Motif ID: SMAD1..7,9.p2

Z-value: 2.496


Transcription factors associated with SMAD1..7,9.p2:

Gene SymbolEntrez IDGene Name
SMAD1 4086 SMAD family member 1
SMAD2 4087 SMAD family member 2
SMAD3 4088 SMAD family member 3
SMAD4 4089 SMAD family member 4
SMAD5 4090 SMAD family member 5
SMAD6 4091 SMAD family member 6
SMAD7 4092 SMAD family member 7
SMAD9 4093 SMAD family member 9



Activity profile for motif SMAD1..7,9.p2.

activity profile for motif SMAD1..7,9.p2


Sorted Z-values histogram for motif SMAD1..7,9.p2

Sorted Z-values for motif SMAD1..7,9.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SMAD1..7,9.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_60475558 3.342 NM_016582
SLC15A3
solute carrier family 15, member 3
chr22_+_23221114 2.552 NM_016327
UPB1
ureidopropionase, beta
chr17_+_19377732 2.350 NM_018242
SLC47A1
solute carrier family 47, member 1
chr10_+_135333667 2.096 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191229360 2.071 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr4_+_191242540 2.030 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr11_+_60626505 2.004 NM_014207
CD5
CD5 molecule
chr10_+_135330357 1.986 NM_033178
NM_012147
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr1_+_20751518 1.900 NM_207334
FAM43B
family with sequence similarity 43, member B
chr9_-_139183675 1.848


chr3_+_44601457 1.814 NM_173658
ZNF660
zinc finger protein 660
chr10_+_135343649 1.810 NM_012147
DUX2
double homeobox 2
chrX_+_102749489 1.739 NM_001006933
NM_032926
TCEAL3

transcription elongation factor A (SII)-like 3

chr22_-_22970850 1.738 NM_001099781
NM_001099782
NM_004121
GGT5


gamma-glutamyltransferase 5


chr4_+_191232653 1.725 NM_033178
NM_012147
NM_001177376
NM_001127387
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L7
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 7
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr17_-_33753218 1.714 NM_001004334
GPR179
G protein-coupled receptor 179
chr3_-_129689394 1.640 NM_001145662
GATA2
GATA binding protein 2
chr4_+_191226073 1.622 NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
chr16_+_56219802 1.615 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr5_+_113725914 1.615 NM_021614
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr9_-_96441654 1.613 NM_000507
FBP1
fructose-1,6-bisphosphatase 1
chr8_+_143542378 1.612 NM_001702
BAI1
brain-specific angiogenesis inhibitor 1
chr21_+_44844924 1.595 NM_198689
KRTAP10-7
keratin associated protein 10-7
chr11_+_113436438 1.594 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr13_-_32822759 1.579 STARD13
StAR-related lipid transfer (START) domain containing 13
chr11_-_18769703 1.571 NM_001039970
NM_006906
NM_032781
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr21_+_44818033 1.566 NM_198687
KRTAP10-4
keratin associated protein 10-4
chr22_+_21318779 1.560 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr8_+_22465368 1.520 SORBS3
sorbin and SH3 domain containing 3
chr2_+_176761552 1.493 NM_024501
HOXD1
homeobox D1
chrX_+_53095230 1.470 NM_018969
GPR173
G protein-coupled receptor 173
chr1_+_15964045 1.464 NM_001024216
FBLIM1
filamin binding LIM protein 1
chr1_-_6368324 1.462 NM_181864
ACOT7
acyl-CoA thioesterase 7
chr1_-_45444812 1.459 NM_020883
ZSWIM5
zinc finger, SWIM-type containing 5
chrX_-_102870207 1.457 NM_001024452
NM_001172285
GLRA4

glycine receptor, alpha 4

chrX_+_44588192 1.422 NM_022076
DUSP21
dual specificity phosphatase 21
chr15_-_50869379 1.416 NM_004498
ONECUT1
one cut homeobox 1
chr4_+_191239247 1.407 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chr21_+_44881700 1.391 NM_181688
KRTAP10-10
keratin associated protein 10-10
chr9_-_96441567 1.342 FBP1
fructose-1,6-bisphosphatase 1
chr1_-_202595666 1.338 NM_014935
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr1_+_8928508 1.333 NM_001215
CA6
carbonic anhydrase VI
chr1_+_3558958 1.321 NM_005427
TP73
tumor protein p73
chr14_+_51850754 1.317 NM_000956
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr15_-_70385709 1.314 NM_001172685
CELF6
CUGBP, Elav-like family member 6
chrX_+_101862297 1.311 NM_001142524
NM_001142525
NM_001142526
NM_001142527
NM_001142528
NM_030639
BHLHB9





basic helix-loop-helix domain containing, class B, 9





chr4_+_191235959 1.309 NM_001177376
DUX4L4
double homeobox 4 like 4
chr7_-_150283794 1.306 NM_172057
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr3_+_148610516 1.301 ZIC1
Zic family member 1 (odd-paired homolog, Drosophila)
chr17_-_70099964 1.288 NM_001115152
CD300LD
CD300 molecule-like family member d
chr15_-_88143721 1.286 ANPEP
alanyl (membrane) aminopeptidase
chr3_+_16901455 1.260 NM_001144382
PLCL2
phospholipase C-like 2
chr15_+_64782468 1.234 SMAD6
SMAD family member 6
chr1_+_63561632 1.213 FOXD3
forkhead box D3
chr3_-_51968995 1.212 PCBP4
poly(rC) binding protein 4
chrX_+_152682772 1.192 NM_001163257
NM_005393
PLXNB3

plexin B3

chr8_+_22493928 1.181 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr22_+_23153529 1.172 NM_000675
ADORA2A
adenosine A2a receptor
chr10_+_125415860 1.153 NM_153442
GPR26
G protein-coupled receptor 26
chr10_-_70846573 1.138 NM_001057
TACR2
tachykinin receptor 2
chr11_-_70350292 1.136 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr12_+_48641545 1.135 NM_001651
AQP5
aquaporin 5
chr22_-_29290875 1.123 NM_004861
GAL3ST1
galactose-3-O-sulfotransferase 1
chr1_+_210864411 1.121 NM_153606
FAM71A
family with sequence similarity 71, member A
chr9_-_96442351 1.095 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr5_+_113726203 1.093 KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr1_+_157408000 1.074 NM_021189
NM_001127173
CADM3

cell adhesion molecule 3

chr21_-_44784499 1.068 NM_198691
KRTAP10-1
keratin associated protein 10-1
chr3_+_11009419 1.066 NM_003042
SLC6A1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
chr10_-_82106479 1.063 NM_138812
DYDC1
DPY30 domain containing 1
chr13_+_95541093 1.057 NM_153456
HS6ST3
heparan sulfate 6-O-sulfotransferase 3
chr8_-_131483395 1.057 NM_018482
ASAP1
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
chr4_+_55218663 1.056 NM_000222
NM_001093772
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr12_-_121780835 1.054 NM_032554
GPR81
G protein-coupled receptor 81
chr9_-_115101140 1.046 NM_145051
RNF183
ring finger protein 183
chr7_+_142459538 1.045 NM_001001667
OR6V1
olfactory receptor, family 6, subfamily V, member 1
chr11_-_70350509 1.045 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr9_-_96442377 1.039 FBP1
fructose-1,6-bisphosphatase 1
chr11_+_74548472 1.036 NM_001145211
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr1_-_202432165 1.026 NM_002256
KISS1
KiSS-1 metastasis-suppressor
chr19_-_40684638 1.022 NM_001035516
DMKN
dermokine
chr9_+_125813849 1.016 LHX2
LIM homeobox 2
chr20_-_23915431 1.015 NM_178312
GGTLC1
gamma-glutamyltransferase light chain 1
chr19_+_3659358 0.999 TJP3
tight junction protein 3 (zona occludens 3)
chr8_+_21971317 0.997 NM_001114135
EPB49
erythrocyte membrane protein band 4.9 (dematin)
chr19_+_40534284 0.990 NM_005303
FFAR1
free fatty acid receptor 1
chr12_-_56496107 0.976 NM_006576
AVIL
advillin
chr11_-_116199145 0.974 NM_000482
APOA4
apolipoprotein A-IV
chr12_+_50104936 0.972 SLC4A8
solute carrier family 4, sodium bicarbonate cotransporter, member 8
chr19_-_56221681 0.965 NM_001136032
KLK11
kallikrein-related peptidase 11
chrX_+_101853912 0.965 NM_001004051
NM_001184874
NM_001184875
NM_001184876
NM_138437
GPRASP2




G protein-coupled receptor associated sorting protein 2




chr9_-_96441409 0.960 FBP1
fructose-1,6-bisphosphatase 1
chr6_+_110406890 0.950 NM_005284
GPR6
G protein-coupled receptor 6
chr3_-_50324815 0.931 NM_153281
HYAL1
hyaluronoglucosaminidase 1
chr1_-_1840564 0.927 NM_178545
TMEM52
transmembrane protein 52
chr12_+_55896844 0.922 NM_007224
NXPH4
neurexophilin 4
chrX_-_135941498 0.921 NM_054021
GPR101
G protein-coupled receptor 101
chr2_-_31659472 0.916 NM_000348
SRD5A2
steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
chr19_+_9064854 0.914 NM_001004456
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr11_-_17522430 0.910 NM_005709
NM_153676
USH1C

Usher syndrome 1C (autosomal recessive, severe)

chr1_-_31618405 0.909 NM_004102
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr9_+_128764324 0.908 NM_001190728
RALGPS1
Ral GEF with PH domain and SH3 binding motif 1
chr14_+_99273751 0.903 EML1
echinoderm microtubule associated protein like 1
chr19_-_46626474 0.887 NM_198540
B3GNT8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
chr17_-_42411587 0.883 NM_203400
RPRML
reprimo-like
chr19_+_4180494 0.881 NM_005755
EBI3
Epstein-Barr virus induced 3
chr22_+_42137955 0.881 NM_001044370
MPPED1
metallophosphoesterase domain containing 1
chrX_+_71318250 0.881 NM_001170747
NM_006223
PIN4

protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)

chr10_+_82106537 0.879 NM_032372
DYDC2
DPY30 domain containing 2
chrX_-_114703273 0.875


chr7_+_154493478 0.875 NM_024012
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A
chr19_-_41034734 0.875 NM_004646
NPHS1
nephrosis 1, congenital, Finnish type (nephrin)
chr21_-_44803049 0.870 NM_198696
KRTAP10-3
keratin associated protein 10-3
chr6_-_25834733 0.863 NM_170745
HIST1H2AA
histone cluster 1, H2aa
chr1_+_24713396 0.861 RCAN3
RCAN family member 3
chrX_+_103297891 0.860 NM_207318
FAM199X
family with sequence similarity 199, X-linked
chr1_-_154913712 0.852 NM_006617
NES
nestin
chr8_-_143820825 0.851 NM_020427
SLURP1
secreted LY6/PLAUR domain containing 1
chr19_-_16145285 0.847 NM_054113
CIB3
calcium and integrin binding family member 3
chr1_-_164402575 0.847 NM_001017961
FAM78B
family with sequence similarity 78, member B
chr1_+_63561317 0.841 NM_012183
FOXD3
forkhead box D3
chr1_-_218168548 0.838 NM_018713
SLC30A10
solute carrier family 30, member 10
chr19_+_40465249 0.836 NM_021175
HAMP
hepcidin antimicrobial peptide
chr7_-_44195405 0.836 NM_000162
GCK
glucokinase (hexokinase 4)
chr22_+_42138034 0.833 MPPED1
metallophosphoesterase domain containing 1
chr6_-_26038817 0.832 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr12_+_50104859 0.831 NM_001039960
NM_004858
SLC4A8

solute carrier family 4, sodium bicarbonate cotransporter, member 8

chr19_+_2200112 0.827 NM_000479
AMH
anti-Mullerian hormone
chrX_-_50573759 0.824 NM_020717
SHROOM4
shroom family member 4
chr11_+_122901543 0.824 GRAMD1B
GRAM domain containing 1B
chr4_+_9392355 0.820 NM_000798
DRD5
dopamine receptor D5
chr7_-_105106844 0.817 NM_138495
ATXN7L1
ataxin 7-like 1
chr16_-_3783475 0.815 CREBBP
CREB binding protein
chr21_+_46370831 0.811 COL6A2
collagen, type VI, alpha 2
chr3_+_42702014 0.810 NM_152393
KBTBD5
kelch repeat and BTB (POZ) domain containing 5
chr11_+_47564805 0.808 NM_001164379
FAM180B
family with sequence similarity 180, member B
chrX_-_128616594 0.801 NM_017413
APLN
apelin
chrX_-_125127760 0.800 NM_001013628
DCAF12L2
DDB1 and CUL4 associated factor 12-like 2
chrX_+_102727068 0.800 NM_001006935
NM_001006937
NM_024863
TCEAL4


transcription elongation factor A (SII)-like 4


chr5_+_156628929 0.798 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chrX_-_106846684 0.797 TSC22D3
TSC22 domain family, member 3
chr2_+_97717300 0.792 NM_207519
ZAP70
zeta-chain (TCR) associated protein kinase 70kDa
chr22_+_18330049 0.790 NM_007310
COMT
catechol-O-methyltransferase
chr4_+_191245840 0.789 NM_033178
NM_012147
NM_001177376
NM_001127388
NM_001127389
NM_001164467
NM_001127386
DUX4
DUX2
DUX4L4
DUX4L6
DUX4L5
DUX4L3
DUX4L2
double homeobox 4
double homeobox 2
double homeobox 4 like 4
double homeobox 4 like 6
double homeobox 4 like 5
double homeobox 4 like 3
double homeobox 4 like 2
chrX_-_62487693 0.788 NM_001012968
SPIN4
spindlin family, member 4
chr21_+_43462209 0.783 NM_000394
CRYAA
crystallin, alpha A
chr1_-_201321999 0.782 NM_002479
MYOG
myogenin (myogenic factor 4)
chr2_+_70981233 0.781 VAX2
ventral anterior homeobox 2
chr2_+_71016503 0.780 NM_001692
ATP6V1B1
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
chr15_-_97368546 0.774 NM_001167902
PGPEP1L
pyroglutamyl-peptidase I-like
chrX_-_108754906 0.768 NM_012282
KCNE1L
KCNE1-like
chr22_+_21407066 0.767


chr17_-_24357014 0.759 NM_001098635
NM_178860
SEZ6

seizure related 6 homolog (mouse)

chrX_+_49531209 0.759 NM_001145073
USP27X
ubiquitin specific peptidase 27, X-linked
chr16_-_47872973 0.757 CBLN1
cerebellin 1 precursor
chr21_-_31175722 0.754 NM_175858
KRTAP11-1
keratin associated protein 11-1
chr1_+_178466064 0.753 NM_033343
LHX4
LIM homeobox 4
chr19_-_53808505 0.751 NM_017708
FAM83E
family with sequence similarity 83, member E
chr11_-_65860450 0.750 NM_004292
RIN1
Ras and Rab interactor 1
chrX_-_114374860 0.749 NM_020871
LRCH2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr18_-_43821491 0.746 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr6_-_24466258 0.745 NM_016356
DCDC2
doublecortin domain containing 2
chr1_+_226261374 0.744 NM_033131
WNT3A
wingless-type MMTV integration site family, member 3A
chr11_+_1420250 0.742 BRSK2
BR serine/threonine kinase 2
chr3_+_46717826 0.741 NM_147196
TMIE
transmembrane inner ear
chr7_-_76667045 0.738 NM_006682
FGL2
fibrinogen-like 2
chr22_-_20235372 0.736 NM_001128635
RIMBP3B
RIMS binding protein 3B
chr21_-_30614477 0.735 NM_203405
KRTAP26-1
keratin associated protein 26-1
chr19_-_56105805 0.733 NM_004917
KLK4
kallikrein-related peptidase 4
chr17_+_43128422 0.732


chr7_-_27108826 0.731 NM_006735
HOXA2
homeobox A2
chr15_+_72253940 0.731 NM_201526
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr7_+_128367961 0.726 NM_001098627
IRF5
interferon regulatory factor 5
chr3_-_62835601 0.721


chr4_-_673107 0.720 MFSD7
major facilitator superfamily domain containing 7
chr2_+_70981223 0.715 NM_012476
VAX2
ventral anterior homeobox 2
chr7_+_75977680 0.715 NM_030570
NM_182684
UPK3B

uroplakin 3B

chrX_-_2896285 0.715 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr21_+_44890758 0.714 NM_198692
KRTAP10-11
keratin associated protein 10-11
chr17_-_17421050 0.713 PEMT
phosphatidylethanolamine N-methyltransferase
chr18_-_45630154 0.711 MYO5B
myosin VB
chrX_+_70438352 0.710 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr9_-_115880281 0.706 AMBP
alpha-1-microglobulin/bikunin precursor
chr17_-_23965305 0.703 NM_001174103
SGK494
uncharacterized serine/threonine-protein kinase SgK494
chr1_+_226712430 0.701 NM_175055
HIST3H2BB
histone cluster 3, H2bb
chr7_+_70235724 0.700 NM_022479
WBSCR17
Williams-Beuren syndrome chromosome region 17
chr21_+_44871467 0.700 NM_198690
KRTAP10-9
keratin associated protein 10-9
chr3_-_15515382 0.699 NM_080538
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr8_+_142501188 0.697 NM_007079
NM_032611
PTP4A3

protein tyrosine phosphatase type IVA, member 3

chr7_+_73080362 0.692 NM_000501
NM_001081752
NM_001081753
NM_001081754
NM_001081755
ELN




elastin




chr22_-_35835548 0.692 TMPRSS6
transmembrane protease, serine 6
chrX_-_37916138 0.692 SRPX
sushi-repeat containing protein, X-linked
chr3_+_52325374 0.685 NM_015512
DNAH1
dynein, axonemal, heavy chain 1
chr1_+_100776280 0.680 NM_022049
GPR88
G protein-coupled receptor 88
chr7_+_73080404 0.677 ELN
elastin
chr16_+_8714326 0.675 NM_000663
ABAT
4-aminobutyrate aminotransferase
chrX_-_12972641 0.673 NM_174901
FAM9C
family with sequence similarity 9, member C
chr15_+_39918302 0.672 NM_001114633
PLA2G4B
phospholipase A2, group IVB (cytosolic)
chrX_-_74062005 0.672 NM_001008537
KIAA2022
KIAA2022
chr11_-_60379998 0.672 NM_004778
GPR44
G protein-coupled receptor 44

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
11.84 2.48e-02 GO:0045095 keratin filament
7.09 4.77e-02 GO:0005882 intermediate filament

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.31 1.95e-05 GO:0001071 nucleic acid binding transcription factor activity
4.31 1.95e-05 GO:0003700 sequence-specific DNA binding transcription factor activity
5.12 3.56e-05 GO:0043565 sequence-specific DNA binding
118.24 1.22e-04 GO:0003840 gamma-glutamyltransferase activity
37.35 5.70e-03 GO:0016755 transferase activity, transferring amino-acyl groups