Motif ID: ZEB1.p2

Z-value: 3.028


Transcription factors associated with ZEB1.p2:

Gene SymbolEntrez IDGene Name
ZEB1 6935 zinc finger E-box binding homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZEB1chr10_+_31610063-0.829.7e-05Click!


Activity profile for motif ZEB1.p2.

activity profile for motif ZEB1.p2


Sorted Z-values histogram for motif ZEB1.p2

Sorted Z-values for motif ZEB1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZEB1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_38755422 10.527 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755238 9.980 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr19_+_38755097 9.796 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr7_+_26331493 7.878 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr4_+_75310852 7.654 NM_001657
AREG
amphiregulin
chr2_+_47596286 6.621 NM_002354
EPCAM
epithelial cell adhesion molecule
chr4_+_75480628 6.606 NM_001657
AREG
amphiregulin
chr18_+_29078026 6.598 NM_001943
DSG2
desmoglein 2
chr2_+_47596447 6.375 EPCAM
epithelial cell adhesion molecule
chr1_+_1981902 6.279 NM_002744
PRKCZ
protein kinase C, zeta
chr6_+_7541837 6.233 DSP
desmoplakin
chr6_+_7541863 6.087 NM_001008844
NM_004415
DSP

desmoplakin

chr6_+_7541892 5.984 DSP
desmoplakin
chr7_+_26331611 5.878 SNX10
sorting nexin 10
chr20_-_6103562 5.842 FERMT1
fermitin family member 1
chr16_+_68771192 5.255 NM_004360
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr21_-_43187197 5.027 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr1_+_60280462 4.857 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr2_-_166650770 4.798 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr19_+_35739519 4.771 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr8_+_95653272 4.484 ESRP1
epithelial splicing regulatory protein 1
chr19_+_35739778 4.293 LSR
lipolysis stimulated lipoprotein receptor
chr16_+_68679229 4.246 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr14_-_67878859 4.245 PLEK2
pleckstrin 2
chr14_-_67878770 4.187 NM_016445
PLEK2
pleckstrin 2
chr2_-_20424627 4.081 NM_002997
SDC1
syndecan 1
chr21_-_43187265 4.069 RIPK4
receptor-interacting serine-threonine kinase 4
chr2_+_17721806 4.002 NM_003385
VSNL1
visinin-like 1
chr11_+_121322848 3.864 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr17_-_39942937 3.841 NM_002230
NM_021991
JUP

junction plakoglobin

chr19_+_35739282 3.713 LSR
lipolysis stimulated lipoprotein receptor
chr16_+_68771214 3.671 CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr14_-_61747956 3.524 TMEM30B
transmembrane protein 30B
chr2_+_17721983 3.424 VSNL1
visinin-like 1
chr19_+_35739838 3.351 LSR
lipolysis stimulated lipoprotein receptor
chr8_+_86376130 3.312 NM_000067
CA2
carbonic anhydrase II
chr1_-_209979388 3.268 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr4_+_4388804 3.180 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr11_+_32851469 3.136 NM_024081
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chrX_+_131157635 3.134 NM_001042452
MST4
serine/threonine protein kinase MST4
chr5_+_76114832 3.089 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr3_-_45187861 2.979 CDCP1
CUB domain containing protein 1
chr6_-_10419786 2.951 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr20_+_61448391 2.855 NM_001853
COL9A3
collagen, type IX, alpha 3
chr3_-_45187897 2.777 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr5_+_167718485 2.768 NM_001161661
NM_001161662
NM_015238
WWC1


WW and C2 domain containing 1


chr20_-_10654139 2.731 JAG1
jagged 1
chr3_-_45187843 2.723 CDCP1
CUB domain containing protein 1
chr17_+_73717515 2.706 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr12_-_52914080 2.661 NM_000424
KRT5
keratin 5
chr11_+_722282 2.648 EPS8L2
EPS8-like 2
chr4_+_4388717 2.599 D4S234E
DNA segment on chromosome 4 (unique) 234 expressed sequence
chr19_-_51487070 2.579 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr4_-_36245893 2.540 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr16_-_68269948 2.535 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr2_-_20425166 2.444 NM_001006946
SDC1
syndecan 1
chr17_+_73717556 2.431 ITGB4
integrin, beta 4
chr5_+_76114881 2.406 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr16_-_11680756 2.404 NM_001136472
NM_001136473
LITAF

lipopolysaccharide-induced TNF factor

chr20_+_25228698 2.369 NM_002862
PYGB
phosphorylase, glycogen; brain
chr17_+_73521744 2.360 NM_001015002
NM_001031803
NM_004524
LLGL2


lethal giant larvae homolog 2 (Drosophila)


chr14_-_61748510 2.346 NM_001017970
TMEM30B
transmembrane protein 30B
chrX_+_152908819 2.341 DUSP9
dual specificity phosphatase 9
chr2_-_216878314 2.324 NM_018000
MREG
melanoregulin
chr20_-_10654429 2.236 NM_000214
JAG1
jagged 1
chr7_-_22396511 2.210 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr17_+_73717596 2.198 ITGB4
integrin, beta 4
chr1_+_183155393 2.153 LAMC2
laminin, gamma 2
chr6_+_36098261 2.046 NM_002754
MAPK13
mitogen-activated protein kinase 13
chr4_+_89300110 1.999 HERC6
hect domain and RLD 6
chr17_-_80041166 1.966 FASN
fatty acid synthase
chr11_-_71159371 1.966 DHCR7
7-dehydrocholesterol reductase
chr17_-_80042414 1.946 FASN
fatty acid synthase
chr10_+_124134093 1.931 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_+_69924407 1.922 NM_018043
ANO1
anoctamin 1, calcium activated chloride channel
chr3_+_186330844 1.908 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr2_+_163200582 1.863 NM_012198
GCA
grancalcin, EF-hand calcium binding protein
chr6_-_47277354 1.850 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr6_-_47277246 1.829 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr7_+_55086922 1.809 EGFR
epidermal growth factor receptor
chr3_+_186330711 1.799 AHSG
alpha-2-HS-glycoprotein
chrX_+_105969875 1.793 NM_194463
RNF128
ring finger protein 128
chrX_-_133119475 1.789 GPC3
glypican 3
chr4_+_89299980 1.787 HERC6
hect domain and RLD 6
chr1_+_154377668 1.774 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr1_-_11714738 1.767 NM_012168
FBXO2
F-box protein 2
chr7_+_115850546 1.763 NM_015641
TES
testis derived transcript (3 LIM domains)
chr3_+_186330859 1.755 AHSG
alpha-2-HS-glycoprotein
chr3_-_189838673 1.725 LEPREL1
leprecan-like 1
chr6_-_47277511 1.718 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr6_-_47277646 1.703 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr20_+_44035203 1.696 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr12_+_56473944 1.690 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr17_-_39684499 1.689 KRT19
keratin 19
chr1_+_46646199 1.674 TSPAN1
tetraspanin 1
chr11_-_115375065 1.660 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr18_+_61144143 1.657 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr2_+_163200623 1.623 GCA
grancalcin, EF-hand calcium binding protein
chr8_-_110657025 1.621 NM_001099753
NM_001099754
NM_001099755
SYBU


syntabulin (syntaxin-interacting)


chr20_+_43991739 1.604 NM_001099791
NM_033542
SYS1-DBNDD2
SYS1

SYS1-DBNDD2 readthrough
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)

chr12_+_56473808 1.596 NM_001982
NM_001005915
ERBB3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

chrX_+_152954965 1.584 NM_001142806
SLC6A8
solute carrier family 6 (neurotransmitter transporter, creatine), member 8
chr20_+_61273786 1.562 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr16_+_68679198 1.561 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr8_+_95653399 1.559 ESRP1
epithelial splicing regulatory protein 1
chr4_+_79472741 1.552 NM_005139
ANXA3
annexin A3
chr17_+_40811261 1.548 NM_016437
TUBG2
tubulin, gamma 2
chr8_+_95653340 1.545 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr18_-_21166440 1.530 NM_000271
NPC1
Niemann-Pick disease, type C1
chr17_+_2680349 1.527 RAP1GAP2
RAP1 GTPase activating protein 2
chr12_-_28122884 1.482 NM_198964
NM_198966
PTHLH

parathyroid hormone-like hormone

chr4_+_85504056 1.476 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr1_+_183155361 1.472 LAMC2
laminin, gamma 2
chr1_+_183155173 1.457 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr16_-_4987056 1.445 NM_002705
PPL
periplakin
chr2_-_165477986 1.432 GRB14
growth factor receptor-bound protein 14
chr19_+_35607218 1.428 FXYD3
FXYD domain containing ion transport regulator 3
chr9_-_100954883 1.426 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr12_-_52886971 1.421 NM_005554
KRT6A
keratin 6A
chr12_+_57984992 1.421 PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr1_+_35247838 1.411 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr20_+_61273823 1.403 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr12_+_57984914 1.400 NM_001146258
NM_001146259
NM_001146260
NM_024779
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr18_-_21166378 1.372 NPC1
Niemann-Pick disease, type C1
chr2_-_165477818 1.368 GRB14
growth factor receptor-bound protein 14
chr11_-_71159442 1.358 NM_001163817
NM_001360
DHCR7

7-dehydrocholesterol reductase

chr5_-_74162614 1.357 NM_015566
FAM169A
family with sequence similarity 169, member A
chr12_-_110939877 1.356 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr1_-_59042827 1.308 TACSTD2
tumor-associated calcium signal transducer 2
chr5_+_218355 1.304 NM_004168
SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr10_+_38645293 1.288 HSD17B7P2
hydroxysteroid (17-beta) dehydrogenase 7 pseudogene 2
chr2_-_122042767 1.286 NM_014553
TFCP2L1
transcription factor CP2-like 1
chr4_+_89299874 1.281 NM_001165136
NM_017912
HERC6

hect domain and RLD 6

chr20_+_44034632 1.275 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr19_+_7702010 1.269 STXBP2
syntaxin binding protein 2
chr1_-_160990862 1.258 F11R
F11 receptor
chr2_-_224903933 1.253 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr19_-_51522953 1.245 NM_145888
KLK10
kallikrein-related peptidase 10
chr8_-_145638929 1.243 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr2_+_216176808 1.243 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr4_+_128703402 1.232 NM_014278
HSPA4L
heat shock 70kDa protein 4-like
chr4_-_151936377 1.227 NM_001199282
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr17_-_80056033 1.221 FASN
fatty acid synthase
chr12_-_85306579 1.219 NM_001146335
NM_018057
NM_182767
SLC6A15


solute carrier family 6 (neutral amino acid transporter), member 15


chr1_-_27240430 1.214 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr1_-_95007139 1.210 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr6_+_30294224 1.202


chr1_+_162760491 1.199 NM_016371
HSD17B7
hydroxysteroid (17-beta) dehydrogenase 7
chr14_+_65171149 1.199 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr12_-_85306569 1.196 SLC6A15
solute carrier family 6 (neutral amino acid transporter), member 15
chr14_+_31343642 1.188 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr15_+_40545348 1.186 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_-_27816542 1.164 WASF2
WAS protein family, member 2
chr1_-_6662681 1.162 KLHL21
kelch-like 21 (Drosophila)
chr16_-_52581713 1.159 NM_001146188
TOX3
TOX high mobility group box family member 3
chr7_+_94536926 1.157 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr12_-_33049664 1.157 NM_001005242
NM_004572
PKP2

plakophilin 2

chr8_-_81083660 1.144 NM_001025253
NM_005079
TPD52

tumor protein D52

chr2_-_235405692 1.143 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr20_-_60942300 1.134 NM_005560
LAMA5
laminin, alpha 5
chr16_-_52580805 1.132 NM_001080430
TOX3
TOX high mobility group box family member 3
chr8_-_28243941 1.130 NM_018660
ZNF395
zinc finger protein 395
chr4_-_151936648 1.124 NM_006726
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr17_+_79935493 1.122 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr17_+_79935410 1.121 NM_001251888
NM_024083
ASPSCR1

alveolar soft part sarcoma chromosome region, candidate 1

chr12_-_63328857 1.120 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr4_-_57301643 1.116 NM_002703
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr3_+_167453431 1.098 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr11_+_68079999 1.094 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr20_+_361272 1.092 NM_021158
TRIB3
tribbles homolog 3 (Drosophila)
chr2_+_64681270 1.090 NM_014181
LGALSL
lectin, galactoside-binding-like
chr19_+_7701976 1.089 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr17_+_65373923 1.083 NM_012417
NM_181671
PITPNC1

phosphatidylinositol transfer protein, cytoplasmic 1

chr3_-_189838907 1.074 NM_018192
LEPREL1
leprecan-like 1
chr7_+_16793320 1.067 NM_014399
TSPAN13
tetraspanin 13
chr1_+_26872306 1.059 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_59043165 1.058 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr18_+_55816546 1.056 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr19_-_51523272 1.031 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr5_-_1524022 1.028 NM_024830
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr2_+_118846029 1.027 NM_016133
INSIG2
insulin induced gene 2
chr16_+_1728283 1.026 HN1L
hematological and neurological expressed 1-like
chr1_+_2005424 1.025 NM_001242874
PRKCZ
protein kinase C, zeta
chr5_+_52284903 1.018 NM_002203
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr3_-_8693723 1.010 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr1_-_161008710 1.007 TSTD1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr12_-_6484904 1.000 NM_001038
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chrX_+_131157231 0.997 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr7_+_17338182 0.992 NM_001621
AHR
aryl hydrocarbon receptor
chr18_-_48724031 0.991 NM_016626
MEX3C
mex-3 homolog C (C. elegans)
chr5_+_218428 0.986 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr1_-_197744529 0.978 NM_001195215
NM_001195216
NM_144977
DENND1B


DENN/MADD domain containing 1B


chr1_+_26872342 0.977 NM_001006665
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_161008733 0.977 NM_001113205
NM_001113206
NM_001113207
TSTD1


F11R
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1


F11 receptor
chr18_+_47088400 0.961 NM_006033
LIPG
lipase, endothelial
chr18_+_55862577 0.958 NM_001144970
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_+_65171243 0.955 PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr11_+_706103 0.952 NM_022772
EPS8L2
EPS8-like 2
chr10_-_118764559 0.948 KIAA1598
KIAA1598
chr4_-_16085666 0.946 PROM1
prominin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.79 3.20e-05 GO:0008544 epidermis development
2.38 4.45e-04 GO:0048513 organ development
1.97 5.59e-04 GO:0048856 anatomical structure development
3.86 6.51e-04 GO:0009887 organ morphogenesis
2.00 1.35e-03 GO:0048731 system development
3.18 1.67e-03 GO:0009888 tissue development
4.51 4.58e-03 GO:0060429 epithelium development
1.80 9.95e-03 GO:0007275 multicellular organismal development
1.74 1.21e-02 GO:0032502 developmental process
13.32 2.52e-02 GO:0031100 organ regeneration

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.94 1.11e-05 GO:0005886 plasma membrane
2.32 1.47e-05 GO:0044459 plasma membrane part
1.91 1.90e-05 GO:0071944 cell periphery
1.55 3.76e-05 GO:0016020 membrane
28.11 1.03e-04 GO:0030057 desmosome
6.37 5.84e-04 GO:0005911 cell-cell junction
1.57 1.47e-03 GO:0044425 membrane part
4.94 5.41e-03 GO:0016323 basolateral plasma membrane
5.51 1.58e-02 GO:0070161 anchoring junction
3.14 2.31e-02 GO:0030054 cell junction
1.32 2.33e-02 GO:0005737 cytoplasm

Nothing significant found in function category.