Motif ID: EWSR1-FLI1.p2

Z-value: 0.949


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EWSR1chr22_+_29663997-0.214.4e-01Click!
FLI1chr11_+_1285637720.185.1e-01Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_152009467 2.508 S100A11
S100 calcium binding protein A11
chr1_-_152009440 2.508 S100A11
S100 calcium binding protein A11
chr1_+_223889253 2.503 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr1_-_152009406 2.458 S100A11
S100 calcium binding protein A11
chr7_+_16793320 2.410 NM_014399
TSPAN13
tetraspanin 13
chr1_-_68299047 2.328 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr1_+_186798031 1.908 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr6_-_10412606 1.809 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_-_68697997 1.741 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr1_-_152009490 1.649 NM_005620
S100A11
S100 calcium binding protein A11
chrX_+_107683015 1.379 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr6_-_134496833 1.371 SGK1
serum/glucocorticoid regulated kinase 1
chr2_-_24307529 1.307 NM_004881
NM_147184
TP53I3

tumor protein p53 inducible protein 3

chr2_+_37571752 1.302 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr6_-_132272311 1.255 NM_001901
CTGF
connective tissue growth factor
chr6_-_134497069 1.147 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr3_-_42307661 1.082 NM_000729
CCK
cholecystokinin
chr17_+_48133357 0.995 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr17_+_48133331 0.945 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr1_-_225840660 0.900 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr17_+_2497233 0.884 PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chrX_-_148586666 0.875 NM_000202
NM_001166550
NM_006123
IDS


iduronate 2-sulfatase


chr2_+_182756665 0.790 SSFA2
sperm specific antigen 2
chr1_+_157963062 0.747 NM_018240
KIRREL
kin of IRRE like (Drosophila)
chr18_-_5630629 0.720 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr20_+_6748744 0.712 NM_001200
BMP2
bone morphogenetic protein 2
chr4_-_16900028 0.701 LDB2
LIM domain binding 2
chr5_-_148442606 0.634 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr4_+_174089889 0.628 NM_017423
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr11_+_101980736 0.614 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr4_-_16900348 0.582 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr12_-_49351263 0.541


chr1_+_19972259 0.538 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr4_-_85887543 0.515 NM_014991
WDFY3
WD repeat and FYVE domain containing 3
chr5_+_86563594 0.514 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chrX_-_107682600 0.497 NM_001847
COL4A6
collagen, type IV, alpha 6
chr2_+_182756468 0.478 NM_001130445
NM_006751
SSFA2

sperm specific antigen 2

chr10_+_23384377 0.468 NM_012228
MSRB2
methionine sulfoxide reductase B2
chr19_-_291168 0.467 NM_177543
PPAP2C
phosphatidic acid phosphatase type 2C
chr13_+_114145307 0.436 NM_017905
TMCO3
transmembrane and coiled-coil domains 3
chr18_+_56530677 0.415 ZNF532
zinc finger protein 532
chr12_-_49351240 0.413 ARF3
ADP-ribosylation factor 3
chr7_-_107204705 0.412 NM_001161520
NM_006348
NM_181733
COG5


component of oligomeric golgi complex 5


chr1_+_153330329 0.409 NM_002965
S100A9
S100 calcium binding protein A9
chr13_+_114145394 0.404 TMCO3
transmembrane and coiled-coil domains 3
chr4_-_16900256 0.393 LDB2
LIM domain binding 2
chr12_-_49351251 0.375 NM_001659
ARF3
ADP-ribosylation factor 3
chr19_-_51487070 0.367 NM_139277
NM_001207053
NM_001243126
NM_005046
KLK7



kallikrein-related peptidase 7



chr12_-_49351129 0.362 ARF3
ADP-ribosylation factor 3
chr8_-_145559831 0.355 NM_031309
SCRT1
scratch homolog 1, zinc finger protein (Drosophila)
chr10_-_126849556 0.347 NM_001083914
CTBP2
C-terminal binding protein 2
chr12_+_85673884 0.342 NM_006982
ALX1
ALX homeobox 1
chr10_+_70883930 0.340 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr1_-_93257950 0.339 NM_005665
EVI5
ecotropic viral integration site 5
chr12_-_49351245 0.331 ARF3
ADP-ribosylation factor 3
chr19_-_51472816 0.325 NM_002774
KLK6
kallikrein-related peptidase 6
chr20_+_42187705 0.319 SGK2
serum/glucocorticoid regulated kinase 2
chr21_+_39628663 0.317 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr17_-_34122547 0.314 NM_001032278
NM_024302
MMP28

matrix metallopeptidase 28

chr19_-_291335 0.300 NM_003712
NM_177526
PPAP2C

phosphatidic acid phosphatase type 2C

chr12_-_49351297 0.299 ARF3
ADP-ribosylation factor 3
chr1_-_20812727 0.298 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_-_163113129 0.297 RGS5
regulator of G-protein signaling 5
chr5_+_86564044 0.281 NM_002890
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr10_+_70883977 0.277 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr17_+_2496902 0.274 NM_000430
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr8_-_93107881 0.270 NM_001198625
NM_001198626
NM_001198627
NM_001198631
NM_001198634
NM_001198679
RUNX1T1





runt-related transcription factor 1; translocated to, 1 (cyclin D-related)





chr19_-_2015628 0.268 NM_017797
BTBD2
BTB (POZ) domain containing 2
chr8_-_29206321 0.266 NM_057158
DUSP4
dual specificity phosphatase 4
chr10_+_70883856 0.265 NM_001035260
NM_004896
VPS26A

vacuolar protein sorting 26 homolog A (S. pombe)

chr12_+_16035495 0.256 STRAP
serine/threonine kinase receptor associated protein
chr10_+_70883987 0.249 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr8_-_22926490 0.241 NM_003842
NM_147187
TNFRSF10B

tumor necrosis factor receptor superfamily, member 10b

chr1_-_226926875 0.239 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr4_+_154125589 0.235 NM_015271
TRIM2
tripartite motif containing 2
chr1_-_153588789 0.235 NM_020672
S100A14
S100 calcium binding protein A14
chr13_+_29233279 0.233 POMP
proteasome maturation protein
chr3_+_33155447 0.230 NM_006371
CRTAP
cartilage associated protein
chr11_+_9685650 0.229 SWAP70
SWAP switching B-cell complex 70kDa subunit
chr3_-_107809754 0.228 NM_001777
NM_198793
CD47

CD47 molecule

chr4_-_57522469 0.226 NM_001145459
NM_139211
HOPX

HOP homeobox

chr10_+_70883943 0.223 VPS26A
vacuolar protein sorting 26 homolog A (S. pombe)
chr17_+_32582295 0.219 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr9_+_34179036 0.214 UBAP1
ubiquitin associated protein 1
chr8_+_30241943 0.209 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr2_-_113542970 0.209 NM_000575
IL1A
interleukin 1, alpha
chr1_-_156470565 0.199 MEF2D
myocyte enhancer factor 2D
chr10_+_106014467 0.195 NM_001191002
NM_004832
GSTO1

glutathione S-transferase omega 1

chr3_-_15900928 0.194 NM_015199
ANKRD28
ankyrin repeat domain 28
chr19_-_47551881 0.194 NM_017854
TMEM160
transmembrane protein 160
chr22_+_31644314 0.193 NM_001031801
NM_016733
LIMK2

LIM domain kinase 2

chrX_-_49965003 0.193 NM_139289
AKAP4
A kinase (PRKA) anchor protein 4
chr13_+_29233140 0.190 NM_015932
POMP
proteasome maturation protein
chr2_+_113816684 0.183 NM_012275
IL36RN
interleukin 36 receptor antagonist
chr11_-_31832758 0.183 PAX6
paired box 6
chr3_-_50378238 0.183 NM_001206957
NM_007182
NM_170714
RASSF1


Ras association (RalGDS/AF-6) domain family member 1


chr9_+_35538890 0.180 RUSC2
RUN and SH3 domain containing 2
chr11_-_31832592 0.176 PAX6
paired box 6
chr9_-_130639939 0.175 NM_000476
AK1
adenylate kinase 1
chrX_-_62974987 0.171 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr9_+_34179023 0.171 UBAP1
ubiquitin associated protein 1
chr8_-_37823986 0.171 NM_000025
ADRB3
adrenergic, beta-3-, receptor
chr7_-_99766191 0.171 GAL3ST4
galactose-3-O-sulfotransferase 4
chr2_+_113816214 0.170 NM_173170
IL36RN
interleukin 36 receptor antagonist
chr3_+_170075494 0.169 SKIL
SKI-like oncogene
chr12_+_123237302 0.168 NM_003677
DENR
density-regulated protein
chr15_+_41523465 0.166 CHP
calcium binding protein P22
chrX_+_56589961 0.163 NM_013444
UBQLN2
ubiquilin 2
chr7_-_99766238 0.162 NM_024637
GAL3ST4
galactose-3-O-sulfotransferase 4
chr12_-_117175634 0.158 NM_024738
C12orf49
chromosome 12 open reading frame 49
chr10_-_103874661 0.152 NM_003893
LDB1
LIM domain binding 1
chr10_-_14372807 0.149 NM_018027
FRMD4A
FERM domain containing 4A
chr11_+_9685624 0.143 NM_015055
SWAP70
SWAP switching B-cell complex 70kDa subunit
chr3_+_170075449 0.142 NM_001145098
NM_005414
SKIL

SKI-like oncogene

chr3_-_192445344 0.142 NM_004113
FGF12
fibroblast growth factor 12
chr9_-_124990706 0.137 NM_001242333
LHX6
LIM homeobox 6
chr3_+_33155559 0.136 CRTAP
cartilage associated protein
chr12_+_14518608 0.134 NM_018179
ATF7IP
activating transcription factor 7 interacting protein
chr2_-_85637473 0.134 CAPG
capping protein (actin filament), gelsolin-like
chr9_+_35538628 0.132 NM_001135999
RUSC2
RUN and SH3 domain containing 2
chrY_+_1351570 0.130 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr10_-_103879933 0.127 NM_001113407
LDB1
LIM domain binding 1
chr8_-_93107442 0.126 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr1_+_44412418 0.126 NM_014652
IPO13
importin 13
chr12_+_49209300 0.125 NM_001206916
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr10_-_35103894 0.124 NM_001184785
NM_001184786
NM_001184787
NM_001184788
NM_001184789
NM_001184790
NM_001184791
NM_001184792
NM_001184793
NM_001184794
NM_019619
PARD3










par-3 partitioning defective 3 homolog (C. elegans)










chrX_+_67718868 0.123 YIPF6
Yip1 domain family, member 6
chr9_+_34179002 0.122 NM_001171201
NM_001171202
NM_001171203
NM_001171204
NM_016525
UBAP1




ubiquitin associated protein 1




chr9_+_34179058 0.121 UBAP1
ubiquitin associated protein 1
chr19_-_11373117 0.120 NM_020812
DOCK6
dedicator of cytokinesis 6
chr11_-_62474810 0.120 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr9_+_125796845 0.116 NM_005294
GPR21
G protein-coupled receptor 21
chr11_-_8832881 0.113 NM_139157
ST5
suppression of tumorigenicity 5
chr12_-_9760481 0.112 NM_002258
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr17_-_7166505 0.107 NM_001185022
CLDN7
claudin 7
chr5_-_64064483 0.104 NM_173829
SREK1IP1
SREK1-interacting protein 1
chr12_-_49177876 0.104 NM_015270
ADCY6
adenylate cyclase 6
chr8_-_93107643 0.102 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_-_21605984 0.098 NM_001113347
ECE1
endothelin converting enzyme 1
chr15_+_41523401 0.098 NM_007236
CHP
calcium binding protein P22
chr15_+_59359061 0.097 RNF111
ring finger protein 111
chr11_-_67141647 0.096 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr8_-_27695543 0.096 PBK
PDZ binding kinase
chr19_+_52901101 0.093 NM_032423
ZNF528
zinc finger protein 528
chrX_+_80457597 0.093 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr6_-_45983279 0.092 NM_016929
CLIC5
chloride intracellular channel 5
chr11_-_62474666 0.091 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_-_233431458 0.091 NM_014801
PCNXL2
pecanex-like 2 (Drosophila)
chr9_-_84303595 0.089 NM_005077
TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chr12_+_49658865 0.088 TUBA1C
tubulin, alpha 1c
chr11_+_2323236 0.087 NM_139022
TSPAN32
tetraspanin 32
chr10_-_102027337 0.087 NM_018294
CWF19L1
CWF19-like 1, cell cycle control (S. pombe)
chr8_+_17433941 0.085 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr11_-_62474869 0.083 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr9_-_84304378 0.082 TLE1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
chrX_+_80457302 0.079 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr20_+_30193083 0.075 NM_002165
NM_181353
ID1

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

chr11_+_58912251 0.074 NM_022074
NM_198847
FAM111A

family with sequence similarity 111, member A

chr3_-_128369710 0.072 NM_002950
RPN1
ribophorin I
chr1_-_27930101 0.072 NM_001029882
AHDC1
AT hook, DNA binding motif, containing 1
chr3_-_56502364 0.071 NM_015576
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr11_-_62475060 0.071 NM_001122955
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr8_-_110986923 0.070 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chrX_-_62974942 0.069 ARHGEF9
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr19_-_11494882 0.069 NM_000121
EPOR
erythropoietin receptor
chr19_-_42759151 0.069 ERF
Ets2 repressor factor
chr22_+_39966757 0.069 NM_001003406
NM_021096
CACNA1I

calcium channel, voltage-dependent, T type, alpha 1I subunit

chr1_+_154193757 0.067 UBAP2L
ubiquitin associated protein 2-like
chr17_+_4843883 0.066 RNF167
ring finger protein 167
chrX_-_62975005 0.065 NM_001173480
NM_015185
ARHGEF9

Cdc42 guanine nucleotide exchange factor (GEF) 9

chrX_+_67718623 0.065 NM_001195214
NM_173834
YIPF6

Yip1 domain family, member 6

chr3_-_128369655 0.063 RPN1
ribophorin I
chr14_+_56584854 0.061 NM_021255
PELI2
pellino homolog 2 (Drosophila)
chr12_+_49658862 0.061 NM_032704
TUBA1C
tubulin, alpha 1c
chr5_+_35856990 0.060 NM_002185
IL7R
interleukin 7 receptor
chr11_+_113930296 0.059 ZBTB16
zinc finger and BTB domain containing 16
chr1_-_223537400 0.059 NM_001037175
NM_017982
SUSD4

sushi domain containing 4

chr1_+_29063443 0.059 NM_001172828
YTHDF2
YTH domain family, member 2
chr12_+_109273856 0.058 NM_001917
DAO
D-amino-acid oxidase
chr11_-_5701371 0.054 TRIM5
tripartite motif containing 5
chr12_+_66582914 0.053 NM_001142523
NM_007199
IRAK3

interleukin-1 receptor-associated kinase 3

chr19_-_17958814 0.052 NM_000215
JAK3
Janus kinase 3
chr3_+_130612806 0.052 NM_001199179
NM_001001485
NM_001199183
NM_001199184
NM_001199185
NM_014382
NM_001001486
NM_001001487
ATP2C1







ATPase, Ca++ transporting, type 2C, member 1







chr11_+_17757494 0.051 NM_001112741
NM_004976
KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1

chr9_-_124989755 0.051 NM_001242334
LHX6
LIM homeobox 6
chr1_+_154193294 0.049 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chr3_+_14166582 0.048 TMEM43
transmembrane protein 43
chr1_+_203444882 0.048 NM_002725
NM_201348
PRELP

proline/arginine-rich end leucine-rich repeat protein

chr20_-_62284701 0.047 NM_015894
STMN3
stathmin-like 3
chr5_-_38595506 0.045 NM_002310
LIFR
leukemia inhibitory factor receptor alpha
chrX_-_78623006 0.042 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr16_-_75569067 0.042 NM_024533
CHST5
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
chr7_+_65540937 0.041 ASL
argininosuccinate lyase
chr1_+_29063132 0.040 NM_001173128
NM_016258
YTHDF2

YTH domain family, member 2

chr16_-_74641014 0.040 NM_001145666
NM_001145667
NM_012201
GLG1


golgi glycoprotein 1


chrX_+_1401570 0.040 NM_001161530
NM_172247
CSF2RA

colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)

chr15_+_84116172 0.039 SH3GL3
SH3-domain GRB2-like 3
chr1_-_17380486 0.038 NM_003000
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr3_-_192126837 0.037 NM_021032
FGF12
fibroblast growth factor 12
chr7_-_138482848 0.037 NM_020632
NM_130840
ATP6V0A4

ATPase, H+ transporting, lysosomal V0 subunit a4


Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.