Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.035


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)



Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_52713098 1.764 NM_018953
HOXC5
homeobox C5
chr1_-_116184846 1.528 NM_001111061
NHLH2
nescient helix loop helix 2
chr20_-_32363268 0.839 NM_001161766
AHCY
adenosylhomocysteinase
chr17_-_76985538 0.838


chr8_+_102574012 0.828 GRHL2
grainyhead-like 2 (Drosophila)
chr15_+_41672543 0.815 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr1_-_116185215 0.799 NM_005599
NHLH2
nescient helix loop helix 2
chr1_+_13784553 0.770 NM_001006624
NM_001006625
PDPN

podoplanin

chr11_-_110888273 0.745 NM_017589
BTG4
B-cell translocation gene 4
chr10_-_123346148 0.739 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr6_-_24753934 0.726 NM_001168375
NM_001168376
NM_001168374
NM_001168377
NM_014809
KIAA0319




KIAA0319




chr2_+_69093641 0.711 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr17_-_36760581 0.705 NM_004138
KRT33A
keratin 33A
chr2_+_17861266 0.693 NM_001105569
MSGN1
mesogenin 1
chr2_+_169634330 0.661 DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_-_27186400 0.643 NM_153715
HOXA10
homeobox A10
chr2_+_220017617 0.638 SPEG
SPEG complex locus
chr2_+_135312655 0.637 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr12_+_10222823 0.631 NM_153022
C12orf59
chromosome 12 open reading frame 59
chr13_+_23042722 0.616 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr10_+_53744043 0.616 NM_012242
DKK1
dickkopf homolog 1 (Xenopus laevis)
chr2_+_190981257 0.608 NM_017694
MFSD6
major facilitator superfamily domain containing 6
chr20_+_17622319 0.591 NM_001159495
BANF2
barrier to autointegration factor 2
chr8_-_42353719 0.589 NM_014420
DKK4
dickkopf homolog 4 (Xenopus laevis)
chr12_-_28016182 0.580 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr17_-_58237742 0.575 NM_001100875
MARCH10
membrane-associated ring finger (C3HC4) 10
chr20_-_42249146 0.551 JPH2
junctophilin 2
chr4_-_77147625 0.548 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr5_+_36642213 0.547 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr9_+_96806235 0.541 C9orf3
chromosome 9 open reading frame 3
chr6_-_159386007 0.541 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr3_-_191650291 0.537 NM_207316
TMEM207
transmembrane protein 207
chr6_+_64339869 0.531 NM_003463
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr3_-_150422474 0.527 NM_000096
CP
ceruloplasmin (ferroxidase)
chr13_+_109932934 0.522 COL4A2
collagen, type IV, alpha 2
chr1_+_205105776 0.518 NM_018724
IL20
interleukin 20
chr3_+_187866464 0.518 NM_000412
HRG
histidine-rich glycoprotein
chr17_-_45427565 0.514 NM_005220
DLX3
distal-less homeobox 3
chr5_-_16791346 0.503 MYO10
myosin X
chr9_-_73715666 0.501 FAM108B1
family with sequence similarity 108, member B1
chr6_-_128883125 0.497 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr14_+_60271203 0.491 NM_001177963
NM_002431
MNAT1

menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)

chr4_-_120462705 0.487 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr9_-_90456824 0.486 NM_001100111
LOC286238
hypothetical protein LOC286238
chr18_+_19826734 0.485 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr5_+_66160359 0.483 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr5_-_16989290 0.480 MYO10
myosin X
chr1_+_183970093 0.470 NM_031935
HMCN1
hemicentin 1
chr7_+_139750311 0.465 NM_001008749
RAB19
RAB19, member RAS oncogene family
chr14_+_20283938 0.459 NM_006683
EDDM3A
epididymal protein 3A
chr20_-_19984685 0.449 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr17_+_7900926 0.444


chr6_+_123151669 0.441 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr12_+_19173669 0.437 NM_001143821
NM_001190860
NM_019012
PLEKHA5


pleckstrin homology domain containing, family A member 5


chr2_+_178893216 0.429 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr2_-_56003859 0.428 NM_004105
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr6_-_138935359 0.423 NM_020464
NHSL1
NHS-like 1
chr6_-_31789824 0.422


chr3_+_42825957 0.418 NM_001296
CCBP2
chemokine binding protein 2
chr5_+_36642424 0.417 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_17719405 0.415 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr7_+_80069439 0.412 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr17_-_35273947 0.411 NM_012481
NM_183228
NM_183229
NM_183230
NM_183231
NM_183232
IKZF3





IKAROS family zinc finger 3 (Aiolos)





chr7_-_91632525 0.407 NM_001161528
LOC401387
leucine-rich repeat and death domain-containing protein
chr2_+_47449951 0.405 EPCAM
epithelial cell adhesion molecule
chr14_-_30746577 0.397


chr6_+_116956868 0.397 NM_153036
FAM26D
family with sequence similarity 26, member D
chr6_-_11887265 0.395 NM_001143948
NM_032744
C6orf105

chromosome 6 open reading frame 105

chr8_-_17624009 0.394 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr15_+_60146467 0.394 NM_207322
C2CD4A
C2 calcium-dependent domain containing 4A
chr17_-_53849888 0.391 RNF43
ring finger protein 43
chr17_-_36779399 0.391 NM_002279
KRT33B
keratin 33B
chr12_+_52689062 0.388 NM_022658
HOXC8
homeobox C8
chr2_+_28572441 0.385 NM_001170585
NM_153021
PLB1

phospholipase B1

chr15_-_49830941 0.384 NM_001143917
LYSMD2
LysM, putative peptidoglycan-binding, domain containing 2
chr6_-_2696152 0.379 NM_001012418
MYLK4
myosin light chain kinase family, member 4
chr20_-_17459973 0.376 NM_001195
BFSP1
beaded filament structural protein 1, filensin
chr6_-_75972473 0.375 COL12A1
collagen, type XII, alpha 1
chr1_+_15957832 0.375 NM_017556
FBLIM1
filamin binding LIM protein 1
chr11_-_85107569 0.372 NM_206929
SYTL2
synaptotagmin-like 2
chr6_+_167624792 0.366 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr18_+_11679135 0.364 NM_182978
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr3_-_15348811 0.361 SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr5_+_131621230 0.361 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr1_-_240679380 0.360 NM_001195811
NM_001195812
PLD5

phospholipase D family, member 5

chr17_-_36347197 0.359 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr1_-_54076521 0.359 TMEM48
transmembrane protein 48
chr10_-_116154504 0.359 NM_001001936
NM_032550
AFAP1L2

actin filament associated protein 1-like 2

chr10_+_71232281 0.356 COL13A1
collagen, type XIII, alpha 1
chr2_+_74629654 0.354 NM_001197260
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr8_-_17624304 0.350 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr1_+_93686154 0.350 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr1_+_239882202 0.349 NM_144625
WDR64
WD repeat domain 64
chr2_+_38009405 0.348 NM_001170792
FAM82A1
family with sequence similarity 82, member A1
chr15_+_49831030 0.346 NM_001142885
NM_014548
TMOD2

tropomodulin 2 (neuronal)

chr4_-_103484841 0.345 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr11_+_113353431 0.345 NM_001161772
HTR3A
5-hydroxytryptamine (serotonin) receptor 3A
chr13_+_112349358 0.344 NM_207440
C13orf35
chromosome 13 open reading frame 35
chr3_-_147696411 0.343 NM_020359
PLSCR2
phospholipid scramblase 2
chr14_-_20572783 0.340 NM_001012264
RNASE13
ribonuclease, RNase A family, 13 (non-active)
chr2_+_228386800 0.337 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr12_-_51065629 0.332 NM_033045
KRT84
keratin 84
chr17_-_53849929 0.331 NM_017763
RNF43
ring finger protein 43
chr12_+_106692291 0.330 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr8_-_6901661 0.329 NM_021010
DEFA5
defensin, alpha 5, Paneth cell-specific
chr9_-_101621964 0.328


chr12_+_52665196 0.326 NM_017409
HOXC10
homeobox C10
chr4_-_10295412 0.326 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr1_-_160260210 0.325 NM_015441
OLFML2B
olfactomedin-like 2B
chr10_-_13789628 0.325 FRMD4A
FERM domain containing 4A
chr4_+_109761170 0.323 NM_000995
NM_033625
RPL34

ribosomal protein L34

chr11_-_87548199 0.322 NM_022337
RAB38
RAB38, member RAS oncogene family
chr18_-_55136673 0.322 NM_181654
CPLX4
complexin 4
chr10_-_123343761 0.322 NM_001144916
FGFR2
fibroblast growth factor receptor 2
chr7_-_83116414 0.322 NM_012431
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr14_-_20098929 0.321 NM_001001673
NM_001110356
NM_001110357
NM_001110358
NM_001110359
NM_001110360
NM_001110361
RNASE9






ribonuclease, RNase A family, 9 (non-active)






chr12_-_25597444 0.316 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr5_+_131621276 0.316 PDLIM4
PDZ and LIM domain 4
chr13_+_100902942 0.315 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr20_-_1396336 0.312 NM_016143
NM_018839
NM_182483
NSFL1C


NSFL1 (p97) cofactor (p47)


chr2_-_127580975 0.312 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr6_+_144649142 0.312 UTRN
utrophin
chr5_-_16989371 0.311 NM_012334
MYO10
myosin X
chr10_-_116382089 0.309 ABLIM1
actin binding LIM protein 1
chr8_+_22075112 0.307 NM_001172357
NM_001172410
NM_003018
SFTPC


surfactant protein C


chr1_+_181028016 0.307 NM_030769
NPL
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr14_-_22521544 0.304 NM_032876
JUB
jub, ajuba homolog (Xenopus laevis)
chr3_-_152541129 0.304 NM_176876
P2RY12
purinergic receptor P2Y, G-protein coupled, 12
chr15_+_71131877 0.304 NM_001172623
NM_001172624
NM_002499
NEO1


neogenin 1


chr18_-_63333487 0.302 DSEL
dermatan sulfate epimerase-like
chr7_-_30032649 0.301 NM_017946
FKBP14
FK506 binding protein 14, 22 kDa
chr8_-_29262240 0.300 NM_057158
DUSP4
dual specificity phosphatase 4
chr3_+_134985566 0.298 NM_021203
SRPRB
signal recognition particle receptor, B subunit
chr11_-_89181390 0.298 NM_020358
TRIM49
tripartite motif containing 49
chr2_+_169631777 0.297 NM_199204
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_+_20653490 0.297 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr5_+_131621287 0.292 PDLIM4
PDZ and LIM domain 4
chr9_-_34719463 0.291 NM_001141917
C9orf144B
transmembrane protein C9orf144B
chr9_+_90193807 0.289 SPIN1
spindlin 1
chr11_-_85108030 0.289 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr7_-_80386258 0.289 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr17_-_36376663 0.288 NM_213656
KRT39
keratin 39
chr7_+_100169184 0.288 NM_003386
NM_173059
ZAN

zonadhesin

chr2_-_207739815 0.288 KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_+_4253143 0.288 NM_001759
CCND2
cyclin D2
chr18_-_44723116 0.287 NM_001190823
SMAD7
SMAD family member 7
chr22_-_35733784 0.286 NM_001163857
NM_178552
C22orf33

chromosome 22 open reading frame 33

chr5_-_58370693 0.286 NM_001197221
NM_001197222
PDE4D

phosphodiesterase 4D, cAMP-specific

chr7_+_80113903 0.286 CD36
CD36 molecule (thrombospondin receptor)
chr1_-_54076695 0.285 NM_001168551
NM_018087
TMEM48

transmembrane protein 48

chr1_+_42701460 0.282 CCDC30
coiled-coil domain containing 30
chr7_+_129771865 0.282 NM_001127441
NM_001127442
NM_080385
CPA5


carboxypeptidase A5


chr1_+_151596953 0.279 NM_002965
S100A9
S100 calcium binding protein A9
chr6_+_155579788 0.278 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr6_-_134680888 0.278 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr1_-_151280201 0.278 NM_006945
SPRR2D
small proline-rich protein 2D
chr2_-_135498716 0.277 NM_001018046
NM_025052
YSK4

YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)

chr11_+_101488380 0.276 NM_001195045
YAP1
Yes-associated protein 1
chr15_+_41772375 0.275 NM_001015001
CKMT1A
creatine kinase, mitochondrial 1A
chr10_-_116154212 0.274 AFAP1L2
actin filament associated protein 1-like 2
chr12_+_8958397 0.274 NM_004426
PHC1
polyhomeotic homolog 1 (Drosophila)
chr10_+_18280773 0.270 NM_001145195
NM_152725
SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr11_-_13474101 0.270 NM_000315
PTH
parathyroid hormone
chr2_+_204509698 0.267 NM_012092
ICOS
inducible T-cell co-stimulator
chr17_-_10362583 0.266 NM_005963
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr7_-_16471817 0.262 NM_015464
SOSTDC1
sclerostin domain containing 1
chr11_+_85690900 0.260 NM_016401
C11orf73
chromosome 11 open reading frame 73
chr20_-_13919256 0.260 NM_025229
SEL1L2
sel-1 suppressor of lin-12-like 2 (C. elegans)
chr2_-_160180197 0.259 BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr20_-_43410437 0.259 NM_002999
SDC4
syndecan 4
chr17_-_36877002 0.254 NM_002278
KRT32
keratin 32
chr10_+_15125900 0.253 NM_001039702
NM_018324
OLAH

oleoyl-ACP hydrolase

chr13_+_24940965 0.252 ATP8A2
ATPase, aminophospholipid transporter, class I, type 8A, member 2
chr10_+_71231649 0.251 NM_001130103
NM_080798
NM_080800
NM_080801
NM_080802
NM_080805
COL13A1





collagen, type XIII, alpha 1





chr21_+_38550533 0.249 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_-_198509808 0.246 NM_001098424
NM_004087
DLG1

discs, large homolog 1 (Drosophila)

chr2_+_187163232 0.245 ITGAV
integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
chr1_-_176329357 0.244 LOC100302401
hypothetical LOC100302401
chr14_+_85066207 0.243 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr14_+_85066265 0.242 FLRT2
fibronectin leucine rich transmembrane protein 2
chr15_-_40570585 0.241 ZFP106
zinc finger protein 106 homolog (mouse)
chr21_+_38550739 0.241 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_53420595 0.241 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr6_-_136829705 0.240 NM_001198615
MAP7
microtubule-associated protein 7
chr6_+_27222839 0.240 NM_080596
HIST1H2AH
histone cluster 1, H2ah
chr17_-_15407497 0.239 NM_001135036
NM_145301
FAM18B2-CDRT4
FAM18B2

FAM18B2-CDRT4 read-through transcript
family with sequence similarity 18, member B2

chr1_-_85131439 0.239 NM_012152
LPAR3
lysophosphatidic acid receptor 3
chr1_-_168310232 0.236 NM_014970
KIFAP3
kinesin-associated protein 3
chr6_-_89984214 0.236 NM_002042
GABRR1
gamma-aminobutyric acid (GABA) receptor, rho 1
chr6_-_32447626 0.235 NM_006781
C6orf10
chromosome 6 open reading frame 10
chr16_-_12805133 0.235 CPPED1
calcineurin-like phosphoesterase domain containing 1
chr15_+_38923470 0.234 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr10_-_91285290 0.234 NM_213606
SLC16A12
solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
chr2_-_86418143 0.233 NM_001164731
NM_001164732
NM_022912
REEP1


receptor accessory protein 1


chr7_-_148356433 0.232 PDIA4
protein disulfide isomerase family A, member 4
chr3_+_29297806 0.232 NM_001003792
NM_001003793
NM_001177711
NM_001177712
NM_014483
RBMS3




RNA binding motif, single stranded interacting protein 3




chr1_-_24386324 0.232 NM_170743
NM_173064
NM_173065
IL28RA


interleukin 28 receptor, alpha (interferon, lambda receptor)


chr13_-_38510183 0.231 C13orf23
chromosome 13 open reading frame 23
chr13_+_28496746 0.230 NM_001033602
MTUS2
microtubule associated tumor suppressor candidate 2
chr1_+_119851348 0.230 NM_000862
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.