Motif ID: NKX6-1,2.p2

Z-value: 1.019


Transcription factors associated with NKX6-1,2.p2:

Gene SymbolEntrez IDGene Name
NKX6-1 4825 NK6 homeobox 1
NKX6-2 84504 NK6 homeobox 2



Activity profile for motif NKX6-1,2.p2.

activity profile for motif NKX6-1,2.p2


Sorted Z-values histogram for motif NKX6-1,2.p2

Sorted Z-values for motif NKX6-1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX6-1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_52696908 1.993 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr9_-_21375258 1.808 NM_000605
IFNA2
interferon, alpha 2
chr12_-_28016182 1.503 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr12_+_52697160 1.180 HOXC5
HOXC6
homeobox C5
homeobox C6
chr4_-_90978469 1.155 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr8_-_82769761 1.131 NM_001010893
SLC10A5
solute carrier family 10 (sodium/bile acid cotransporter family), member 5
chr3_-_171070314 1.103 NM_024727
LRRC31
leucine rich repeat containing 31
chr13_+_23042722 1.097 NM_148957
TNFRSF19
tumor necrosis factor receptor superfamily, member 19
chr1_-_116184846 1.071 NM_001111061
NHLH2
nescient helix loop helix 2
chr22_-_34892170 1.005 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr10_-_100985548 0.951 NM_001166244
NM_001166245
NM_001166246
NM_021828
HPSE2



heparanase 2



chr3_-_148607096 0.944 NM_032153
ZIC4
Zic family member 4
chr20_+_19985289 0.929 NM_001167816
C20orf26
chromosome 20 open reading frame 26
chr5_+_140709907 0.905 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr17_-_53849888 0.902 RNF43
ring finger protein 43
chr20_-_19984685 0.893 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr10_-_14412813 0.891 NM_018027
FRMD4A
FERM domain containing 4A
chr6_-_46811388 0.874 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr2_+_68815416 0.797 NM_001007231
NM_001166277
ARHGAP25

Rho GTPase activating protein 25

chr17_-_36074812 0.795 NM_152349
KRT222
keratin 222
chr11_-_7684516 0.794 NM_198185
OVCH2
ovochymase 2 (gene/pseudogene)
chr12_-_56422120 0.770 NM_014770
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr18_-_55136673 0.764 NM_181654
CPLX4
complexin 4
chr8_-_37916803 0.757 NM_152413
GOT1L1
glutamic-oxaloacetic transaminase 1-like 1
chr2_+_218698980 0.684 NM_001557
CXCR2
chemokine (C-X-C motif) receptor 2
chr19_-_47623340 0.682 NM_005357
LIPE
lipase, hormone-sensitive
chr4_-_77147625 0.677 NM_002416
CXCL9
chemokine (C-X-C motif) ligand 9
chr2_+_169465995 0.663 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr20_-_18425811 0.659 NM_006606
RBBP9
retinoblastoma binding protein 9
chr5_+_49997489 0.637 NM_001178055
PARP8
poly (ADP-ribose) polymerase family, member 8
chr4_+_75393053 0.637 NM_001013442
EPGN
epithelial mitogen homolog (mouse)
chr20_+_16676997 0.632 NM_020157
OTOR
otoraplin
chr14_-_56342097 0.618 NM_172337
OTX2
orthodenticle homeobox 2
chr17_-_53849929 0.607 NM_017763
RNF43
ring finger protein 43
chr15_-_74091817 0.591 NM_138573
NRG4
neuregulin 4
chr15_-_40089736 0.583 NM_001080490
PLA2G4E
phospholipase A2, group IVE
chr5_+_166644420 0.582 NM_001122679
ODZ2
odz, odd Oz/ten-m homolog 2 (Drosophila)
chr3_+_2117246 0.575 NM_175607
CNTN4
contactin 4
chr7_+_120752656 0.574 NM_016087
WNT16
wingless-type MMTV integration site family, member 16
chr6_+_132901119 0.569 NM_175057
TAAR9
trace amine associated receptor 9 (gene/pseudogene)
chr6_-_128263868 0.569 NM_001010923
NM_001164685
THEMIS

thymocyte selection associated

chr15_+_46271158 0.566 NM_001145668
CTXN2
SLC12A1
cortexin 2
solute carrier family 12 (sodium/potassium/chloride transporters), member 1
chr7_+_94135384 0.556 PEG10
paternally expressed 10
chr10_-_69661860 0.553 NM_145178
ATOH7
atonal homolog 7 (Drosophila)
chr12_+_52680143 0.547 NM_006897
HOXC9
homeobox C9
chr2_+_218698242 0.545 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr8_-_109868945 0.542 NM_153015
TMEM74
transmembrane protein 74
chr22_+_38903825 0.541 NM_001162501
NM_015088
TNRC6B

trinucleotide repeat containing 6B

chr3_-_139531417 0.539 NM_178130
TXNDC6
thioredoxin domain containing 6
chr16_+_20682812 0.525 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr3_+_150065732 0.518 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr8_-_114518194 0.509 NM_052900
NM_198123
CSMD3

CUB and Sushi multiple domains 3

chr2_+_73864823 0.509 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chr5_+_140719773 0.505 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr2_+_135312655 0.505 NM_138326
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr2_-_131073329 0.491 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr20_+_41569727 0.483 NM_032107
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr3_-_15814678 0.483 NM_001195098
ANKRD28
ankyrin repeat domain 28
chr12_-_16652202 0.475 NM_001001395
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_68136056 0.471 NM_213609
FAM19A1
family with sequence similarity 19 (chemokine (C-C motif)-like), member A1
chr12_+_53178834 0.469 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr11_-_123695302 0.468 NM_001002918
OR8D2
olfactory receptor, family 8, subfamily D, member 2
chr11_-_40271086 0.463 LRRC4C
leucine rich repeat containing 4C
chr3_-_74652952 0.455 NM_020872
CNTN3
contactin 3 (plasmacytoma associated)
chr17_-_36403910 0.454 NM_033185
KRTAP3-3
keratin associated protein 3-3
chr2_-_219614481 0.448 NM_152389
NM_194302
CCDC108

coiled-coil domain containing 108

chr14_-_60185659 0.448 NM_005982
SIX1
SIX homeobox 1
chr1_-_234511917 0.448 NM_019891
ERO1LB
ERO1-like beta (S. cerevisiae)
chr12_+_52708460 0.445 NM_004503
HOXC6
homeobox C6
chr20_+_51235228 0.442 NM_001193421
TSHZ2
teashirt zinc finger homeobox 2
chr8_+_79591074 0.442 PKIA
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr7_+_23252945 0.441 GPNMB
glycoprotein (transmembrane) nmb
chr7_-_92693716 0.438 NM_001039372
HEPACAM2
HEPACAM family member 2
chr15_+_92700167 0.438 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr14_+_38772870 0.438 NM_054024
MIA2
melanoma inhibitory activity 2
chr14_+_61532293 0.435 NM_031914
SYT16
synaptotagmin XVI
chr2_+_130995136 0.432 NM_032545
NM_001079530
CFC1
CFC1B
cripto, FRL-1, cryptic family 1
cripto, FRL-1, cryptic family 1B
chr6_-_64087806 0.432 NM_001143940
NM_016571
LGSN

lengsin, lens protein with glutamine synthetase domain

chr7_+_23252909 0.431 GPNMB
glycoprotein (transmembrane) nmb
chr11_-_117552545 0.430 NM_004588
SCN2B
sodium channel, voltage-gated, type II, beta
chr5_-_13997588 0.427 NM_001369
DNAH5
dynein, axonemal, heavy chain 5
chr1_+_78858675 0.424 NM_006820
IFI44L
interferon-induced protein 44-like
chr12_+_106692291 0.422 NM_203436
ASCL4
achaete-scute complex homolog 4 (Drosophila)
chr8_-_28403652 0.422 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr11_-_117552355 0.420 SCN2B
sodium channel, voltage-gated, type II, beta
chr6_-_26151863 0.418 NM_021062
HIST1H2BB
histone cluster 1, H2bb
chr12_+_28301399 0.416 NM_018318
CCDC91
coiled-coil domain containing 91
chr13_-_45323757 0.406 NM_198849
SIAH3
seven in absentia homolog 3 (Drosophila)
chr14_-_59167284 0.403 RTN1
reticulon 1
chr12_+_70618892 0.403 NM_173353
TPH2
tryptophan hydroxylase 2
chr14_+_30098079 0.400 NM_017769
G2E3
G2/M-phase specific E3 ubiquitin protein ligase
chr6_+_114285209 0.397 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr13_+_22653059 0.391 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr4_+_155703581 0.390 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_+_26359805 0.384 NM_003524
HIST1H2BH
histone cluster 1, H2bh
chr6_+_41128917 0.379 NM_006789
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr8_-_15140162 0.373 NM_139167
SGCZ
sarcoglycan, zeta
chr4_-_40212670 0.372 NM_019027
RBM47
RNA binding motif protein 47
chr13_+_27392136 0.372 NM_000209
PDX1
pancreatic and duodenal homeobox 1
chr22_+_38627129 0.368 GRAP2
GRB2-related adaptor protein 2
chr7_+_23252926 0.368 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_28305464 0.366 NM_182899
CREB5
cAMP responsive element binding protein 5
chr6_+_26071255 0.365 TRIM38
tripartite motif containing 38
chr2_-_156894927 0.365 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr4_-_10295412 0.364 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr20_+_23293020 0.363 NM_022482
GZF1
GDNF-inducible zinc finger protein 1
chr2_-_165768798 0.362 NM_001081676
NM_001081677
NM_006922
SCN3A


sodium channel, voltage-gated, type III, alpha subunit


chr14_-_98807574 0.361 NM_022898
NM_138576
BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein)

chr9_+_115303527 0.360 NM_130795
RGS3
regulator of G-protein signaling 3
chr7_+_23252911 0.358 GPNMB
glycoprotein (transmembrane) nmb
chr10_-_90601655 0.355 NM_144590
ANKRD22
ankyrin repeat domain 22
chr2_-_74424041 0.351 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr18_-_3209986 0.351 NM_003803
NM_019856
MYOM1

myomesin 1, 185kDa

chr2_+_234490781 0.351 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr8_-_122722674 0.351 NM_005328
HAS2
hyaluronan synthase 2
chr7_+_23252915 0.350 GPNMB
glycoprotein (transmembrane) nmb
chr2_-_225519974 0.348 DOCK10
dedicator of cytokinesis 10
chr14_-_59167139 0.346 RTN1
reticulon 1
chr10_-_115413630 0.345 NM_006175
NM_198060
NRAP

nebulin-related anchoring protein

chr3_+_99555387 0.344 NM_001005517
OR5K4
olfactory receptor, family 5, subfamily K, member 4
chr10_-_96819064 0.342 NM_000770
NM_001198853
NM_001198854
NM_001198855
CYP2C8



cytochrome P450, family 2, subfamily C, polypeptide 8



chr4_+_100714995 0.338 MTTP
microsomal triglyceride transfer protein
chr1_+_67404756 0.337 NM_144701
IL23R
interleukin 23 receptor
chr11_+_17289030 0.336


chr1_-_154665807 0.336 NM_006365
C1orf61
chromosome 1 open reading frame 61
chr6_+_26070957 0.336 NM_006355
TRIM38
tripartite motif containing 38
chr2_+_204509698 0.335 NM_012092
ICOS
inducible T-cell co-stimulator
chr3_+_133518900 0.331 NM_001099
NM_001134194
ACPP

acid phosphatase, prostate

chr9_-_21340885 0.329 NM_021002
IFNA6
interferon, alpha 6
chr7_-_22828922 0.328 NM_019059
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr14_-_59167067 0.328 RTN1
reticulon 1
chr12_+_69148120 0.327


chr7_-_93027057 0.327 NM_001164738
CALCR
calcitonin receptor
chr5_+_140762551 0.326 NM_018921
NM_032089
PCDHGA9

protocadherin gamma subfamily A, 9

chr1_-_67366807 0.326 NM_001013674
C1orf141
chromosome 1 open reading frame 141
chr6_+_72979234 0.324 NM_001168407
NM_001168408
RIMS1

regulating synaptic membrane exocytosis 1

chr12_+_56230110 0.323 NM_004984
KIF5A
kinesin family member 5A
chr5_-_88004891 0.322 LOC645323
hypothetical LOC645323
chr4_+_151722526 0.319 NM_006439
MAB21L2
mab-21-like 2 (C. elegans)
chr5_+_140780797 0.318 PCDHGA11
protocadherin gamma subfamily A, 11
chr8_+_24354387 0.318 NM_003817
ADAM7
ADAM metallopeptidase domain 7
chr12_-_10464308 0.316 NM_002261
NM_007333
KLRC3

killer cell lectin-like receptor subfamily C, member 3

chr2_-_227952249 0.316 NM_024795
TM4SF20
transmembrane 4 L six family member 20
chr4_-_23500706 0.315 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr4_+_54790020 0.314 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr14_-_98807307 0.312 BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr6_+_26548678 0.310 NM_006994
NM_197974
BTN3A3

butyrophilin, subfamily 3, member A3

chr11_+_65026382 0.310


chr12_-_92489652 0.307 LOC144481
hypothetical protein LOC144481
chr4_+_54790190 0.305 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr2_-_80385227 0.304 LRRTM1
leucine rich repeat transmembrane neuronal 1
chr11_+_123600553 0.303 NM_001007249
OR8G2
olfactory receptor, family 8, subfamily G, member 2
chr17_+_57801309 0.303 NM_001144933
EFCAB3
EF-hand calcium binding domain 3
chr11_+_122258600 0.300 NM_024806
NM_199124
C11orf63

chromosome 11 open reading frame 63

chr4_-_100575313 0.299 NM_001166504
NM_000673
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr3_-_198784590 0.299 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr17_+_55269974 0.296


chr12_-_86947276 0.295 NM_152589
C12orf50
chromosome 12 open reading frame 50
chr1_+_207944807 0.295 NM_005525
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr12_-_53664722 0.295 NM_001136030
KIAA0748
KIAA0748
chr6_+_50789215 0.295 NM_172238
TFAP2D
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr4_+_84175262 0.294 NM_016129
COPS4
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr3_+_149930656 0.290 NM_032049
AGTR1
angiotensin II receptor, type 1
chr6_+_49626071 0.290 NM_001145652
C6orf141
chromosome 6 open reading frame 141
chr3_-_45812916 0.289 SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr16_+_31178778 0.287 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr1_-_89261021 0.282 NM_018284
GBP3
guanylate binding protein 3
chr8_+_79590890 0.280 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr22_-_35733784 0.279 NM_001163857
NM_178552
C22orf33

chromosome 22 open reading frame 33

chr12_-_23993830 0.278 NM_006940
SOX5
SRY (sex determining region Y)-box 5
chr2_+_158666627 0.277 NM_173355
UPP2
uridine phosphorylase 2
chr12_+_49522967 0.276 NM_182559
TMPRSS12
transmembrane (C-terminal) protease, serine 12
chr9_+_92629525 0.274 NM_001174167
SYK
spleen tyrosine kinase
chr2_-_104834344 0.273 LOC100506421
hypothetical LOC100506421
chr2_+_220017617 0.272 SPEG
SPEG complex locus
chr3_+_99592199 0.269 NM_001005516
OR5K3
olfactory receptor, family 5, subfamily K, member 3
chr9_-_72926333 0.269 NM_001007471
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr12_-_93921586 0.267 NDUFA12
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12
chr4_+_40953652 0.267 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr13_+_48582389 0.267 NM_014923
FNDC3A
fibronectin type III domain containing 3A
chr9_+_76302071 0.266 NM_006914
RORB
RAR-related orphan receptor B
chr5_+_108111421 0.264 NM_005246
FER
fer (fps/fes related) tyrosine kinase
chr7_+_23252802 0.263 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr13_-_35327798 0.262 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr4_-_187114407 0.262 SORBS2
sorbin and SH3 domain containing 2
chr8_-_134184491 0.261 NM_001045556
NM_001045557
SLA

Src-like-adaptor

chr14_-_59167193 0.260 NM_206852
RTN1
reticulon 1
chr11_+_26310253 0.259 NM_031418
ANO3
anoctamin 3
chr20_+_30161173 0.258 TM9SF4
transmembrane 9 superfamily protein member 4
chr14_-_20636909 0.256 NM_001101672
ZNF219
zinc finger protein 219
chr16_+_31178828 0.254 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr14_-_57030227 0.253 NM_018168
C14orf105
chromosome 14 open reading frame 105
chr6_-_32892705 0.253 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr17_-_10217046 0.251 NM_003802
MYH13
myosin, heavy chain 13, skeletal muscle
chr1_-_20374273 0.250 NM_001105572
PLA2G2C
phospholipase A2, group IIC
chr3_-_57209319 0.250 NM_003865
HESX1
HESX homeobox 1
chr18_+_59405513 0.250 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr3_-_121884091 0.249 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr9_-_21156609 0.246 NM_002175
IFNA21
interferon, alpha 21
chr2_+_201756048 0.246 CASP10
caspase 10, apoptosis-related cysteine peptidase

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.