Motif ID: E2F1..5.p2

Z-value: 1.949


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding



Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_72271218 2.129 NM_001098484
NM_001134742
SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4

chr10_-_131652007 2.025 NM_001005463
EBF3
early B-cell factor 3
chr6_+_135544214 1.987 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr10_+_124885556 1.876 NM_001105574
HMX3
H6 family homeobox 3
chr10_-_131652364 1.797 EBF3
early B-cell factor 3
chr8_+_31616809 1.570 NM_013962
NRG1
neuregulin 1
chr7_+_98084531 1.398 NM_002523
NPTX2
neuronal pentraxin II
chr7_+_113513600 1.370 FOXP2
forkhead box P2
chr19_-_62043867 1.348 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr18_-_68361742 1.332 CBLN2
cerebellin 2 precursor
chr17_-_44042924 1.314 HOXB7
homeobox B7
chr3_-_124650081 1.311 NM_183357
ADCY5
adenylate cyclase 5
chr6_+_135544170 1.302 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr6_+_135544138 1.262 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr8_+_65656164 1.259 BHLHE22
basic helix-loop-helix family, member e22
chr3_+_148609841 1.258 NM_003412
ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr9_-_103540682 1.252 NM_133445
GRIN3A
glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
chr2_+_171280046 1.215 NM_001003845
SP5
Sp5 transcription factor
chr15_+_64782468 1.210 SMAD6
SMAD family member 6
chr19_-_12807221 1.185 NM_031429
RTBDN
retbindin
chr7_+_50314801 1.168 NM_006060
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr6_+_72949092 1.164 RIMS1
regulating synaptic membrane exocytosis 1
chr5_-_101659864 1.159 NM_180991
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr8_-_144583718 1.144 NM_201589
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
chr2_+_171280182 1.139


chr16_+_1979959 1.124 NM_004209
SYNGR3
synaptogyrin 3
chr13_-_78075683 1.116 NM_006237
POU4F1
POU class 4 homeobox 1
chr16_-_60627536 1.110 NM_001796
CDH8
cadherin 8, type 2
chr14_+_20608179 1.106 NM_018071
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr10_-_73518269 1.094 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr10_-_73518284 1.078 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chrX_-_131919896 1.077 HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr11_-_31789334 1.074 PAX6
paired box 6
chr9_-_121171400 1.072 NM_014618
DBC1
deleted in bladder cancer 1
chr4_-_104860277 1.069 NM_001059
TACR3
tachykinin receptor 3
chr8_-_132122016 1.055 NM_001115
ADCY8
adenylate cyclase 8 (brain)
chr14_+_50776635 1.043 NM_030755
TMX1
thioredoxin-related transmembrane protein 1
chr17_-_44043361 1.031 NM_004502
HOXB7
homeobox B7
chr16_+_71256497 1.030


chr20_-_5048443 1.019 NM_182649
PCNA
proliferating cell nuclear antigen
chr17_-_44043278 1.012 HOXB7
homeobox B7
chr11_-_31789360 1.005 PAX6
paired box 6
chr7_+_113513726 0.998 FOXP2
forkhead box P2
chr7_+_113513828 0.994 FOXP2
forkhead box P2
chr2_-_50428395 0.982 NM_138735
NRXN1
neurexin 1
chr10_-_73518315 0.980 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr12_-_79855618 0.979 NM_004664
LIN7A
lin-7 homolog A (C. elegans)
chr12_-_123965099 0.975 UBC
ubiquitin C
chr12_+_4788602 0.948 NM_002235
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr10_-_99521701 0.946 NM_003015
SFRP5
secreted frizzled-related protein 5
chr20_-_21326046 0.944 NM_033176
NKX2-4
NK2 homeobox 4
chr9_-_119217128 0.936 NM_014010
ASTN2
astrotactin 2
chr14_+_74418345 0.933 NM_001933
DLST
dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
chr19_-_6453224 0.922 NM_006087
TUBB4
tubulin, beta 4
chr6_-_3102690 0.922 NM_001069
TUBB2A
tubulin, beta 2A
chr10_+_96295511 0.922 NM_018063
HELLS
helicase, lymphoid-specific
chr12_-_79855580 0.920 LIN7A
lin-7 homolog A (C. elegans)
chr2_+_219141761 0.912 NM_005444
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr11_-_31789431 0.905 NM_000280
NM_001604
PAX6

paired box 6

chr13_+_48692472 0.899 NM_001507
MLNR
motilin receptor
chr14_+_37748345 0.897 SSTR1
somatostatin receptor 1
chr15_+_45263517 0.888 NM_001198999
SEMA6D
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr9_-_78710698 0.875 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr6_+_27941012 0.874 NM_003511
HIST1H2AI
HIST1H2AL
histone cluster 1, H2ai
histone cluster 1, H2al
chr18_+_48121067 0.863 DCC
deleted in colorectal carcinoma
chr14_-_20642214 0.862


chr9_-_23811808 0.857 ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr12_-_1983845 0.855 NM_152640
DCP1B
DCP1 decapping enzyme homolog B (S. cerevisiae)
chrX_-_139414890 0.845 NM_005634
SOX3
SRY (sex determining region Y)-box 3
chr1_+_238321794 0.840 NM_020066
FMN2
formin 2
chrX_-_135677022 0.834 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr11_-_31789168 0.834 PAX6
paired box 6
chr1_-_29321599 0.833 NM_001171868
TMEM200B
transmembrane protein 200B
chr9_-_119217147 0.828 ASTN2
astrotactin 2
chr1_+_3558958 0.824 NM_005427
TP73
tumor protein p73
chr11_-_117252541 0.820 FXYD6
FXYD domain containing ion transport regulator 6
chr15_+_39008822 0.817 NM_019074
DLL4
delta-like 4 (Drosophila)
chr7_-_19123765 0.807 TWIST1
twist homolog 1 (Drosophila)
chr2_-_667367 0.807 NM_152834
TMEM18
transmembrane protein 18
chr3_+_140148765 0.803 NM_001040061
C3orf72
chromosome 3 open reading frame 72
chr19_-_44386731 0.792 NM_001080468
SYCN
syncollin
chr6_-_27914095 0.785 NM_003510
HIST1H2AK
histone cluster 1, H2ak
chr2_+_15998090 0.783 NM_005378
MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr22_-_40194602 0.781 NM_032758
PHF5A
PHD finger protein 5A
chr12_+_5411534 0.777 NM_001102654
NTF3
neurotrophin 3
chr3_+_138965844 0.776 SOX14
SRY (sex determining region Y)-box 14
chr8_-_95634845 0.770 NM_015496
NM_183009
KIAA1429

KIAA1429

chr17_-_47591691 0.764 CA10
carbonic anhydrase X
chr7_+_3307445 0.760 NM_152744
SDK1
sidekick homolog 1, cell adhesion molecule (chicken)
chr2_-_139254273 0.758 NM_007226
NXPH2
neurexophilin 2
chr2_+_172658453 0.755 NM_001038493
NM_178120
DLX1

distal-less homeobox 1

chr9_-_23811842 0.753 NM_001171195
ELAVL2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr2_-_164300758 0.752 NM_018086
FIGN
fidgetin
chr10_-_132999798 0.742 TCERG1L
transcription elongation regulator 1-like
chr3_-_140148671 0.735 NM_023067
FOXL2
forkhead box L2
chr13_+_102047286 0.735 NM_003291
TPP2
tripeptidyl peptidase II
chr3_+_135996990 0.735 EPHB1
EPH receptor B1
chr17_+_40089270 0.725 NM_001145080
C17orf104
chromosome 17 open reading frame 104
chr7_-_19123787 0.715 NM_000474
TWIST1
twist homolog 1 (Drosophila)
chr10_-_60606195 0.709


chr10_+_60606352 0.708 NM_032439
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr12_-_9492030 0.708 DDX11
DDX12
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12
chr3_+_54131731 0.706 NM_018398
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr16_-_2767129 0.705 NM_007108
NM_207013
TCEB2

transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)

chr13_+_44592647 0.702 GTF2F2
general transcription factor IIF, polypeptide 2, 30kDa
chr10_+_115793795 0.701 NM_000684
ADRB1
adrenergic, beta-1-, receptor
chr2_+_15998010 0.695 MYCN
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr2_+_219532590 0.693 NM_003936
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr2_+_233206208 0.692 EFHD1
EF-hand domain family, member D1
chr22_+_34126104 0.686 NM_006739
MCM5
minichromosome maintenance complex component 5
chr7_+_88226617 0.675 NM_181646
ZNF804B
zinc finger protein 804B
chr4_-_56197115 0.672 NM_006681
NMU
neuromedin U
chr22_+_33983444 0.666 NM_001003681
HMGXB4
HMG box domain containing 4
chr15_+_43510054 0.663 NM_032413
NM_197955
C15orf48

chromosome 15 open reading frame 48

chr2_-_175754366 0.655 NM_001002258
NM_001190329
NM_001689
ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr6_-_144370947 0.652 PLAGL1
pleiomorphic adenoma gene-like 1
chr22_+_34126154 0.651 MCM5
minichromosome maintenance complex component 5
chr12_-_43555607 0.647 NM_001145109
NELL2
NEL-like 2 (chicken)
chr8_+_128817658 0.646 MYC
v-myc myelocytomatosis viral oncogene homolog (avian)
chr3_+_54131613 0.641 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr10_+_60606514 0.641 PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr2_+_233206181 0.637 EFHD1
EF-hand domain family, member D1
chr6_-_116681863 0.634 NM_021648
TSPYL4
TSPY-like 4
chrX_+_82649924 0.628 NM_000307
POU3F4
POU class 3 homeobox 4
chr22_-_42589543 0.627 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr1_-_25129354 0.618 NM_004350
RUNX3
runt-related transcription factor 3
chr1_+_93317374 0.615 NM_001164391
NM_001164392
NM_001164393
NM_007358
MTF2



metal response element binding transcription factor 2



chr14_+_28306633 0.612 FOXG1
forkhead box G1
chr2_-_144991386 0.609 ZEB2
zinc finger E-box binding homeobox 2
chr17_+_26183074 0.604 NM_024857
ATAD5
ATPase family, AAA domain containing 5
chr9_+_831689 0.603 NM_021951
DMRT1
doublesex and mab-3 related transcription factor 1
chr17_-_47591123 0.599 NM_020178
CA10
carbonic anhydrase X
chr16_+_85101605 0.598 NM_001451
FOXF1
forkhead box F1
chr15_+_22751162 0.596 NM_003097
NM_022804
NM_005678
SNRPN
SNURF

small nuclear ribonucleoprotein polypeptide N
SNRPN upstream reading frame

chr9_-_112840064 0.596 NM_001401
NM_057159
LPAR1

lysophosphatidic acid receptor 1

chr4_+_55218663 0.594 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chrX_+_101792949 0.593 NM_001099410
NM_001099411
NM_014710
NM_001184727
GPRASP1



G protein-coupled receptor associated sorting protein 1



chr2_-_144991556 0.592 ZEB2
zinc finger E-box binding homeobox 2
chr16_+_65756138 0.591 HSF4
heat shock transcription factor 4
chr2_-_219566364 0.590 NM_005209
NM_057093
NM_057094
CRYBA2


crystallin, beta A2


chr13_+_33290254 0.587 RFC3
replication factor C (activator 1) 3, 38kDa
chr14_+_34521854 0.585 NM_001146282
NM_003136
SRP54

signal recognition particle 54kDa

chr14_+_34521945 0.584 SRP54
signal recognition particle 54kDa
chr10_+_106391032 0.581 SORCS3
sortilin-related VPS10 domain containing receptor 3
chr16_+_69115225 0.580 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr3_+_135996734 0.578 NM_004441
EPHB1
EPH receptor B1
chr20_+_34357604 0.578 DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr17_-_47591949 0.578 CA10
carbonic anhydrase X
chr2_-_70848621 0.577 NM_001185055
NM_001617
NM_017482
NM_017488
ADD2



adducin 2 (beta)



chr17_+_62391216 0.576 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr10_+_22580992 0.573


chrX_-_64171317 0.565 NM_001178032
ZC4H2
zinc finger, C4H2 domain containing
chr5_-_132976121 0.559 NM_015082
FSTL4
follistatin-like 4
chr6_+_1336077 0.558


chr8_-_144862266 0.556 NM_001162914
LOC100130274
coiled-coil domain containing 121-like
chr2_-_232037454 0.552 NCL
nucleolin
chr2_+_233206450 0.552 NM_025202
EFHD1
EF-hand domain family, member D1
chr16_+_69115189 0.550 NM_012426
SF3B3
splicing factor 3b, subunit 3, 130kDa
chr5_+_122452739 0.549 NM_001136239
PRDM6
PR domain containing 6
chr16_+_65756084 0.548 HSF4
heat shock transcription factor 4
chr10_-_132999973 0.548 NM_174937
TCERG1L
transcription elongation regulator 1-like
chr14_-_20807346 0.547 NM_001077442
NM_001077443
NM_004500
NM_031314
HNRNPC



heterogeneous nuclear ribonucleoprotein C (C1/C2)



chr19_+_868285 0.546 NM_032551
KISS1R
KISS1 receptor
chr15_+_42507123 0.543 CTDSPL2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr6_+_14033402 0.542 NM_001165033
RNF182
ring finger protein 182
chr13_+_99432258 0.540 NM_007129
ZIC2
Zic family member 2 (odd-paired homolog, Drosophila)
chr3_-_134863316 0.539 NM_007027
TOPBP1
topoisomerase (DNA) II binding protein 1
chr2_+_177785667 0.531 NM_194247
HNRNPA3P1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
heterogeneous nuclear ribonucleoprotein A3
chr6_+_99389300 0.526 NM_005604
POU3F2
POU class 3 homeobox 2
chr3_+_113180517 0.525 NM_018394
ABHD10
abhydrolase domain containing 10
chr4_+_106287391 0.524 NM_001127208
NM_017628
TET2

tet oncogene family member 2

chr17_+_35277942 0.523 NM_198844
NM_199321
ZPBP2

zona pellucida binding protein 2

chr16_+_85101734 0.523 FOXF1
forkhead box F1
chr20_+_2030527 0.521 NM_080836
STK35
serine/threonine kinase 35
chr16_-_23515104 0.521 NM_005003
NDUFAB1
NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
chr12_-_123965539 0.520 NM_021009
UBC
ubiquitin C
chr12_-_61830882 0.518 AVPR1A
arginine vasopressin receptor 1A
chr4_+_39734902 0.516 NM_018177
N4BP2
NEDD4 binding protein 2
chr3_+_144321286 0.512 NM_004267
CHST2
carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
chr13_+_97426713 0.512 IPO5
importin 5
chrX_+_104953215 0.511 NRK
Nik related kinase
chr16_+_69115227 0.510 SF3B3
splicing factor 3b, subunit 3, 130kDa
chr20_-_39199936 0.509


chr8_-_24869945 0.507 NM_006158
NEFL
neurofilament, light polypeptide
chr2_-_202811459 0.507 NM_001005781
NM_001005782
NM_003352
SUMO1


SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)


chr15_+_28705656 0.505 ARHGAP11B
Rho GTPase activating protein 11B
chr1_+_66230977 0.501 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr16_+_65756179 0.499 HSF4
heat shock transcription factor 4
chr2_+_210344972 0.498 UNC80
unc-80 homolog (C. elegans)
chr11_+_817584 0.497 NM_173584
EFCAB4A
EF-hand calcium binding domain 4A
chr19_-_53832381 0.497 NM_001352
DBP
D site of albumin promoter (albumin D-box) binding protein
chr2_-_225615556 0.494 NM_014689
DOCK10
dedicator of cytokinesis 10
chr16_-_87535106 0.493 NM_175931
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr5_+_50714714 0.490 NM_002202
ISL1
ISL LIM homeobox 1
chr13_-_72254071 0.487 NM_001128226
NM_014953
DIS3

DIS3 mitotic control homolog (S. cerevisiae)

chr12_+_6514645 0.487 GAPDH
glyceraldehyde-3-phosphate dehydrogenase
chr17_-_16197433 0.480 NM_181716
CENPV
centromere protein V
chr10_+_134893766 0.478 NM_003577
UTF1
undifferentiated embryonic cell transcription factor 1
chr17_-_17340219 0.475 NM_016084
RASD1
RAS, dexamethasone-induced 1
chr17_+_56884560 0.473 TBX4
T-box 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.28 7.15e-03 GO:0032501 multicellular organismal process
3.04 1.29e-02 GO:0051171 regulation of nitrogen compound metabolic process
9.20 4.80e-02 GO:0007610 behavior
2.88 4.99e-02 GO:0009889 regulation of biosynthetic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
88.70 1.27e-02 GO:0004016 adenylate cyclase activity
4.50 1.46e-02 GO:0030528 transcription regulator activity
81.88 1.50e-02 GO:0070412 R-SMAD binding