Motif ID: ETS1,2.p2

Z-value: 1.767


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ETS1chr11_-_128391888-0.234.0e-01Click!
ETS2chr21_+_40177754-0.165.6e-01Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_6233684 2.670 NM_000552
VWF
von Willebrand factor
chr2_-_110371669 2.513 NM_144710
NM_178584
SEPT10

septin 10

chr2_-_110371404 2.393 SEPT10
septin 10
chr2_+_33661392 2.321 NM_170672
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_49318663 2.209 NM_001143781
FKBP11
FK506 binding protein 11, 19 kDa
chr1_-_31230594 2.176 LAPTM5
lysosomal protein transmembrane 5
chr8_+_82192717 1.932 NM_001444
FABP5
fatty acid binding protein 5 (psoriasis-associated)
chr10_-_88717319 1.904 NM_024756
MMRN2
multimerin 2
chr1_-_31230673 1.857 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr10_-_98031154 1.825 NM_001114094
NM_013314
BLNK

B-cell linker

chr16_+_30194925 1.819 CORO1A
coronin, actin binding protein, 1A
chr9_+_116356407 1.756 RGS3
regulator of G-protein signaling 3
chr8_+_74903563 1.743 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr14_-_23284617 1.739 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr7_-_150329735 1.685 NM_001244071
NM_001244072
NM_024711
GIMAP6


GTPase, IMAP family member 6


chr19_+_49838700 1.676 CD37
CD37 molecule
chr19_+_49838734 1.669 CD37
CD37 molecule
chr7_-_150329285 1.665 GIMAP6
GTPase, IMAP family member 6
chr5_-_149792276 1.535 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr13_+_31287614 1.534 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr14_+_21249209 1.515 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr19_+_49838673 1.478 NM_001040031
NM_001774
CD37

CD37 molecule

chr21_-_46340874 1.476 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_102953716 1.469 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr21_-_46340821 1.438 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_+_49838646 1.386 CD37
CD37 molecule
chr12_+_7055736 1.383 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr9_+_116356199 1.366 NM_144489
RGS3
regulator of G-protein signaling 3
chrX_+_114827818 1.348 NM_001136025
NM_001172335
PLS3

plastin 3

chr1_-_183559669 1.317 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr12_+_7055753 1.312 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr22_-_37545944 1.296 NM_000878
IL2RB
interleukin 2 receptor, beta
chr6_-_11382501 1.255 NM_001142393
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr7_-_5569200 1.251 ACTB
actin, beta
chr11_+_5710816 1.241 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr20_+_44441334 1.202 UBE2C
ubiquitin-conjugating enzyme E2C
chr7_+_150264457 1.187 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr21_-_46340776 1.144 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr11_+_60223281 1.124 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr5_-_94417544 1.124 NM_001002796
MCTP1
multiple C2 domains, transmembrane 1
chr17_+_32582295 1.116 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr12_+_53693454 1.114 NM_021640
C12orf10
chromosome 12 open reading frame 10
chr17_-_79269082 1.104 NM_001037984
NM_138570
SLC38A10

solute carrier family 38, member 10

chr14_+_105953531 1.095 CRIP1
cysteine-rich protein 1 (intestinal)
chr1_-_183560010 1.090 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr2_+_118846029 1.087 NM_016133
INSIG2
insulin induced gene 2
chr20_-_23066828 1.087 NM_012072
CD93
CD93 molecule
chr22_-_17680485 1.072 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr14_-_23284565 1.072 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_-_183559463 1.062 NCF2
neutrophil cytosolic factor 2
chrY_+_2709596 1.054 NM_001008
RPS4Y1
ribosomal protein S4, Y-linked 1
chr9_-_88969323 1.053 NM_001185059
NM_001185074
NM_024617
ZCCHC6


zinc finger, CCHC domain containing 6


chr16_+_66400524 1.047 NM_001795
CDH5
cadherin 5, type 2 (vascular endothelium)
chr7_+_150434435 1.036 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr13_+_111806070 1.035 ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr20_+_44441247 1.031 NM_007019
NM_181799
NM_181800
NM_181802
NM_181803
UBE2C




ubiquitin-conjugating enzyme E2C




chrY_+_2709630 1.020 RPS4Y1
ribosomal protein S4, Y-linked 1
chr6_+_110012423 1.016 NM_014845
FIG4
FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
chr1_+_186798031 1.010 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr5_+_156693051 0.987 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr16_+_81812899 0.975 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr17_-_38721701 0.971 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr10_-_91102430 0.965 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr16_+_81812925 0.960 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr22_+_37309618 0.953 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr12_+_27397077 0.953 NM_015000
STK38L
serine/threonine kinase 38 like
chr5_-_151066445 0.950 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr9_-_21335239 0.946 NM_018847
KLHL9
kelch-like 9 (Drosophila)
chr22_-_37640287 0.942 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr20_+_44441671 0.938 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr16_+_30483959 0.931 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr13_+_111806038 0.927 NM_003899
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7
chr3_-_11685395 0.923 NM_001128219
VGLL4
vestigial like 4 (Drosophila)
chr4_-_84035888 0.908 PLAC8
placenta-specific 8
chr22_+_37257004 0.899 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chr20_+_44746889 0.898 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr22_-_37640187 0.889 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr17_+_25958192 0.871 LGALS9
lectin, galactoside-binding, soluble, 9
chr5_-_149792370 0.868 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr1_-_160617042 0.866 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr15_+_75074417 0.865 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr3_-_121379757 0.864 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr12_-_49319211 0.860 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr9_-_130616957 0.858 ENG
endoglin
chr9_-_130617009 0.858 NM_000118
NM_001114753
ENG

endoglin

chr2_-_96811138 0.856 NM_004418
DUSP2
dual specificity phosphatase 2
chr12_+_6602521 0.853 NCAPD2
non-SMC condensin I complex, subunit D2
chr17_+_25958217 0.850 LGALS9
lectin, galactoside-binding, soluble, 9
chr4_+_2813966 0.838 SH3BP2
SH3-domain binding protein 2
chr1_+_32716839 0.823 NM_005356
LCK
lymphocyte-specific protein tyrosine kinase
chr15_+_81589240 0.822 NM_004513
IL16
interleukin 16
chr6_-_112080284 0.820 NM_153048
FYN
FYN oncogene related to SRC, FGR, YES
chr3_-_121379701 0.817 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr9_-_130616760 0.795 ENG
endoglin
chr3_-_124842442 0.794 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr15_-_71184611 0.790 NM_020147
THAP10
THAP domain containing 10
chr19_+_42381189 0.788 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chrX_+_154611748 0.786 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr2_+_237478379 0.785 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr12_-_110888106 0.783 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr12_+_7060433 0.780 NM_002831
NM_080549
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr11_+_65190272 0.774


chr16_+_30484049 0.757 ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr7_+_93551015 0.755 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr12_-_15114495 0.754 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr9_-_130616592 0.753 ENG
endoglin
chr9_-_123676849 0.753 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr11_-_89224413 0.744 NM_001143836
NM_016931
NOX4

NADPH oxidase 4

chr10_+_129705299 0.744 NM_006504
PTPRE
protein tyrosine phosphatase, receptor type, E
chr12_-_6798619 0.743 NM_001039920
NM_001135734
ZNF384

zinc finger protein 384

chr11_+_7618416 0.740 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr9_+_77703412 0.738 OSTF1
osteoclast stimulating factor 1
chr11_+_5710926 0.738 TRIM22
tripartite motif containing 22
chrX_+_128913881 0.737 NM_018990
SASH3
SAM and SH3 domain containing 3
chr14_-_24036532 0.735 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr10_+_26727651 0.735 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr14_-_106691698 0.734


chr12_-_6798528 0.730 NM_133476
ZNF384
zinc finger protein 384
chr12_-_110888098 0.729 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr2_+_219081864 0.729 NM_152862
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr19_-_19754452 0.724 NM_016573
GMIP
GEM interacting protein
chr1_-_79472360 0.721 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr1_+_32739711 0.720 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr2_-_175462428 0.716 WIPF1
WAS/WASL interacting protein family, member 1
chrX_+_128913897 0.709 SASH3
SAM and SH3 domain containing 3
chr10_+_26727692 0.707 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr2_+_30369800 0.695 YPEL5
yippee-like 5 (Drosophila)
chr2_+_30369868 0.691 YPEL5
yippee-like 5 (Drosophila)
chr6_-_32784727 0.689 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr14_-_106573348 0.689 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr9_+_116342939 0.687 NM_021106
RGS3
regulator of G-protein signaling 3
chr1_+_43766565 0.683 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr2_+_30369749 0.683 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr12_-_110888152 0.682 NM_005719
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr6_-_109776946 0.682 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr17_+_25958151 0.678 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr6_-_109776942 0.676 MICAL1
microtubule associated monoxygenase, calponin and LIM domain containing 1
chr1_+_203734283 0.672 NM_001136190
NM_017773
LAX1

lymphocyte transmembrane adaptor 1

chr6_-_29527701 0.671 NM_006398
UBD
ubiquitin D
chr5_-_73936299 0.671 ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr12_-_92539614 0.668 NM_001731
BTG1
B-cell translocation gene 1, anti-proliferative
chr3_+_50284325 0.667 NM_001166425
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr10_+_129845806 0.662 NM_130435
PTPRE
protein tyrosine phosphatase, receptor type, E
chr6_-_32497925 0.662 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr3_+_48507209 0.658 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr12_+_7060554 0.658 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_+_64088886 0.658 NM_001172818
PGM1
phosphoglucomutase 1
chr19_-_19754369 0.657 GMIP
GEM interacting protein
chr14_+_76618244 0.655 NM_017926
NM_017972
C14orf118

chromosome 14 open reading frame 118

chr5_-_151066492 0.653 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr17_-_62097937 0.653 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr1_+_183114214 0.650 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr16_+_81812897 0.648 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr3_-_171528227 0.646 NM_001130081
NM_002662
PLD1

phospholipase D1, phosphatidylcholine-specific

chr8_+_56792392 0.643 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr9_-_123688352 0.640 TRAF1
TNF receptor-associated factor 1
chr21_+_18885296 0.638 CXADR
coxsackie virus and adenovirus receptor
chr14_+_24702102 0.635 NM_001002002
NM_016576
GMPR2

guanosine monophosphate reductase 2

chr12_+_7060538 0.634 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_-_53601051 0.632 ITGB7
integrin, beta 7
chr20_+_44746948 0.632 CD40
CD40 molecule, TNF receptor superfamily member 5
chr4_+_8200918 0.631 NM_018986
SH3TC1
SH3 domain and tetratricopeptide repeats 1
chr12_+_7060517 0.629 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_27952591 0.628 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr14_+_76618289 0.626 C14orf118
chromosome 14 open reading frame 118
chr22_-_37882214 0.624 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr2_-_69870705 0.623 AAK1
AP2 associated kinase 1
chr8_+_56792345 0.622 NM_001111097
NM_002350
LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

chr10_+_114135965 0.620 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_-_225266710 0.620 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr7_+_73624328 0.619 LAT2
linker for activation of T cells family, member 2
chr19_+_3178735 0.617 NM_003775
S1PR4
sphingosine-1-phosphate receptor 4
chr5_-_171615095 0.617 STK10
serine/threonine kinase 10
chr15_-_93198602 0.616 NM_207446
FAM174B
family with sequence similarity 174, member B
chr14_-_77923888 0.613 NM_001193314
NM_001193315
NM_001193316
NM_001193317
NM_022067
C14orf133




chromosome 14 open reading frame 133




chr12_+_7060543 0.611 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr8_-_101322180 0.611 RNF19A
ring finger protein 19A
chr17_+_18380097 0.610 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr17_+_19551835 0.609 NM_000382
NM_001031806
ALDH3A2

aldehyde dehydrogenase 3 family, member A2

chr4_+_68424444 0.608 NM_012108
STAP1
signal transducing adaptor family member 1
chr13_-_99229226 0.605 NM_001032296
STK24
serine/threonine kinase 24
chr3_+_11267666 0.601 NM_001098211
HRH1
histamine receptor H1
chr9_+_128509616 0.599 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr7_+_73624347 0.599 LAT2
linker for activation of T cells family, member 2
chr6_-_75994477 0.598 TMEM30A
transmembrane protein 30A
chr12_+_7060531 0.597 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_-_110888079 0.597 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr3_-_149095458 0.596 TM4SF1
transmembrane 4 L six family member 1
chr6_-_29527477 0.594 UBD
ubiquitin D
chr1_+_236305831 0.592 NM_003272
GPR137B
G protein-coupled receptor 137B
chr16_+_67571980 0.591 FAM65A
family with sequence similarity 65, member A
chr7_-_37488408 0.590 ELMO1
engulfment and cell motility 1
chr21_+_18885104 0.589 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr15_-_80263460 0.589 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr10_+_114136014 0.586 ACSL5
acyl-CoA synthetase long-chain family member 5
chr7_+_150434679 0.583 GIMAP5
GTPase, IMAP family member 5
chr12_-_110888134 0.582 ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr12_+_66218141 0.581 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr14_+_105953256 0.579 NM_001311
CRIP1
cysteine-rich protein 1 (intestinal)
chr22_+_22786283 0.576



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.90 2.15e-03 GO:0002376 immune system process
4.81 4.02e-03 GO:0006952 defense response
50.75 1.03e-02 GO:0002702 positive regulation of production of molecular mediator of immune response
4.49 2.00e-02 GO:0006955 immune response
143.75 2.86e-02 GO:0043615 astrocyte cell migration
11.25 3.01e-02 GO:0050870 positive regulation of T cell activation
5.47 3.29e-02 GO:0001775 cell activation
3.72 4.39e-02 GO:0022607 cellular component assembly

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
11.25 5.69e-03 GO:0009897 external side of plasma membrane

Nothing significant found in function category.