Motif ID: TFEB.p2

Z-value: 2.715


Transcription factors associated with TFEB.p2:

Gene SymbolEntrez IDGene Name
TFEB 7942 transcription factor EB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TFEBchr6_-_41702734,
chr6_-_41703938
-0.401.3e-01Click!


Activity profile for motif TFEB.p2.

activity profile for motif TFEB.p2


Sorted Z-values histogram for motif TFEB.p2

Sorted Z-values for motif TFEB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFEB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_113951537 14.932 LAMP1
lysosomal-associated membrane protein 1
chr13_+_113951461 14.296 NM_005561
LAMP1
lysosomal-associated membrane protein 1
chr19_+_49458031 11.939 NM_004324
NM_138761
NM_138763
NM_138764
BAX



BCL2-associated X protein



chrX_+_102631408 11.322 NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr13_+_113951589 10.384 LAMP1
lysosomal-associated membrane protein 1
chr19_+_49458129 10.375 BAX
BCL2-associated X protein
chr19_+_49458151 9.353 BAX
BCL2-associated X protein
chr20_+_44520021 9.235 CTSA
cathepsin A
chr7_-_47622127 9.043 TNS3
tensin 3
chr5_+_34656367 8.929 NM_001145522
NM_015577
RAI14

retinoic acid induced 14

chr1_-_153508597 8.588 NM_014624
S100A6
S100 calcium binding protein A6
chr5_+_34656482 8.360 RAI14
retinoic acid induced 14
chr3_-_49395697 8.207 GPX1
glutathione peroxidase 1
chr1_-_68697997 8.105 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr3_-_49395751 8.006 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chrX_-_100914816 7.827 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr7_-_47621741 7.815 NM_022748
TNS3
tensin 3
chr22_+_35777087 7.634 HMOX1
heme oxygenase (decycling) 1
chr20_+_44519965 7.581 CTSA
cathepsin A
chr12_-_49318663 7.567 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr5_+_34656595 7.333 NM_001145520
RAI14
retinoic acid induced 14
chr6_+_151646634 7.140 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chrX_-_34675366 7.063 NM_031442
TMEM47
transmembrane protein 47
chr20_+_44519924 7.057 CTSA
cathepsin A
chr6_+_151561508 6.997 AKAP12
A kinase (PRKA) anchor protein 12
chr5_+_52776408 6.805 FST
follistatin
chr1_-_155210887 6.536 GBA
glucosidase, beta, acid
chr19_-_10764449 6.434 LOC147727
uncharacterized LOC147727
chr6_+_151561094 6.329 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr1_-_155211049 6.325 NM_001171812
NM_000157
GBA

glucosidase, beta, acid

chr15_-_73925658 6.298 NM_001161363
NM_001161364
NM_012428
NM_017455
NPTN



neuroplastin



chr15_-_73925555 6.213 NPTN
neuroplastin
chr21_-_27543134 6.029 NM_000484
NM_001136129
NM_001136130
NM_001204301
NM_001204302
NM_001204303
NM_201413
NM_201414
APP







amyloid beta (A4) precursor protein







chr17_+_42422490 5.985 NM_002087
GRN
granulin
chr17_+_42422627 5.876 GRN
granulin
chrX_+_100805415 5.665 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr5_+_52776479 5.659 FST
follistatin
chr1_-_154193044 5.648 C1orf43
chromosome 1 open reading frame 43
chr3_+_112280871 5.496 NM_017945
SLC35A5
solute carrier family 35, member A5
chr1_+_11866240 5.399 CLCN6
chloride channel 6
chr3_+_158519911 5.224 MFSD1
major facilitator superfamily domain containing 1
chr12_-_56122840 5.144 NM_001040034
NM_001780
CD63

CD63 molecule

chr2_+_46926049 5.019 NM_014011
SOCS5
suppressor of cytokine signaling 5
chrX_+_102840412 5.002 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr17_+_42422665 4.988 GRN
granulin
chr12_-_56122792 4.888 CD63
CD63 molecule
chr12_-_65153182 4.878 GNS
glucosamine (N-acetyl)-6-sulfatase
chr10_-_32217687 4.699 ARHGAP12
Rho GTPase activating protein 12
chr20_+_44520203 4.695 CTSA
cathepsin A
chr12_-_56122800 4.682 CD63
CD63 molecule
chr7_-_47621635 4.655 TNS3
tensin 3
chr17_-_46688362 4.579 NM_004502
HOXB7
homeobox B7
chr16_-_67514989 4.559 NM_004691
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr12_-_65153189 4.556 NM_002076
GNS
glucosamine (N-acetyl)-6-sulfatase
chr9_+_115913227 4.553 NM_001860
SLC31A2
solute carrier family 31 (copper transporters), member 2
chr3_+_112280911 4.525 SLC35A5
solute carrier family 35, member A5
chr12_-_56122748 4.456 CD63
CD63 molecule
chr3_+_158991035 4.453 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr18_-_21977785 4.449 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr1_+_154193294 4.367 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr9_+_115913266 4.352 SLC31A2
solute carrier family 31 (copper transporters), member 2
chr7_-_30029284 4.296 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr6_+_151561653 4.296 AKAP12
A kinase (PRKA) anchor protein 12
chr7_+_23286384 4.249 GPNMB
glycoprotein (transmembrane) nmb
chr19_+_40854529 4.227 PLD3
phospholipase D family, member 3
chr16_-_88923233 4.171 GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr3_+_51428720 4.126 RBM15B
RNA binding motif protein 15B
chr1_-_31845818 4.102 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr3_+_132136503 4.029 NM_015268
DNAJC13
DnaJ (Hsp40) homolog, subfamily C, member 13
chr22_+_38599026 3.957 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr1_-_39325317 3.947 NM_022157
RRAGC
Ras-related GTP binding C
chrX_+_55744049 3.889 NM_006064
NM_016656
RRAGB

Ras-related GTP binding B

chr4_+_128651518 3.864 NM_031291
SLC25A31
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31
chr6_-_80656870 3.862 NM_022726
ELOVL4
ELOVL fatty acid elongase 4
chr3_+_33318911 3.856 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr13_-_110438896 3.826 NM_003749
IRS2
insulin receptor substrate 2
chr2_+_173292306 3.757 NM_000210
NM_001079818
ITGA6

integrin, alpha 6

chr19_-_5680910 3.744 NM_205767
C19orf70
chromosome 19 open reading frame 70
chr8_+_1772095 3.732 NM_014629
ARHGEF10
Rho guanine nucleotide exchange factor (GEF) 10
chr3_+_51428698 3.707 NM_013286
RBM15B
RNA binding motif protein 15B
chr16_+_31044881 3.705 NM_004604
STX4
syntaxin 4
chr17_-_76975932 3.704 NM_005567
LGALS3BP
lectin, galactoside-binding, soluble, 3 binding protein
chr7_-_27183225 3.701 NM_019102
HOXA5
homeobox A5
chr3_+_128445026 3.701 RAB7A
RAB7A, member RAS oncogene family
chr4_+_78078332 3.646 NM_004354
CCNG2
cyclin G2
chr10_-_93392857 3.640 NM_005398
PPP1R3C
protein phosphatase 1, regulatory subunit 3C
chr8_-_126104007 3.638 KIAA0196
KIAA0196
chr1_-_241520467 3.620 NM_002924
RGS7
regulator of G-protein signaling 7
chr7_+_23286390 3.610 GPNMB
glycoprotein (transmembrane) nmb
chr19_+_10764896 3.586 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr1_-_153508463 3.569 S100A6
S100 calcium binding protein A6
chr5_-_72744351 3.512 NM_004472
FOXD1
forkhead box D1
chr22_+_35777051 3.510 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr3_+_128445033 3.509 RAB7A
RAB7A, member RAS oncogene family
chr8_-_126103873 3.496 KIAA0196
KIAA0196
chr11_+_9685650 3.492 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr7_+_23286386 3.483 GPNMB
glycoprotein (transmembrane) nmb
chr12_-_110434028 3.442 GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chrX_+_100663205 3.439 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr7_-_27205123 3.436 HOXA9
homeobox A9
chr12_+_56109832 3.431 BLOC1S1-RDH5
BLOC1S1
BLOC1S1-RDH5 readthrough
biogenesis of lysosomal organelles complex-1, subunit 1
chr11_-_8892909 3.430 ST5
suppression of tumorigenicity 5
chr3_+_128445024 3.430 RAB7A
RAB7A, member RAS oncogene family
chr3_+_128444978 3.424 NM_004637
RAB7A
RAB7A, member RAS oncogene family
chr8_-_126104004 3.394 KIAA0196
KIAA0196
chr4_-_77134987 3.356 NM_001204255
NM_005506
SCARB2

scavenger receptor class B, member 2

chrX_-_102319080 3.307 BEX1
brain expressed, X-linked 1
chr13_-_50159628 3.263 RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr7_-_27205148 3.258 NM_152739
HOXA9
homeobox A9
chr19_-_48018317 3.253 NM_003827
NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr10_-_32217762 3.246 NM_018287
ARHGAP12
Rho GTPase activating protein 12
chr8_-_11725509 3.238 CTSB
cathepsin B
chrX_+_101975641 3.233 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr10_-_3827418 3.232 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr9_-_131709783 3.204 NM_014908
DOLK
dolichol kinase
chr3_-_99594915 3.168 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr11_-_27723061 3.157 NM_170733
BDNF
brain-derived neurotrophic factor
chr21_-_27543044 3.153 APP
amyloid beta (A4) precursor protein
chr8_-_126103926 3.141 KIAA0196
KIAA0196
chr1_-_153508495 3.135 S100A6
S100 calcium binding protein A6
chr7_+_23286420 3.133 GPNMB
glycoprotein (transmembrane) nmb
chr14_-_54955664 3.131 GMFB
glia maturation factor, beta
chr5_-_150537306 3.129 ANXA6
annexin A6
chr17_-_7137722 3.123 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr16_+_31044849 3.110 STX4
syntaxin 4
chrX_+_100663229 3.108 HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr9_-_16870664 3.101 BNC2
basonuclin 2
chr4_+_39184023 3.079 NM_025132
WDR19
WD repeat domain 19
chr9_-_21994414 3.056 NM_058195
CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr8_-_126104021 3.055 KIAA0196
KIAA0196
chr13_-_50159706 3.051 NM_018191
RCBTB1
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
chr2_-_183903225 3.037 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr5_-_172755195 3.035 STC2
stanniocalcin 2
chr8_+_74903563 3.021 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr11_+_9685624 3.014 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr4_+_668250 2.996 MYL5
myosin, light chain 5, regulatory
chr12_-_65153148 2.986 GNS
glucosamine (N-acetyl)-6-sulfatase
chr1_-_241520384 2.976 RGS7
regulator of G-protein signaling 7
chr2_+_223916861 2.947 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr8_+_26240522 2.917 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr3_+_158519888 2.913 MFSD1
major facilitator superfamily domain containing 1
chr10_+_46222647 2.859 NM_001169106
NM_001169107
NM_015262
FAM21C


family with sequence similarity 21, member C


chr7_+_17338182 2.843 NM_001621
AHR
aryl hydrocarbon receptor
chrX_+_102611379 2.841 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr5_+_52776263 2.814 NM_006350
NM_013409
FST

follistatin

chr4_+_78078394 2.809 CCNG2
cyclin G2
chr2_-_20251788 2.780 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr11_-_1785104 2.741 CTSD
cathepsin D
chr2_+_238395863 2.733 NM_001042467
NM_024101
MLPH

melanophilin

chr10_+_51827710 2.719 FAM21A
family with sequence similarity 21, member A
chr4_+_668312 2.710 MYL5
myosin, light chain 5, regulatory
chr9_-_123476578 2.685 NM_001080497
MEGF9
multiple EGF-like-domains 9
chr3_-_112280759 2.632 ATG3
ATG3 autophagy related 3 homolog (S. cerevisiae)
chrX_+_100878350 2.627 NM_177948
ARMCX3
armadillo repeat containing, X-linked 3
chr12_+_6833425 2.621 NM_001164093
COPS7A
COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)
chr9_-_16870719 2.612 NM_017637
BNC2
basonuclin 2
chr8_-_126104045 2.604 NM_014846
KIAA0196
KIAA0196
chr4_-_100242487 2.595 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr3_+_158519714 2.585 NM_001167903
NM_022736
MFSD1

major facilitator superfamily domain containing 1

chr5_-_172198160 2.579 NM_004417
DUSP1
dual specificity phosphatase 1
chr8_-_95274520 2.570 GEM
GTP binding protein overexpressed in skeletal muscle
chr16_-_88923348 2.568 NM_000512
GALNS
galactosamine (N-acetyl)-6-sulfate sulfatase
chr10_-_3827205 2.558 KLF6
Kruppel-like factor 6
chr11_+_101980736 2.557 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr14_-_92572950 2.555 NM_001127696
NM_001127697
NM_001164774
NM_001164776
NM_001164777
NM_001164778
NM_001164779
NM_001164780
NM_001164781
NM_001164782
NM_004993
NM_030660
ATXN3











ataxin 3











chr19_-_48018163 2.554 NAPA
N-ethylmaleimide-sensitive factor attachment protein, alpha
chr11_+_67776016 2.552 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chrX_-_102319096 2.549 NM_018476
BEX1
brain expressed, X-linked 1
chrX_+_102883891 2.547 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr3_-_187463474 2.524 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr16_-_1525020 2.515 CLCN7
chloride channel 7
chr14_-_69446038 2.499 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chrX_+_100878101 2.452 NM_016607
NM_177947
ARMCX3

armadillo repeat containing, X-linked 3

chr15_-_40213087 2.417 NM_007223
GPR176
G protein-coupled receptor 176
chr11_-_1785087 2.411 CTSD
cathepsin D
chr9_-_21994379 2.408 CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
chr13_-_96296919 2.393 NM_014934
NM_198968
DZIP1

DAZ interacting protein 1

chr17_-_46688279 2.389 HOXB7
homeobox B7
chr5_+_149340287 2.387 NM_000112
SLC26A2
solute carrier family 26 (sulfate transporter), member 2
chrX_-_100872926 2.375 NM_001009584
NM_001184768
NM_019007
ARMCX6


armadillo repeat containing, X-linked 6


chr8_-_95274540 2.369 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr2_+_232063340 2.365 NM_025139
ARMC9
armadillo repeat containing 9
chr10_+_51827654 2.356 NM_001005751
FAM21C
FAM21A
family with sequence similarity 21, member C
family with sequence similarity 21, member A
chr2_+_232063378 2.353 ARMC9
armadillo repeat containing 9
chr20_+_56884839 2.350 RAB22A
RAB22A, member RAS oncogene family
chr17_-_46687925 2.346 HOXB7
homeobox B7
chr6_+_123110345 2.309 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr6_+_42018250 2.303 NM_138572
TAF8
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
chr1_-_205290756 2.297 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr3_+_158519925 2.280 MFSD1
major facilitator superfamily domain containing 1
chr3_+_158519877 2.278 MFSD1
major facilitator superfamily domain containing 1
chr2_+_228189919 2.278 MFF
mitochondrial fission factor
chr2_+_220042901 2.258 NM_024293
FAM134A
family with sequence similarity 134, member A
chr17_-_57184034 2.245 TRIM37
tripartite motif containing 37
chr6_-_84937313 2.239 NM_014895
KIAA1009
KIAA1009
chr2_+_232063379 2.225 ARMC9
armadillo repeat containing 9
chr14_-_74959976 2.223 NPC2
Niemann-Pick disease, type C2
chrX_-_106960268 2.216 NM_004089
TSC22D3
TSC22 domain family, member 3
chr5_+_150827138 2.215 NM_078483
SLC36A1
solute carrier family 36 (proton/amino acid symporter), member 1
chr14_+_45431333 2.202 NM_015091
FAM179B
family with sequence similarity 179, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
10.20 1.03e-03 GO:0007033 vacuole organization

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
5.22 3.87e-10 GO:0005773 vacuole
5.29 1.42e-08 GO:0000323 lytic vacuole
5.29 1.42e-08 GO:0005764 lysosome
5.06 9.03e-04 GO:0005774 vacuolar membrane
4.86 1.38e-03 GO:0044437 vacuolar part
25.50 1.92e-03 GO:0071203 WASH complex
5.05 1.47e-02 GO:0005765 lysosomal membrane
1.30 4.10e-02 GO:0044444 cytoplasmic part

Nothing significant found in function category.