Motif ID: ALX1.p2

Z-value: 0.925


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1



Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_-_21207303 2.288 NM_002173
IFNA16
interferon, alpha 16
chr1_+_115373937 1.596 NM_000549
TSHB
thyroid stimulating hormone, beta
chr11_-_123695302 1.349 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr2_-_162717159 1.204 NM_002054
GCG
glucagon
chr9_-_21192201 1.126 NM_021057
IFNA7
interferon, alpha 7
chr8_-_111056099 0.979 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr12_-_10850845 0.943 NM_023918
TAS2R8
taste receptor, type 2, member 8
chr5_+_140215778 0.939 NM_018901
NM_031859
NM_031860
PCDHA10


protocadherin alpha 10


chr20_+_34019942 0.916 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr11_-_128242342 0.885 NM_153764
NM_153765
NM_153766
NM_153767
KCNJ1



potassium inwardly-rectifying channel, subfamily J, member 1



chr15_+_36014748 0.883 NM_152453
TMCO5A
transmembrane and coiled-coil domains 5A
chr9_-_21340885 0.878 NM_021002
IFNA6
interferon, alpha 6
chr4_-_120462705 0.866 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr9_-_21358005 0.798 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr3_+_35658852 0.791 NM_016300
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr5_+_140537554 0.786 NM_019120
PCDHB8
protocadherin beta 8
chr2_-_199922047 0.768 SATB2
SATB homeobox 2
chr19_+_59158101 0.702 NM_031895
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr4_-_123761615 0.689 NM_021803
IL21
interleukin 21
chr5_+_140594121 0.681 PCDHB18
protocadherin beta 18 pseudogene
chr2_+_130995136 0.604 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr8_-_15140162 0.593 NM_139167
SGCZ
sarcoglycan, zeta
chr8_+_38704860 0.589 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr8_-_110730183 0.588 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr5_+_36644187 0.570 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_+_100512877 0.543 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr12_-_4358968 0.542 NM_020638
FGF23
fibroblast growth factor 23
chr9_+_5221401 0.541 NM_002195
INSL4
insulin-like 4 (placenta)
chr4_+_70950747 0.538 NM_002159
HTN1
histatin 1
chr19_-_4486202 0.533 NM_001013706
PLIN5
perilipin 5
chrX_-_131089552 0.527 NM_194277
FRMD7
FERM domain containing 7
chr9_-_21218132 0.525 NM_021268
IFNA17
interferon, alpha 17
chr4_-_107508040 0.519 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr5_+_140762551 0.500 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr5_+_57823017 0.493 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr8_+_7821268 0.491 NM_001193630
LOC100132396
zinc finger protein 705D-like
chr5_+_140573692 0.488 NM_018933
PCDHB13
protocadherin beta 13
chr4_+_158361185 0.485 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr2_+_102456193 0.483 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr12_-_11354620 0.476 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr6_-_128281434 0.473 NM_001164687
THEMIS
thymocyte selection associated
chr18_-_68362702 0.472 NM_182511
CBLN2
cerebellin 2 precursor
chr19_-_14030970 0.471 NM_001145028
PALM3
paralemmin 3
chr2_-_131073329 0.464 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chrX_-_21686079 0.461 NM_014332
SMPX
small muscle protein, X-linked
chr3_+_150065732 0.461 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr12_+_9871343 0.458 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr7_+_115650240 0.456 NM_152829
TES
testis derived transcript (3 LIM domains)
chr7_+_20653490 0.455 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr11_+_123625632 0.455 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr16_-_70763849 0.449 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr5_+_132433979 0.444 HSPA4
heat shock 70kDa protein 4
chr3_-_152541129 0.437 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr2_-_207291364 0.436 NM_001093730
DYTN
dystrotelin
chr8_-_33576907 0.433 NM_024025
DUSP26
dual specificity phosphatase 26 (putative)
chr14_-_20098929 0.430 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr5_+_61910318 0.427 NM_181506
LRRC70
leucine rich repeat containing 70
chr17_+_29707583 0.424 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr15_-_88023576 0.423 NM_001145311
NM_002666
PLIN1

perilipin 1

chr3_+_108578877 0.423 NM_032600
CCDC54
coiled-coil domain containing 54
chr7_-_87068106 0.422 ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr18_+_28023984 0.422 NM_005925
MEP1B
meprin A, beta
chr8_-_12220195 0.418 NM_001195257
NM_001037804
LOC100133267
DEFB130
defensin, beta 130-like
defensin, beta 130
chr6_+_105511615 0.411 NM_001004317
LIN28B
lin-28 homolog B (C. elegans)
chr4_+_141484046 0.411 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr6_-_76259976 0.410 NM_015687
FILIP1
filamin A interacting protein 1
chr9_-_21156609 0.408 NM_002175
IFNA21
interferon, alpha 21
chr3_-_38810504 0.405 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr14_+_61532293 0.404 NM_031914
SYT16
synaptotagmin XVI
chr8_-_33577033 0.393 DUSP26
dual specificity phosphatase 26 (putative)
chr5_-_176258920 0.388 NM_002115
HK3
hexokinase 3 (white cell)
chr12_-_54150188 0.383 NM_001005499
OR6C70
olfactory receptor, family 6, subfamily C, member 70
chrX_+_51562894 0.381 NM_001005332
MAGED1
melanoma antigen family D, 1
chr12_-_61832856 0.380 NM_000706
AVPR1A
arginine vasopressin receptor 1A
chr1_+_67404756 0.378 NM_144701
IL23R
interleukin 23 receptor
chr11_+_88550687 0.378 NM_000372
TYR
tyrosinase (oculocutaneous albinism IA)
chr11_-_7906784 0.375 NM_001004461
OR10A6
olfactory receptor, family 10, subfamily A, member 6
chr1_+_54132447 0.375 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr5_-_177140071 0.373 NM_173663
FAM153A
FAM153C
family with sequence similarity 153, member A
family with sequence similarity 153, member C
chr9_-_106401514 0.373 NM_001004482
OR13C5
olfactory receptor, family 13, subfamily C, member 5
chr7_+_101810018 0.366


chr5_+_140723939 0.365 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr5_-_149446319 0.365 CSF1R
colony stimulating factor 1 receptor
chr9_-_28709302 0.364 NM_152570
LINGO2
leucine rich repeat and Ig domain containing 2
chr7_+_99263571 0.362 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr5_-_149446366 0.361 CSF1R
colony stimulating factor 1 receptor
chr3_+_129124591 0.359 NM_207335
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr12_-_11030777 0.359 NM_176890
TAS2R50
taste receptor, type 2, member 50
chr1_+_180685878 0.358 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr19_-_63138551 0.354 NM_133460
ZNF418
zinc finger protein 418
chr14_-_74400288 0.354 NM_001080408
PROX2
prospero homeobox 2
chr11_-_76800525 0.348 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr4_-_21308415 0.345 NM_001035003
KCNIP4
Kv channel interacting protein 4
chr11_+_7574992 0.343 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_-_149446303 0.342 CSF1R
colony stimulating factor 1 receptor
chr14_+_20306425 0.339 NM_022360
EDDM3B
epididymal protein 3B
chr5_+_140605330 0.336 NM_018935
PCDHB15
protocadherin beta 15
chr21_+_30895276 0.336 NM_181620
KRTAP22-1
keratin associated protein 22-1
chr2_+_98329049 0.334 NM_001079878
NM_001298
CNGA3

cyclic nucleotide gated channel alpha 3

chr19_+_54128750 0.334 NM_014475
DHDH
dihydrodiol dehydrogenase (dimeric)
chr5_+_140200995 0.334 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr11_-_57947358 0.334 NM_001005566
OR5B2
olfactory receptor, family 5, subfamily B, member 2
chr6_-_10939095 0.330 NM_005906
MAK
male germ cell-associated kinase
chr9_-_21295311 0.329 NM_002169
IFNA5
interferon, alpha 5
chr1_-_180908639 0.327 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr12_+_4569504 0.327 NM_003845
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr11_+_113351006 0.320 NM_000869
NM_213621
HTR3A

5-hydroxytryptamine (serotonin) receptor 3A

chr17_+_18566060 0.319 NM_001037330
TRIM16L
tripartite motif containing 16-like
chr2_+_207512522 0.316 NM_173077
CPO
carboxypeptidase O
chr5_-_149446287 0.314 CSF1R
colony stimulating factor 1 receptor
chr19_-_10558906 0.314 NM_005498
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr2_+_86998248 0.311 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr7_+_27248688 0.310 NM_001989
EVX1
even-skipped homeobox 1
chr11_-_13474101 0.309 NM_000315
PTH
parathyroid hormone
chr17_-_16497882 0.307 NM_020787
ZNF624
zinc finger protein 624
chr5_+_140227951 0.306 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr18_+_19826734 0.306 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr1_+_156991133 0.305 NM_001005184
OR6K6
olfactory receptor, family 6, subfamily K, member 6
chr19_+_7468444 0.303 NM_198534
C19orf45
chromosome 19 open reading frame 45
chrX_-_6156655 0.301 NM_181332
NLGN4X
neuroligin 4, X-linked
chr1_-_155788775 0.300 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr4_-_77547481 0.300 NM_001042784
CCDC158
coiled-coil domain containing 158
chr5_+_140532385 0.298 NM_018940
PCDHB7
protocadherin beta 7
chrX_+_77889861 0.296 NM_005296
LPAR4
lysophosphatidic acid receptor 4
chr10_-_21226536 0.296 NM_006393
NEBL
nebulette
chr12_-_21818881 0.296 NM_004982
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr22_-_15682555 0.295 NM_175878
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr11_-_59707074 0.292 NM_022349
NM_152851
NM_152852
MS4A6A


membrane-spanning 4-domains, subfamily A, member 6A


chr2_-_88946767 0.287


chr3_+_35697432 0.287 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr5_+_140583098 0.287 NM_018934
PCDHB14
protocadherin beta 14
chr3_+_28406990 0.283 NM_001040432
ZCWPW2
zinc finger, CW type with PWWP domain 2
chr10_-_23673777 0.278 NM_153714
C10orf67
chromosome 10 open reading frame 67
chr10_-_13316333 0.278 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr1_-_76170563 0.277 NM_080868
ASB17
ankyrin repeat and SOCS box containing 17
chr9_-_106407728 0.276 NM_001004481
OR13C2
olfactory receptor, family 13, subfamily C, member 2
chr14_+_73153300 0.276 NM_001037162
ACOT6
acyl-CoA thioesterase 6
chr19_-_5821546 0.276 NM_002034
FUT5
fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
chr14_+_100365390 0.275 MEG3
maternally expressed 3 (non-protein coding)
chr12_-_9987277 0.274 LOC100506159
hypothetical LOC100506159
chr9_-_27287106 0.272 NM_001161585
NM_020641
C9orf11

chromosome 9 open reading frame 11

chr7_+_156677777 0.271


chr3_-_12561962 0.267 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr7_+_37689903 0.265


chr19_-_23225001 0.263 ZNF724P
zinc finger protein 724, pseudogene
chr19_-_61431470 0.261 NM_024303
ZSCAN5A
zinc finger and SCAN domain containing 5A
chr5_-_132228375 0.258 NM_005260
GDF9
growth differentiation factor 9
chr9_+_6231677 0.256 NM_033439
IL33
interleukin 33
chr19_+_9984861 0.253 NM_015725
RDH8
retinol dehydrogenase 8 (all-trans)
chr17_-_77498399 0.251 NM_001145113
MYADML2
myeloid-associated differentiation marker-like 2
chr9_+_101628829 0.249 NM_173200
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr3_+_122769467 0.249 NM_001012659
ARGFX
arginine-fifty homeobox
chr1_-_197173159 0.248 LOC100131234
familial acute myelogenous leukemia related factor
chr9_+_106496480 0.244 NM_001004484
OR13D1
olfactory receptor, family 13, subfamily D, member 1
chr19_+_21480229 0.244 NM_001001415
ZNF429
zinc finger protein 429
chr6_+_70633168 0.243 NM_001858
COL19A1
collagen, type XIX, alpha 1
chr17_+_44564820 0.242 NM_001159388
B4GALNT2
beta-1,4-N-acetyl-galactosaminyl transferase 2
chr5_+_140742585 0.241 NM_018920
NM_032087
PCDHGA7

protocadherin gamma subfamily A, 7

chr1_-_180840016 0.241 NM_002928
RGS16
regulator of G-protein signaling 16
chr4_+_71283383 0.240 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr12_-_10853940 0.239 NM_023917
TAS2R9
taste receptor, type 2, member 9
chr1_+_195010552 0.236 NM_001166624
NM_021023
CFHR3

complement factor H-related 3

chr9_-_21177529 0.235 NM_021068
IFNA4
interferon, alpha 4
chr5_-_149446182 0.235 CSF1R
colony stimulating factor 1 receptor
chr4_-_87247829 0.234 NM_138981
MAPK10
mitogen-activated protein kinase 10
chr4_-_160175782 0.233 NM_152543
C4orf45
chromosome 4 open reading frame 45
chr3_-_17716515 0.232 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr10_+_29617995 0.232 NM_032517
LYZL1
lysozyme-like 1
chr22_+_31526801 0.228 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr11_+_59920062 0.227 NM_001079692
NM_032597
MS4A14

membrane-spanning 4-domains, subfamily A, member 14

chr19_-_21438525 0.226


chr12_+_52696908 0.226 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr15_+_92700167 0.225 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr4_+_156807311 0.222 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr10_-_91092410 0.220 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr8_-_7710547 0.219 NM_001037668
NM_001040705
DEFB107A
DEFB107B
defensin, beta 107A
defensin, beta 107B
chr4_-_15549047 0.219 NM_005130
FGFBP1
fibroblast growth factor binding protein 1
chr1_+_51340487 0.219 NM_001136508
C1orf185
chromosome 1 open reading frame 185
chr5_-_22889487 0.217 NM_004061
CDH12
cadherin 12, type 2 (N-cadherin 2)
chr3_-_52688768 0.217 NM_018165
NM_181042
PBRM1

polybromo 1

chr6_-_26216299 0.216 NM_005323
HIST1H1T
histone cluster 1, H1t
chr3_+_150028130 0.213 NM_001871
CPB1
carboxypeptidase B1 (tissue)
chr19_+_9347991 0.212 NM_001172651
ZNF177
zinc finger protein 177
chr10_+_13668944 0.212 NM_003675
PRPF18
PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
chr1_+_150005754 0.212 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chrX_+_82649924 0.212 NM_000307
POU3F4
POU class 3 homeobox 4
chr11_+_73339011 0.211 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr13_+_23042722 0.210 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr12_-_11399776 0.210 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr3_+_160473784 0.210 SCHIP1
schwannomin interacting protein 1
chr11_-_113971607 0.210 FAM55D
family with sequence similarity 55, member D
chr14_+_93455010 0.209 NM_138344
FAM181A
family with sequence similarity 181, member A
chr4_+_71126376 0.209 NM_152997
C4orf7
chromosome 4 open reading frame 7
chr11_+_63282639 0.207 RTN3
reticulon 3
chr9_-_21375258 0.204 NM_000605
IFNA2
interferon, alpha 2
chr19_+_7639971 0.203 NM_001193374
NM_020415
RETN

resistin

chr1_+_171871283 0.203 NM_001195190
LOC730159
hypothetical protein LOC730159
chr12_+_108452117 0.202 UBE3B
ubiquitin protein ligase E3B
chr18_-_54447168 0.200 NM_052947
ALPK2
alpha-kinase 2
chr5_-_22889192 0.200 CDH12
cadherin 12, type 2 (N-cadherin 2)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
189.33 1.73e-03 GO:0060338 regulation of type I interferon-mediated signaling pathway
10.12 5.55e-03 GO:0010033 response to organic substance
91.70 7.49e-03 GO:0060337 type I interferon-mediated signaling pathway
91.70 7.49e-03 GO:0071357 cellular response to type I interferon
90.25 7.73e-03 GO:0034340 response to type I interferon
90.25 7.73e-03 GO:0060759 regulation of response to cytokine stimulus
7.18 2.21e-02 GO:0007166 cell surface receptor linked signaling pathway

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
8.89 1.41e-02 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
709.54 1.37e-05 GO:0005132 interferon-alpha/beta receptor binding
11.99 3.45e-04 GO:0005102 receptor binding
57.49 2.35e-03 GO:0005179 hormone activity
30.84 8.16e-03 GO:0005126 cytokine receptor binding
28.68 9.43e-03 GO:0005125 cytokine activity