Motif ID: ONECUT1,2.p2

Z-value: 1.291


Transcription factors associated with ONECUT1,2.p2:

Gene SymbolEntrez IDGene Name
ONECUT1 3175 one cut homeobox 1
ONECUT2 9480 one cut homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ONECUT2chr18_+_551027770.702.5e-03Click!
ONECUT1chr15_-_530820870.639.1e-03Click!


Activity profile for motif ONECUT1,2.p2.

activity profile for motif ONECUT1,2.p2


Sorted Z-values histogram for motif ONECUT1,2.p2

Sorted Z-values for motif ONECUT1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ONECUT1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_30130982 5.844 NM_033229
TRIM15
tripartite motif containing 15
chr10_+_7745341 3.998 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745354 3.965 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745284 3.884 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745229 3.868 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chrX_-_131573638 3.794 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr10_+_7745325 3.778 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr5_-_149792370 3.665 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr6_-_41715078 3.277 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr5_-_149792276 3.274 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr18_+_29171729 3.095 NM_000371
TTR
transthyretin
chrX_+_46940235 2.984 RGN
regucalcin (senescence marker protein-30)
chr6_+_31895201 2.958 NM_000063
NM_001145903
C2

complement component 2

chr11_+_22696318 2.729 NM_005256
GAS2
growth arrest-specific 2
chr4_-_155511838 2.721 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chr6_+_31913852 2.582 CFB
complement factor B
chr10_-_98031154 2.494 NM_001114094
NM_013314
BLNK

B-cell linker

chr7_+_94297448 2.481 PEG10
paternally expressed 10
chr4_-_69886112 2.464 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr15_-_60919642 2.336 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr3_-_148939784 2.249 NM_000096
CP
ceruloplasmin (ferroxidase)
chr20_-_34241830 2.069 NM_003915
CPNE1
copine I
chr6_+_64286348 1.998 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr22_+_23054862 1.898 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr13_-_46679143 1.728 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr16_+_69680959 1.672 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr1_+_111413820 1.622 NM_001040033
CD53
CD53 molecule
chr1_+_198608136 1.612 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr4_-_69817478 1.599 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr7_+_45933096 1.589


chr1_+_198608244 1.580 PTPRC
protein tyrosine phosphatase, receptor type, C
chr9_-_123812535 1.548 NM_001735
C5
complement component 5
chr2_-_89165652 1.531


chr1_+_212788359 1.524 NM_001206486
ATF3
activating transcription factor 3
chr4_+_69681709 1.520 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr14_-_23426356 1.512 HAUS4
HAUS augmin-like complex, subunit 4
chr7_-_100239136 1.454 NM_003227
TFR2
transferrin receptor 2
chr3_-_183273407 1.445 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr3_-_170744767 1.420 NM_000340
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr1_+_198608216 1.388 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_-_56494930 1.369 NM_017763
RNF43
ring finger protein 43
chr7_+_94292737 1.341 PEG10
paternally expressed 10
chr8_+_123794043 1.325 ZHX2
zinc fingers and homeoboxes 2
chr4_-_70080448 1.300 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr1_+_15990300 1.277


chr5_+_70944968 1.269 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr17_-_64225496 1.253 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_-_48389514 1.208 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr14_+_39736529 1.206 CTAGE5
CTAGE family, member 5
chr15_-_37391893 1.112 MEIS2
Meis homeobox 2
chr3_-_49459870 1.106 AMT
aminomethyltransferase
chr14_-_23426265 1.093 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chr7_-_23509972 1.089 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr10_-_101841593 1.085 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr9_+_35673852 1.071 NM_001216
CA9
carbonic anhydrase IX
chrX_-_32430370 1.062 NM_004011
NM_004012
DMD

dystrophin

chr3_-_49460110 1.050 NM_000481
NM_001164710
NM_001164711
NM_001164712
AMT



aminomethyltransferase



chr2_-_88427535 1.041 NM_001443
FABP1
fatty acid binding protein 1, liver
chr13_-_46756295 1.040 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_+_33043702 0.998 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr3_-_105421044 0.987 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr5_+_68667280 0.971 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr10_-_52645384 0.967 A1CF
APOBEC1 complementation factor
chr6_-_79675672 0.959 PHIP
pleckstrin homology domain interacting protein
chr19_-_39826676 0.941 NM_004877
GMFG
glia maturation factor, gamma
chr10_-_116392099 0.930 ABLIM1
actin binding LIM protein 1
chr11_+_22689653 0.897 NM_177553
GAS2
growth arrest-specific 2
chr12_-_9268440 0.886 A2M
alpha-2-macroglobulin
chr10_+_102732285 0.877 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr7_+_120702818 0.871 C7orf58
chromosome 7 open reading frame 58
chrX_-_131547536 0.869 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr10_+_63661012 0.859 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr21_-_43735705 0.843 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr11_+_22688156 0.817 NM_001143830
GAS2
growth arrest-specific 2
chr17_+_72439187 0.797 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr10_-_52645430 0.779 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr5_+_139876504 0.764 ANKHD1
ankyrin repeat and KH domain containing 1
chr5_+_176516550 0.750 NM_022963
FGFR4
fibroblast growth factor receptor 4
chr17_-_49124128 0.739 NM_001251971
SPAG9
sperm associated antigen 9
chr13_-_46756291 0.738 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_121774208 0.735 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr4_-_116034932 0.721 NM_022569
NDST4
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr14_-_38064176 0.710 FOXA1
forkhead box A1
chr6_+_74171610 0.706 MTO1
mitochondrial translation optimization 1 homolog (S. cerevisiae)
chr15_-_80263460 0.702 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr4_+_74301932 0.699 NM_001134
AFP
alpha-fetoprotein
chr13_-_46756326 0.681 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_-_32920812 0.678 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr6_+_100054649 0.674 NM_021620
PRDM13
PR domain containing 13
chr6_+_56954985 0.672 ZNF451
zinc finger protein 451
chr6_-_41703938 0.661 NM_001167827
TFEB
transcription factor EB
chr4_-_84035888 0.654 PLAC8
placenta-specific 8
chr3_+_12392993 0.652 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr20_+_48552928 0.648 RNF114
ring finger protein 114
chr1_-_51887740 0.644 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr6_+_56954978 0.643 ZNF451
zinc finger protein 451
chr5_+_68666861 0.626 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr15_-_65412175 0.625 PDCD7
programmed cell death 7
chr7_+_6617035 0.622 NM_001134387
NM_001134388
NM_001134389
NM_018106
ZDHHC4



zinc finger, DHHC-type containing 4



chr1_-_151431648 0.616 POGZ
pogo transposable element with ZNF domain
chr7_+_94539209 0.610 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chrX_-_33357725 0.603 NM_000109
DMD
dystrophin
chr12_+_8332789 0.601 FAM66C
family with sequence similarity 66, member C
chr4_+_187187117 0.593 NM_000128
F11
coagulation factor XI
chr8_-_80993009 0.586 NM_001025252
TPD52
tumor protein D52
chr6_+_43738177 0.584 VEGFA
vascular endothelial growth factor A
chr19_-_48389571 0.583 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr20_+_48552902 0.583 NM_018683
RNF114
ring finger protein 114
chr6_+_30227335 0.570 HLA-L
major histocompatibility complex, class I, L, pseudogene
chr18_-_47814691 0.570 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr6_+_56954801 0.568 NM_001031623
NM_015555
ZNF451

zinc finger protein 451

chr20_+_48552935 0.559 RNF114
ring finger protein 114
chrX_-_24690740 0.558 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chrX_-_129272014 0.555 NM_001130846
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr6_+_43738394 0.547 VEGFA
vascular endothelial growth factor A
chr13_-_75901897 0.543 TBC1D4
TBC1 domain family, member 4
chr12_+_54892567 0.540 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr10_-_42863435 0.534 LOC441666
zinc finger protein 91 pseudogene
chr14_+_21457964 0.533 NM_001029991
NM_022734
METTL17

methyltransferase like 17

chr17_-_38721701 0.528 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr20_+_32150139 0.511 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr3_-_197300193 0.506 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr2_+_143886969 0.499 ARHGAP15
Rho GTPase activating protein 15
chr2_-_167005641 0.497 NM_001202435
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr15_+_74900712 0.494 NM_003992
CLK3
CDC-like kinase 3
chr3_-_178969402 0.492 NM_014407
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr15_+_93443418 0.489 NM_001042572
NM_001271
CHD2

chromodomain helicase DNA binding protein 2

chr4_-_38806410 0.482 NM_003263
TLR1
toll-like receptor 1
chr16_+_81812897 0.482 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr4_-_151770611 0.481 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr5_-_98262217 0.480 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr19_+_36486042 0.472 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr2_-_166930130 0.464 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr6_+_56954889 0.463 ZNF451
zinc finger protein 451
chr6_+_32407618 0.457 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr4_+_187187342 0.453 F11
coagulation factor XI
chr10_+_97471535 0.448 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr17_+_7461591 0.437 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr3_-_79817058 0.436 NM_002941
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr17_-_41623652 0.436 NM_001079675
ETV4
ets variant 4
chr1_-_109935869 0.429 NM_001205228
SORT1
sortilin 1
chr4_-_89978117 0.428 NM_014883
FAM13A
family with sequence similarity 13, member A
chr2_-_172087823 0.418 NM_001136554
TLK1
tousled-like kinase 1
chr22_+_22723972 0.417


chr6_-_133084585 0.409 NM_078488
VNN2
vanin 2
chr13_-_49018802 0.407 NM_005767
LPAR6
lysophosphatidic acid receptor 6
chr14_+_39735500 0.404 NM_001247988
NM_203356
CTAGE5

CTAGE family, member 5

chr2_+_163200582 0.404 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr10_+_102123420 0.398


chr5_-_42811959 0.396 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr14_-_38064440 0.394 NM_004496
FOXA1
forkhead box A1
chr5_+_159614373 0.388 NM_001130958
FABP6
fatty acid binding protein 6, ileal
chr3_-_12586962 0.387 NM_001195279
LOC100129480
uncharacterized LOC100129480
chr6_-_79787784 0.382 PHIP
pleckstrin homology domain interacting protein
chr1_+_28764660 0.381 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr6_-_44280986 0.379 NM_020745
AARS2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr6_-_26056647 0.377 NM_005319
HIST1H1C
histone cluster 1, H1c
chr14_+_58894709 0.375 NM_014749
KIAA0586
KIAA0586
chr14_+_39649711 0.371 PNN
pinin, desmosome associated protein
chr18_+_13611664 0.370 NM_001003674
NM_001003675
C18orf1

chromosome 18 open reading frame 1

chr5_+_115898218 0.369


chr2_+_162272619 0.369 NM_006593
TBR1
T-box, brain, 1
chr1_+_212209129 0.369 DTL
denticleless homolog (Drosophila)
chr16_+_69958900 0.365 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr7_+_26331611 0.350 SNX10
sorting nexin 10
chr2_-_214015053 0.350 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr16_+_81812899 0.349 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr16_+_30064470 0.344 ALDOA
aldolase A, fructose-bisphosphate
chr1_-_894620 0.342 NOC2L
nucleolar complex associated 2 homolog (S. cerevisiae)
chr8_-_103137134 0.342 NM_001040630
NCALD
neurocalcin delta
chr15_+_67000929 0.336 NM_001142861
SMAD6
SMAD family member 6
chr3_+_171561138 0.333 NM_001164436
TMEM212
transmembrane protein 212
chr2_-_20512016 0.331 PUM2
pumilio homolog 2 (Drosophila)
chr4_-_89744154 0.326 NM_001015045
FAM13A
family with sequence similarity 13, member A
chr17_-_29648631 0.325 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr2_+_143886898 0.323 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr22_-_37098620 0.322 NM_006078
CACNG2
calcium channel, voltage-dependent, gamma subunit 2
chrX_+_107288199 0.321 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chrX_-_33229428 0.320 NM_004006
DMD
dystrophin
chr8_-_30585442 0.320 NM_000637
NM_001195102
NM_001195103
NM_001195104
GSR



glutathione reductase



chr6_-_27799304 0.318 NM_003541
HIST1H4A
HIST1H4F
HIST1H4K
HIST1H4J
histone cluster 1, H4a
histone cluster 1, H4f
histone cluster 1, H4k
histone cluster 1, H4j
chrX_-_102319080 0.318 BEX1
brain expressed, X-linked 1
chr7_+_102023016 0.317


chr2_+_128928040 0.316 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr5_+_69321071 0.316 NM_001178087
NM_022978
NM_021967
NM_022968
SERF1B

SERF1A

small EDRK-rich factor 1B (centromeric)

small EDRK-rich factor 1A (telomeric)

chr2_+_86333304 0.315 NM_017952
PTCD3
Pentatricopeptide repeat domain 3
chr3_+_142375738 0.314 NM_001172312
PLS1
plastin 1
chr16_+_30064410 0.314 NM_000034
ALDOA
aldolase A, fructose-bisphosphate
chrX_-_102319096 0.313 NM_018476
BEX1
brain expressed, X-linked 1
chr9_-_70490164 0.311 NM_001024916
NM_201453
CBWD5
CBWD3
COBW domain containing 5
COBW domain containing 3
chr20_-_48530275 0.309 NM_001135773
SPATA2
spermatogenesis associated 2
chr15_-_51630735 0.306 NM_000103
NM_031226
CYP19A1

cytochrome P450, family 19, subfamily A, polypeptide 1

chr4_-_84035908 0.304 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr10_-_7682741 0.303 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr3_+_9476506 0.302


chr7_-_25268057 0.300 NM_022150
NPVF
neuropeptide VF precursor
chr18_+_55888750 0.294 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_+_177028804 0.293 NM_006898
HOXD3
homeobox D3
chr12_+_1017011 0.291 WNK1
WNK lysine deficient protein kinase 1
chr3_+_141043054 0.286 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
15.62 8.46e-05 GO:0002252 immune effector process
23.98 6.12e-04 GO:0072376 protein activation cascade
20.56 1.32e-03 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
19.98 1.52e-03 GO:0002250 adaptive immune response
18.22 2.41e-03 GO:0006959 humoral immune response
28.07 3.83e-03 GO:0006956 complement activation
22.13 9.96e-03 GO:0016064 immunoglobulin mediated immune response
21.72 1.07e-02 GO:0019724 B cell mediated immunity
18.27 2.13e-02 GO:0002449 lymphocyte mediated immunity
8.48 2.20e-02 GO:0002253 activation of immune response
28.77 4.95e-02 GO:0006958 complement activation, classical pathway

Nothing significant found in compartment category.

Nothing significant found in function category.