Motif ID: PRRX1,2.p2

Z-value: 1.537


Transcription factors associated with PRRX1,2.p2:

Gene SymbolEntrez IDGene Name
PRRX1 5396 paired related homeobox 1
PRRX2 51450 paired related homeobox 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRRX1chr1_+_1706333120.476.7e-02Click!
PRRX2chr9_+_1324280160.332.1e-01Click!


Activity profile for motif PRRX1,2.p2.

activity profile for motif PRRX1,2.p2


Sorted Z-values histogram for motif PRRX1,2.p2

Sorted Z-values for motif PRRX1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PRRX1,2.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_38172862 8.526 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr12_-_91505215 5.726 LUM
lumican
chr3_+_158787040 5.133 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr3_-_55515361 4.571 WNT5A
wingless-type MMTV integration site family, member 5A
chr11_+_5710816 4.561 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr1_+_151032866 4.536 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032880 4.535 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_+_159557649 4.513 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr2_+_189839132 4.488 COL3A1
collagen, type III, alpha 1
chr1_+_151032683 4.419 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_+_159557745 4.417 SCHIP1
schwannomin interacting protein 1
chr12_-_91505541 4.355 NM_002345
LUM
lumican
chr18_-_21891469 4.050 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chrX_+_135230736 3.954 NM_001159700
FHL1
four and a half LIM domains 1
chr9_-_14086901 3.919 NFIB
nuclear factor I/B
chr11_+_5710926 3.826 TRIM22
tripartite motif containing 22
chr20_+_9288446 3.742 NM_000933
PLCB4
phospholipase C, beta 4
chr8_-_49833823 3.632 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr2_-_190927321 3.617 NM_005259
MSTN
myostatin
chr1_-_103496768 3.548 COL11A1
collagen, type XI, alpha 1
chr2_+_189839078 3.344 NM_000090
COL3A1
collagen, type III, alpha 1
chr12_-_91576805 3.305 NM_001920
DCN
decorin
chr2_+_189839113 3.180 COL3A1
collagen, type III, alpha 1
chr10_-_95241943 3.101 NM_013451
NM_133337
MYOF

myoferlin

chr2_-_163099877 3.094 NM_004460
FAP
fibroblast activation protein, alpha
chrX_-_13835012 3.087 GPM6B
glycoprotein M6B
chr6_+_83072922 3.045 NM_006670
TPBG
trophoblast glycoprotein
chr20_+_9198036 3.044 NM_182797
PLCB4
phospholipase C, beta 4
chr7_+_102553343 3.024 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr12_+_54422193 2.979 NM_004503
HOXC6
homeobox C6
chr1_+_84630575 2.950 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr7_-_27205123 2.928 HOXA9
homeobox A9
chr12_-_50595303 2.882 NM_001243775
LIMA1
LIM domain and actin binding 1
chr3_+_158991035 2.795 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr4_+_169418167 2.767 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr11_+_35198199 2.756 CD44
CD44 molecule (Indian blood group)
chr17_-_10452939 2.756 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr7_-_27205148 2.682 NM_152739
HOXA9
homeobox A9
chr18_-_53089722 2.659 NM_001243233
TCF4
transcription factor 4
chr12_-_91576579 2.642 DCN
decorin
chr21_-_27253197 2.636 APP
amyloid beta (A4) precursor protein
chr4_+_169552752 2.564 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chr17_-_46622274 2.564 NM_002145
HOXB2
homeobox B2
chr6_+_121756744 2.509 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr3_+_35722428 2.492 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr9_-_14398981 2.462 NM_001190738
NFIB
nuclear factor I/B
chr11_-_58343308 2.442 NM_004811
LPXN
leupaxin
chr4_-_111563278 2.434 NM_001204397
NM_001204398
NM_001204399
NM_153426
NM_153427
PITX2




paired-like homeodomain 2




chrX_+_114827818 2.411 NM_001136025
NM_001172335
PLS3

plastin 3

chr10_+_17270257 2.384 NM_003380
VIM
vimentin
chr6_-_169654047 2.373 NM_003247
THBS2
thrombospondin 2
chr21_+_30517897 2.338 C21orf7
chromosome 21 open reading frame 7
chr8_-_122653493 2.332 NM_005328
HAS2
hyaluronan synthase 2
chr6_-_169653922 2.260 THBS2
thrombospondin 2
chrX_-_10535476 2.232 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr12_-_50616425 2.204 NM_001113547
LIMA1
LIM domain and actin binding 1
chr6_-_46293628 2.175 NM_005822
RCAN2
regulator of calcineurin 2
chr11_-_27742224 2.134 NM_001143805
NM_001143806
NM_170732
BDNF


brain-derived neurotrophic factor


chr13_+_102104941 2.089 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr12_-_53012332 2.075 NM_175068
KRT73
keratin 73
chr3_+_69812620 2.073 NM_001184967
MITF
microphthalmia-associated transcription factor
chr2_-_207082626 2.053 NM_001098199
NM_005279
GPR1

G protein-coupled receptor 1

chrX_+_135251795 2.050 NM_001167819
FHL1
four and a half LIM domains 1
chr5_+_125758818 2.038 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr2_-_55199894 1.988


chr1_-_68697997 1.982 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr5_-_39394423 1.980 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr17_-_10421858 1.922 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr1_+_196621007 1.918 NM_000186
NM_001014975
CFH

complement factor H

chr12_+_14538232 1.909 ATF7IP
activating transcription factor 7 interacting protein
chr1_+_84630374 1.909 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr3_-_123339178 1.888 MYLK
myosin light chain kinase
chr17_-_46682333 1.822 NM_018952
HOXB6
homeobox B6
chr15_+_100173182 1.810 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr11_+_114167168 1.803 NNMT
nicotinamide N-methyltransferase
chr3_-_114790221 1.796 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr5_+_125759076 1.762 GRAMD3
GRAM domain containing 3
chr8_+_54764367 1.759 NM_170587
RGS20
regulator of G-protein signaling 20
chr1_+_84647342 1.742 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr10_-_126716452 1.737 NM_022802
CTBP2
C-terminal binding protein 2
chr13_-_34250899 1.734 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_+_141346401 1.730 NM_001201365
NM_183399
RNF14

ring finger protein 14

chr5_+_140771482 1.710 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr2_-_211179765 1.668 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr11_-_104905849 1.667 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr10_+_11047274 1.665 CELF2
CUGBP, Elav-like family member 2
chr5_+_125695787 1.648 NM_001146319
GRAMD3
GRAM domain containing 3
chr17_-_46671322 1.638 HOXB5
homeobox B5
chr16_+_7382750 1.631 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr5_+_34687663 1.628 NM_001145523
RAI14
retinoic acid induced 14
chr10_+_11047253 1.623 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr11_+_114166534 1.612 NM_006169
NNMT
nicotinamide N-methyltransferase
chr4_+_169013687 1.611 NM_007193
ANXA10
annexin A10
chr1_-_93342706 1.588 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr5_+_36606456 1.581 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr3_-_114478117 1.569 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr5_+_36606667 1.567 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_-_110933683 1.563 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr10_+_63808968 1.512 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr1_-_201465700 1.485 NM_001193572
CSRP1
cysteine and glycine-rich protein 1
chr3_-_151034514 1.481 NM_023915
GPR87
G protein-coupled receptor 87
chr9_-_13250313 1.480 NM_003829
MPDZ
multiple PDZ domain protein
chr15_+_32933869 1.476 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr3_+_35721115 1.465 NM_001025068
NM_001025069
ARPP21

cAMP-regulated phosphoprotein, 21kDa

chr22_-_36236264 1.449 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr1_+_153003677 1.446 NM_003125
SPRR1B
small proline-rich protein 1B
chr9_-_117880411 1.435 NM_002160
TNC
tenascin C
chr2_-_31352489 1.419 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr1_-_89530890 1.410 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr22_-_36236330 1.406 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr3_-_69037498 1.404 C3orf64
chromosome 3 open reading frame 64
chr7_+_129932973 1.396 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr2_-_44586854 1.380 NM_001042385
NM_001042386
PREPL

prolyl endopeptidase-like

chr3_-_114102488 1.379 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr5_-_88119604 1.354 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr7_+_134576187 1.350 CALD1
caldesmon 1
chr7_-_41742666 1.347 NM_002192
INHBA
inhibin, beta A
chr1_-_42965948 1.333 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr5_+_71502700 1.327 MAP1B
microtubule-associated protein 1B
chr1_+_78470593 1.324 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr1_+_171154387 1.315 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr10_+_63661012 1.313 NM_032199
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_+_61086897 1.305 NM_025185
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr11_+_69467210 1.298 CCND1
cyclin D1
chr8_+_9953061 1.291 NM_001135671
NM_001199729
MSRA

methionine sulfoxide reductase A

chr3_+_135741576 1.290 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr12_-_52967608 1.285 NM_175053
KRT74
keratin 74
chrX_+_102631267 1.277 NM_206915
NM_206917
NGFRAP1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr1_+_84630014 1.273 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr6_-_75970566 1.263 TMEM30A
transmembrane protein 30A
chr2_-_151344145 1.248 NM_005168
RND3
Rho family GTPase 3
chr3_-_167191808 1.248 NM_006217
SERPINI2
serpin peptidase inhibitor, clade I (pancpin), member 2
chr5_+_155753755 1.247 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr11_-_27741192 1.242 NM_001143807
BDNF
brain-derived neurotrophic factor
chr18_+_61554938 1.240 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr2_-_56150862 1.236 EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr20_+_9458460 1.234 PLCB4
phospholipase C, beta 4
chr7_+_18535351 1.229 NM_001204145
NM_001204146
NM_014707
NM_178423
HDAC9



histone deacetylase 9



chr1_-_173174611 1.225 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr17_-_10325266 1.225 NM_002472
MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr3_+_69812961 1.209 NM_006722
MITF
microphthalmia-associated transcription factor
chr22_-_36236421 1.186 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr14_+_62164339 1.176 NM_001243084
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr5_+_65372744 1.175 ERBB2IP
erbb2 interacting protein
chr9_+_115913227 1.175 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr9_+_97521930 1.169 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr9_+_115913266 1.165 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr1_-_244006471 1.160 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr2_+_152214105 1.158 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr5_+_140743755 1.142 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr10_+_11207053 1.138 CELF2
CUGBP, Elav-like family member 2
chr2_-_55237255 1.127 NM_007008
RTN4
reticulon 4
chr12_+_54410893 1.123 HOXC5
HOXC6
homeobox C5
homeobox C6
chr1_+_86889768 1.115 NM_006536
CLCA2
chloride channel accessory 2
chr12_-_90049818 1.111 NM_001001323
NM_001682
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr7_-_87856282 1.109 NM_198901
SRI
sorcin
chr4_+_55095263 1.098 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chrX_+_7137471 1.093 NM_000351
STS
steroid sulfatase (microsomal), isozyme S
chr12_-_105322056 1.088 NM_032148
SLC41A2
solute carrier family 41, member 2
chr10_+_75673346 1.084 PLAU
plasminogen activator, urokinase
chr5_-_111312522 1.081 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr5_+_35856990 1.076 NM_002185
IL7R
interleukin 7 receptor
chr3_-_8811263 1.071 NM_000916
OXTR
oxytocin receptor
chrX_-_13835187 1.069 GPM6B
glycoprotein M6B
chr3_-_189840225 1.068 NM_001134418
LEPREL1
leprecan-like 1
chr11_+_131780537 1.060 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr14_-_92413738 1.057 FBLN5
fibulin 5
chr9_+_33624214 1.054 ANXA2P2
annexin A2 pseudogene 2
chr11_+_131240370 1.053 NM_001048209
NTM
neurotrimin
chr8_-_18666295 1.042 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr1_-_193155723 1.035 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr10_+_11206928 1.032 NM_001025076
NM_001083591
CELF2

CUGBP, Elav-like family member 2

chr1_-_110933635 1.010 SLC16A4
solute carrier family 16, member 4 (monocarboxylic acid transporter 5)
chr7_+_134576150 1.005 NM_033139
NM_033140
CALD1

caldesmon 1

chr5_+_140810181 0.992 PCDHGA12
protocadherin gamma subfamily A, 12
chr13_+_53035227 0.979 CKAP2
cytoskeleton associated protein 2
chr2_-_216241321 0.979 FN1
fibronectin 1
chr10_+_124320180 0.978 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chrX_+_80457302 0.976 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chrX_-_10544852 0.967 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr4_+_41700736 0.967 LIMCH1
LIM and calponin homology domains 1
chr3_-_55521330 0.964 NM_003392
WNT5A
wingless-type MMTV integration site family, member 5A
chr9_-_95298251 0.962 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr10_-_69752385 0.960 HERC4
hect domain and RLD 4
chr3_-_55521567 0.959 WNT5A
wingless-type MMTV integration site family, member 5A
chr2_-_56151273 0.947 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr3_+_157154579 0.946 NM_002852
PTX3
pentraxin 3, long
chr1_+_101185195 0.945 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr3_+_138066489 0.945 NM_001252091
NM_012219
MRAS

muscle RAS oncogene homolog

chr12_-_16759733 0.940 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr9_+_79115548 0.937 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr12_-_56106061 0.936 NM_001144997
ITGA7
integrin, alpha 7
chr8_-_120651019 0.932 NM_001040092
NM_001130863
NM_006209
ENPP2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr5_+_140800536 0.927 NM_018914
NM_032091
NM_032092
PCDHGA11


protocadherin gamma subfamily A, 11


chr5_+_53751430 0.924 NM_006308
HSPB3
heat shock 27kDa protein 3
chr15_-_72563627 0.921 NM_020214
PARP6
poly (ADP-ribose) polymerase family, member 6
chr1_-_94147201 0.919 NM_003567
BCAR3
breast cancer anti-estrogen resistance 3
chr13_-_45010937 0.918 TSC22D1
TSC22 domain family, member 1
chr6_-_117747017 0.917 NM_002944
ROS1
c-ros oncogene 1 , receptor tyrosine kinase
chr9_-_19786886 0.911 NM_001193288
NM_020344
SLC24A2

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.89 8.14e-06 GO:0007517 muscle organ development
5.57 4.92e-04 GO:0061061 muscle structure development
7.49 7.21e-04 GO:0043062 extracellular structure organization
9.20 2.01e-03 GO:0030198 extracellular matrix organization
5.89 6.39e-03 GO:0003012 muscle system process
1.80 9.81e-03 GO:0007275 multicellular organismal development
4.55 1.09e-02 GO:0001501 skeletal system development
1.87 1.88e-02 GO:0048731 system development
2.13 1.97e-02 GO:0048513 organ development
5.78 2.14e-02 GO:0006936 muscle contraction
2.99 2.50e-02 GO:0007155 cell adhesion
2.99 2.50e-02 GO:0022610 biological adhesion
6.54 2.53e-02 GO:0043627 response to estrogen stimulus
1.56 3.75e-02 GO:0032501 multicellular organismal process
8.99 4.39e-02 GO:0048706 embryonic skeletal system development
1.76 4.60e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
9.08 8.08e-05 GO:0044420 extracellular matrix part
4.85 9.06e-04 GO:0005578 proteinaceous extracellular matrix
21.97 3.59e-03 GO:0005859 muscle myosin complex
19.77 5.60e-03 GO:0016460 myosin II complex
4.01 5.95e-03 GO:0031012 extracellular matrix
6.66 1.14e-02 GO:0030016 myofibril
6.24 1.71e-02 GO:0043292 contractile fiber
26.96 2.06e-02 GO:0005583 fibrillar collagen
2.02 2.19e-02 GO:0005576 extracellular region
11.99 4.27e-02 GO:0005581 collagen

Nothing significant found in function category.