Motif ID: ATF4.p2

Z-value: 1.099


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)



Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_586997 2.342 NM_014410
CLUL1
clusterin-like 1 (retinal)
chr6_+_139497933 1.129 NM_016217
HECA
headcase homolog (Drosophila)
chr11_-_76862197 1.065 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr1_+_1994943 0.997 NM_001033581
PRKCZ
protein kinase C, zeta
chr5_-_176760242 0.981 NM_001029886
PFN3
profilin 3
chr4_+_85723080 0.944 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr7_-_44992729 0.848 C7orf40
chromosome 7 open reading frame 40
chr19_+_10388448 0.837 PDE4A
phosphodiesterase 4A, cAMP-specific
chr2_+_219453487 0.790 NM_025216
WNT10A
wingless-type MMTV integration site family, member 10A
chr16_+_22732982 0.782 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr9_-_126573349 0.778 NM_001489
NM_033334
NR6A1

nuclear receptor subfamily 6, group A, member 1

chr5_+_112877251 0.763 NM_022828
YTHDC2
YTH domain containing 2
chr17_-_4589387 0.753 CXCL16
chemokine (C-X-C motif) ligand 16
chr21_-_42060334 0.697 RIPK4
receptor-interacting serine-threonine kinase 4
chr1_+_29435534 0.668 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr21_-_42060266 0.654 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr1_-_226670928 0.617 TRIM17
tripartite motif containing 17
chr5_-_1935764 0.613 NM_016358
IRX4
iroquois homeobox 4
chr19_-_7459867 0.597 NM_080662
PEX11G
peroxisomal biogenesis factor 11 gamma
chr7_-_140270749 0.594 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr8_+_128875902 0.548 PVT1
Pvt1 oncogene (non-protein coding)
chr1_+_55277795 0.530 PCSK9
proprotein convertase subtilisin/kexin type 9
chr5_+_139534874 0.518 C5orf32
chromosome 5 open reading frame 32
chr7_-_36372971 0.513 NM_015314
KIAA0895
KIAA0895
chr6_-_34772565 0.513 NM_022758
NM_024294
C6orf106

chromosome 6 open reading frame 106

chr12_+_52665196 0.509 NM_017409
HOXC10
homeobox C10
chr19_-_15421761 0.505 NM_021241
WIZ
widely interspaced zinc finger motifs
chr14_+_67156386 0.475 ARG2
arginase, type II
chr4_-_8493327 0.470 NM_001101667
NM_003501
ACOX3

acyl-CoA oxidase 3, pristanoyl

chr10_+_85889164 0.468 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr7_+_30140868 0.467 NM_152793
C7orf41
chromosome 7 open reading frame 41
chr7_-_127833231 0.462 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr17_-_30929669 0.447 NM_000286
PEX12
peroxisomal biogenesis factor 12
chr16_+_70437394 0.435 NM_001137675
ATXN1L
ataxin 1-like
chr16_-_3707450 0.433 NM_016292
TRAP1
TNF receptor-associated protein 1
chr3_+_142143329 0.431 NM_001104647
NM_018155
SLC25A36

solute carrier family 25, member 36

chr8_+_42315132 0.429 NM_002690
POLB
polymerase (DNA directed), beta
chr14_+_67156323 0.427 NM_001172
ARG2
arginase, type II
chr1_+_13899272 0.425 NM_001135610
PRDM2
PR domain containing 2, with ZNF domain
chr7_-_22363036 0.424 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr4_-_68898294 0.422 NM_001031732
NM_133370
YTHDC1

YTH domain containing 1

chr5_+_177473071 0.416 NM_015111
N4BP3
NEDD4 binding protein 3
chr2_+_96790298 0.414 NM_020184
CNNM4
cyclin M4
chr6_+_64340408 0.401 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_44891471 0.395 NM_033224
PURB
purine-rich element binding protein B
chr4_-_186584031 0.388 NM_018359
UFSP2
UFM1-specific peptidase 2
chr1_+_208178198 0.386 SYT14
synaptotagmin XIV
chr3_-_16281287 0.385 NM_001047434
NM_206831
DPH3

DPH3, KTI11 homolog (S. cerevisiae)

chr19_+_13124889 0.384 IER2
immediate early response 2
chr6_-_34772495 0.384 C6orf106
chromosome 6 open reading frame 106
chr7_+_151353707 0.379 NM_022087
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr16_-_2258067 0.378 RNPS1
RNA binding protein S1, serine-rich domain
chr6_+_43319199 0.377 NM_032538
TTBK1
tau tubulin kinase 1
chr5_-_54504590 0.374 NM_001145734
NM_001170402
NM_152623
CDC20B


cell division cycle 20 homolog B (S. cerevisiae)


chr5_-_150060739 0.373 RBM22
RNA binding motif protein 22
chr17_-_28644118 0.371 NM_183377
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr8_-_11361594 0.366 NM_053279
FAM167A
family with sequence similarity 167, member A
chr11_-_66367279 0.363


chr5_-_32480586 0.363 NM_016107
ZFR
zinc finger RNA binding protein
chr17_+_50697319 0.362 NM_002126
HLF
hepatic leukemia factor
chr7_+_140042932 0.360 NM_004546
NDUFB2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr20_+_44070946 0.358 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr11_+_66367458 0.356 NM_001032279
NM_005133
RCE1

RCE1 homolog, prenyl protein peptidase (S. cerevisiae)

chr7_-_64873123 0.356 LOC441242
hypothetical LOC441242
chr16_+_22733307 0.354 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr19_+_1892157 0.353 NM_001319
CSNK1G2
casein kinase 1, gamma 2
chr10_-_113933457 0.351 NM_020918
GPAM
glycerol-3-phosphate acyltransferase, mitochondrial
chr16_+_1696162 0.348 NM_001040439
NM_015133
MAPK8IP3

mitogen-activated protein kinase 8 interacting protein 3

chr3_+_141136691 0.348 NM_022131
CLSTN2
calsyntenin 2
chr14_-_54563554 0.347 NM_001008396
NM_007086
WDHD1

WD repeat and HMG-box DNA binding protein 1

chr8_+_26296439 0.347 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr5_-_150060790 0.343 NM_018047
RBM22
RNA binding motif protein 22
chr1_+_60053050 0.342 NM_015888
HOOK1
hook homolog 1 (Drosophila)
chr17_+_52688842 0.341 NM_138962
MSI2
musashi homolog 2 (Drosophila)
chr10_-_99084417 0.341 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr11_-_61341011 0.340 NM_013402
FADS1
fatty acid desaturase 1
chr4_+_119732338 0.333 LOC729218
hypothetical LOC729218
chr3_-_33734544 0.332 CLASP2
cytoplasmic linker associated protein 2
chr1_+_55277736 0.330 NM_174936
PCSK9
proprotein convertase subtilisin/kexin type 9
chr8_+_82807218 0.329 NM_152284
CHMP4C
chromatin modifying protein 4C
chr16_-_68880908 0.326 NM_001605
AARS
alanyl-tRNA synthetase
chr12_+_4253143 0.326 NM_001759
CCND2
cyclin D2
chr3_+_10043139 0.324 FANCD2
Fanconi anemia, complementation group D2
chr6_+_35334663 0.318 ZNF76
zinc finger protein 76
chr18_+_22060383 0.317 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr6_+_89848229 0.313 PNRC1
proline-rich nuclear receptor coactivator 1
chr6_-_91063301 0.313 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr11_+_9439087 0.313 NM_003442
ZNF143
zinc finger protein 143
chr1_+_51855343 0.311 OSBPL9
oxysterol binding protein-like 9
chr6_+_64339869 0.308 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr17_-_8092078 0.306 CTC1
CTS telomere maintenance complex component 1
chr11_+_108040983 0.304 NM_004398
DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr19_+_13124870 0.304 IER2
immediate early response 2
chr5_+_56505412 0.302 NM_022913
GPBP1
GC-rich promoter binding protein 1
chr3_-_120665113 0.299 NM_018266
TMEM39A
transmembrane protein 39A
chr15_+_71131877 0.297 NM_001172623
NM_001172624
NM_002499
NEO1


neogenin 1


chr14_-_54563520 0.296 WDHD1
WD repeat and HMG-box DNA binding protein 1
chr14_-_76564727 0.296 NM_024496
IRF2BPL
interferon regulatory factor 2 binding protein-like
chr1_+_26368969 0.295 NM_015871
ZNF593
zinc finger protein 593
chr9_-_98841186 0.294 NM_001333
CTSL2
cathepsin L2
chr20_-_33329319 0.293 EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chrX_-_102452461 0.290 NM_001168399
NM_001168400
NM_001168401
NM_032621
BEX2



brain expressed X-linked 2



chr15_-_64577122 0.290 NM_006049
SNAPC5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr20_+_13150417 0.289 NM_080826
ISM1
isthmin 1 homolog (zebrafish)
chr12_+_56284867 0.287 NM_178502
DTX3
deltex homolog 3 (Drosophila)
chr12_+_19483578 0.287 NM_001114176
NM_153207
AEBP2

AE binding protein 2

chr1_+_39229474 0.285 NM_001136275
NM_024595
AKIRIN1

akirin 1

chr8_+_28006502 0.283 NM_018091
ELP3
elongation protein 3 homolog (S. cerevisiae)
chr14_+_67156405 0.283 ARG2
arginase, type II
chr17_-_20886680 0.281 NM_015276
USP22
ubiquitin specific peptidase 22
chr18_+_55718171 0.281 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr19_+_1892184 0.280 CSNK1G2
casein kinase 1, gamma 2
chr17_+_22645268 0.280 WSB1
WD repeat and SOCS box containing 1
chr4_-_187884721 0.278


chr1_+_27972269 0.278 NM_177424
STX12
syntaxin 12
chr4_-_84475328 0.276 NM_001166498
NM_006665
HPSE

heparanase

chr16_-_68880844 0.276 AARS
alanyl-tRNA synthetase
chr17_+_50697355 0.273 HLF
hepatic leukemia factor
chr21_-_43172729 0.272 NM_018669
NM_033661
WDR4

WD repeat domain 4

chr15_+_38520594 0.271 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr17_-_8000362 0.267 PER1
period homolog 1 (Drosophila)
chr6_-_121697305 0.264 NM_152730
C6orf170
chromosome 6 open reading frame 170
chr5_-_16561936 0.263 NM_019000
FAM134B
family with sequence similarity 134, member B
chr8_-_145097031 0.261 NM_201380
PLEC
plectin
chr3_+_3143599 0.261 NM_182916
TRNT1
tRNA nucleotidyl transferase, CCA-adding, 1
chr3_-_58175437 0.260 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr1_+_210848592 0.260 NM_001040619
NM_001674
ATF3

activating transcription factor 3

chr1_-_20916789 0.259 NM_001122819
NM_020816
KIF17

kinesin family member 17

chr6_-_38715613 0.256 BTBD9
BTB (POZ) domain containing 9
chr3_+_38181972 0.256 NM_005109
OXSR1
oxidative-stress responsive 1
chr19_+_47080285 0.254 NM_199002
ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
chr17_+_26839143 0.253 RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr6_-_38715567 0.250 BTBD9
BTB (POZ) domain containing 9
chr17_+_24095135 0.248 NM_004295
TRAF4
TNF receptor-associated factor 4
chr1_-_172103745 0.248 GAS5
growth arrest-specific 5 (non-protein coding)
chr4_-_658035 0.245 NM_007100
ATP5I
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
chr7_+_55999559 0.245 NM_001483
GBAS
glioblastoma amplified sequence
chr1_-_20685314 0.245 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr10_+_14960787 0.245 NM_001193424
NM_001193426
NM_001193425
NM_001193427
NM_024670
SUV39H2




suppressor of variegation 3-9 homolog 2 (Drosophila)




chr12_-_56111054 0.244 R3HDM2
R3H domain containing 2
chr3_+_127170717 0.243 NM_001012337
ROPN1B
rhophilin associated tail protein 1B
chr17_+_54124952 0.243 NM_002876
NM_058216
RAD51C

RAD51 homolog C (S. cerevisiae)

chr1_-_154665807 0.241 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr1_-_17318452 0.241 NM_007365
PADI2
peptidyl arginine deiminase, type II
chr9_-_139068269 0.240 NM_001246
NM_203468
ENTPD2

ectonucleoside triphosphate diphosphohydrolase 2

chr7_-_158314963 0.239 NM_020728
ESYT2
extended synaptotagmin-like protein 2
chr12_+_132217285 0.238 NM_015394
ZNF10
zinc finger protein 10
chr17_-_4589911 0.237 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr19_+_54226941 0.237 NM_033378
CGB1
CGB2
chorionic gonadotropin, beta polypeptide 1
chorionic gonadotropin, beta polypeptide 2
chr3_+_186483408 0.234 LOC100505749
MAP3K13
hypothetical LOC100505749
mitogen-activated protein kinase kinase kinase 13
chr12_-_56452144 0.234 NM_005371
NM_023033
METTL1

methyltransferase like 1

chr6_+_56927882 0.233 BEND6
BEN domain containing 6
chr15_-_27349300 0.233 NM_138704
NDNL2
necdin-like 2
chr19_-_34395947 0.233 NM_006003
UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr14_+_75521806 0.232 NM_001102564
NM_052873
C14orf179

chromosome 14 open reading frame 179

chr14_+_54563587 0.232 NM_080867
NM_199421
SOCS4

suppressor of cytokine signaling 4

chr3_+_33293915 0.230 NM_012157
NM_001171713
FBXL2

F-box and leucine-rich repeat protein 2

chr5_+_174084137 0.230 NM_002449
MSX2
msh homeobox 2
chr4_-_1980756 0.228 NM_005663
WHSC2
Wolf-Hirschhorn syndrome candidate 2
chr19_-_34395861 0.228 UQCRFS1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr19_-_18175731 0.227 NM_002866
RAB3A
RAB3A, member RAS oncogene family
chr11_-_61340804 0.227 FADS1
fatty acid desaturase 1
chr5_-_175775966 0.226 CLTB
clathrin, light chain B
chr8_-_97316933 0.226 NM_006294
UQCRB
ubiquinol-cytochrome c reductase binding protein
chr10_+_101409159 0.225 NM_020354
ENTPD7
ectonucleoside triphosphate diphosphohydrolase 7
chr6_+_126319540 0.224 NM_138571
HINT3
histidine triad nucleotide binding protein 3
chr7_+_120378052 0.223 NM_019071
NM_198267
ING3

inhibitor of growth family, member 3

chr6_+_64340388 0.223 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr19_+_13719677 0.219 NM_030818
CCDC130
coiled-coil domain containing 130
chr1_-_16355013 0.218 NM_004431
EPHA2
EPH receptor A2
chr4_-_120595218 0.218


chr15_-_89338728 0.218 NM_003981
NM_199413
NM_199414
PRC1


protein regulator of cytokinesis 1


chr11_+_64448628 0.218 NM_006244
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr12_-_6732392 0.217 MLF2
myeloid leukemia factor 2
chr17_-_37794102 0.216 STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr17_-_8092098 0.216 NM_025099
CTC1
CTS telomere maintenance complex component 1
chr7_-_42918013 0.215 NM_001099858
NM_024054
C7orf25

chromosome 7 open reading frame 25

chr10_+_22674379 0.213 NM_012443
NM_172242
SPAG6

sperm associated antigen 6

chr9_-_37455384 0.213 NM_014872
ZBTB5
zinc finger and BTB domain containing 5
chr11_-_6590004 0.211 NM_006284
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr6_+_27890772 0.211 NM_003521
HIST1H2BM
histone cluster 1, H2bm
chr7_-_150352484 0.210 NM_173681
ATG9B
ATG9 autophagy related 9 homolog B (S. cerevisiae)
chr4_+_8493396 0.210 NM_152544
METTL19
methyltransferase like 19
chr11_+_62405736 0.209 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr7_+_4980144 0.208 RNF216L
ring finger protein 216-like
chr17_-_37793885 0.205 NM_213662
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr18_+_11841388 0.202 NM_020412
CHMP1B
chromatin modifying protein 1B
chr7_-_72114342 0.202 NM_001013739
STAG3L3
STAG3L2
STAG3L1
stromal antigen 3-like 3
stromal antigen 3-like 2
stromal antigen 3-like 1
chr5_+_78567604 0.202 NM_152405
JMY
junction mediating and regulatory protein, p53 cofactor
chr7_+_38184393 0.200 STARD3NL
STARD3 N-terminal like
chr19_+_17047569 0.199 NM_001130065
NM_004145
MYO9B

myosin IXB

chr4_+_146622154 0.198 NM_005900
SMAD1
SMAD family member 1
chr7_+_127015650 0.198 NM_001662
ARF5
ADP-ribosylation factor 5
chr4_-_80079393 0.198 NM_001040202
PAQR3
progestin and adipoQ receptor family member III
chr8_+_71744153 0.198 NM_001011720
XKR9
XK, Kell blood group complex subunit-related family, member 9
chr6_+_33047952 0.196 BRD2
bromodomain containing 2
chr12_+_19484044 0.196 AEBP2
AE binding protein 2
chr7_+_100302885 0.194 NM_003302
TRIP6
thyroid hormone receptor interactor 6
chr9_-_37455429 0.194 ZBTB5
zinc finger and BTB domain containing 5
chr4_-_78216145 0.194 NM_006835
CCNI
cyclin I

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.