Motif ID: ATF4.p2

Z-value: 1.277


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ATF4chr22_+_39916563-0.523.9e-02Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_18284578 2.078 NM_006332
IFI30
interferon, gamma-inducible protein 30
chr7_-_140624280 2.035 NM_004333
BRAF
v-raf murine sarcoma viral oncogene homolog B1
chr19_+_18284631 1.961 IFI30
interferon, gamma-inducible protein 30
chr17_-_8151373 1.677 NM_025099
CTC1
CTS telomere maintenance complex component 1
chr7_+_5632435 1.588 NM_003088
FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr1_+_26496382 1.530 NM_015871
ZNF593
zinc finger protein 593
chr12_+_132629014 1.525 NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr14_+_68086633 1.489 ARG2
arginase, type II
chr12_+_132628978 1.419 NM_024078
NOC4L
nucleolar complex associated 4 homolog (S. cerevisiae)
chr7_-_105925329 1.418 NAMPT
nicotinamide phosphoribosyltransferase
chr18_+_57567191 1.404 NM_021127
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr19_-_9731883 1.389 NM_152289
ZNF561
zinc finger protein 561
chr7_-_105925410 1.383 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr1_+_52082755 1.350 OSBPL9
oxysterol binding protein-like 9
chr6_-_31774579 1.316 LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr7_+_116660263 1.237 ST7
suppression of tumorigenicity 7
chr3_-_33759684 1.194 NM_015097
CLASP2
cytoplasmic linker associated protein 2
chr11_+_3818953 1.192 NM_001145438
PGAP2
post-GPI attachment to proteins 2
chr17_-_8151353 1.163 CTC1
CTS telomere maintenance complex component 1
chr1_-_52870058 1.139 NM_001190818
NM_001190819
NM_004153
ORC1


origin recognition complex, subunit 1


chr11_-_3818971 1.135 NM_005387
NM_016320
NM_139131
NM_139132
NUP98



nucleoporin 98kDa



chr4_-_122744782 1.129 CCNA2
cyclin A2
chr5_+_5422766 1.121


chr2_+_74757243 1.110 HTRA2
HtrA serine peptidase 2
chr11_+_67351276 1.105 GSTP1
glutathione S-transferase pi 1
chr11_+_4116077 1.104 RRM1
ribonucleotide reductase M1
chr11_+_4116059 1.104 RRM1
ribonucleotide reductase M1
chr22_+_21271619 1.099 NM_005207
CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr10_-_64576123 1.093 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr18_+_20513277 1.088 NM_002894
RBBP8
retinoblastoma binding protein 8
chr1_+_91966653 1.076 NM_001134420
CDC7
cell division cycle 7 homolog (S. cerevisiae)
chr3_+_185303961 1.054 NM_021627
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr16_-_3767449 1.054 NM_016292
TRAP1
TNF receptor-associated protein 1
chr11_+_4115923 1.053 NM_001033
RRM1
ribonucleotide reductase M1
chr11_-_77184549 1.046 NM_001128620
NM_002576
PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr6_-_31774725 1.041 NM_021177
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr11_+_117857062 1.030 NM_001558
IL10RA
interleukin 10 receptor, alpha
chr8_-_17104266 1.024 NM_013354
NM_054026
CNOT7

CCR4-NOT transcription complex, subunit 7

chr11_-_28129646 1.012 KIF18A
kinesin family member 18A
chr7_-_124570036 0.990 NM_001042594
NM_015450
POT1

protection of telomeres 1 homolog (S. pombe)

chr16_+_22825481 0.971 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr19_+_4402658 0.963 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr15_+_31619043 0.959 NM_015995
KLF13
Kruppel-like factor 13
chr3_-_33759540 0.951 CLASP2
cytoplasmic linker associated protein 2
chr6_-_53213699 0.948 ELOVL5
ELOVL fatty acid elongase 5
chr16_-_20911560 0.947 NM_173475
DCUN1D3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr1_+_26856252 0.936 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr6_+_47445440 0.932 NM_012120
CD2AP
CD2-associated protein
chr7_-_73668693 0.920 RFC2
replication factor C (activator 1) 2, 40kDa
chr14_-_55493770 0.911 WDHD1
WD repeat and HMG-box DNA binding protein 1
chr4_-_122744978 0.906 NM_001237
CCNA2
cyclin A2
chr10_+_22634373 0.888 NM_001253854
NM_001253855
NM_012443
NM_172242
SPAG6



sperm associated antigen 6



chr19_+_1067536 0.876 HMHA1
histocompatibility (minor) HA-1
chr7_+_5632453 0.875 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr19_+_10362912 0.861 MRPL4
mitochondrial ribosomal protein L4
chr22_+_21771661 0.852 NM_015094
HIC2
hypermethylated in cancer 2
chr19_+_18284619 0.852 IFI30
interferon, gamma-inducible protein 30
chr10_-_64576074 0.851 EGR2
early growth response 2
chr7_+_107531585 0.847 NM_000108
DLD
dihydrolipoamide dehydrogenase
chr6_-_34664517 0.842 C6orf106
chromosome 6 open reading frame 106
chr19_+_10362886 0.838 MRPL4
mitochondrial ribosomal protein L4
chr17_-_40540576 0.832 STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr19_-_47617008 0.816 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr5_+_112849352 0.814 NM_022828
YTHDC2
YTH domain containing 2
chr6_-_90062610 0.813 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr16_+_2039945 0.805 NM_004209
SYNGR3
synaptogyrin 3
chr18_-_267987 0.803 NM_005131
THOC1
THO complex 1
chr8_+_61591239 0.796 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr7_-_73668732 0.793 NM_002914
NM_181471
RFC2

replication factor C (activator 1) 2, 40kDa

chr1_-_158656487 0.792 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr7_+_44646220 0.790 OGDH
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
chr22_+_21271721 0.784 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr1_+_26856259 0.772 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_-_23003443 0.769 NM_005028
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr14_-_106237675 0.767 IGHM
immunoglobulin heavy constant mu
chr19_-_55918980 0.765 UBE2S
ubiquitin-conjugating enzyme E2S
chr14_-_55493804 0.761 NM_001008396
NM_007086
WDHD1

WD repeat and HMG-box DNA binding protein 1

chr7_+_107531618 0.758 DLD
dihydrolipoamide dehydrogenase
chr12_+_132629009 0.746


chr4_+_17812524 0.742 NM_022346
NCAPG
non-SMC condensin I complex, subunit G
chr7_+_107531616 0.741 DLD
dihydrolipoamide dehydrogenase
chr11_-_3818706 0.738 NUP98
nucleoporin 98kDa
chr12_+_104359557 0.737 NM_003211
TDG
thymine-DNA glycosylase
chr3_-_150480917 0.735 SIAH2
seven in absentia homolog 2 (Drosophila)
chr11_+_95523608 0.731 NM_001243776
NM_001243777
NM_014679
CEP57


centrosomal protein 57kDa


chr22_+_23222897 0.727 CYAT1
immunoglobulin lambda light chain-like
chr8_+_26149043 0.719 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr14_-_55369163 0.717 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr3_-_150480963 0.716 NM_005067
SIAH2
seven in absentia homolog 2 (Drosophila)
chr11_-_28129687 0.709 KIF18A
kinesin family member 18A
chr11_-_28129701 0.704 NM_031217
KIF18A
kinesin family member 18A
chr11_-_3818736 0.701 NUP98
nucleoporin 98kDa
chr3_-_101395611 0.699 NM_014415
ZBTB11
zinc finger and BTB domain containing 11
chr1_-_47184790 0.692


chr22_+_39898248 0.683 NM_019008
SMCR7L
Smith-Magenis syndrome chromosome region, candidate 7-like
chr5_+_44808967 0.679 NM_016640
MRPS30
mitochondrial ribosomal protein S30
chr7_-_45151272 0.676 TBRG4
transforming growth factor beta regulator 4
chr7_-_128045995 0.674 NM_001142573
NM_001142574
NM_001142575
IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chr9_-_131644176 0.673 NM_001122671
NM_001122672
NM_004059
CCBL1


cysteine conjugate-beta lyase, cytoplasmic


chr19_-_14530129 0.670 DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr17_+_33914278 0.667 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr19_-_14529853 0.659 DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr8_-_17104103 0.654 CNOT7
CCR4-NOT transcription complex, subunit 7
chr1_-_202896368 0.654 NM_021633
KLHL12
kelch-like 12 (Drosophila)
chr4_+_75310852 0.652 NM_001657
AREG
amphiregulin
chr12_-_132628841 0.650 NM_175066
DDX51
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr8_+_26149004 0.648 NM_002717
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr4_-_104119475 0.647 NM_001813
CENPE
centromere protein E, 312kDa
chr19_-_40336944 0.644 FBL
fibrillarin
chr7_+_152456820 0.642 NM_001040135
NM_020445
ACTR3B

ARP3 actin-related protein 3 homolog B (yeast)

chr17_-_40540491 0.641 NM_003150
NM_139276
STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

chr19_-_40337018 0.641 NM_001436
FBL
fibrillarin
chr14_-_103995336 0.640


chr2_-_24149899 0.639 NM_001242338
NM_017552
ATAD2B

ATPase family, AAA domain containing 2B

chr6_-_90062450 0.639 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr8_+_42195972 0.639 NM_002690
POLB
polymerase (DNA directed), beta
chr5_-_133561745 0.636 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr3_-_150480887 0.636 SIAH2
seven in absentia homolog 2 (Drosophila)
chr1_+_212209129 0.636 DTL
denticleless homolog (Drosophila)
chr1_-_51425740 0.636 FAF1
Fas (TNFRSF6) associated factor 1
chr5_-_16617085 0.635 NM_001034850
FAM134B
family with sequence similarity 134, member B
chr18_+_2571587 0.634 NDC80
NDC80 kinetochore complex component homolog (S. cerevisiae)
chr6_-_91006460 0.632 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr2_+_97001506 0.631 NCAPH
non-SMC condensin I complex, subunit H
chr2_+_61108702 0.630 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr19_-_40336997 0.629 FBL
fibrillarin
chr18_+_2571509 0.624 NM_006101
NDC80
NDC80 kinetochore complex component homolog (S. cerevisiae)
chr10_-_99094427 0.624 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr1_-_156698188 0.622 ISG20L2
interferon stimulated exonuclease gene 20kDa-like 2
chr4_+_108910869 0.618 NM_001184705
NM_005327
HADH

hydroxyacyl-CoA dehydrogenase

chr22_+_21271723 0.615 CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like
chr17_-_40540359 0.615 NM_213662
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr13_+_34392254 0.612 RFC3
replication factor C (activator 1) 3, 38kDa
chr11_+_66610882 0.609 NM_001032279
NM_005133
RCE1

RCE1 homolog, prenyl protein protease (S. cerevisiae)

chr4_+_142142044 0.605 NM_014487
ZNF330
zinc finger protein 330
chr17_+_685606 0.604 RNMTL1
RNA methyltransferase like 1
chr8_+_23386386 0.603 SLC25A37
solute carrier family 25, member 37
chr7_+_23221445 0.602 NM_007342
NUPL2
nucleoporin like 2
chr1_-_15850692 0.599 CASP9
caspase 9, apoptosis-related cysteine peptidase
chr9_-_178913 0.597 NM_001145355
NM_001145356
NM_018491
CBWD1


COBW domain containing 1


chr1_-_15850718 0.594 CASP9
caspase 9, apoptosis-related cysteine peptidase
chr19_+_13056656 0.593 RAD23A
RAD23 homolog A (S. cerevisiae)
chr12_+_4382882 0.591 NM_001759
CCND2
cyclin D2
chr6_+_44214786 0.591 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr10_+_119000583 0.584 NM_003054
SLC18A2
solute carrier family 18 (vesicular monoamine), member 2
chr11_+_118955569 0.583 NM_000190
HMBS
hydroxymethylbilane synthase
chr6_-_27100528 0.581 NM_021058
HIST1H2BJ
histone cluster 1, H2bj
chr8_+_86089618 0.579 NM_001083588
NM_001951
E2F5

E2F transcription factor 5, p130-binding

chr11_+_108535773 0.579 NM_004398
DDX10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr22_+_24236579 0.577 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr1_-_149399159 0.576 NM_001024599
HIST2H2BF
histone cluster 2, H2bf
chr7_+_107204402 0.573 NM_181581
DUS4L
dihydrouridine synthase 4-like (S. cerevisiae)
chr14_-_95786095 0.568 NM_024734
CLMN
calmin (calponin-like, transmembrane)
chr4_+_142142073 0.568 ZNF330
zinc finger protein 330
chr16_-_4897265 0.567 NM_032569
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr6_+_30524485 0.566 NM_001077497
NM_025263
PRR3

proline rich 3

chr8_+_26149080 0.566 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr7_+_44646120 0.565 NM_001003941
NM_001165036
NM_002541
OGDH


oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)


chr11_+_34127110 0.564 NM_001144030
NM_024662
NAT10

N-acetyltransferase 10 (GCN5-related)

chr11_+_117857123 0.564 IL10RA
interleukin 10 receptor, alpha
chr3_-_197476567 0.557 NM_001145642
KIAA0226
KIAA0226
chr1_-_229643996 0.557 NUP133
nucleoporin 133kDa
chr6_+_26204779 0.552 NM_003545
HIST1H4E
histone cluster 1, H4e
chr2_+_114195267 0.551 NM_172003
CBWD2
CBWD1
COBW domain containing 2
COBW domain containing 1
chr7_+_56019552 0.550 NM_015969
MRPS17
mitochondrial ribosomal protein S17
chr9_-_70490106 0.548 CBWD5
CBWD3
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 6
chr6_-_53213586 0.548 ELOVL5
ELOVL fatty acid elongase 5
chr14_+_60715950 0.548 NM_021003
NM_177951
PPM1A

protein phosphatase, Mg2+/Mn2+ dependent, 1A

chr5_-_138211054 0.546 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr16_+_68298326 0.544 NM_001076785
NM_003983
SLC7A6

solute carrier family 7 (amino acid transporter light chain, y+L system), member 6

chr5_-_1882764 0.544 NM_016358
IRX4
iroquois homeobox 4
chr1_-_236767787 0.542 NM_018072
HEATR1
HEAT repeat containing 1
chr5_-_175964223 0.542 NM_014901
RNF44
ring finger protein 44
chr4_+_108911042 0.541 HADH
hydroxyacyl-CoA dehydrogenase
chr19_-_14530155 0.539 NM_005804
DDX39A
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr9_-_140353785 0.538 NM_001130969
NM_001130970
NM_001130971
NM_001178064
NM_015537
NELF




nasal embryonic LHRH factor




chr15_+_51973549 0.537 NM_001165257
NM_013243
SCG3

secretogranin III

chr1_-_31769599 0.537 NM_004814
SNRNP40
small nuclear ribonucleoprotein 40kDa (U5)
chr9_-_70490123 0.533 CBWD3
COBW domain containing 3
chr9_-_70490138 0.527 CBWD6
COBW domain containing 6
chr9_+_70856838 0.527 NM_201453
CBWD5
CBWD3
CBWD6
COBW domain containing 5
COBW domain containing 3
COBW domain containing 6
chr16_+_81040847 0.525 CENPN
centromere protein N
chr4_-_146019296 0.524 NM_014885
ANAPC10
anaphase promoting complex subunit 10
chr8_+_23386468 0.524 SLC25A37
solute carrier family 25, member 37
chr9_-_70490145 0.523 CBWD5
COBW domain containing 5
chr18_+_9708299 0.521 RAB31
RAB31, member RAS oncogene family
chr7_+_96635289 0.521 NM_005222
DLX6
distal-less homeobox 6
chr16_+_56225301 0.519 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr20_+_35201948 0.509 NM_021809
TGIF2
TGFB-induced factor homeobox 2
chr3_+_140660639 0.508 NM_001104647
NM_018155
SLC25A36

solute carrier family 25, member 36

chr1_-_15850776 0.496 NM_001229
NM_032996
CASP9

caspase 9, apoptosis-related cysteine peptidase

chr22_+_22550112 0.495


chr18_+_23806385 0.494 NM_005640
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chrX_+_41193409 0.493 DDX3X
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
chr1_+_212208918 0.492 NM_016448
DTL
denticleless homolog (Drosophila)
chr2_+_74781846 0.491 DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr9_-_70490164 0.485 NM_001024916
NM_201453
CBWD5
CBWD3
COBW domain containing 5
COBW domain containing 3
chr6_-_91006580 0.485 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr6_+_44214853 0.484 HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr1_-_51425795 0.483 FAF1
Fas (TNFRSF6) associated factor 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.59 1.78e-02 GO:0000278 mitotic cell cycle

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.27 2.39e-03 GO:0005829 cytosol
2.10 3.14e-03 GO:0005634 nucleus
174.49 3.20e-03 GO:0005828 kinetochore microtubule
3.00 6.12e-03 GO:0031974 membrane-enclosed lumen
3.23 1.43e-02 GO:0031981 nuclear lumen
2.88 1.95e-02 GO:0070013 intracellular organelle lumen
2.82 2.42e-02 GO:0043233 organelle lumen

Nothing significant found in function category.