

B-cell linker

chr11_-_111249902 1.552 POU2AF1
POU class 2 associating factor 1
chr11_+_60223281 1.513 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr6_+_32407618 1.352 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr6_-_32557431 1.327 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr5_-_149792276 1.300 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_41715078 1.296 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr2_+_17721983 1.291 VSNL1
visinin-like 1
chr1_-_111743261 1.222 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr10_-_90712510 1.190 NM_001613
ACTA2
actin, alpha 2, smooth muscle, aorta
chr14_+_105953531 1.186 CRIP1
cysteine-rich protein 1 (intestinal)
chr8_+_123793894 1.161 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr8_+_123793988 1.160 ZHX2
zinc fingers and homeoboxes 2
chr2_+_228678556 1.127 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr7_+_26403944 1.123 NM_001199838
SNX10
sorting nexin 10
chr1_-_111743297 1.055 DENND2D
DENN/MADD domain containing 2D
chr11_-_111250156 1.046 NM_006235
POU2AF1
POU class 2 associating factor 1
chr8_+_123794043 1.032 ZHX2
zinc fingers and homeoboxes 2
chr16_-_88717395 0.960 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr3_+_121774208 0.937 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr9_+_2621740 0.897 NM_001018056
NM_003383
VLDLR

very low density lipoprotein receptor

chr13_+_31287614 0.830 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr7_+_26331611 0.824 SNX10
sorting nexin 10
chr6_+_29974352 0.807 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr7_+_26331493 0.805 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr22_+_22569155 0.787


chr7_+_94292816 0.781 PEG10
paternally expressed 10
chr16_-_11680756 0.779 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr7_-_37488408 0.771 ELMO1
engulfment and cell motility 1
chr1_-_25256767 0.770 NM_004350
RUNX3
runt-related transcription factor 3
chr10_+_7745341 0.767 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr17_-_29648631 0.757 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr1_-_25291474 0.750 NM_001031680
RUNX3
runt-related transcription factor 3
chr2_-_238322770 0.747 COL6A3
collagen, type VI, alpha 3
chr8_-_122653493 0.739 NM_005328
HAS2
hyaluronan synthase 2
chr2_+_17721806 0.734 NM_003385
VSNL1
visinin-like 1
chr10_+_7745325 0.726 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr19_+_50922194 0.724 NM_001243998
NM_001243999
NM_001244000
NM_003121
SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chr6_+_32605182 0.707 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_-_238322840 0.704 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr9_+_2622052 0.703 VLDLR
very low density lipoprotein receptor
chr11_+_1889902 0.698 NM_001013253
LSP1
lymphocyte-specific protein 1
chrX_+_128913881 0.692 NM_018990
SASH3
SAM and SH3 domain containing 3
chr6_-_31324955 0.692 HLA-B
major histocompatibility complex, class I, B
chr6_-_31324898 0.692 HLA-B
major histocompatibility complex, class I, B
chr14_-_106733392 0.687 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chrX_+_128913897 0.683 SASH3
SAM and SH3 domain containing 3
chr2_+_68592432 0.678 PLEK
pleckstrin
chr20_-_52199635 0.675 NM_006526
ZNF217
zinc finger protein 217
chr10_+_7745354 0.675 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr16_+_57406398 0.674 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr22_+_37257004 0.671 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr1_-_221915458 0.665 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr5_-_42811959 0.664 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr17_-_29641094 0.657 NM_006495
EVI2B
ecotropic viral integration site 2B
chr6_-_31324975 0.657 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr3_+_133495925 0.649 TF
transferrin
chrX_-_32173585 0.649 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr10_+_7745284 0.646 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_186330711 0.646 AHSG
alpha-2-HS-glycoprotein
chr22_-_37545944 0.639 NM_000878
IL2RB
interleukin 2 receptor, beta
chr19_-_7766978 0.638 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr1_-_221915393 0.638 DUSP10
dual specificity phosphatase 10
chr17_-_29641087 0.632 EVI2B
ecotropic viral integration site 2B
chr22_+_23165273 0.622


chr6_+_29855506 0.612


chr3_+_179370779 0.610 NM_003940
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr2_+_86668488 0.609 NM_001146688
KDM3A
lysine (K)-specific demethylase 3A
chr3_-_79817058 0.608 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_-_32634287 0.608 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr17_-_29641068 0.607 EVI2B
ecotropic viral integration site 2B
chr12_+_100867739 0.602 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr10_-_95360959 0.601 NM_006744
RBP4
retinol binding protein 4, plasma
chr3_-_55515361 0.599 WNT5A
wingless-type MMTV integration site family, member 5A
chr19_-_6720585 0.597 NM_000064
C3
complement component 3
chr3_-_81810816 0.595 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_+_64088886 0.594 NM_001172818
PGM1
phosphoglucomutase 1
chr7_+_94292737 0.591 PEG10
paternally expressed 10
chr14_-_106539099 0.591 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr19_+_42381189 0.590 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr3_+_186330844 0.590 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr10_+_7745229 0.588 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_221915426 0.585 DUSP10
dual specificity phosphatase 10
chr3_-_182880463 0.585 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr20_+_46130656 0.583 NCOA3
nuclear receptor coactivator 3
chr1_+_212738675 0.583 NM_001030287
ATF3
activating transcription factor 3
chr3_+_186330859 0.573 AHSG
alpha-2-HS-glycoprotein
chr3_-_114343791 0.569 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_81812925 0.568 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr9_+_117092068 0.567 NM_000608
ORM2
orosomucoid 2
chr2_+_231729623 0.564 ITM2C
integral membrane protein 2C
chr13_+_31309644 0.563 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr14_-_106829736 0.561 IGHA1
IGHD
IGHG3
IGHM
SKAP2
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
src kinase associated phosphoprotein 2
chr9_+_2622099 0.560 VLDLR
very low density lipoprotein receptor
chr12_+_7169192 0.555


chr2_+_102979096 0.554 NM_003855
IL18R1
interleukin 18 receptor 1
chr14_-_106494166 0.553 IGHV4-31
IGHA1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
chr5_-_150537306 0.551 ANXA6
annexin A6
chr1_-_156399183 0.546 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr9_+_2622134 0.543 VLDLR
very low density lipoprotein receptor
chr2_-_239197091 0.534 NM_022817
PER2
period homolog 2 (Drosophila)
chr16_+_81812899 0.526 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr2_+_86668428 0.526 KDM3A
lysine (K)-specific demethylase 3A
chr16_-_4896197 0.525 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr6_-_31550065 0.524 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr7_-_37488554 0.518 NM_014800
ELMO1
engulfment and cell motility 1
chr13_-_46756326 0.515 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_41703938 0.513 NM_001167827
TFEB
transcription factor EB
chr4_-_110723127 0.512 CFI
complement factor I
chr14_-_106877689 0.511 IGHV4-31
IGH@
IGHA1
IGHA2
IGHG1
IGHG4
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy locus
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 4 (G4m marker)
immunoglobulin heavy constant mu
chr1_-_25256364 0.505 RUNX3
runt-related transcription factor 3
chr5_-_150537335 0.503 NM_001155
ANXA6
annexin A6
chr3_+_53195214 0.503 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr5_+_156696351 0.503 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr21_-_46340821 0.502 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr20_-_61557818 0.499 DIDO1
death inducer-obliterator 1
chr10_-_74856590 0.497 P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr13_-_46756295 0.497 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_-_81810618 0.496 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr13_+_76334796 0.495 NM_015842
LMO7
LIM domain 7
chr16_-_21289637 0.492 CRYM
crystallin, mu
chr3_+_48507209 0.488 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr5_-_150467220 0.488 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr21_-_46340776 0.485 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_127413739 0.485 GYPC
glycophorin C (Gerbich blood group)
chr12_-_53601051 0.483 ITGB7
integrin, beta 7
chr8_+_26435920 0.481 NM_001244604
DPYSL2
dihydropyrimidinase-like 2
chr20_+_46130600 0.478 NM_001174087
NM_001174088
NM_006534
NM_181659
NCOA3



nuclear receptor coactivator 3



chr1_+_156119734 0.478 NM_001193301
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr3_+_100211554 0.475 TMEM45A
transmembrane protein 45A
chr10_-_74856656 0.474 NM_000917
NM_001017962
NM_001142595
NM_001142596
P4HA1



prolyl 4-hydroxylase, alpha polypeptide I



chr4_+_113970784 0.473 NM_001148
NM_020977
ANK2

ankyrin 2, neuronal

chr7_+_94297448 0.473 PEG10
paternally expressed 10
chr12_-_103311053 0.472 PAH
phenylalanine hydroxylase
chr17_+_25958245 0.471 LGALS9
lectin, galactoside-binding, soluble, 9
chr10_+_16478941 0.466 NM_001001484
NM_030664
PTER

phosphotriesterase related

chr12_+_53693454 0.464 NM_021640
C12orf10
chromosome 12 open reading frame 10
chr14_+_24563369 0.462 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr12_+_25205180 0.462 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr2_-_37899227 0.460 NM_006449
CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
chr5_-_88119604 0.457 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr7_+_101928390 0.454 NM_020979
SH2B2
SH2B adaptor protein 2
chr14_+_65878579 0.454 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr8_-_17942410 0.451 NM_001127505
NM_004315
ASAH1

N-acylsphingosine amidohydrolase (acid ceramidase) 1

chr10_+_76586299 0.448 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chr7_+_101928417 0.447 SH2B2
SH2B adaptor protein 2
chr1_+_26644458 0.443 CD52
CD52 molecule
chr17_+_53342356 0.443 HLF
hepatic leukemia factor
chr14_-_106452693 0.439 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_+_117085302 0.437 NM_000607
ORM1
orosomucoid 1
chr19_+_49838673 0.435 NM_001040031
NM_001774
CD37

CD37 molecule

chr2_-_220436267 0.435 NM_001173408
NM_001173431
NM_015311
OBSL1


obscurin-like 1


chr20_-_22564893 0.432 FOXA2
forkhead box A2
chr20_+_55966440 0.430 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr10_+_114135937 0.429 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr5_-_150466696 0.428 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr12_+_4382882 0.427 NM_001759
CCND2
cyclin D2
chr5_-_150537261 0.427 ANXA6
annexin A6
chr2_+_62932786 0.424 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr12_+_54447660 0.422 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr6_+_29855349 0.422 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr4_+_74301932 0.421 NM_001134
AFP
alpha-fetoprotein
chr6_-_32821743 0.418 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr13_-_47012324 0.418 KIAA0226L
KIAA0226-like
chr14_-_107113943 0.414 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_12391708 0.413 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr9_-_132805256 0.413 FNBP1
formin binding protein 1
chr3_+_16974581 0.412 NM_015184
PLCL2
phospholipase C-like 2
chr13_+_113777112 0.412 NM_000504
F10
coagulation factor X
chr1_-_31230594 0.411 LAPTM5
lysosomal protein transmembrane 5
chr2_-_242255114 0.411 NM_005336
HDLBP
high density lipoprotein binding protein
chr4_-_110723334 0.410 NM_000204
CFI
complement factor I
chr4_-_141348760 0.407 NM_001130675
NM_004362
CLGN

calmegin

chr4_+_100495972 0.406 MTTP
microsomal triglyceride transfer protein
chr6_+_57037333 0.405 BAG2
BCL2-associated athanogene 2
chr1_+_12185955 0.404 NM_152942
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr3_+_48507621 0.400 TREX1
three prime repair exonuclease 1
chr16_+_57392694 0.399 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr14_-_107013474 0.399 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_-_178789597 0.395 NM_022470
NM_152240
ZMAT3

zinc finger, matrin-type 3

chr5_+_53751430 0.393 NM_006308
HSPB3
heat shock 27kDa protein 3
chr1_+_212782103 0.392 ATF3
activating transcription factor 3
chr2_-_220436010 0.392 OBSL1
obscurin-like 1
chr19_+_49838700 0.392 CD37
CD37 molecule
chr5_+_133451297 0.391 NM_001134851
NM_201632
NM_201634
NM_213648
TCF7



transcription factor 7 (T-cell specific, HMG-box)



chr1_+_181002560 0.390 NM_001194999
NM_001195000
NM_001195035
NM_001531
MR1



major histocompatibility complex, class I-related



chr3_-_178789535 0.387 ZMAT3
zinc finger, matrin-type 3
chr19_+_49838646 0.386 CD37
CD37 molecule
chr1_-_57045129 0.385 PPAP2B
phosphatidic acid phosphatase type 2B
chr7_-_37488894 0.383 NM_001206480
ELMO1
engulfment and cell motility 1
chr14_+_75988765 0.382 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr7_-_99573637 0.380 NM_001185
AZGP1
alpha-2-glycoprotein 1, zinc-binding
chr17_+_34171647 0.378 TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
11.85 2.12e-09 GO:0006955 immune response
7.36 5.56e-07 GO:0002376 immune system process
158.15 1.34e-06 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
60.86 2.21e-06 GO:0019882 antigen processing and presentation
16.48 1.45e-02 GO:0051251 positive regulation of lymphocyte activation
15.38 1.89e-02 GO:0002696 positive regulation of leukocyte activation
15.11 2.03e-02 GO:0050867 positive regulation of cell activation
13.16 3.47e-02 GO:0051249 regulation of lymphocyte activation
24.07 4.28e-02 GO:0006959 humoral immune response
11.98 4.98e-02 GO:0002694 regulation of leukocyte activation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
180.74 2.01e-07 GO:0042613 MHC class II protein complex
84.37 5.41e-06 GO:0042611 MHC protein complex
26.68 5.91e-04 GO:0005770 late endosome
40.42 2.47e-03 GO:0031902 late endosome membrane
8.53 1.00e-02 GO:0005768 endosome
12.33 1.22e-02 GO:0010008 endosome membrane
12.21 1.26e-02 GO:0044440 endosomal part
11.44 1.62e-02 GO:0000323 lytic vacuole
11.44 1.62e-02 GO:0005764 lysosome
20.90 1.77e-02 GO:0005765 lysosomal membrane
9.63 3.12e-02 GO:0005773 vacuole
15.73 4.09e-02 GO:0005774 vacuolar membrane
15.11 4.60e-02 GO:0044437 vacuolar part
14.87 4.81e-02 GO:0009897 external side of plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
47.48 4.77e-04 GO:0003823 antigen binding