Motif ID: ATF2.p2

Z-value: 1.695


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2



Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_111777651 2.919 PITX2
paired-like homeodomain 2
chr2_-_27384617 2.815 NM_003353
UCN
urocortin
chr4_-_111777584 2.723 PITX2
paired-like homeodomain 2
chr2_+_220116986 2.136 NM_001005209
TMEM198
transmembrane protein 198
chr15_+_74416156 2.006 NM_145805
ISL2
ISL LIM homeobox 2
chr5_-_176760242 1.974 NM_001029886
PFN3
profilin 3
chr2_+_220117009 1.949 TMEM198
transmembrane protein 198
chr15_+_74416129 1.916 ISL2
ISL LIM homeobox 2
chr5_+_140747586 1.898 NM_003736
NM_032098
PCDHGB4

protocadherin gamma subfamily B, 4

chr11_-_31796061 1.877 NM_001127612
PAX6
paired box 6
chr22_-_27787793 1.863 NM_015370
C22orf31
chromosome 22 open reading frame 31
chr19_+_18584666 1.755 NM_012109
TMEM59L
transmembrane protein 59-like
chr12_+_52665196 1.731 NM_017409
HOXC10
homeobox C10
chr2_-_96899396 1.638 NM_017789
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr12_+_70119785 1.629 LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr10_+_22674379 1.603 NM_012443
NM_172242
SPAG6

sperm associated antigen 6

chr1_+_29435534 1.592 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr9_+_125813672 1.443 NM_004789
LHX2
LIM homeobox 2
chrX_+_117992603 1.423 LONRF3
LON peptidase N-terminal domain and ring finger 3
chr6_-_127822227 1.401 NM_014702
KIAA0408
KIAA0408
chrX_-_13866565 1.399 NM_001001994
GPM6B
glycoprotein M6B
chr6_+_108593907 1.376 NM_003269
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr5_-_95794416 1.366 NM_000439
PCSK1
proprotein convertase subtilisin/kexin type 1
chr10_-_95350949 1.302 NM_006744
RBP4
retinol binding protein 4, plasma
chr21_-_42060266 1.275 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr11_-_107087943 1.251 NM_003063
SLN
sarcolipin
chr7_-_37923040 1.220 NM_003014
SFRP4
secreted frizzled-related protein 4
chr3_-_21767819 1.218 NM_024697
ZNF385D
zinc finger protein 385D
chr21_-_42060334 1.213 RIPK4
receptor-interacting serine-threonine kinase 4
chr12_+_52680143 1.189 NM_006897
HOXC9
homeobox C9
chr17_+_50697319 1.184 NM_002126
HLF
hepatic leukemia factor
chr1_+_65385799 1.173 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr4_-_187884721 1.171


chr11_+_108798047 1.164 NM_207645
C11orf87
chromosome 11 open reading frame 87
chrX_+_84385649 1.152 NM_021998
ZNF711
zinc finger protein 711
chr2_+_5750229 1.152 NM_003108
SOX11
SRY (sex determining region Y)-box 11
chr6_+_39868116 1.139


chr22_-_42589543 1.129 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr11_-_13474101 1.098 NM_000315
PTH
parathyroid hormone
chr16_-_4528739 1.076 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chrX_-_10605726 1.069 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr14_+_59782222 1.062 NM_177952
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr5_-_132976094 1.056 FSTL4
follistatin-like 4
chr17_+_50697355 1.048 HLF
hepatic leukemia factor
chr20_+_10147455 1.024 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chr16_-_53520208 1.017 CRNDE
colorectal neoplasia differentially expressed (non-protein coding)
chr5_-_132976121 1.016 NM_015082
FSTL4
follistatin-like 4
chr9_+_125813849 1.009 LHX2
LIM homeobox 2
chr6_+_39868126 0.994 DAAM2
dishevelled associated activator of morphogenesis 2
chr8_-_26780645 0.987


chr1_+_99502655 0.979 LPPR4
lipid phosphate phosphatase-related protein type 4
chr13_-_24643778 0.967 NM_152704
NM_199138
FAM123A

family with sequence similarity 123A

chr4_-_156517394 0.964 MAP9
microtubule-associated protein 9
chr10_-_73518269 0.963 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr10_-_73518284 0.960 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_-_37922902 0.958 SFRP4
secreted frizzled-related protein 4
chr10_-_52315436 0.948 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr4_-_156517544 0.943 NM_001039580
MAP9
microtubule-associated protein 9
chr1_-_152431175 0.930 NM_152263
TPM3
tropomyosin 3
chr4_-_156517423 0.930 MAP9
microtubule-associated protein 9
chr11_+_108798084 0.912 C11orf87
chromosome 11 open reading frame 87
chr2_+_219991342 0.908 NM_001927
DES
desmin
chr10_-_99780336 0.907 CRTAC1
cartilage acidic protein 1
chr3_+_186563529 0.900 NM_004721
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chrX_+_117992623 0.893 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr2_-_213723298 0.871 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr1_-_203657803 0.867 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chr10_-_73518315 0.856 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr4_+_54790190 0.846 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chrX_-_131918905 0.839 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr2_-_200028977 0.821 SATB2
SATB homeobox 2
chr9_-_126573349 0.818 NM_001489
NM_033334
NR6A1

nuclear receptor subfamily 6, group A, member 1

chr12_+_52697160 0.816 HOXC5
HOXC6
homeobox C5
homeobox C6
chr7_-_100595552 0.815 NM_003378
VGF
VGF nerve growth factor inducible
chr8_-_27171852 0.807 STMN4
stathmin-like 4
chr8_-_102872354 0.804 NCALD
neurocalcin delta
chr20_+_17155680 0.801 PCSK2
proprotein convertase subtilisin/kexin type 2
chr5_-_88004891 0.798 LOC645323
hypothetical LOC645323
chr8_-_27171814 0.794 NM_030795
STMN4
stathmin-like 4
chr4_+_88939725 0.784 NM_004967
IBSP
integrin-binding sialoprotein
chr16_+_54782802 0.775 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr8_-_102872372 0.773 NCALD
neurocalcin delta
chr3_+_138965844 0.762 SOX14
SRY (sex determining region Y)-box 14
chr21_+_25933459 0.762 NM_021219
JAM2
junctional adhesion molecule 2
chr15_-_70399523 0.760 CELF6
CUGBP, Elav-like family member 6
chr19_-_56919032 0.760 NM_001523
HAS1
hyaluronan synthase 1
chr2_-_220116508 0.756 NM_024536
CHPF
chondroitin polymerizing factor
chr21_+_38550739 0.742 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr15_-_70399551 0.731 NM_052840
CELF6
CUGBP, Elav-like family member 6
chr11_-_129803712 0.727 NM_007037
ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr20_+_9442995 0.725 C20orf103
chromosome 20 open reading frame 103
chr5_+_36642213 0.721 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr1_-_149955870 0.721 NM_007185
CELF3
CUGBP, Elav-like family member 3
chr11_-_14950366 0.718 NM_001033952
NM_001033953
NM_001741
CALCA


calcitonin-related polypeptide alpha


chr13_-_24643620 0.714 FAM123A
family with sequence similarity 123A
chr3_-_159872960 0.710 NM_020169
LXN
latexin
chr17_+_4743645 0.702 NM_001145536
C17orf107
chromosome 17 open reading frame 107
chr1_-_199635057 0.691 LAD1
ladinin 1
chr2_-_96899326 0.672 SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr17_+_12510030 0.670 MYOCD
myocardin
chr8_-_10734700 0.669 NM_017884
PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr8_+_26296439 0.668 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr7_+_73080362 0.664 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chr14_+_100362204 0.663 MEG3
maternally expressed 3 (non-protein coding)
chr15_-_70399301 0.658 NM_001172684
CELF6
CUGBP, Elav-like family member 6
chr7_+_116907252 0.656 NM_000492
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr17_-_23151601 0.655 NM_000625
NOS2
nitric oxide synthase 2, inducible
chr9_+_17568952 0.652 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr3_+_141136691 0.652 NM_022131
CLSTN2
calsyntenin 2
chrX_+_151975421 0.645 NM_013364
PNMA3
paraneoplastic antigen MA3
chr8_-_67253234 0.644 NM_000756
CRH
corticotropin releasing hormone
chr10_-_99780574 0.641 NM_018058
CRTAC1
cartilage acidic protein 1
chr12_-_7547552 0.637 NM_004244
NM_203416
CD163

CD163 molecule

chr16_-_2258067 0.629 RNPS1
RNA binding protein S1, serine-rich domain
chr1_+_154297588 0.628 NM_020387
RAB25
RAB25, member RAS oncogene family
chr7_+_73080387 0.621 ELN
elastin
chr17_-_23151522 0.616 NOS2
nitric oxide synthase 2, inducible
chr3_-_12561962 0.616 NM_001195279
LOC100129480
hypothetical protein LOC100129480
chr5_+_170668892 0.615 NM_021025
TLX3
T-cell leukemia homeobox 3
chr1_+_99502435 0.615 NM_001166252
NM_014839
LPPR4

lipid phosphate phosphatase-related protein type 4

chr3_-_126136261 0.613 NM_033049
MUC13
mucin 13, cell surface associated
chr21_+_38550533 0.612 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_39340414 0.611 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chrX_-_83644054 0.611 NM_001177478
NM_001177479
NM_144657
HDX


highly divergent homeobox


chr2_-_152664056 0.610 CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr10_+_35524835 0.608 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr2_-_224175293 0.606 SCG2
secretogranin II
chr7_+_128099581 0.603 NM_001012454
NM_001128926
FAM71F2

family with sequence similarity 71, member F2

chr1_+_210275735 0.598 DTL
denticleless homolog (Drosophila)
chr14_-_46882144 0.594 NM_182830
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
chr7_+_73080404 0.591 ELN
elastin
chr10_+_95838801 0.587 NM_001165979
PLCE1
phospholipase C, epsilon 1
chr5_-_1935764 0.584 NM_016358
IRX4
iroquois homeobox 4
chr8_-_72437020 0.584 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr15_-_71448657 0.583 NM_005477
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr5_-_153837975 0.581 HAND1
heart and neural crest derivatives expressed 1
chr17_-_13445942 0.579 NM_006042
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr15_-_81412354 0.579 NM_004839
NM_199330
NM_199331
NM_199332
HOMER2



homer homolog 2 (Drosophila)



chr4_+_41395493 0.575 LIMCH1
LIM and calponin homology domains 1
chr11_-_8572321 0.570 STK33
serine/threonine kinase 33
chr17_+_30938391 0.568 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr14_+_71469538 0.568 NM_004296
RGS6
regulator of G-protein signaling 6
chr19_+_50196526 0.567 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr14_+_20568184 0.563 NM_173846
TPPP2
tubulin polymerization-promoting protein family member 2
chr19_+_55671468 0.563 NM_175063
NM_206538
C19orf63

chromosome 19 open reading frame 63

chr17_+_26839143 0.555 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr4_+_113958652 0.554 NM_001127493
ANK2
ankyrin 2, neuronal
chr8_-_10734792 0.550 PINX1
PIN2/TERF1 interacting, telomerase inhibitor 1
chr4_-_44145580 0.549 NM_198353
KCTD8
potassium channel tetramerisation domain containing 8
chr16_-_3008162 0.547 NM_021195
CLDN6
claudin 6
chr20_+_17155617 0.541 NM_002594
PCSK2
proprotein convertase subtilisin/kexin type 2
chr12_-_16652202 0.538 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chrX_-_13745108 0.535 GPM6B
glycoprotein M6B
chr8_+_65655367 0.534 NM_152414
BHLHE22
basic helix-loop-helix family, member e22
chr4_-_41445693 0.533 NM_003924
PHOX2B
paired-like homeobox 2b
chrX_-_13866451 0.532 GPM6B
glycoprotein M6B
chr2_-_135498716 0.530 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr2_-_133895795 0.530 NCKAP5
NCK-associated protein 5
chr14_-_79748273 0.527 NM_000793
NM_013989
DIO2

deiodinase, iodothyronine, type II

chr17_+_41945391 0.527 NM_001006607
LRRC37A2
LRRC37A
leucine rich repeat containing 37, member A2
leucine rich repeat containing 37A
chrX_-_47364173 0.526 NM_006950
NM_133499
SYN1

synapsin I

chr10_+_68355797 0.522 NM_178011
LRRTM3
leucine rich repeat transmembrane neuronal 3
chr7_-_121731721 0.522 NM_001024613
NM_001160264
FEZF1

FEZ family zinc finger 1

chr14_+_100362236 0.522 MEG3
maternally expressed 3 (non-protein coding)
chr11_-_129803515 0.518 ADAMTS8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr11_-_35397675 0.517 NM_004171
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr16_+_54782751 0.514 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr8_-_42742729 0.510 NM_004198
CHRNA6
cholinergic receptor, nicotinic, alpha 6
chr7_+_73080422 0.507 ELN
elastin
chr8_+_134272463 0.506 NM_003882
NM_080838
WISP1

WNT1 inducible signaling pathway protein 1

chr12_-_7935010 0.504 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr17_+_38306339 0.500 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr1_-_210275402 0.500 NM_015434
INTS7
integrator complex subunit 7
chr10_+_50557689 0.498 NM_001042427
NM_182554
C10orf53

chromosome 10 open reading frame 53

chr18_+_13208777 0.494 NM_181481
NM_181482
C18orf1

chromosome 18 open reading frame 1

chr17_-_75385371 0.494 NM_020649
CBX8
chromobox homolog 8
chr9_+_126460511 0.492


chr1_+_177261678 0.492 NM_014864
FAM20B
family with sequence similarity 20, member B
chr5_+_118719591 0.489 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chrX_-_13745134 0.486 GPM6B
glycoprotein M6B
chr15_-_29950070 0.485 OTUD7A
OTU domain containing 7A
chr11_+_117735502 0.484 NM_004788
UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr22_+_40286957 0.482 NM_014460
CSDC2
cold shock domain containing C2, RNA binding
chr1_+_210275541 0.480 NM_016448
DTL
denticleless homolog (Drosophila)
chr20_-_13919256 0.479 NM_025229
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr14_+_92721048 0.477 NM_015676
NM_001098621
C14orf109

chromosome 14 open reading frame 109

chr1_-_7835681 0.476 NM_006786
UTS2
urotensin 2
chr5_+_126140213 0.476 NM_005573
LMNB1
lamin B1
chr19_+_60487345 0.475 NM_032430
BRSK1
BR serine/threonine kinase 1
chr1_+_7766966 0.474 PER3
period homolog 3 (Drosophila)
chr12_+_70120028 0.473 NM_003667
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr15_-_70399181 0.468 CELF6
CUGBP, Elav-like family member 6
chr15_-_21444085 0.467 NM_019066
MAGEL2
MAGE-like 2
chr11_+_24475091 0.466 NM_001009909
LUZP2
leucine zipper protein 2
chrX_-_47364039 0.460


chr8_-_26780665 0.460 ADRA1A
adrenergic, alpha-1A-, receptor
chrX_+_50044279 0.459 NM_033031
NM_033670
CCNB3

cyclin B3

chrX_-_13745234 0.459 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr6_+_97117144 0.459 NM_001170807
NM_020482
FHL5

four and a half LIM domains 5

chr15_+_36776090 0.459 NM_207444
C15orf53
chromosome 15 open reading frame 53

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.19 3.12e-03 GO:0007399 nervous system development
3.54 3.16e-03 GO:0030154 cell differentiation
2.59 3.99e-03 GO:0032502 developmental process
3.44 4.37e-03 GO:0048869 cellular developmental process
2.78 6.22e-03 GO:0048856 anatomical structure development
2.92 6.92e-03 GO:0048731 system development
7.00 1.30e-02 GO:0007417 central nervous system development
2.55 1.99e-02 GO:0007275 multicellular organismal development
2.99 2.22e-02 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.91 2.96e-02 GO:0010556 regulation of macromolecule biosynthetic process
31.40 3.15e-02 GO:0048663 neuron fate commitment
3.08 3.31e-02 GO:0006355 regulation of transcription, DNA-dependent
2.83 4.11e-02 GO:0010468 regulation of gene expression
2.96 4.89e-02 GO:0051252 regulation of RNA metabolic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
6.42 2.95e-04 GO:0043565 sequence-specific DNA binding
4.46 5.32e-03 GO:0003700 sequence-specific DNA binding transcription factor activity