Motif ID: FOXA2.p3

Z-value: 2.283


Transcription factors associated with FOXA2.p3:

Gene SymbolEntrez IDGene Name
FOXA2 3170 forkhead box A2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXA2chr20_-_225648930.952.3e-08Click!


Activity profile for motif FOXA2.p3.

activity profile for motif FOXA2.p3


Sorted Z-values histogram for motif FOXA2.p3

Sorted Z-values for motif FOXA2.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA2.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_69886112 12.807 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr2_-_21225640 10.768 APOB
apolipoprotein B (including Ag(x) antigen)
chr4_+_6695565 9.226 NM_005980
S100P
S100 calcium binding protein P
chr12_-_9268440 9.135 A2M
alpha-2-macroglobulin
chr12_-_9268513 9.098 A2M
alpha-2-macroglobulin
chr17_-_64225496 8.835 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr3_-_148939784 8.785 NM_000096
CP
ceruloplasmin (ferroxidase)
chr4_-_70080448 8.724 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr2_-_21266809 8.657 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_-_26697224 7.996 VTN
vitronectin
chr1_-_169555624 7.843 F5
coagulation factor V (proaccelerin, labile factor)
chr10_+_7745229 7.749 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_-_41715078 7.645 NM_001166424
NM_002630
PGC

progastricsin (pepsinogen C)

chr22_+_21128378 7.588 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr17_-_26697310 7.498 VTN
vitronectin
chr1_-_169555710 7.388 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr10_+_7745325 7.388 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_9268475 7.341 A2M
alpha-2-macroglobulin
chr10_+_7745341 7.239 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745284 7.038 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr18_+_29171729 7.005 NM_000371
TTR
transthyretin
chr12_-_9268522 6.961 NM_000014
A2M
alpha-2-macroglobulin
chr2_-_21266915 6.841 NM_000384
APOB
apolipoprotein B (including Ag(x) antigen)
chr10_+_7745354 6.836 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr3_+_186330859 6.588 AHSG
alpha-2-HS-glycoprotein
chr17_+_53344966 6.551 HLF
hepatic leukemia factor
chr14_-_94789641 6.454 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr17_-_26697293 6.116 VTN
vitronectin
chr3_+_186330844 5.904 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr17_+_72427535 5.862 NM_022036
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_+_11674241 5.527 NM_014668
GREB1
growth regulation by estrogen in breast cancer 1
chr10_-_69597768 5.391 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr4_+_70146216 4.985 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr6_+_31895201 4.772 NM_000063
NM_001145903
C2

complement component 2

chr4_+_69681709 4.664 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr3_+_186330711 4.518 AHSG
alpha-2-HS-glycoprotein
chr17_-_7017971 4.364 ASGR2
asialoglycoprotein receptor 2
chr4_+_71062241 4.337 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr19_+_18496966 4.292 NM_004864
GDF15
growth differentiation factor 15
chr5_-_42811959 4.289 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr1_-_161193375 4.198 NM_001643
APOA2
apolipoprotein A-II
chr18_+_55816546 4.122 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr2_-_188419049 4.059 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr17_-_26697358 4.008 NM_000638
VTN
vitronectin
chr11_+_22688156 3.782 NM_001143830
GAS2
growth arrest-specific 2
chr9_-_75568232 3.565 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr11_+_22696318 3.563 NM_005256
GAS2
growth arrest-specific 2
chr3_-_120401401 3.558 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr9_-_116840673 3.552 NM_001633
AMBP
alpha-1-microglobulin/bikunin precursor
chr4_+_74281884 3.482 ALB
albumin
chr1_+_207277577 3.460 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr10_+_101542554 3.362 ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_-_188419185 3.287 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr10_+_102732285 3.264 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr12_-_53343607 3.223 KRT8
keratin 8
chr2_-_21266893 3.155 APOB
apolipoprotein B (including Ag(x) antigen)
chr10_-_54531394 3.060 NM_000242
MBL2
mannose-binding lectin (protein C) 2, soluble
chr4_-_69817478 3.027 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr3_-_120400957 2.937 HGD
homogentisate 1,2-dioxygenase
chr13_-_48987017 2.889 LPAR6
lysophosphatidic acid receptor 6
chr6_-_25930838 2.877 NM_005835
SLC17A2
solute carrier family 17 (sodium phosphate), member 2
chr13_-_48987247 2.797 LPAR6
lysophosphatidic acid receptor 6
chr16_-_87970107 2.748 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr10_+_101542460 2.713 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_-_200325200 2.662 SATB2
SATB homeobox 2
chr12_-_71551564 2.626 TSPAN8
tetraspanin 8
chr6_+_64356430 2.610 NM_015153
PHF3
PHD finger protein 3
chr4_+_155484131 2.567 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr6_+_31623668 2.565 NM_019101
APOM
apolipoprotein M
chr2_-_65593866 2.561 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr1_-_57431620 2.449 NM_000066
C8B
complement component 8, beta polypeptide
chr3_-_149086884 2.422 TM4SF1
transmembrane 4 L six family member 1
chr1_-_146697155 2.395 NM_001144829
NM_001144830
NM_001461
FMO5


flavin containing monooxygenase 5


chr13_-_48987652 2.386 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr2_-_165424993 2.378 GRB14
growth factor receptor-bound protein 14
chr12_+_100867550 2.370 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr7_-_87342569 2.364 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr1_-_231560789 2.340 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chr2_-_20527120 2.292 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr17_+_41006094 2.279 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr9_-_116840604 2.265 AMBP
alpha-1-microglobulin/bikunin precursor
chr7_+_94539209 2.259 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr1_-_182354649 2.228 GLUL
glutamate-ammonia ligase
chr7_+_134832765 2.177 NM_018295
TMEM140
transmembrane protein 140
chr7_+_112063131 2.099 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr7_+_45933096 2.085


chr2_-_88427535 2.071 NM_001443
FABP1
fatty acid binding protein 1, liver
chr5_+_92918924 1.985 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr21_-_43786602 1.959 NM_003225
TFF1
trefoil factor 1
chr7_-_50628744 1.945 NM_000790
NM_001242886
NM_001242887
NM_001242888
NM_001242889
NM_001242890
DDC





dopa decarboxylase (aromatic L-amino acid decarboxylase)





chr12_+_100867739 1.904 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr3_-_49459870 1.903 AMT
aminomethyltransferase
chr12_-_71551778 1.899 NM_004616
TSPAN8
tetraspanin 8
chr1_-_20306908 1.888 NM_000300
NM_001161727
NM_001161728
PLA2G2A


phospholipase A2, group IIA (platelets, synovial fluid)


chr2_+_113885137 1.881 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr17_-_7018049 1.875 NM_001181
NM_001201352
NM_080912
NM_080913
ASGR2



asialoglycoprotein receptor 2



chr11_+_22689653 1.851 NM_177553
GAS2
growth arrest-specific 2
chr4_-_186732208 1.846 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr18_-_52626636 1.844 NM_025214
CCDC68
coiled-coil domain containing 68
chr21_-_43735462 1.829 TFF3
trefoil factor 3 (intestinal)
chr4_-_70361578 1.821 NM_021139
UGT2B4
UDP glucuronosyltransferase 2 family, polypeptide B4
chr14_-_38064176 1.806 FOXA1
forkhead box A1
chr4_+_140586921 1.725 NM_001204366
NM_001204367
NM_001204368
NM_002413
MGST2



microsomal glutathione S-transferase 2



chr1_+_54359859 1.723 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chrX_+_115567746 1.714 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr2_+_113885145 1.703 IL1RN
interleukin 1 receptor antagonist
chr1_-_182357871 1.675 GLUL
glutamate-ammonia ligase
chr4_+_187187117 1.640 NM_000128
F11
coagulation factor XI
chr14_-_21493858 1.640 NDRG2
NDRG family member 2
chr6_+_31623688 1.635 APOM
apolipoprotein M
chr2_-_166930130 1.626 NM_001165963
NM_001165964
NM_006920
SCN1A


sodium channel, voltage-gated, type I, alpha subunit


chr9_-_75567915 1.623 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr10_-_125853102 1.609 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr6_-_31845446 1.583 NM_001178045
SLC44A4
solute carrier family 44, member 4
chr18_+_55888799 1.582 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chrX_-_131547536 1.576 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr1_+_227127993 1.574 ADCK3
aarF domain containing kinase 3
chr1_+_214161859 1.564 NM_002763
PROX1
prospero homeobox 1
chr1_+_227127959 1.564 ADCK3
aarF domain containing kinase 3
chr1_-_182357757 1.562 GLUL
glutamate-ammonia ligase
chr14_-_21493910 1.546 NM_016250
NM_201535
NM_201536
NM_201537
NDRG2



NDRG family member 2



chr2_+_170440846 1.508 NM_004792
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr4_+_187187342 1.492 F11
coagulation factor XI
chr2_+_242127923 1.467 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr8_+_126442557 1.456 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr4_+_74269971 1.446 NM_000477
ALB
albumin
chr12_+_121416548 1.442 NM_000545
HNF1A
HNF1 homeobox A
chr13_-_75901897 1.436 TBC1D4
TBC1 domain family, member 4
chr1_+_114471995 1.422 NM_152696
NM_198268
HIPK1

homeodomain interacting protein kinase 1

chr20_-_45976626 1.393 ZMYND8
zinc finger, MYND-type containing 8
chr13_-_49018802 1.392 NM_005767
LPAR6
lysophosphatidic acid receptor 6
chr12_+_13349716 1.358 EMP1
epithelial membrane protein 1
chr3_+_52811601 1.354 NM_002215
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr19_+_15160194 1.348 NM_012114
CASP14
caspase 14, apoptosis-related cysteine peptidase
chr1_+_226016428 1.340 EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr12_+_8332789 1.333 FAM66C
family with sequence similarity 66, member C
chr22_+_35462125 1.326 NM_001008494
ISX
intestine-specific homeobox
chr1_-_247054277 1.326 AHCTF1
AT hook containing transcription factor 1
chr17_-_202557 1.316 RPH3AL
rabphilin 3A-like (without C2 domains)
chr11_-_63933493 1.276 NM_014067
MACROD1
MACRO domain containing 1
chr11_-_46939908 1.252 NM_002334
LRP4
low density lipoprotein receptor-related protein 4
chr2_-_216259197 1.237 FN1
fibronectin 1
chr9_-_112191105 1.235 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr17_-_39684499 1.217 KRT19
keratin 19
chr1_-_160492982 1.203 NM_001184714
NM_001184715
NM_001184716
NM_052931
SLAMF6



SLAM family member 6



chr2_+_113875469 1.190 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chrX_-_15288172 1.181 NM_001031739
NM_001168530
NM_024087
ASB9


ankyrin repeat and SOCS box containing 9


chr1_+_227127999 1.176 ADCK3
aarF domain containing kinase 3
chr10_+_82173574 1.162 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr10_-_101841593 1.160 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr16_-_4896197 1.155 GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr14_-_21567069 1.154 NM_001101672
ZNF219
zinc finger protein 219
chr17_-_16097882 1.114 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr7_+_112092112 1.113 NM_001197079
IFRD1
interferon-related developmental regulator 1
chr2_+_170441102 1.099 PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr11_-_63933204 1.088 MACROD1
MACRO domain containing 1
chr2_+_32502956 1.086 NM_032312
YIPF4
Yip1 domain family, member 4
chr17_-_202617 1.085 NM_001190411
NM_001190412
NM_001190413
NM_006987
RPH3AL



rabphilin 3A-like (without C2 domains)



chr3_-_48471401 1.084 NM_001130082
PLXNB1
plexin B1
chr4_+_124317884 1.079 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr2_+_211421322 1.056 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr21_-_43735705 1.044 NM_003226
TFF3
trefoil factor 3 (intestinal)
chr20_-_45313122 1.039 NM_001011554
NM_001193340
SLC13A3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

chr12_-_48398284 1.033 NM_001844
NM_033150
COL2A1

collagen, type II, alpha 1

chr6_+_31590468 1.020


chr17_-_34308455 1.018 NM_004590
CCL16
chemokine (C-C motif) ligand 16
chr9_+_102677457 1.003 STX17
syntaxin 17
chr4_+_100495972 1.002 MTTP
microsomal triglyceride transfer protein
chr2_+_32502971 0.976 YIPF4
Yip1 domain family, member 4
chr11_-_70935807 0.974 NM_012309
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr4_+_140587086 0.967 MGST2
microsomal glutathione S-transferase 2
chr1_-_35920081 0.959 KIAA0319L
KIAA0319-like
chr10_-_45474210 0.935 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr15_+_42052574 0.933 MGA
MAX gene associated
chr12_-_89746238 0.919 DUSP6
dual specificity phosphatase 6
chr1_+_39922262 0.906 MACF1
microtubule-actin crosslinking factor 1
chr3_+_193853930 0.903 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr5_+_59784004 0.902 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr2_-_27579277 0.900 GTF3C2
general transcription factor IIIC, polypeptide 2, beta 110kDa
chr8_+_17822093 0.895 PCM1
pericentriolar material 1
chr12_-_96390002 0.870 NM_002108
HAL
histidine ammonia-lyase
chr3_+_12392993 0.868 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr12_-_89745997 0.861 DUSP6
dual specificity phosphatase 6
chr1_-_67520028 0.852 NM_015139
SLC35D1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr8_-_17579729 0.844 NM_001001931
MTUS1
microtubule associated tumor suppressor 1
chr10_+_81073763 0.840 ZMIZ1
zinc finger, MIZ-type containing 1
chr18_+_55888750 0.837 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr15_-_60919642 0.835 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr3_-_25683825 0.824 TOP2B
topoisomerase (DNA) II beta 180kDa
chr1_+_52082545 0.824 NM_024586
NM_148906
NM_148908
NM_148909
OSBPL9



oxysterol binding protein-like 9



chr14_+_32183774 0.807 NM_001201574
NUBPL
nucleotide binding protein-like
chr7_+_47694841 0.806 NM_001123065
C7orf65
chromosome 7 open reading frame 65
chr2_+_219646448 0.806 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr14_-_31926597 0.801 NM_080664
C14orf126
chromosome 14 open reading frame 126
chr20_+_32150139 0.791 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr6_+_27777713 0.767 NM_003536
HIST1H3H
histone cluster 1, H3h
chr12_+_120972155 0.764 RNF10
ring finger protein 10
chr16_+_69958900 0.752 NM_199424
WWP2
WW domain containing E3 ubiquitin protein ligase 2
chr1_+_226012974 0.750 NM_000120
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr8_+_67687415 0.748 NM_013257
NM_170709
SGK3

serum/glucocorticoid regulated kinase family, member 3


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
14.55 4.64e-05 GO:0072376 protein activation cascade
2.12 7.57e-03 GO:0065008 regulation of biological quality
21.82 2.01e-02 GO:0072378 blood coagulation, fibrin clot formation
20.78 2.46e-02 GO:0034367 macromolecular complex remodeling
20.78 2.46e-02 GO:0034368 protein-lipid complex remodeling
20.78 2.46e-02 GO:0034369 plasma lipoprotein particle remodeling

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.27 2.57e-08 GO:0005615 extracellular space
3.66 1.60e-07 GO:0044421 extracellular region part
2.76 8.69e-07 GO:0005576 extracellular region
12.59 9.22e-04 GO:0031983 vesicle lumen
24.24 2.28e-03 GO:0034361 very-low-density lipoprotein particle
24.24 2.28e-03 GO:0034385 triglyceride-rich lipoprotein particle
5.15 2.99e-03 GO:0005792 microsome
4.99 3.96e-03 GO:0042598 vesicular fraction
11.61 8.21e-03 GO:0031093 platelet alpha granule lumen
11.37 9.10e-03 GO:0034774 secretory granule lumen
10.91 1.11e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
29.75 1.44e-02 GO:0042627 chylomicron
9.74 1.92e-02 GO:0031091 platelet alpha granule
13.64 2.43e-02 GO:0032994 protein-lipid complex
13.64 2.43e-02 GO:0034358 plasma lipoprotein particle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
12.32 2.75e-04 GO:0004867 serine-type endopeptidase inhibitor activity
7.73 1.68e-03 GO:0004866 endopeptidase inhibitor activity
7.59 1.91e-03 GO:0030414 peptidase inhibitor activity
7.40 2.31e-03 GO:0061135 endopeptidase regulator activity
4.92 6.79e-03 GO:0004857 enzyme inhibitor activity
6.11 9.30e-03 GO:0061134 peptidase regulator activity
17.45 1.37e-02 GO:0015020 glucuronosyltransferase activity
9.57 3.19e-02 GO:0005319 lipid transporter activity