Motif ID: ESR1.p2

Z-value: 1.724


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ESR1chr6_+_152011630-0.184.9e-01Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_57976550 3.037 NM_001253835
NM_001553
IGFBP7

insulin-like growth factor binding protein 7

chr11_+_129939792 2.617 APLP2
amyloid beta (A4) precursor-like protein 2
chr6_+_148663953 2.520 SASH1
SAM and SH3 domain containing 1
chr11_+_129939807 2.425 APLP2
amyloid beta (A4) precursor-like protein 2
chr11_+_129939787 2.419 APLP2
amyloid beta (A4) precursor-like protein 2
chr16_+_55515468 2.224 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr6_+_148663728 2.206 NM_015278
SASH1
SAM and SH3 domain containing 1
chr7_-_47621635 2.196 TNS3
tensin 3
chr11_+_129939667 2.184 NM_001142276
NM_001142277
NM_001142278
NM_001642
APLP2



amyloid beta (A4) precursor-like protein 2



chr1_-_94702916 2.118 ARHGAP29
Rho GTPase activating protein 29
chr17_-_74707000 2.038 NM_001008528
NM_001008529
NM_198530
MXRA7


matrix-remodelling associated 7


chr7_-_47621741 2.035 NM_022748
TNS3
tensin 3
chr6_+_7541837 2.008 DSP
desmoplakin
chr6_+_7541892 1.981 DSP
desmoplakin
chr2_-_1748317 1.948 PXDN
peroxidasin homolog (Drosophila)
chr19_+_45349560 1.920 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr6_+_7541863 1.880 NM_001008844
NM_004415
DSP

desmoplakin

chr4_-_122618098 1.860 ANXA5
annexin A5
chr1_-_94703252 1.844 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr12_-_124457099 1.840 NM_025140
CCDC92
coiled-coil domain containing 92
chr2_-_175869910 1.830 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr17_+_79651035 1.803 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr4_-_122618129 1.722 ANXA5
annexin A5
chr18_+_55711890 1.701 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr10_+_115438934 1.682 NM_033340
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr4_-_122618140 1.677 NM_001154
ANXA5
annexin A5
chr8_-_17658385 1.667 NM_001001924
NM_001001925
MTUS1

microtubule associated tumor suppressor 1

chr6_+_17393610 1.638 NM_006366
CAP2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr9_+_123963728 1.601 GSN
gelsolin
chr21_+_42540054 1.591 BACE2
beta-site APP-cleaving enzyme 2
chr21_+_42540092 1.589 BACE2
beta-site APP-cleaving enzyme 2
chr13_+_110959592 1.573 NM_001846
COL4A2
collagen, type IV, alpha 2
chr6_-_47277354 1.563 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr16_+_82660573 1.552 CDH13
cadherin 13, H-cadherin (heart)
chr16_+_56659584 1.520 NM_175617
MT1E
metallothionein 1E
chr9_-_99382073 1.516 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr5_-_122372413 1.511 NM_000943
PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr11_+_129939847 1.505 APLP2
amyloid beta (A4) precursor-like protein 2
chr6_+_148664124 1.489 SASH1
SAM and SH3 domain containing 1
chr11_+_832965 1.444 CD151
CD151 molecule (Raph blood group)
chr13_-_110959441 1.441 NM_001845
COL4A1
collagen, type IV, alpha 1
chr17_-_3571905 1.435 NM_001204698
NM_014604
TAX1BP3

Tax1 (human T-cell leukemia virus type I) binding protein 3

chr11_-_116708334 1.430 NM_000039
APOA1
apolipoprotein A-I
chr15_-_52587851 1.429 NM_018728
MYO5C
myosin VC
chr5_+_150400132 1.417 GPX3
glutathione peroxidase 3 (plasma)
chr2_-_1748240 1.410 PXDN
peroxidasin homolog (Drosophila)
chrX_+_117861523 1.406 NM_001560
IL13RA1
interleukin 13 receptor, alpha 1
chr18_+_55711746 1.388 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr18_+_55711388 1.381 NM_001144967
NM_001243960
NM_015277
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like


chr6_-_47277246 1.355 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr17_+_79650961 1.352 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr17_+_79651042 1.345 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr11_-_82611358 1.328 NM_005040
NM_199418
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr9_+_706744 1.317 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr16_+_66400524 1.306 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr22_-_19929447 1.300 TXNRD2
thioredoxin reductase 2
chr9_-_74383301 1.298 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr19_-_18717631 1.276 NM_004750
CRLF1
cytokine receptor-like factor 1
chr19_-_18717467 1.268 CRLF1
cytokine receptor-like factor 1
chr19_-_18717577 1.262 CRLF1
cytokine receptor-like factor 1
chr6_-_52441714 1.258 TRAM2
translocation associated membrane protein 2
chr19_+_15218141 1.252 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr2_-_1748285 1.251 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr6_+_107811272 1.245 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr10_-_126849556 1.244 NM_001083914
CTBP2
C-terminal binding protein 2
chr14_-_69445772 1.236 ACTN1
actinin, alpha 1
chr22_-_19929333 1.228 NM_006440
TXNRD2
thioredoxin reductase 2
chr9_+_137533643 1.211 NM_000093
COL5A1
collagen, type V, alpha 1
chr14_+_105941061 1.186 NM_001312
CRIP2
cysteine-rich protein 2
chr6_+_142622797 1.181 NM_001032394
NM_001032395
NM_020455
NM_198569
GPR126



G protein-coupled receptor 126



chr17_-_3571819 1.179 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr22_+_38142316 1.171 TRIOBP
TRIO and F-actin binding protein
chr11_-_2162340 1.169 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr9_-_84303595 1.169 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr3_+_52529351 1.167 NM_015136
STAB1
stabilin 1
chr17_-_74707066 1.166 MXRA7
matrix-remodelling associated 7
chr2_-_224903933 1.163 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr2_-_216300770 1.162 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr11_-_63381940 1.157 NM_001128203
PLA2G16
phospholipase A2, group XVI
chr5_+_176513819 1.155 NM_002011
NM_213647
FGFR4

fibroblast growth factor receptor 4

chr1_+_151512760 1.134 NM_001126337
NM_020127
TUFT1

tuftelin 1

chr17_+_79651072 1.133 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr10_-_62703822 1.128 NM_001242359
NM_014836
RHOBTB1

Rho-related BTB domain containing 1

chr6_-_52441815 1.124 NM_012288
TRAM2
translocation associated membrane protein 2
chr11_-_63381840 1.114 PLA2G16
phospholipase A2, group XVI
chr20_-_61569227 1.110 DIDO1
death inducer-obliterator 1
chr3_+_171757413 1.097 NM_022763
FNDC3B
fibronectin type III domain containing 3B
chr22_+_38142255 1.087 TRIOBP
TRIO and F-actin binding protein
chr11_-_63381485 1.083 PLA2G16
phospholipase A2, group XVI
chr11_-_63381907 1.082 NM_007069
PLA2G16
phospholipase A2, group XVI
chr17_-_7297826 1.082 PLSCR3
phospholipid scramblase 3
chr5_+_150399980 1.078 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr13_-_103451271 1.061 NM_024089
KDELC1
KDEL (Lys-Asp-Glu-Leu) containing 1
chr22_-_19929250 1.057 TXNRD2
thioredoxin reductase 2
chr19_-_4400470 1.055 NM_001199943
NM_003025
SH3GL1

SH3-domain GRB2-like 1

chr8_+_38854524 1.045 ADAM9
ADAM metallopeptidase domain 9
chr9_+_97488943 1.038 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chr19_+_45349584 1.020 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr3_+_52489617 1.014 NISCH
nischarin
chr9_+_97488993 1.006 C9orf3
chromosome 9 open reading frame 3
chr22_+_44319685 0.995 PNPLA3
patatin-like phospholipase domain containing 3
chr3_+_52529370 0.992 STAB1
stabilin 1
chr7_-_30029284 0.979 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr8_+_38854431 0.975 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr7_+_45927958 0.972 NM_000596
IGFBP1
insulin-like growth factor binding protein 1
chr4_+_4861371 0.965 NM_002448
MSX1
msh homeobox 1
chr22_+_44319674 0.960 PNPLA3
patatin-like phospholipase domain containing 3
chr21_+_46825291 0.958


chrX_-_51239295 0.958 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr7_+_94139331 0.956 CASD1
CAS1 domain containing 1
chr22_+_38302296 0.948 MICALL1
MICAL-like 1
chr16_+_8768403 0.946 NM_020686
ABAT
4-aminobutyrate aminotransferase
chr22_+_44319618 0.942 NM_025225
PNPLA3
patatin-like phospholipase domain containing 3
chr22_+_38142230 0.932 NM_007032
NM_138632
TRIOBP

TRIO and F-actin binding protein

chr12_-_122326516 0.927 NM_001171993
HPD
4-hydroxyphenylpyruvate dioxygenase
chr19_+_42829760 0.922 NM_001410
MEGF8
multiple EGF-like-domains 8
chr19_+_676346 0.919 NM_005860
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr19_+_35532640 0.908 HPN
hepsin
chr2_+_85360373 0.903 NM_031283
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr17_-_48264039 0.891 COL1A1
collagen, type I, alpha 1
chr19_-_4400357 0.888 NM_001199944
SH3GL1
SH3-domain GRB2-like 1
chr1_+_17944810 0.882 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr19_+_50016490 0.872 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_+_52345437 0.866 NM_004302
NM_020328
ACVR1B

activin A receptor, type IB

chr5_-_1112106 0.862 NM_006598
SLC12A7
solute carrier family 12 (potassium/chloride transporters), member 7
chr19_+_35550794 0.862 HPN
hepsin
chr2_-_110371669 0.855 NM_144710
NM_178584
SEPT10

septin 10

chr4_-_41216455 0.849 NM_001166050
NM_004307
NM_173075
APBB2


amyloid beta (A4) precursor protein-binding, family B, member 2


chr11_+_68079999 0.849 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr19_+_35532617 0.840 HPN
hepsin
chr19_+_50016435 0.828 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr7_+_94138991 0.823 NM_022900
CASD1
CAS1 domain containing 1
chr17_-_78194085 0.817 NM_000199
SGSH
N-sulfoglucosamine sulfohydrolase
chr4_+_184020343 0.809 NM_024949
WWC2
WW and C2 domain containing 2
chr22_+_29702950 0.802 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr19_-_11373117 0.801 NM_020812
DOCK6
dedicator of cytokinesis 6
chr21_+_18885104 0.797 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr2_+_36583369 0.795 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr9_-_13279562 0.795 MPDZ
multiple PDZ domain protein
chr21_+_18885296 0.793 CXADR
coxsackie virus and adenovirus receptor
chr15_+_33010174 0.787 NM_001191322
NM_001191323
NM_013372
GREM1


gremlin 1


chr7_+_143079354 0.785 ZYX
zyxin
chr9_-_140083010 0.784 ANAPC2
anaphase promoting complex subunit 2
chr16_+_56659679 0.783 MT1E
metallothionein 1E
chr9_+_112810877 0.783 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr13_+_98795410 0.775 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr22_-_37915209 0.774 NM_014550
CARD10
caspase recruitment domain family, member 10
chr12_+_66218879 0.760 HMGA2
high mobility group AT-hook 2
chr2_+_219646448 0.758 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr2_-_242447919 0.754 STK25
serine/threonine kinase 25
chr9_-_14313509 0.751 NFIB
nuclear factor I/B
chr1_-_68299047 0.732 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr10_+_75670861 0.732 NM_001145031
NM_002658
PLAU

plasminogen activator, urokinase

chrX_+_135229536 0.731 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr17_+_74380943 0.730 SPHK1
sphingosine kinase 1
chr16_-_122573 0.724 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr20_-_23618382 0.723 NM_000099
CST3
cystatin C
chr3_-_81810816 0.718 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_-_201476248 0.718 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr4_-_89080010 0.712 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr11_+_833007 0.710 CD151
CD151 molecule (Raph blood group)
chr6_-_47277511 0.709 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_19923457 0.709 NM_001204088
NM_001204089
NM_001032363
NM_001204082
NM_001204083
C1orf151-NBL1

MINOS1


C1orf151-NBL1 readthrough

mitochondrial inner membrane organizing system 1


chr1_-_201476241 0.708 CSRP1
cysteine and glycine-rich protein 1
chr19_+_50016500 0.706 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr12_-_106533810 0.703 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr2_+_110371887 0.701 NM_023016
ANKRD57
ankyrin repeat domain 57
chr17_+_75136985 0.697 NM_001039573
NM_001143998
NM_001143999
NM_003003
SEC14L1



SEC14-like 1 (S. cerevisiae)



chr1_+_77748286 0.697 NM_012093
AK5
adenylate kinase 5
chr4_-_157892545 0.695 NM_016205
PDGFC
platelet derived growth factor C
chr16_+_82660390 0.695 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr13_+_113741668 0.689 MCF2L
MCF.2 cell line derived transforming sequence-like
chr3_-_81810618 0.684 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_-_209979388 0.683 NM_001206696
NM_006147
IRF6

interferon regulatory factor 6

chr2_-_20850822 0.680 NM_022460
HS1BP3
HCLS1 binding protein 3
chr1_-_27240430 0.679 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr2_-_242448000 0.676 NM_006374
STK25
serine/threonine kinase 25
chr1_-_201476218 0.673 CSRP1
cysteine and glycine-rich protein 1
chr13_-_37633568 0.671 NM_001014286
NM_017569
FAM48A

family with sequence similarity 48, member A

chr19_-_44124013 0.666 NM_182498
ZNF428
zinc finger protein 428
chr13_+_113622758 0.664 MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_-_37381920 0.658 NM_198993
STAC2
SH3 and cysteine rich domain 2
chr17_+_74381419 0.655 SPHK1
sphingosine kinase 1
chr1_-_201475966 0.654 NM_001193571
CSRP1
cysteine and glycine-rich protein 1
chr2_+_182756468 0.650 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr9_-_16870664 0.648 BNC2
basonuclin 2
chr6_-_47277646 0.646 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr2_-_242447449 0.645 STK25
serine/threonine kinase 25
chr19_-_44123732 0.641 ZNF428
zinc finger protein 428
chr2_+_219283809 0.639 NM_007127
VIL1
villin 1
chr11_+_832909 0.636 NM_001039490
NM_004357
NM_139029
NM_139030
CD151



CD151 molecule (Raph blood group)



chr1_-_95392501 0.633 NM_001839
CNN3
calponin 3, acidic
chr22_-_36783977 0.632 MYH9
myosin, heavy chain 9, non-muscle
chr22_-_36783851 0.624 MYH9
myosin, heavy chain 9, non-muscle
chr20_-_23030141 0.620 NM_000361
THBD
thrombomodulin
chr22_+_38597938 0.619 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr17_+_79651052 0.616


chr14_+_96505566 0.610 NM_001252507
C14orf132
chromosome 14 open reading frame 132
chr8_-_13134028 0.609 DLC1
deleted in liver cancer 1
chr9_-_140083034 0.608 NM_013366
ANAPC2
anaphase promoting complex subunit 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
21.05 1.46e-02 GO:0007266 Rho protein signal transduction
1.49 4.41e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.50 1.37e-03 GO:0044421 extracellular region part
5.93 1.64e-03 GO:0031012 extracellular matrix
2.47 1.78e-02 GO:0005576 extracellular region
64.88 3.52e-02 GO:0005587 collagen type IV
3.23 4.50e-02 GO:0005615 extracellular space
55.61 4.92e-02 GO:0030935 sheet-forming collagen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
17.18 1.03e-04 GO:0005201 extracellular matrix structural constituent
1.51 6.07e-03 GO:0005515 protein binding
20.86 3.29e-02 GO:0071814 protein-lipid complex binding