Motif ID: EN1,2.p2

Z-value: 2.262


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2



Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_30188845 4.050 NM_007028
TRIM31
tripartite motif containing 31
chr12_+_10351683 3.276 NM_002262
NM_007334
KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr10_+_114144512 3.104 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_157526127 2.791 NM_002001
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr11_-_123182266 2.550 NM_001005325
OR6M1
olfactory receptor, family 6, subfamily M, member 1
chr1_+_31823097 2.359 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr2_+_96355661 2.330 NM_178495
NM_001163524
ITPRIPL1

inositol 1,4,5-triphosphate receptor interacting protein-like 1

chr6_-_119512035 2.233 NM_001100411
FAM184A
family with sequence similarity 184, member A
chr5_-_77880731 2.182 LHFPL2
lipoma HMGIC fusion partner-like 2
chr9_-_110658030 1.989 NM_006686
ACTL7B
actin-like 7B
chr12_+_63510481 1.984


chr1_+_200775864 1.895 NM_001197131
PPP1R12B
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr22_+_19660361 1.892 AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr3_+_120375053 1.883 NM_006952
UPK1B
uroplakin 1B
chr12_-_103846186 1.869 NM_032148
SLC41A2
solute carrier family 41, member 2
chr1_-_202726068 1.798 NM_002646
PIK3C2B
phosphoinositide-3-kinase, class 2, beta polypeptide
chr11_-_58947001 1.781 NM_001001954
OR5A2
olfactory receptor, family 5, subfamily A, member 2
chr12_+_54316910 1.728 NM_206899
OR10P1
olfactory receptor, family 10, subfamily P, member 1
chr4_+_157044296 1.720 NM_005651
TDO2
tryptophan 2,3-dioxygenase
chr3_-_38967055 1.696 NM_014139
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr1_+_160618143 1.695 NM_001085375
C1orf226
chromosome 1 open reading frame 226
chr6_+_30212488 1.675 NM_138700
TRIM40
tripartite motif containing 40
chr12_+_10054492 1.674 NM_001129998
NM_205852
CLEC12B

C-type lectin domain family 12, member B

chr10_+_95362334 1.668 NM_006204
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
chr1_+_169421011 1.660 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr8_+_128497038 1.653 NM_001159542
POU5F1B
POU class 5 homeobox 1B
chr6_-_132980901 1.643 NM_014626
TAAR2
trace amine associated receptor 2
chr11_+_123625632 1.608 NM_001002905
OR8G1
olfactory receptor, family 8, subfamily G, member 1
chr11_-_123918759 1.597 NM_001005195
OR8B12
olfactory receptor, family 8, subfamily B, member 12
chr2_-_158008763 1.565 NM_004288
CYTIP
cytohesin 1 interacting protein
chr1_-_157950898 1.547 NM_000567
CRP
C-reactive protein, pentraxin-related
chr1_-_154484341 1.542 NM_198406
NM_024897
PAQR6

progestin and adipoQ receptor family member VI

chr1_-_150328153 1.523 NM_001008536
TCHHL1
trichohyalin-like 1
chr2_-_87102453 1.488 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr19_-_46048033 1.480 NM_000762
CYP2A6
cytochrome P450, family 2, subfamily A, polypeptide 6
chr3_+_52788976 1.476 NM_001166435
NM_001166436
ITIH1

inter-alpha (globulin) inhibitor H1

chr1_+_54786394 1.438 NM_015547
NM_147161
ACOT11

acyl-CoA thioesterase 11

chr2_-_162717159 1.411 NM_002054
GCG
glucagon
chr11_-_123685871 1.391 NM_001002917
OR8D1
olfactory receptor, family 8, subfamily D, member 1
chr3_+_188197029 1.379


chr15_+_37330176 1.356 NM_207445
C15orf54
chromosome 15 open reading frame 54
chr3_-_125192888 1.356 NM_017578
ROPN1
rhophilin associated tail protein 1
chr5_+_67558217 1.353 NM_181523
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_-_77147625 1.351 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr18_-_56190980 1.350 NM_005912
MC4R
melanocortin 4 receptor
chr10_+_105027431 1.317 INA
internexin neuronal intermediate filament protein, alpha
chr3_-_188903038 1.314 NM_001004312
RTP2
receptor (chemosensory) transporter protein 2
chr1_-_156784518 1.293 NM_001005189
OR6Y1
olfactory receptor, family 6, subfamily Y, member 1
chr17_-_4589911 1.288 NM_001100812
NM_022059
CXCL16

chemokine (C-X-C motif) ligand 16

chr11_-_26700121 1.225 NM_178498
SLC5A12
solute carrier family 5 (sodium/glucose cotransporter), member 12
chr22_+_23921072 1.222 KIAA1671
KIAA1671
chr19_+_46286207 1.214 NM_000766
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr8_+_22900863 1.210 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr10_-_28611020 1.202 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr1_+_169484256 1.194 NM_002021
FMO1
flavin containing monooxygenase 1
chr6_-_25834733 1.190 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr11_+_123315459 1.184 NM_001001965
OR4D5
olfactory receptor, family 4, subfamily D, member 5
chr10_-_104587069 1.182 NM_000102
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr14_-_94053933 1.179 NM_173850
SERPINA12
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr6_+_146390474 1.161 NM_000838
NM_001114329
GRM1

glutamate receptor, metabotropic 1

chr19_-_14030970 1.154 NM_001145028
PALM3
paralemmin 3
chr14_+_75907442 1.145 NM_004452
ESRRB
estrogen-related receptor beta
chr11_+_59979857 1.139 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr19_+_45973139 1.127 NM_006533
MIA
melanoma inhibitory activity
chr10_+_5228756 1.127 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr3_-_188935363 1.110 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr2_-_113310796 1.104 NM_000576
IL1B
interleukin 1, beta
chr15_+_84021271 1.075 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr12_+_119617060 1.073


chr7_+_94377145 1.062 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory (inhibitor) subunit 9A


chr14_-_99911409 1.062 WARS
tryptophanyl-tRNA synthetase
chrX_-_50403412 1.035 SHROOM4
shroom family member 4
chr14_+_69993969 1.030 NM_003813
ADAM21
ADAM metallopeptidase domain 21
chr11_+_7574992 1.024 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_36209672 1.020 NM_181535
KRT28
keratin 28
chr5_+_79651545 1.018 NM_032567
SPZ1
spermatogenic leucine zipper 1
chr12_-_7172641 1.016 NM_031491
RBP5
retinol binding protein 5, cellular
chr17_-_60439764 1.015 GNA13
guanine nucleotide binding protein (G protein), alpha 13
chr2_+_231569082 1.011 NM_139073
SPATA3
spermatogenesis associated 3
chr12_+_84792203 1.011 NM_006183
NTS
neurotensin
chr11_-_62508946 1.008 NM_004790
NM_153276
NM_153277
NM_153278
SLC22A6



solute carrier family 22 (organic anion transporter), member 6



chr1_-_229627412 0.998 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr17_-_40843530 0.994 ARHGAP27
Rho GTPase activating protein 27
chr3_+_38238080 0.987 OXSR1
oxidative-stress responsive 1
chrX_+_55666557 0.980 NM_198451
FOXR2
forkhead box R2
chr11_+_55776251 0.980 NM_001004747
OR5T3
olfactory receptor, family 5, subfamily T, member 3
chr1_-_203657803 0.979 NM_001001552
NM_001199050
NM_001199051
NM_001199052
LEMD1



LEM domain containing 1



chrX_+_49480643 0.977 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr3_+_45902999 0.967 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr6_+_132901119 0.966 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr3_-_18455207 0.962 NM_001131010
SATB1
SATB homeobox 1
chr19_+_46201665 0.959 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr8_+_86538307 0.955 NM_005181
CA3
carbonic anhydrase III, muscle specific
chr10_-_98021144 0.953 NM_001114094
NM_013314
BLNK

B-cell linker

chr1_+_144124547 0.949 NM_145277
NM_202004
NM_213652
NM_213653
HFE2



hemochromatosis type 2 (juvenile)



chr1_+_33710818 0.943 NM_145238
ZSCAN20
zinc finger and SCAN domain containing 20
chrX_+_38305634 0.939 NM_004615
TSPAN7
tetraspanin 7
chr17_-_36594652 0.938 NM_033060
KRTAP4-1
keratin associated protein 4-1
chr20_+_58004811 0.937 NM_021810
CDH26
cadherin 26
chr4_-_647974 0.928 PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr15_+_41672543 0.918 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr21_-_38792173 0.917 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chrX_+_41433169 0.911 NM_001097579
NM_005300
GPR34

G protein-coupled receptor 34

chr19_+_61624 0.909 NM_001005240
OR4F4
OR4F17
olfactory receptor, family 4, subfamily F, member 4
olfactory receptor, family 4, subfamily F, member 17
chr11_+_54891935 0.909 NM_001005275
OR4A15
olfactory receptor, family 4, subfamily A, member 15
chrX_-_100015783 0.906 NM_007052
NM_013955
NOX1

NADPH oxidase 1

chr12_-_119249938 0.906 NM_000928
PLA2G1B
phospholipase A2, group IB (pancreas)
chr13_+_52114565 0.899 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr22_+_20929199 0.897 NM_007128
VPREB1
pre-B lymphocyte 1
chr1_+_151015471 0.891 NM_178354
LCE1F
late cornified envelope 1F
chr3_+_185233312 0.886 NM_001163646
HTR3D
5-hydroxytryptamine (serotonin) receptor 3 family member D
chr11_+_123391491 0.885 NM_001004462
OR10G4
olfactory receptor, family 10, subfamily G, member 4
chr17_-_29507663 0.867 NM_001094
ACCN1
amiloride-sensitive cation channel 1, neuronal
chr12_+_108452117 0.860 UBE3B
ubiquitin protein ligase E3B
chr12_-_55790355 0.850 NM_001178079
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr11_+_57123927 0.849 SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr17_+_29670171 0.846 NM_005623
CCL8
chemokine (C-C motif) ligand 8
chr9_-_70345549 0.841 NM_153237
C9orf71
chromosome 9 open reading frame 71
chr12_-_66933492 0.826 NM_020525
IL22
interleukin 22
chrX_-_109570113 0.822 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr11_-_123758448 0.820 NM_001005468
OR8B2
olfactory receptor, family 8, subfamily B, member 2
chr3_+_185253528 0.818 NM_130770
HTR3C
5-hydroxytryptamine (serotonin) receptor 3, family member C
chr4_+_74500748 0.817 ALB
albumin
chr12_+_6424293 0.809 NM_001242
CD27
CD27 molecule
chr7_-_86433139 0.809 NM_152748
KIAA1324L
KIAA1324-like
chr1_-_220788048 0.801 NM_024746
HHIPL2
HHIP-like 2
chr11_-_6870306 0.799 NM_003700
OR2D2
olfactory receptor, family 2, subfamily D, member 2
chr11_+_6762823 0.797 NM_001004489
OR2AG1
olfactory receptor, family 2, subfamily AG, member 1
chr3_+_142253432 0.794 NM_080862
SPSB4
splA/ryanodine receptor domain and SOCS box containing 4
chr12_+_49922592 0.793 DAZAP2
DAZ associated protein 2
chr15_-_50375143 0.789 NM_018728
MYO5C
myosin VC
chr7_+_28418668 0.787 NM_182898
CREB5
cAMP responsive element binding protein 5
chr3_+_42702014 0.775 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr18_+_70352779 0.772 CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr10_+_105026773 0.764 NM_032727
INA
internexin neuronal intermediate filament protein, alpha
chr15_-_88150823 0.764 ANPEP
alanyl (membrane) aminopeptidase
chr11_+_7463175 0.749 NM_198474
OLFML1
olfactomedin-like 1
chr1_-_148854503 0.747


chr8_-_87824996 0.746 NM_019098
CNGB3
cyclic nucleotide gated channel beta 3
chr1_-_156056456 0.743 NM_001159397
NM_001159398
NM_052938
FCRL1


Fc receptor-like 1


chr7_+_117651947 0.741 NM_019644
ANKRD7
ankyrin repeat domain 7
chr1_+_224083047 0.741 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr1_-_164402575 0.737 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr19_+_51535801 0.737 HIF3A
hypoxia inducible factor 3, alpha subunit
chr1_-_180908639 0.735 NM_001102450
NM_033345
RGS8

regulator of G-protein signaling 8

chr4_-_107508040 0.734 NM_001195138
LOC100507096
GTPase IMAP family member-like
chr6_+_42231121 0.729 NM_000409
GUCA1A
guanylate cyclase activator 1A (retina)
chr18_-_29273979 0.724 NM_001105528
C18orf34
chromosome 18 open reading frame 34
chr8_-_7275279 0.723 NM_001081551
DEFB103A
DEFB103B
defensin, beta 103A
defensin, beta 103B
chr1_+_210864411 0.720 NM_153606
FAM71A
family with sequence similarity 71, member A
chr1_+_242281175 0.720 NM_205768
ZNF238
zinc finger protein 238
chr1_-_120737466 0.718 NM_001004340
NM_001017986
FCGR1A
FCGR1B

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Fc fragment of IgG, high affinity Ib, receptor (CD64)

chrX_+_50670474 0.714 NM_005448
BMP15
bone morphogenetic protein 15
chr1_-_7998265 0.708 ERRFI1
ERBB receptor feedback inhibitor 1
chr9_-_111230926 0.705 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr6_-_41811916 0.703 NM_001167827
TFEB
transcription factor EB
chr1_-_150065176 0.702 NM_001001523
RORC
RAR-related orphan receptor C
chr4_+_77575276 0.699 NM_020859
SHROOM3
shroom family member 3
chr5_+_57823017 0.698 NM_152687
GAPT
GRB2-binding adaptor protein, transmembrane
chr22_+_19651446 0.694 NM_001146288
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
chr12_-_119172339 0.690 NM_025157
PXN
paxillin
chr8_-_125649926 0.689 MTSS1
metastasis suppressor 1
chr20_+_34019942 0.688 NM_080834
C20orf152
chromosome 20 open reading frame 152
chr15_-_40173949 0.682 NM_178034
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr17_+_70244553 0.678 NM_001163989
RAB37
RAB37, member RAS oncogene family
chr17_-_31441390 0.674 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr18_+_30652223 0.673 NM_001198942
NM_001198944
NM_032980
NM_032981
DTNA



dystrobrevin, alpha



chr6_+_155453114 0.673 NM_012454
TIAM2
T-cell lymphoma invasion and metastasis 2
chr9_-_4142182 0.672 NM_152629
GLIS3
GLIS family zinc finger 3
chr7_+_123083096 0.658 NM_207163
LMOD2
leiomodin 2 (cardiac)
chr6_+_116889248 0.656 NM_001010919
FAM26F
family with sequence similarity 26, member F
chr12_-_94469357 0.656 NM_032147
USP44
ubiquitin specific peptidase 44
chr7_-_75876830 0.655 NM_080744
SRCRB4D
scavenger receptor cysteine rich domain containing, group B (4 domains)
chr1_-_156567835 0.655 NM_001764
CD1B
CD1b molecule
chr10_-_43383912 0.655 NM_005674
ZNF239
zinc finger protein 239
chr12_+_111829191 0.654 OAS1
2',5'-oligoadenylate synthetase 1, 40/46kDa
chr15_+_60726801 0.653 NM_015059
TLN2
talin 2
chr11_-_64403712 0.652 EHD1
EH-domain containing 1
chr6_-_30236667 0.647 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr4_+_72321113 0.645 SLC4A4
solute carrier family 4, sodium bicarbonate cotransporter, member 4
chr14_-_76958984 0.645 NM_138791
NM_001113475
C14orf148

chromosome 14 open reading frame 148

chr6_-_41114905 0.639 NM_173561
UNC5CL
unc-5 homolog C (C. elegans)-like
chr1_-_161439248 0.638 NM_001195303
RGS5
regulator of G-protein signaling 5
chr18_+_70352649 0.634 NM_032649
CNDP1
carnosine dipeptidase 1 (metallopeptidase M20 family)
chr1_-_120737416 0.633 FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr11_+_20027185 0.632 NAV2
neuron navigator 2
chr11_+_20577521 0.632 NM_004211
SLC6A5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chrX_+_106057984 0.631 CLDN2
claudin 2
chr2_+_38031099 0.629 NM_001170793
NM_144713
FAM82A1

family with sequence similarity 82, member A1

chr8_-_67253234 0.627 NM_000756
CRH
corticotropin releasing hormone
chr8_+_133948384 0.625 NM_003235
TG
thyroglobulin
chr7_+_143378393 0.624 NM_012365
OR2A5
olfactory receptor, family 2, subfamily A, member 5
chr1_-_142559339 0.623 NM_001123068
PPIAL4G
peptidylprolyl isomerase A (cyclophilin A)-like 4G
chr15_+_57286313 0.621 NM_033195
LDHAL6B
lactate dehydrogenase A-like 6B
chr3_+_189353502 0.619 LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_60969392 0.618 NM_173667
FLJ37543
hypothetical protein FLJ37543
chr3_+_46594079 0.615 NM_003212
TDGF1
teratocarcinoma-derived growth factor 1
chr14_-_79747592 0.615 NM_001007023
DIO2
deiodinase, iodothyronine, type II
chr11_-_7917642 0.601 NM_001003745
OR10A3
olfactory receptor, family 10, subfamily A, member 3
chr5_-_169749215 0.600 NM_004137
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.89 4.32e-03 GO:0071944 cell periphery
1.86 8.74e-03 GO:0005886 plasma membrane
2.89 3.23e-02 GO:0000267 cell fraction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
230.08 1.88e-03 GO:0008389 coumarin 7-hydroxylase activity
2.62 9.06e-03 GO:0004872 receptor activity
2.39 1.26e-02 GO:0004871 signal transducer activity
2.39 1.26e-02 GO:0060089 molecular transducer activity
2.91 1.29e-02 GO:0004888 transmembrane receptor activity
4.95 1.91e-02 GO:0004984 olfactory receptor activity