Motif ID: SP1.p2

Z-value: 0.976


Transcription factors associated with SP1.p2:

Gene SymbolEntrez IDGene Name
SP1 6667 Sp1 transcription factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SP1chr12_+_53774422-0.514.2e-02Click!


Activity profile for motif SP1.p2.

activity profile for motif SP1.p2


Sorted Z-values histogram for motif SP1.p2

Sorted Z-values for motif SP1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SP1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_12990731 2.112 NM_006094
DLC1
deleted in liver cancer 1
chr3_-_185542807 1.758 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr2_+_10183630 1.729 NM_003597
NM_001177716
KLF11

Kruppel-like factor 11

chr12_-_13153200 1.489 NM_015987
HEBP1
heme binding protein 1
chr6_+_3000026 1.463 NM_000904
NQO2
NAD(P)H dehydrogenase, quinone 2
chr11_-_2950593 1.451 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr15_-_30114536 1.446 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr17_-_74707066 1.428 MXRA7
matrix-remodelling associated 7
chr19_-_18548118 1.373 NM_001253389
ISYNA1
inositol-3-phosphate synthase 1
chr19_+_45349560 1.280 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr7_+_73868397 1.261 GTF2IRD1
GTF2I repeat domain containing 1
chr12_-_13153047 1.232 HEBP1
heme binding protein 1
chr19_+_45349584 1.228 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr12_-_106532447 1.225 NUAK1
NUAK family, SNF1-like kinase, 1
chr10_-_15210610 1.144 NM_004808
NMT2
N-myristoyltransferase 2
chr6_-_31697568 1.143 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr17_-_74707000 1.141 NM_001008528
NM_001008529
NM_198530
MXRA7


matrix-remodelling associated 7


chr22_-_36424397 1.127 NM_001082578
NM_001082579
RBFOX2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr6_+_37137882 1.119 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr11_-_86666211 1.118 NM_012193
FZD4
frizzled family receptor 4
chr7_+_73868236 1.099 GTF2IRD1
GTF2I repeat domain containing 1
chr21_-_44495894 1.072 NM_000071
CBS
cystathionine-beta-synthase
chr19_+_45349392 1.066 NM_001042724
NM_002856
PVRL2

poliovirus receptor-related 2 (herpesvirus entry mediator B)

chr19_-_55658310 1.058 TNNT1
troponin T type 1 (skeletal, slow)
chr2_+_235860616 1.053 NM_014521
SH3BP4
SH3-domain binding protein 4
chr10_+_134351272 1.038 NM_005539
INPP5A
inositol polyphosphate-5-phosphatase, 40kDa
chr3_-_43663467 1.037 NM_001204831
NM_001204832
NM_001204833
NM_001204834
NM_018075
ANO10




anoctamin 10




chr3_-_43663421 1.033 ANO10
anoctamin 10
chr21_-_44496423 1.021 NM_001178008
NM_001178009
CBS

cystathionine-beta-synthase

chr3_+_110790460 1.021 NM_001243286
NM_015480
PVRL3

poliovirus receptor-related 3

chr19_+_54694118 1.017 NM_024075
TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr11_+_46403279 1.017 MDK
midkine (neurite growth-promoting factor 2)
chr7_-_1498961 1.014 MICALL2
MICAL-like 2
chr2_-_216300770 1.013 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr11_+_46403260 1.003 MDK
midkine (neurite growth-promoting factor 2)
chr11_+_46403205 0.988 NM_002391
MDK
midkine (neurite growth-promoting factor 2)
chr17_-_76921076 0.978 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_225840660 0.965 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr21_+_46825001 0.963 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr5_-_176900653 0.956 NM_004395
DBN1
drebrin 1
chr11_+_129939667 0.944 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chrX_+_43514157 0.940 MAOA
monoamine oxidase A
chr1_+_93913566 0.933 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr11_+_832965 0.930 CD151
CD151 molecule (Raph blood group)
chr10_-_81205091 0.930 NM_153367
ZCCHC24
zinc finger, CCHC domain containing 24
chr17_-_80606095 0.923 NM_019613
WDR45L
WDR45-like
chr22_+_23229959 0.920 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr6_-_31698033 0.911 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr17_-_76921205 0.905 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_227505796 0.893 NM_003607
NM_014826
CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)

chr12_-_124457099 0.881 NM_025140
CCDC92
coiled-coil domain containing 92
chr10_+_94449678 0.880 NM_002729
HHEX
hematopoietically expressed homeobox
chr11_+_129939847 0.874 APLP2
amyloid beta (A4) precursor-like protein 2
chr11_+_833007 0.874 CD151
CD151 molecule (Raph blood group)
chr7_-_143599163 0.853 NM_014719
NM_001206938
FAM115A

family with sequence similarity 115, member A

chr14_-_107179043 0.840 IGHA1
immunoglobulin heavy constant alpha 1
chr20_-_23618382 0.840 NM_000099
CST3
cystatin C
chr8_-_11725622 0.834 CTSB
cathepsin B
chr7_+_73868111 0.828 NM_001199207
NM_005685
NM_016328
GTF2IRD1


GTF2I repeat domain containing 1


chr6_+_17393610 0.826 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr1_-_20812727 0.825 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr9_+_138371627 0.813 NM_014811
PPP1R26
protein phosphatase 1, regulatory subunit 26
chr7_-_150675236 0.806 NM_000238
NM_172056
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr17_-_76921453 0.796 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr6_-_32551993 0.795 HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr21_+_46825291 0.794


chr11_+_832909 0.785 NM_001039490
NM_004357
NM_139029
NM_139030
CD151



CD151 molecule (Raph blood group)



chr6_-_31697953 0.776 DDAH2
dimethylarginine dimethylaminohydrolase 2
chrX_-_153775427 0.771 G6PD
glucose-6-phosphate dehydrogenase
chr11_+_129939807 0.770 APLP2
amyloid beta (A4) precursor-like protein 2
chr9_+_139560193 0.770 NM_201446
EGFL7
EGF-like-domain, multiple 7
chr1_+_245133652 0.769 EFCAB2
EF-hand calcium binding domain 2
chr1_-_153606567 0.769 NM_001024210
S100A13
S100 calcium binding protein A13
chr11_+_46403302 0.768 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr11_+_129939792 0.767 APLP2
amyloid beta (A4) precursor-like protein 2
chr8_-_11725628 0.759 NM_001908
NM_147780
NM_147781
NM_147782
NM_147783
CTSB




cathepsin B




chr6_-_2971981 0.755 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr19_-_18548788 0.754 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr11_-_61658853 0.752 NM_021727
FADS3
fatty acid desaturase 3
chr14_-_53417636 0.750 FERMT2
fermitin family member 2
chr6_+_33043702 0.749 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr5_-_176900591 0.748 DBN1
drebrin 1
chr8_-_11725595 0.747 CTSB
cathepsin B
chr6_-_2971787 0.747 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr11_-_12030622 0.746 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr14_-_106092256 0.735 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr5_-_16936371 0.735 NM_012334
MYO10
myosin X
chr11_+_46402333 0.734 NM_001012334
MDK
midkine (neurite growth-promoting factor 2)
chr5_+_141488314 0.729 NM_030571
NDFIP1
Nedd4 family interacting protein 1
chr3_-_129325175 0.720 NM_015103
PLXND1
plexin D1
chr11_-_111249902 0.717 POU2AF1
POU class 2 associating factor 1
chr17_-_882905 0.713 NM_022463
NXN
nucleoredoxin
chr19_-_50143350 0.704 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr10_-_118764559 0.702 KIAA1598
KIAA1598
chr10_-_118764727 0.701 KIAA1598
KIAA1598
chr19_+_50016435 0.699 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_+_6554032 0.693 NM_001242
CD27
CD27 molecule
chr6_-_33041266 0.692 NM_033554
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr19_+_3094528 0.692 GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr3_-_45267804 0.690 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr3_-_38066277 0.687 NM_001130964
PLCD1
phospholipase C, delta 1
chrX_+_117861523 0.679 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr22_+_23040394 0.678 IGL@
immunoglobulin lambda locus
chr11_-_12030882 0.675 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr2_-_158732341 0.670 NM_001111067
ACVR1
activin A receptor, type I
chr5_+_71403040 0.665 NM_005909
MAP1B
microtubule-associated protein 1B
chr14_-_53417808 0.664 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr11_-_12030539 0.663 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr14_-_106110894 0.653 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr14_-_106209380 0.652 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_85155885 0.645 NM_001166295
NM_001166417
NM_001166293
NM_001166294
NM_014021
SSX2IP




synovial sarcoma, X breakpoint 2 interacting protein




chr2_+_24272583 0.644 NM_004116
NM_054033
FKBP1B

FK506 binding protein 1B, 12.6 kDa

chr14_-_106111114 0.641 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr14_-_69446038 0.640 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr9_-_131872907 0.639 NM_000755
CRAT
carnitine O-acetyltransferase
chr2_-_183902747 0.638 NCKAP1
NCK-associated protein 1
chr7_-_151216596 0.638 RHEB
Ras homolog enriched in brain
chr14_-_106237675 0.637 IGHM
immunoglobulin heavy constant mu
chr8_-_11725587 0.636 CTSB
cathepsin B
chr7_-_151216691 0.632 RHEB
Ras homolog enriched in brain
chr20_+_44034632 0.630 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr1_+_180124023 0.629 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr13_-_110438896 0.623 NM_003749
IRS2
insulin receptor substrate 2
chr19_+_50016500 0.622 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr7_-_151216765 0.616 RHEB
Ras homolog enriched in brain
chr1_+_180124031 0.612 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr8_-_11725509 0.611 CTSB
cathepsin B
chr18_-_812268 0.608 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr2_-_169103886 0.608 NM_013233
STK39
serine threonine kinase 39
chr9_+_103235489 0.608 NM_003692
TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr8_-_25315941 0.606 NM_017634
KCTD9
potassium channel tetramerisation domain containing 9
chr1_+_180123906 0.606 NM_001004128
NM_002826
QSOX1

quiescin Q6 sulfhydryl oxidase 1

chr1_+_180124013 0.605 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr6_+_32709162 0.601 NM_020056
HLA-DQA1
HLA-DQA2
major histocompatibility complex, class II, DQ alpha 1
major histocompatibility complex, class II, DQ alpha 2
chr22_+_23165273 0.596


chr9_-_74383301 0.592 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr19_-_54693453 0.591 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr22_-_37545944 0.591 NM_000878
IL2RB
interleukin 2 receptor, beta
chr12_+_3068442 0.589 NM_003213
NM_201441
NM_201443
TEAD4


TEA domain family member 4


chr7_-_1499107 0.589 NM_182924
MICALL2
MICAL-like 2
chr7_+_73624086 0.584 NM_014146
NM_032463
NM_032464
LAT2


linker for activation of T cells family, member 2


chr9_+_103235634 0.584 TMEFF1
transmembrane protein with EGF-like and two follistatin-like domains 1
chr2_+_24272627 0.581 FKBP1B
FK506 binding protein 1B, 12.6 kDa
chr9_+_139560243 0.579 EGFL7
EGF-like-domain, multiple 7
chr19_+_3094266 0.579 NM_002067
GNA11
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
chr5_+_141488384 0.578 NDFIP1
Nedd4 family interacting protein 1
chrX_-_137793394 0.577 FGF13
fibroblast growth factor 13
chr10_-_735522 0.577 NM_014974
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr7_-_131241321 0.576 NM_001018111
NM_005397
PODXL

podocalyxin-like

chr4_-_177713664 0.576 NM_005429
VEGFC
vascular endothelial growth factor C
chr10_+_114709963 0.572 NM_001146274
NM_001146283
NM_001146284
NM_001146285
NM_001146286
NM_001198525
NM_001198526
NM_001198527
NM_001198528
NM_001198529
NM_001198530
NM_001198531
NM_030756
TCF7L2












transcription factor 7-like 2 (T-cell specific, HMG-box)












chrX_-_153775064 0.571 NM_000402
G6PD
glucose-6-phosphate dehydrogenase
chr9_-_131872782 0.570 CRAT
carnitine O-acetyltransferase
chr1_-_15850776 0.570 NM_001229
NM_032996
CASP9

caspase 9, apoptosis-related cysteine peptidase

chr2_-_218843541 0.566 TNS1
tensin 1
chr5_-_176899870 0.556 NM_080881
DBN1
drebrin 1
chr3_-_45267620 0.553 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr10_-_126849010 0.551 CTBP2
C-terminal binding protein 2
chr2_+_47596447 0.547 EPCAM
epithelial cell adhesion molecule
chr11_-_65640199 0.547 NM_016938
EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr17_-_41174327 0.547 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr6_-_52441714 0.543 TRAM2
translocation associated membrane protein 2
chr17_-_62657997 0.542 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr11_+_129939787 0.538 APLP2
amyloid beta (A4) precursor-like protein 2
chr12_+_6875686 0.538 PTMS
parathymosin
chr7_-_32931363 0.534 KBTBD2
kelch repeat and BTB (POZ) domain containing 2
chr17_-_41174402 0.533 VAT1
vesicle amine transport protein 1 homolog (T. californica)
chr1_+_178995055 0.532 NM_014864
FAM20B
family with sequence similarity 20, member B
chr15_-_30114336 0.531 TJP1
tight junction protein 1 (zona occludens 1)
chr14_+_101193275 0.528 DLK1
delta-like 1 homolog (Drosophila)
chr7_+_73624328 0.527 LAT2
linker for activation of T cells family, member 2
chr1_-_38471170 0.527 NM_001243878
NM_004468
FHL3

four and a half LIM domains 3

chr10_+_121410751 0.527 NM_004281
BAG3
BCL2-associated athanogene 3
chr5_-_179233772 0.526 NM_014275
MGAT4B
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
chr7_+_73624347 0.524 LAT2
linker for activation of T cells family, member 2
chr17_+_72462521 0.524 NM_007261
CD300A
CD300a molecule
chr6_-_52441815 0.520 NM_012288
TRAM2
translocation associated membrane protein 2
chr7_+_116140097 0.520 NM_001206748
CAV2
caveolin 2
chr3_+_122044010 0.518 NM_005213
CSTA
cystatin A (stefin A)
chr20_+_44035203 0.518 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr6_-_32634287 0.518 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr1_+_111772332 0.517 NM_001025199
CHI3L2
chitinase 3-like 2
chr14_-_106174914 0.515 IGHA1
immunoglobulin heavy constant alpha 1
chr19_+_50016490 0.514 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr9_-_123688352 0.513 TRAF1
TNF receptor-associated factor 1
chr19_-_1567875 0.511 NM_001174118
NM_203304
MEX3D

mex-3 homolog D (C. elegans)

chr19_-_54693414 0.511 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr19_-_11308184 0.510 NM_001136191
KANK2
KN motif and ankyrin repeat domains 2
chr10_+_121410891 0.509 BAG3
BCL2-associated athanogene 3
chr13_-_46961634 0.506 NM_025113
KIAA0226L
KIAA0226-like
chr13_-_46961379 0.504 KIAA0226L
KIAA0226-like
chr21_+_42797977 0.504 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr7_+_106685007 0.504 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr2_-_36825234 0.504 NM_001042548
NM_005102
FEZ2

fasciculation and elongation protein zeta 2 (zygin II)

chr16_+_85932766 0.501 NM_002163
IRF8
interferon regulatory factor 8
chr6_+_106960326 0.499 AIM1
absent in melanoma 1
chr13_-_46961314 0.496 KIAA0226L
KIAA0226-like
chr1_-_25291474 0.495 NM_001031680
RUNX3
runt-related transcription factor 3
chr10_-_17659365 0.495 NM_014241
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr7_+_77166331 0.494 PTPN12
protein tyrosine phosphatase, non-receptor type 12

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.