Motif ID: FOSL2.p2

Z-value: 1.088


Transcription factors associated with FOSL2.p2:

Gene SymbolEntrez IDGene Name
FOSL2 2355 FOS-like antigen 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOSL2chr2_+_28615695,
chr2_+_28616346
0.467.6e-02Click!


Activity profile for motif FOSL2.p2.

activity profile for motif FOSL2.p2


Sorted Z-values histogram for motif FOSL2.p2

Sorted Z-values for motif FOSL2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOSL2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_133494275 2.925 TF
transferrin
chr11_-_115088628 2.308 CADM1
cell adhesion molecule 1
chr7_+_23286277 2.139 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr8_-_27472188 2.106 CLU
clusterin
chr7_+_23286386 1.911 GPNMB
glycoprotein (transmembrane) nmb
chr7_+_23286390 1.910 GPNMB
glycoprotein (transmembrane) nmb
chr2_-_216259197 1.840 FN1
fibronectin 1
chr7_+_23286384 1.772 GPNMB
glycoprotein (transmembrane) nmb
chr18_+_21452981 1.693 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr22_+_23040394 1.687 IGL@
immunoglobulin lambda locus
chr14_-_94855120 1.680 NM_000295
SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_+_80193649 1.648 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr14_-_94854910 1.635 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr22_+_22758538 1.597


chr6_+_83072922 1.516 NM_006670
TPBG
trophoblast glycoprotein
chr22_+_22735134 1.509 CYAT1
immunoglobulin lambda light chain-like
chr11_+_121461070 1.446 SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr7_+_23286420 1.438 GPNMB
glycoprotein (transmembrane) nmb
chr6_-_30712294 1.408 NM_003897
IER3
immediate early response 3
chr11_+_101983170 1.358 NM_001195045
YAP1
Yes-associated protein 1
chr5_-_149535420 1.352 NM_002609
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr14_-_94849552 1.351 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chrX_+_115567746 1.346 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr10_-_95360959 1.308 NM_006744
RBP4
retinol binding protein 4, plasma
chr21_-_27512668 1.269 NM_001136016
APP
amyloid beta (A4) precursor protein
chr17_-_38721701 1.187 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr8_-_27472298 1.187 NM_001831
CLU
clusterin
chr12_+_7023490 1.153 NM_001975
ENO2
enolase 2 (gamma, neuronal)
chr19_-_57336373 1.122 NM_001146186
PEG3
paternally expressed 3
chr11_+_2924504 1.118 SLC22A18
solute carrier family 22, member 18
chr20_+_43343523 1.093 WISP2
WNT1 inducible signaling pathway protein 2
chr6_-_138428477 1.063 NM_022121
PERP
PERP, TP53 apoptosis effector
chr17_+_75446735 1.058 SEPT9
septin 9
chr22_+_22569155 1.013


chr6_-_134496833 1.010 SGK1
serum/glucocorticoid regulated kinase 1
chr22_+_22735207 0.989 IGLJ3
immunoglobulin lambda joining 3
chr8_+_126442557 0.982 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr3_-_32023237 0.965 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr5_+_35856990 0.953 NM_002185
IL7R
interleukin 7 receptor
chr9_-_116840673 0.937 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr20_+_34742656 0.937 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr11_-_8739398 0.937 ST5
suppression of tumorigenicity 5
chr1_+_171060017 0.918 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr11_+_706103 0.912 NM_022772
EPS8L2
EPS8-like 2
chr7_-_107643330 0.879 NM_002291
LAMB1
laminin, beta 1
chr6_+_106959729 0.879 NM_001624
AIM1
absent in melanoma 1
chr12_-_91573264 0.875 NM_133503
DCN
decorin
chr1_-_108231122 0.874 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr2_-_89292396 0.858 IGKC
immunoglobulin kappa constant
chr8_-_17752847 0.848 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr7_+_73245192 0.836 NM_001305
CLDN4
claudin 4
chr3_-_120401401 0.834 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr4_+_6695565 0.818 NM_005980
S100P
S100 calcium binding protein P
chr22_+_39916563 0.813 NM_001675
NM_182810
ATF4

activating transcription factor 4 (tax-responsive enhancer element B67)

chr18_-_74207145 0.799 NM_014643
ZNF516
zinc finger protein 516
chr6_+_33043702 0.794 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr22_+_22723972 0.793


chr6_+_138188352 0.782 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr1_+_154377668 0.778 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr8_-_41166931 0.776 NM_003012
SFRP1
secreted frizzled-related protein 1
chr17_+_75315632 0.771 SEPT9
septin 9
chr2_+_152214105 0.766 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr3_-_8693723 0.747 NM_015931
C3orf32
chromosome 3 open reading frame 32
chr22_+_23165273 0.739


chr10_+_63808968 0.733 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr7_-_137028275 0.728 PTN
pleiotrophin
chr11_-_2162340 0.725 NM_001127598
IGF2
insulin-like growth factor 2 (somatomedin A)
chr15_+_89182038 0.724 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr18_+_61442611 0.719 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr16_-_11680146 0.718 NM_004862
LITAF
lipopolysaccharide-induced TNF factor
chr17_+_7482938 0.703 CD68
CD68 molecule
chr5_+_150020201 0.702 NM_001109974
NM_007286
SYNPO

synaptopodin

chr16_+_31366529 0.697 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr7_-_137028370 0.696 PTN
pleiotrophin
chr17_-_7590731 0.695 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr22_-_45608232 0.692 KIAA0930
KIAA0930
chr10_+_7745229 0.689 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_57045214 0.682 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_-_152830448 0.682 NM_001005747
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr17_+_7482804 0.678 NM_001251
NM_001040059
CD68

CD68 molecule

chr3_+_187930720 0.677 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr3_-_187454247 0.668 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr11_-_6341708 0.668 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr18_+_56338678 0.667 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr3_-_114343791 0.664 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr17_+_21191347 0.663 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr19_-_6591012 0.663 CD70
CD70 molecule
chr11_-_71781091 0.657 NUMA1
nuclear mitotic apparatus protein 1
chr19_-_11688441 0.655 ACP5
acid phosphatase 5, tartrate resistant
chr21_-_27543134 0.653 NM_000484
NM_001136129
NM_001136130
NM_001204301
NM_001204302
NM_001204303
NM_201413
NM_201414
APP







amyloid beta (A4) precursor protein







chr15_-_71146427 0.650 NM_018357
NM_197958
LARP6

La ribonucleoprotein domain family, member 6

chr4_+_169753105 0.648 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr9_-_116840604 0.648 AMBP
alpha-1-microglobulin/bikunin precursor
chr10_-_88854686 0.648 NM_005271
GLUD1
glutamate dehydrogenase 1
chr9_+_79056581 0.646 NM_001097634
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr5_-_150521200 0.640 NM_001193544
ANXA6
annexin A6
chr1_+_32043745 0.640 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr15_+_81071708 0.639 NM_018689
KIAA1199
KIAA1199
chr10_+_5136589 0.636 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr11_-_102714240 0.632 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr2_+_191208326 0.632 INPP1
inositol polyphosphate-1-phosphatase
chr1_-_209824641 0.620 NM_001017402
LAMB3
laminin, beta 3
chr1_-_57045129 0.616 PPAP2B
phosphatidic acid phosphatase type 2B
chr18_+_56338617 0.616 NM_006785
NM_173844
MALT1

mucosa associated lymphoid tissue lymphoma translocation gene 1

chr10_+_7745354 0.611 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_+_29794743 0.611 NM_002127
HLA-G
major histocompatibility complex, class I, G
chr19_-_11688484 0.611 ACP5
acid phosphatase 5, tartrate resistant
chr17_+_7482980 0.604 CD68
CD68 molecule
chr15_+_22892517 0.604 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr17_+_75315590 0.604 NM_006640
SEPT9
septin 9
chr2_+_191208618 0.602 INPP1
inositol polyphosphate-1-phosphatase
chr2_+_46926049 0.602 NM_014011
SOCS5
suppressor of cytokine signaling 5
chr14_-_24777153 0.597 CIDEB
cell death-inducing DFFA-like effector b
chr1_-_156675237 0.597 NM_001878
NM_001199723
CRABP2

cellular retinoic acid binding protein 2

chr1_-_153538305 0.592 NM_005978
S100A2
S100 calcium binding protein A2
chr21_-_27543445 0.586 NM_001136131
APP
amyloid beta (A4) precursor protein
chr14_-_24777184 0.580 CIDEB
cell death-inducing DFFA-like effector b
chr2_-_163099877 0.577 NM_004460
FAP
fibroblast activation protein, alpha
chr10_+_5136556 0.574 NM_003739
AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr4_-_84035888 0.573 PLAC8
placenta-specific 8
chr5_-_138533998 0.566 SIL1
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
chr21_-_27543044 0.565 APP
amyloid beta (A4) precursor protein
chr1_+_209929378 0.563 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr7_+_134212343 0.560 NM_020299
AKR1B10
aldo-keto reductase family 1, member B10 (aldose reductase)
chr20_+_43343884 0.559 NM_003881
WISP2
WNT1 inducible signaling pathway protein 2
chr13_-_38172862 0.558 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr8_+_42995553 0.558 NM_152419
HGSNAT
heparan-alpha-glucosaminide N-acetyltransferase
chr10_+_7745341 0.553 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr16_-_30124829 0.551 NM_024307
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr8_+_56015013 0.547 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr2_+_102770401 0.546 NM_000877
IL1R1
interleukin 1 receptor, type I
chr17_+_28707495 0.545 NM_001199775
CPD
carboxypeptidase D
chr18_+_55888838 0.539 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_65613971 0.538 AK4
adenylate kinase 4
chr3_-_120400957 0.537 HGD
homogentisate 1,2-dioxygenase
chr2_+_191208195 0.534 NM_001128928
NM_002194
INPP1

inositol polyphosphate-1-phosphatase

chr5_-_138534026 0.534 NM_001037633
NM_022464
SIL1

SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)

chr2_-_165697852 0.531 COBLL1
COBL-like 1
chr5_-_138533982 0.531 SIL1
SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae)
chr4_-_89080010 0.531 NM_004827
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr18_+_268147 0.530


chr17_-_39768939 0.530 NM_005557
KRT16
keratin 16
chr2_+_113875469 0.525 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr1_-_57045235 0.524 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr4_+_47487230 0.521 NM_020453
ATP10D
ATPase, class V, type 10D
chr10_-_5060191 0.513 NM_001354
NM_205845
AKR1C2

aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)

chr22_+_22735202 0.511


chr2_-_165697927 0.510 NM_014900
COBLL1
COBL-like 1
chr15_+_22892714 0.506 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr15_+_67458492 0.502 NM_001145104
SMAD3
SMAD family member 3
chr9_-_116840545 0.501 AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_89442551 0.496 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr8_-_103666018 0.488 NM_001032282
KLF10
Kruppel-like factor 10
chr15_+_22892723 0.486 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr14_-_64970319 0.485 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr18_+_55888799 0.484 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_-_24777160 0.484 CIDEB
cell death-inducing DFFA-like effector b
chr19_+_39279849 0.479 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr4_-_69886112 0.479 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr17_-_767287 0.478 NM_001205319
NXN
nucleoredoxin
chr7_+_116312412 0.470 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr7_-_93519990 0.468 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr10_+_5136613 0.468 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr17_+_72429835 0.464 NM_018653
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr8_+_26240522 0.463 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr13_-_30423599 0.462 UBL3
ubiquitin-like 3
chr22_+_22712091 0.461 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chrX_+_105937067 0.459 NM_024539
RNF128
ring finger protein 128
chr4_-_71532206 0.458 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr19_-_11688508 0.454 NM_001611
ACP5
acid phosphatase 5, tartrate resistant
chrX_-_10851808 0.452 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr7_-_36429695 0.448 NM_001100425
KIAA0895
KIAA0895
chr18_+_61144143 0.446 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr22_+_23229959 0.445 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_23213671 0.441 IGLV4-3
immunoglobulin lambda variable 4-3
chr1_-_27240430 0.439 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr7_+_129932973 0.437 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr20_+_31017187 0.436 ASXL1
additional sex combs like 1 (Drosophila)
chrX_-_2886285 0.434 ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr9_-_123688352 0.433 TRAF1
TNF receptor-associated factor 1
chr15_+_22892683 0.432 NM_014608
CYFIP1
cytoplasmic FMR1 interacting protein 1
chr7_+_48128225 0.432 NM_181597
UPP1
uridine phosphorylase 1
chr16_+_31366468 0.432 NM_000887
ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr3_-_124842442 0.431 SLC12A8
solute carrier family 12 (potassium/chloride transporters), member 8
chr4_-_71532341 0.431 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr10_-_101769640 0.429 NM_015221
DNMBP
dynamin binding protein
chr1_+_205473683 0.428 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr19_+_35550794 0.426 HPN
hepsin
chr21_-_43786602 0.425 NM_003225
TFF1
trefoil factor 1
chr19_-_44174497 0.420 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr8_+_11561710 0.418 NM_002052
GATA4
GATA binding protein 4
chr7_+_94023872 0.418 NM_000089
COL1A2
collagen, type I, alpha 2
chr16_+_27438578 0.415 NM_021798
IL21R
interleukin 21 receptor
chr7_-_137028433 0.415 PTN
pleiotrophin
chr2_+_69201704 0.413 NM_019617
GKN1
gastrokine 1
chr19_-_6670598 0.411 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr6_-_134497069 0.410 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr10_+_7745325 0.406 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr15_-_80263460 0.405 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr5_-_121414011 0.405 NM_002317
LOX
lysyl oxidase

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
34.22 6.61e-05 GO:0002576 platelet degranulation
15.56 3.30e-03 GO:0006887 exocytosis
8.92 9.50e-03 GO:0071702 organic substance transport
12.20 1.07e-02 GO:0030168 platelet activation
8.50 1.25e-02 GO:0046903 secretion
6.20 1.95e-02 GO:0006915 apoptosis
6.09 2.18e-02 GO:0012501 programmed cell death
5.98 2.45e-02 GO:0007155 cell adhesion
5.98 2.45e-02 GO:0022610 biological adhesion
9.96 2.81e-02 GO:0032940 secretion by cell
7.20 3.14e-02 GO:0007596 blood coagulation
7.20 3.14e-02 GO:0050817 coagulation
7.15 3.26e-02 GO:0007599 hemostasis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
43.10 1.35e-04 GO:0031093 platelet alpha granule lumen
42.20 1.48e-04 GO:0034774 secretory granule lumen
40.51 1.74e-04 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
38.96 2.04e-04 GO:0031983 vesicle lumen
36.18 2.76e-04 GO:0031091 platelet alpha granule
14.09 1.53e-03 GO:0030141 stored secretory granule
3.42 2.84e-03 GO:0044459 plasma membrane part
2.62 3.77e-03 GO:0005886 plasma membrane
2.59 4.54e-03 GO:0071944 cell periphery
6.01 6.77e-03 GO:0016023 cytoplasmic membrane-bounded vesicle
5.88 7.76e-03 GO:0031988 membrane-bounded vesicle
4.23 8.11e-03 GO:0005887 integral to plasma membrane
4.18 8.96e-03 GO:0031226 intrinsic to plasma membrane
5.66 9.91e-03 GO:0031410 cytoplasmic vesicle
5.46 1.25e-02 GO:0031982 vesicle
17.49 4.57e-02 GO:0019717 synaptosome

Nothing significant found in function category.