Motif ID: NR4A2.p2

Z-value: 1.664


Transcription factors associated with NR4A2.p2:

monomer

Gene SymbolEntrez IDGene Name
NR4A2 4929 nuclear receptor subfamily 4, group A, member 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR4A2chr2_-_157189040-0.495.3e-02Click!


Activity profile for motif NR4A2.p2.

activity profile for motif NR4A2.p2


Sorted Z-values histogram for motif NR4A2.p2

Sorted Z-values for motif NR4A2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NR4A2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_106174914 2.390 IGHA1
immunoglobulin heavy constant alpha 1
chr22_+_23213671 2.198 IGLV4-3
immunoglobulin lambda variable 4-3
chr5_-_149792370 2.043 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr5_-_149792276 1.907 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr11_+_7535000 1.785 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr4_-_111563278 1.655 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chr1_+_236849753 1.619 NM_001103
ACTN2
actinin, alpha 2
chr2_-_158300517 1.492 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_+_64088886 1.481 NM_001172818
PGM1
phosphoglucomutase 1
chr12_-_53601051 1.479 ITGB7
integrin, beta 7
chr7_+_69063768 1.364 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr11_+_22696318 1.333 NM_005256
GAS2
growth arrest-specific 2
chr1_-_161193190 1.317 APOA2
apolipoprotein A-II
chr6_+_89790412 1.306 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr19_-_11689765 1.299 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr12_-_16759430 1.295 LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_52886971 1.275 NM_005554
KRT6A
keratin 6A
chr3_+_121774208 1.270 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr1_-_111743261 1.244 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr11_+_65190272 1.220


chr9_+_112887780 1.208 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr18_-_46469118 1.200 NM_001190823
SMAD7
SMAD family member 7
chr19_+_49838673 1.188 NM_001040031
NM_001774
CD37

CD37 molecule

chr4_+_68424444 1.186 NM_012108
STAP1
signal transducing adaptor family member 1
chr19_+_49838646 1.179 CD37
CD37 molecule
chrX_-_21776158 1.155 NM_014332
SMPX
small muscle protein, X-linked
chr12_-_16759531 1.153 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_-_21225640 1.087 APOB
apolipoprotein B (including Ag(x) antigen)
chr6_+_89790464 1.082 PNRC1
proline-rich nuclear receptor coactivator 1
chr19_+_49838734 1.064 CD37
CD37 molecule
chr14_-_106208537 1.063


chr12_-_16759939 1.038 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_+_100495972 1.034 MTTP
microsomal triglyceride transfer protein
chr11_-_58345593 1.023 NM_001143995
LPXN
leupaxin
chr3_-_47957475 1.021


chr12_-_52867521 1.017 NM_173086
KRT6C
keratin 6C
chr1_+_46640748 1.003 NM_005727
TSPAN1
tetraspanin 1
chr19_+_49838700 1.001 CD37
CD37 molecule
chr1_+_64059479 0.998 NM_001172819
PGM1
phosphoglucomutase 1
chr17_-_46507481 0.995 NM_001075099
NM_003726
SKAP1

src kinase associated phosphoprotein 1

chr2_+_170366211 0.995 NM_006063
KBTBD10
kelch repeat and BTB (POZ) domain containing 10
chr2_+_228678556 0.994 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr1_-_229569839 0.990 NM_001100
ACTA1
actin, alpha 1, skeletal muscle
chr12_+_25205180 0.984 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr1_-_116311330 0.965 CASQ2
calsequestrin 2 (cardiac muscle)
chr12_-_53600999 0.962 NM_000889
ITGB7
integrin, beta 7
chr17_-_38721701 0.954 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr16_+_72088507 0.950 NM_001126102
NM_005143
HP

haptoglobin

chr11_-_58343308 0.948 NM_004811
LPXN
leupaxin
chr1_-_201346804 0.944 NM_000364
NM_001001430
NM_001001431
NM_001001432
TNNT2



troponin T type 2 (cardiac)



chr19_-_11689591 0.944 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr5_+_125800786 0.938 NM_001146322
GRAMD3
GRAM domain containing 3
chr15_+_52311432 0.932 MAPK6
mitogen-activated protein kinase 6
chr3_+_100238063 0.925 TMEM45A
transmembrane protein 45A
chr19_-_41255827 0.925 NM_198476
C19orf54
chromosome 19 open reading frame 54
chr1_-_116311161 0.925 CASQ2
calsequestrin 2 (cardiac muscle)
chr17_+_4854383 0.920 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr17_+_27370155 0.909 PIPOX
pipecolic acid oxidase
chr19_-_39108534 0.908 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr14_-_106208695 0.888


chr15_+_78441737 0.865 IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr17_-_39743085 0.859 NM_000526
KRT14
keratin 14
chr20_-_34241830 0.850 NM_003915
CPNE1
copine I
chr1_+_152881022 0.840 NM_005547
IVL
involucrin
chr2_+_85804689 0.826 VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr4_-_40517913 0.824 NM_019027
RBM47
RNA binding motif protein 47
chr10_-_101841593 0.812 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr16_+_27413482 0.809 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr2_-_211168315 0.807 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr12_-_16759733 0.801 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr12_-_16758839 0.801 NM_001243612
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_-_111743297 0.790 DENND2D
DENN/MADD domain containing 2D
chr11_-_47470687 0.786 NM_005055
NM_032645
RAPSN

receptor-associated protein of the synapse

chr5_-_150537306 0.783 ANXA6
annexin A6
chr6_+_32605182 0.783 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr16_-_68269948 0.780 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr2_-_216878314 0.771 NM_018000
MREG
melanoregulin
chr9_-_6645564 0.758 NM_000170
GLDC
glycine dehydrogenase (decarboxylating)
chr11_+_116700620 0.752 NM_000040
APOC3
apolipoprotein C-III
chr17_-_56494889 0.746 RNF43
ring finger protein 43
chr14_-_107131217 0.743 IGHA1
immunoglobulin heavy constant alpha 1
chr9_-_123689172 0.739 NM_005658
TRAF1
TNF receptor-associated factor 1
chr3_-_50340979 0.739 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr22_+_22735134 0.731 CYAT1
immunoglobulin lambda light chain-like
chr5_-_150537335 0.726 NM_001155
ANXA6
annexin A6
chr13_-_46756326 0.721 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr13_-_46679143 0.717 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr17_+_2680349 0.699 RAP1GAP2
RAP1 GTPase activating protein 2
chr12_-_16760935 0.697 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr1_-_169555624 0.695 F5
coagulation factor V (proaccelerin, labile factor)
chr17_+_27369917 0.695 NM_016518
PIPOX
pipecolic acid oxidase
chr17_+_52978022 0.693 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr11_+_1886394 0.690 NM_001242932
LSP1
lymphocyte-specific protein 1
chr15_+_78441678 0.690 NM_005530
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr1_-_169555710 0.687 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr17_+_48610045 0.687 NM_017957
EPN3
epsin 3
chr8_-_29206321 0.680 NM_057158
DUSP4
dual specificity phosphatase 4
chr11_+_7618416 0.673 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr19_-_41256371 0.673 C19orf54
chromosome 19 open reading frame 54
chr12_-_52914080 0.672 NM_000424
KRT5
keratin 5
chr5_-_150537261 0.672 ANXA6
annexin A6
chr3_-_151034514 0.668 NM_023915
GPR87
G protein-coupled receptor 87
chr2_-_89165652 0.658


chr10_+_63808968 0.653 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr4_+_41614911 0.642 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr22_+_22712091 0.641 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr1_+_32739711 0.633 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr5_-_74162614 0.632 NM_015566
FAM169A
family with sequence similarity 169, member A
chr20_+_9458460 0.626 PLCB4
phospholipase C, beta 4
chr5_+_49961732 0.623 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr16_+_56966025 0.618 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr12_-_28124915 0.616 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr16_+_30386097 0.616 NM_013292
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chr14_-_107179043 0.611 IGHA1
immunoglobulin heavy constant alpha 1
chr14_-_106691698 0.608


chr6_-_41702734 0.607 NM_007162
TFEB
transcription factor EB
chr17_-_2614926 0.606 NM_015229
KIAA0664
KIAA0664
chr16_+_28943259 0.596 NM_001178098
NM_001770
CD19

CD19 molecule

chr2_+_85804613 0.594 NM_003761
VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr14_-_24036939 0.590 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr6_+_7541863 0.584 NM_001008844
NM_004415
DSP

desmoplakin

chrX_+_38420690 0.579 NM_004615
TSPAN7
tetraspanin 7
chr17_-_46507599 0.575 SKAP1
src kinase associated phosphoprotein 1
chr15_+_52311438 0.572 MAPK6
mitogen-activated protein kinase 6
chr12_+_7060433 0.556 NM_002831
NM_080549
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr3_-_52488030 0.555 NM_003280
TNNC1
troponin C type 1 (slow)
chr14_-_65409445 0.554 NM_002083
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr6_+_31543340 0.553 NM_000594
TNF
tumor necrosis factor
chr15_+_52311408 0.545 NM_002748
MAPK6
mitogen-activated protein kinase 6
chr1_+_174769034 0.543 NM_001243765
RABGAP1L
RAB GTPase activating protein 1-like
chr17_-_39675078 0.542 NM_002275
KRT15
keratin 15
chr20_+_49126920 0.542 PTPN1
protein tyrosine phosphatase, non-receptor type 1
chr21_-_44845920 0.542 SIK1
salt-inducible kinase 1
chr22_-_43343046 0.535 NM_007229
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr7_+_94536926 0.535 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr2_+_234621637 0.529 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr4_-_155533800 0.528 FGG
fibrinogen gamma chain
chr16_+_31366529 0.524 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr10_+_76586299 0.520 NM_012330
KAT6B
K(lysine) acetyltransferase 6B
chr2_+_85804724 0.517 VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr1_-_161193375 0.515 NM_001643
APOA2
apolipoprotein A-II
chr13_-_46756295 0.515 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_133118789 0.514 NM_003571
BFSP2
beaded filament structural protein 2, phakinin
chr16_+_6069094 0.509 NM_001142333
NM_018723
RBFOX1

RNA binding protein, fox-1 homolog (C. elegans) 1

chr11_+_121461070 0.509 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr6_-_31550065 0.508 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr10_+_88428167 0.508 NM_001171610
LDB3
LIM domain binding 3
chr17_-_39768939 0.506 NM_005557
KRT16
keratin 16
chr15_-_34681891 0.504 NM_181077
GOLGA8A
GOLGA8B
golgin A8 family, member A
golgin A8 family, member B
chr1_-_183559669 0.500 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr19_-_7293876 0.496 NM_000208
NM_001079817
INSR

insulin receptor

chr3_-_78666943 0.494 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr3_-_197024879 0.486 DLG1
discs, large homolog 1 (Drosophila)
chr14_-_94854910 0.485 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_43737937 0.483 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr14_-_23288912 0.483 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr3_+_113251217 0.481 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr15_-_83621350 0.478 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr17_+_70117168 0.476 SOX9
SRY (sex determining region Y)-box 9
chr8_-_131028674 0.473 FAM49B
family with sequence similarity 49, member B
chr12_-_772525 0.472 NM_016533
NINJ2
ninjurin 2
chr7_+_99775521 0.466 NM_012447
STAG3
stromal antigen 3
chr1_-_209824641 0.466 NM_001017402
LAMB3
laminin, beta 3
chr12_-_56106061 0.465 NM_001144997
ITGA7
integrin, alpha 7
chr3_-_194072004 0.458 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr7_+_94285676 0.458 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr22_+_21128378 0.457 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr7_+_129932973 0.457 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr2_+_102979096 0.455 NM_003855
IL18R1
interleukin 18 receptor 1
chr13_+_43136871 0.454 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr6_+_7541892 0.454 DSP
desmoplakin
chr14_-_55369163 0.453 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr1_-_203144910 0.452 NM_004997
MYBPH
myosin binding protein H
chr22_-_34316325 0.452 NM_004737
NM_133642
LARGE

like-glycosyltransferase

chr4_-_103266577 0.452 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr17_+_70117177 0.451 SOX9
SRY (sex determining region Y)-box 9
chr13_-_46756291 0.450 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_68592317 0.450 NM_002664
PLEK
pleckstrin
chrX_-_105282714 0.448 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr2_-_190927321 0.448 NM_005259
MSTN
myostatin
chr4_-_15940362 0.448 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr10_+_114133838 0.445 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr17_+_70117154 0.442 NM_000346
SOX9
SRY (sex determining region Y)-box 9
chr11_-_34379526 0.441 NM_145804
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr5_+_59784004 0.440 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr16_+_31366468 0.439 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr16_+_8807426 0.438 ABAT
4-aminobutyrate aminotransferase
chr7_+_94285620 0.436 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr14_-_96180402 0.434 NM_001098725
NM_021966
TCL1A

T-cell leukemia/lymphoma 1A

chr17_-_56494930 0.432 NM_017763
RNF43
ring finger protein 43
chr12_-_6484904 0.431 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr17_+_48610077 0.428 EPN3
epsin 3
chr6_-_6320897 0.427 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr1_-_209825797 0.424 NM_000228
LAMB3
laminin, beta 3
chr19_+_45449228 0.424 NM_000483
APOC2
apolipoprotein C-II
chr1_+_213031596 0.423 NM_014053
FLVCR1
feline leukemia virus subgroup C cellular receptor 1
chr22_-_43355886 0.423 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr1_-_182573393 0.422 NM_002928
RGS16
regulator of G-protein signaling 16
chr16_-_52581713 0.421 NM_001146188
TOX3
TOX high mobility group box family member 3
chr18_-_47339854 0.420 ACAA2
acetyl-CoA acyltransferase 2

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
85.21 1.75e-02 GO:0042627 chylomicron
52.09 4.83e-02 GO:0034361 very-low-density lipoprotein particle
52.09 4.83e-02 GO:0034385 triglyceride-rich lipoprotein particle

Nothing significant found in function category.