Motif ID: RUNX1..3.p2

Z-value: 2.883


Transcription factors associated with RUNX1..3.p2:

Gene SymbolEntrez IDGene Name
RUNX1 861 runt-related transcription factor 1
RUNX2 860 runt-related transcription factor 2
RUNX3 864 runt-related transcription factor 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RUNX3chr1_-_252914740.783.7e-04Click!
RUNX1chr21_-_36421586,
chr21_-_36421630
-0.621.1e-02Click!
RUNX2chr6_+_45390376,
chr6_+_45390284
0.185.2e-01Click!


Activity profile for motif RUNX1..3.p2.

activity profile for motif RUNX1..3.p2


Sorted Z-values histogram for motif RUNX1..3.p2

Sorted Z-values for motif RUNX1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX1..3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_23847321 10.944 PRKCB
protein kinase C, beta
chr16_+_23847271 9.107 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr1_-_25291474 7.526 NM_001031680
RUNX3
runt-related transcription factor 3
chr17_-_29641094 6.570 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_-_29641068 6.323 EVI2B
ecotropic viral integration site 2B
chr16_+_23847359 6.322 PRKCB
protein kinase C, beta
chr17_-_29641087 6.179 EVI2B
ecotropic viral integration site 2B
chr8_-_102803438 6.084 NM_032041
NCALD
neurocalcin delta
chr2_-_158300517 6.010 NM_004288
CYTIP
cytohesin 1 interacting protein
chr8_-_102803178 5.967 NCALD
neurocalcin delta
chr8_-_102803196 5.813 NCALD
neurocalcin delta
chr10_+_70847857 4.898 SRGN
serglycin
chr1_+_198608136 4.810 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr13_-_46756295 4.757 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr9_-_123688352 4.649 TRAF1
TNF receptor-associated factor 1
chr4_-_71532206 4.601 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr11_+_1889902 4.486 NM_001013253
LSP1
lymphocyte-specific protein 1
chr1_+_198608216 4.250 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_-_34524054 4.172 NM_001001437
NM_021006
CCL3L3
CCL3
CCL3L1
chemokine (C-C motif) ligand 3-like 3
chemokine (C-C motif) ligand 3
chemokine (C-C motif) ligand 3-like 1
chr4_-_71532341 4.099 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr10_+_70847817 4.056 NM_002727
SRGN
serglycin
chr1_+_192544856 3.936 NM_002922
RGS1
regulator of G-protein signaling 1
chr4_-_84035908 3.899 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr22_+_23222897 3.825 CYAT1
immunoglobulin lambda light chain-like
chr1_+_198608244 3.805 PTPRC
protein tyrosine phosphatase, receptor type, C
chr4_-_84035888 3.794 PLAC8
placenta-specific 8
chr12_-_102872329 3.788 NM_001111284
IGF1
insulin-like growth factor 1 (somatomedin C)
chr16_+_30194925 3.711 CORO1A
coronin, actin binding protein, 1A
chr6_-_32163299 3.523 NM_022107
GPSM3
G-protein signaling modulator 3
chr11_+_22696318 3.477 NM_005256
GAS2
growth arrest-specific 2
chrX_+_48542159 3.334 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_-_34417386 3.313 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr1_+_209929378 3.197 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr14_+_75988838 3.013 BATF
basic leucine zipper transcription factor, ATF-like
chr14_+_75988765 2.986 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr13_-_46756291 2.980 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_-_89165652 2.946


chr7_+_116660291 2.914 ST7
suppression of tumorigenicity 7
chr11_-_5275904 2.903 NM_000184
HBG1
HBG2
hemoglobin, gamma A
hemoglobin, gamma G
chr7_+_116660263 2.853 ST7
suppression of tumorigenicity 7
chr1_-_114414245 2.852 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr12_+_25205180 2.810 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr1_+_32716839 2.775 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr22_+_22786283 2.754


chr2_+_127413739 2.707 GYPC
glycophorin C (Gerbich blood group)
chr22_+_22712091 2.676 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr1_+_174843523 2.604 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chrX_-_135863104 2.548 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr6_+_31543340 2.546 NM_000594
TNF
tumor necrosis factor
chr22_+_23054862 2.537 IGLV3-21
IGLJ3
IGLC1
immunoglobulin lambda variable 3-21
immunoglobulin lambda joining 3
immunoglobulin lambda constant 1 (Mcg marker)
chr19_-_36233311 2.527 NM_024660
IGFLR1
IGF-like family receptor 1
chrX_+_9431314 2.500 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr11_-_67205151 2.499 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr12_+_25205488 2.496 LRMP
lymphoid-restricted membrane protein
chrX_-_135863033 2.491 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr22_+_40297085 2.478 NM_004810
GRAP2
GRB2-related adaptor protein 2
chrX_+_78200828 2.459 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chrX_-_78623006 2.451 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr5_-_88119604 2.442 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr3_+_4535030 2.426 NM_001099952
NM_001168272
NM_002222
ITPR1


inositol 1,4,5-trisphosphate receptor, type 1


chr2_-_175462428 2.373 WIPF1
WAS/WASL interacting protein family, member 1
chr16_+_29674564 2.360 SPN
sialophorin
chr4_-_38806410 2.334 NM_003263
TLR1
toll-like receptor 1
chr6_+_31540092 2.329 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr22_+_40297183 2.303 GRAP2
GRB2-related adaptor protein 2
chr6_+_31539875 2.288 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chrX_+_49160124 2.272 NM_001098413
GAGE10
G antigen 10
chrX_-_135863502 2.226 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr6_-_32920812 2.173 NM_006120
HLA-DMA
major histocompatibility complex, class II, DM alpha
chr17_-_79008372 2.143 FLJ90757
uncharacterized LOC440465
chr17_-_29648631 2.142 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr1_-_9117554 2.097 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr17_+_72462521 1.949 NM_007261
CD300A
CD300a molecule
chr22_+_44464996 1.923 NM_001243385
PARVB
parvin, beta
chr9_-_123689172 1.913 NM_005658
TRAF1
TNF receptor-associated factor 1
chr12_+_93771607 1.910 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr3_+_98250742 1.885 NM_005290
GPR15
G protein-coupled receptor 15
chr13_-_46756326 1.857 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_41255827 1.849 NM_198476
C19orf54
chromosome 19 open reading frame 54
chrX_-_30595883 1.848 NM_025159
CXorf21
chromosome X open reading frame 21
chr1_-_159046555 1.827 NM_004833
AIM2
absent in melanoma 2
chr14_-_107013474 1.812 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr22_+_23134980 1.762


chr1_+_39922262 1.754 MACF1
microtubule-actin crosslinking factor 1
chrX_-_119005575 1.745 NM_006978
RNF113A
ring finger protein 113A
chr2_+_68592432 1.726 PLEK
pleckstrin
chr1_+_32739711 1.714 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr16_+_226678 1.701 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr14_-_106691698 1.699


chr2_+_74756531 1.686 NM_013247
NM_145074
HTRA2

HtrA serine peptidase 2

chr1_-_207095198 1.684 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chrX_-_70838298 1.653 NM_001142797
NM_001504
CXCR3

chemokine (C-X-C motif) receptor 3

chr15_+_75494233 1.614 C15orf39
chromosome 15 open reading frame 39
chr2_+_127413678 1.613 NM_002101
NM_016815
GYPC

glycophorin C (Gerbich blood group)

chr15_-_37393364 1.612 NM_001220482
NM_002399
MEIS2

Meis homeobox 2

chr2_+_33701320 1.610 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_-_106780535 1.596 IGHA1
IGHA2
IGHD
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_+_156696351 1.554 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr2_-_214015053 1.537 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr11_-_128457452 1.534 NM_001143820
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
chr4_+_40198526 1.528 NM_004310
RHOH
ras homolog gene family, member H
chr6_-_32784727 1.507 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr15_+_75494196 1.502 NM_015492
C15orf39
chromosome 15 open reading frame 39
chr7_+_120628867 1.497 C7orf58
chromosome 7 open reading frame 58
chr15_-_55563091 1.493 NM_183236
RAB27A
RAB27A, member RAS oncogene family
chr11_-_57195052 1.491 NM_017611
SLC43A3
solute carrier family 43, member 3
chr2_+_68592317 1.488 NM_002664
PLEK
pleckstrin
chr15_+_75494235 1.473 C15orf39
chromosome 15 open reading frame 39
chr2_+_182321618 1.468 NM_000885
ITGA4
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr16_+_27438578 1.445 NM_021798
IL21R
interleukin 21 receptor
chr3_+_113251217 1.443 NM_017699
SIDT1
SID1 transmembrane family, member 1
chr5_-_137071462 1.425 KLHL3
kelch-like 3 (Drosophila)
chr21_+_42733916 1.423 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chrX_-_31526414 1.402 NM_004014
DMD
dystrophin
chr5_+_75699003 1.397 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr7_+_120628722 1.392 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr17_+_46185125 1.345 SNX11
sorting nexin 11
chr1_+_179051218 1.344 TOR3A
torsin family 3, member A
chr1_-_169680677 1.328 NM_000655
SELL
selectin L
chrX_-_118726852 1.317 NM_001173488
NKRF
NFKB repressing factor
chr14_+_100531764 1.301 EVL
Enah/Vasp-like
chr2_-_200325200 1.297 SATB2
SATB homeobox 2
chr22_+_21996541 1.296 NM_022044
SDF2L1
stromal cell-derived factor 2-like 1
chr10_+_11047274 1.279 CELF2
CUGBP, Elav-like family member 2
chr2_+_103035148 1.272 NM_003853
IL18RAP
interleukin 18 receptor accessory protein
chr12_+_13349716 1.250 EMP1
epithelial membrane protein 1
chr22_-_37640187 1.249 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr10_-_11574273 1.248 NM_001080491
USP6NL
USP6 N-terminal like
chr3_+_133118789 1.234 NM_003571
BFSP2
beaded filament structural protein 2, phakinin
chr7_+_150068252 1.233 NM_014374
REPIN1
replication initiator 1
chr10_+_11047253 1.225 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr22_+_39378404 1.219 NM_004900
APOBEC3D
APOBEC3B
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
chrX_-_124097601 1.209 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chr22_+_21996572 1.208 SDF2L1
stromal cell-derived factor 2-like 1
chr6_-_31846766 1.206 SLC44A4
solute carrier family 44, member 4
chr13_+_31309644 1.206 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr6_-_31846751 1.197 SLC44A4
solute carrier family 44, member 4
chr22_+_21996591 1.189 SDF2L1
stromal cell-derived factor 2-like 1
chr12_-_9913415 1.185 NM_001781
CD69
CD69 molecule
chr6_-_31846816 1.182 NM_001178044
NM_025257
SLC44A4

solute carrier family 44, member 4

chr6_-_30710219 1.181 NM_005803
FLOT1
flotillin 1
chr11_-_67450536 1.179 RPL37
ribosomal protein L37
chr13_-_41593405 1.179 ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_-_89442551 1.176 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr22_+_22988781 1.149 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr14_+_100531745 1.148 NM_016337
EVL
Enah/Vasp-like
chr17_-_39197663 1.146 NM_030967
KRTAP1-3
KRTAP1-1
keratin associated protein 1-3
keratin associated protein 1-1
chr2_-_64881040 1.142 NM_014755
SERTAD2
SERTA domain containing 2
chr16_+_85645014 1.137 NM_001134473
KIAA0182
KIAA0182
chr22_+_21996615 1.137 SDF2L1
stromal cell-derived factor 2-like 1
chr12_-_24103953 1.132 SOX5
SRY (sex determining region Y)-box 5
chr13_-_41593491 1.128 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr10_-_65028825 1.125 NM_004241
JMJD1C
jumonji domain containing 1C
chrX_-_40036581 1.124 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr1_+_179051111 1.117 NM_022371
TOR3A
torsin family 3, member A
chr4_-_88312221 1.110 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr3_-_121264780 1.100 NM_199420
POLQ
polymerase (DNA directed), theta
chrX_-_112066353 1.096 NM_001113490
AMOT
angiomotin
chr1_+_203734283 1.085 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chrX_-_15872882 1.082 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr3_+_141043054 1.081 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr6_+_32605182 1.077 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr16_+_202853 1.074 NM_005332
HBZ
hemoglobin, zeta
chr19_-_14048877 1.069 PODNL1
podocan-like 1
chr12_-_58146025 1.050 CDK4
cyclin-dependent kinase 4
chr1_-_160832466 1.048 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chr2_+_33701678 1.034 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr7_+_20686965 1.030 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr4_+_68424444 1.008 NM_012108
STAP1
signal transducing adaptor family member 1
chr19_+_13875352 1.008 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr1_-_150738255 1.004 CTSS
cathepsin S
chrX_-_15872938 0.997 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr1_+_111770280 0.986 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chrX_-_49460568 0.985 NM_003785
PAGE1
P antigen family, member 1 (prostate associated)
chr22_+_21771661 0.983 NM_015094
HIC2
hypermethylated in cancer 2
chr5_-_137071703 0.976 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr1_+_11333502 0.975 UBIAD1
UbiA prenyltransferase domain containing 1
chr4_-_88312329 0.970 NM_016245
HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr6_-_35696359 0.965 NM_001145775
FKBP5
FK506 binding protein 5
chr15_-_55562483 0.954 NM_183234
NM_004580
RAB27A

RAB27A, member RAS oncogene family

chr12_-_24103842 0.954 SOX5
SRY (sex determining region Y)-box 5
chr15_-_72668740 0.952 HEXA
hexosaminidase A (alpha polypeptide)
chrX_+_48542193 0.949 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chrX_-_15872905 0.945


chr2_+_228678556 0.944 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr2_+_74757243 0.935 HTRA2
HtrA serine peptidase 2
chr22_+_37257004 0.924 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr15_-_72668301 0.924 NM_000520
HEXA
hexosaminidase A (alpha polypeptide)
chr22_-_37640287 0.921 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_-_184006828 0.913 NM_015101
GLT25D2
glycosyltransferase 25 domain containing 2
chrX_+_151927733 0.902 NM_001129828
NM_001129826
NM_001080848
NM_004909
CSAG3

CSAG2

CSAG family, member 3

CSAG family, member 2

chr6_+_14117857 0.898 NM_001040280
NM_004233
CD83

CD83 molecule

chr12_+_9822205 0.894 NM_001197318
NM_013269
NM_001004419
NM_001197317
NM_001197319
CLEC2D




C-type lectin domain family 2, member D




chrY_-_2368963 0.888 NM_145177
NM_001171136
NM_004729
DHRSX
ZBED1

dehydrogenase/reductase (SDR family) X-linked
zinc finger, BED-type containing 1

chr11_-_5255712 0.888 NM_000519
HBD
hemoglobin, delta
chr10_+_97515408 0.888 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr5_+_176875325 0.887 NM_001174102
PRR7
proline rich 7 (synaptic)
chr19_+_13875345 0.887 MRI1
methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
chr14_-_107113943 0.884 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr2_+_74756986 0.879 HTRA2
HtrA serine peptidase 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.88 8.13e-12 GO:0002376 immune system process
4.38 1.15e-08 GO:0006955 immune response
4.53 1.90e-05 GO:0001775 cell activation
7.14 6.85e-05 GO:0046649 lymphocyte activation
6.19 1.03e-04 GO:0045321 leukocyte activation
3.59 1.72e-04 GO:0002682 regulation of immune system process
4.15 8.53e-04 GO:0050776 regulation of immune response
5.07 1.03e-03 GO:0050778 positive regulation of immune response
3.20 1.13e-03 GO:0006952 defense response
8.93 1.94e-03 GO:0050851 antigen receptor-mediated signaling pathway
5.42 3.63e-03 GO:0002253 activation of immune response
8.20 3.69e-03 GO:0002429 immune response-activating cell surface receptor signaling pathway
7.96 4.62e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
9.63 5.04e-03 GO:0050852 T cell receptor signaling pathway
28.69 5.89e-03 GO:0050854 regulation of antigen receptor-mediated signaling pathway
2.79 9.75e-03 GO:0009611 response to wounding
1.95 1.18e-02 GO:0006950 response to stress
3.56 1.20e-02 GO:0007596 blood coagulation
3.56 1.20e-02 GO:0050817 coagulation
3.53 1.30e-02 GO:0007599 hemostasis
3.68 1.63e-02 GO:0002684 positive regulation of immune system process
5.76 1.68e-02 GO:0050863 regulation of T cell activation
5.52 2.38e-02 GO:0002757 immune response-activating signal transduction
5.42 2.74e-02 GO:0002764 immune response-regulating signaling pathway
4.55 4.47e-02 GO:0050865 regulation of cell activation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
36.51 3.66e-04 GO:0005833 hemoglobin complex
15.69 1.81e-03 GO:0005884 actin filament
50.20 2.39e-03 GO:0001891 phagocytic cup
21.52 4.11e-02 GO:0042613 MHC class II protein complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
20.08 6.08e-07 GO:0003823 antigen binding
33.47 6.22e-04 GO:0005344 oxygen transporter activity