Motif ID: GATA6.p2

Z-value: 1.829


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GATA6chr18_+_197494030.019.7e-01Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_202853 8.205 NM_005332
HBZ
hemoglobin, zeta
chr12_-_54689536 7.255 NM_006163
NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr7_-_100239136 5.185 NM_003227
TFR2
transferrin receptor 2
chr6_-_49604524 5.028 NM_000324
RHAG
Rh-associated glycoprotein
chr12_+_69742130 4.578 NM_000239
LYZ
lysozyme
chr17_-_62084282 4.497 NM_000873
ICAM2
intercellular adhesion molecule 2
chr19_-_13213973 4.496 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr19_+_10397642 4.239 NM_001039132
NM_001544
NM_022377
ICAM4


intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)


chr8_-_38008332 3.273 NM_000349
STAR
steroidogenic acute regulatory protein
chr11_-_116708334 3.151 NM_000039
APOA1
apolipoprotein A-I
chr16_-_89043215 2.978 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr19_-_13213513 2.978 LYL1
lymphoblastic leukemia derived sequence 1
chr1_-_158656487 2.818 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr4_-_144940439 2.813 NM_002100
GYPB
glycophorin B (MNS blood group)
chrX_+_15525430 2.599 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr4_-_144826659 2.524 NM_002102
NM_198682
GYPE

glycophorin E (MNS blood group)

chrX_-_55057408 2.501 NM_000032
NM_001037967
NM_001037968
ALAS2


aminolevulinate, delta-, synthase 2


chr19_-_12997956 2.336 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr11_+_118958696 2.262 NM_001024382
HMBS
hydroxymethylbilane synthase
chr19_-_55668956 2.244 NM_000363
TNNI3
troponin I type 3 (cardiac)
chr7_+_150690838 2.182 NM_001160109
NM_001160110
NM_001160111
NOS3


nitric oxide synthase 3 (endothelial cell)


chr8_-_86290333 2.140 NM_001128829
NM_001128830
NM_001128831
NM_001738
CA1



carbonic anhydrase I



chr11_-_57158103 2.112 NM_001243245
NM_002728
PRG2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

chrX_-_105282714 2.110 NM_000354
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr17_-_64225496 2.106 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_+_100495972 2.027 MTTP
microsomal triglyceride transfer protein
chr7_-_142659412 2.015 NM_000420
KEL
Kell blood group, metallo-endopeptidase
chr9_-_75567915 1.992 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr19_-_13213669 1.946 LYL1
lymphoblastic leukemia derived sequence 1
chr7_-_142659397 1.895 KEL
Kell blood group, metallo-endopeptidase
chrX_+_65382432 1.861 NM_138737
HEPH
hephaestin
chr1_-_27240430 1.730 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr16_+_31539202 1.710 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chrX_+_65382627 1.654 HEPH
hephaestin
chr2_-_88427535 1.610 NM_001443
FABP1
fatty acid binding protein 1, liver
chr18_+_29171729 1.482 NM_000371
TTR
transthyretin
chr16_-_46782104 1.476 NM_182493
MYLK3
myosin light chain kinase 3
chr2_-_44065888 1.452 NM_022436
ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr1_-_155271186 1.449 NM_000298
PKLR
pyruvate kinase, liver and RBC
chrX_-_78623006 1.445 NM_001171581
NM_004867
ITM2A

integral membrane protein 2A

chr2_-_188419049 1.396 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr17_+_4675175 1.345 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr4_+_155484131 1.327 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr10_-_52645430 1.319 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr11_-_5291372 1.307 NM_005330
HBE1
hemoglobin, epsilon 1
chr17_-_39092714 1.280 KRT23
keratin 23 (histone deacetylase inducible)
chr16_+_20775311 1.276 NM_005622
NM_202000
ACSM3

acyl-CoA synthetase medium-chain family member 3

chr20_-_45976626 1.258 ZMYND8
zinc finger, MYND-type containing 8
chr14_-_37641864 1.251 NM_001171170
NM_030631
SLC25A21

solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21

chr1_-_25747276 1.220 NM_020485
NM_138616
NM_138617
NM_138618
RHCE



RHD
Rh blood group, CcEe antigens



Rh blood group, D antigen
chr11_-_5255712 1.214 NM_000519
HBD
hemoglobin, delta
chr2_-_21225640 1.196 APOB
apolipoprotein B (including Ag(x) antigen)
chr13_-_46756295 1.165 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_48389514 1.161 SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr1_+_43291230 1.105 NM_018538
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr19_-_48389571 1.104 NM_003167
SULT2A1
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr11_-_66206260 1.097 NM_016050
NM_170738
NM_170739
MRPL11


mitochondrial ribosomal protein L11


chr11_+_73357222 1.083 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr10_+_7745354 1.079 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_14996381 1.058 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr10_-_7682741 1.057 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr11_-_85780899 1.055 NM_001206947
PICALM
phosphatidylinositol binding clathrin assembly protein
chr11_+_61008643 1.052 NM_014224
PGA5
pepsinogen 5, group I (pepsinogen A)
chr10_-_21186530 1.046 NM_006393
NEBL
nebulette
chr2_+_138721807 1.031 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr4_-_186697065 1.017 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr21_-_39870303 1.012 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr5_-_59783885 1.010 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr4_+_69962191 0.996 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr8_-_95449131 0.962 NM_001205263
RAD54B
RAD54 homolog B (S. cerevisiae)
chr1_-_24469571 0.960 NM_021258
IL22RA1
interleukin 22 receptor, alpha 1
chr3_+_69812961 0.952 NM_006722
MITF
microphthalmia-associated transcription factor
chr7_+_20655244 0.947 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr10_+_7745284 0.935 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_6233684 0.916 NM_000552
VWF
von Willebrand factor
chr14_+_102276279 0.901 PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr10_+_7745229 0.889 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_149858114 0.882 NM_003528
HIST2H2BE
histone cluster 2, H2be
chr15_-_64126133 0.882 NM_003922
HERC1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr2_+_169757749 0.872 NM_001081686
NM_021176
G6PC2

glucose-6-phosphatase, catalytic, 2

chr10_-_11574273 0.864 NM_001080491
USP6NL
USP6 N-terminal like
chr12_-_123706393 0.857 NM_022782
MPHOSPH9
M-phase phosphoprotein 9
chr20_+_43029973 0.847 HNF4A
hepatocyte nuclear factor 4, alpha
chr2_-_99279935 0.846 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr14_-_94849552 0.844 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr12_-_63328857 0.844 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr20_-_54967221 0.834 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr13_-_46756326 0.827 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr2_+_27719702 0.780 NM_001486
GCKR
glucokinase (hexokinase 4) regulator
chr10_-_52645384 0.763 A1CF
APOBEC1 complementation factor
chr9_-_75568232 0.757 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr12_+_53818864 0.744 AMHR2
anti-Mullerian hormone receptor, type II
chr1_-_155270738 0.744 NM_181871
PKLR
pyruvate kinase, liver and RBC
chr10_+_70847857 0.736 SRGN
serglycin
chr7_+_112063131 0.735 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr17_+_33914278 0.725 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr1_+_198608244 0.712 PTPRC
protein tyrosine phosphatase, receptor type, C
chr21_+_38792600 0.703 NM_130438
NM_001396
DYRK1A

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

chr1_+_198608216 0.702 PTPRC
protein tyrosine phosphatase, receptor type, C
chr17_-_8424217 0.702 MYH10
myosin, heavy chain 10, non-muscle
chr12_+_7169192 0.697


chrX_+_115567746 0.685 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr10_+_7745325 0.674 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_71148063 0.643 PTPRR
protein tyrosine phosphatase, receptor type, R
chr1_+_50574589 0.640 NM_001144774
NM_021952
ELAVL4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

chr11_+_60970983 0.637 NM_001079807
PGA3
PGA4
pepsinogen 3, group I (pepsinogen A)
pepsinogen 4, group I (pepsinogen A)
chr4_-_69886112 0.634 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr3_-_50649110 0.633 NM_013324
NM_145071
CISH

cytokine inducible SH2-containing protein

chr10_-_99531712 0.633 NM_003015
SFRP5
secreted frizzled-related protein 5
chr17_-_47841468 0.627 FAM117A
family with sequence similarity 117, member A
chr4_-_122148620 0.622 NM_001244764
TNIP3
TNFAIP3 interacting protein 3
chr17_+_74381186 0.620 NM_001142602
SPHK1
sphingosine kinase 1
chr2_+_241808161 0.600 NM_000030
AGXT
alanine-glyoxylate aminotransferase
chr14_-_23877480 0.599 NM_002471
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr9_+_139557378 0.597 NM_016215
EGFL7
EGF-like-domain, multiple 7
chr7_-_112727832 0.592 NM_001146265
NM_018970
GPR85

G protein-coupled receptor 85

chr13_+_111367328 0.589 NM_005537
ING1
inhibitor of growth family, member 1
chr7_+_20686965 0.583 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr16_+_56817367 0.582 NM_001242796
NUP93
nucleoporin 93kDa
chr4_-_74088773 0.582 ANKRD17
ankyrin repeat domain 17
chr3_+_133495925 0.582 TF
transferrin
chr2_+_220436953 0.579 NM_002191
INHA
inhibin, alpha
chr3_-_137851123 0.576 NM_016161
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr10_+_35426709 0.570 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr6_-_33168448 0.567 RXRB
retinoid X receptor, beta
chr19_+_10781648 0.560 ILF3
interleukin enhancer binding factor 3, 90kDa
chr3_-_178984789 0.558 NM_001163677
NM_171828
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr4_-_100140330 0.556 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chrX_+_107288199 0.554 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr6_+_167704802 0.554 NM_001143947
NM_018974
UNC93A

unc-93 homolog A (C. elegans)

chr1_+_26644458 0.549 CD52
CD52 molecule
chr3_+_148583042 0.549 NM_001870
CPA3
carboxypeptidase A3 (mast cell)
chr19_-_11494882 0.545 NM_000121
EPOR
erythropoietin receptor
chr1_-_169555710 0.544 NM_000130
F5
coagulation factor V (proaccelerin, labile factor)
chr4_-_103265818 0.544 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr1_-_26393984 0.542 NM_032588
TRIM63
tripartite motif containing 63
chr3_-_183273407 0.533 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr1_-_151826042 0.529 NM_182578
THEM5
thioesterase superfamily member 5
chr1_+_26644380 0.527 NM_001803
CD52
CD52 molecule
chr2_+_109204777 0.525 LIMS1
LIM and senescent cell antigen-like domains 1
chr3_-_47933997 0.514 MAP4
microtubule-associated protein 4
chr18_-_45663667 0.511 NM_001039360
ZBTB7C
zinc finger and BTB domain containing 7C
chr19_-_55549612 0.511 NM_001083899
NM_016363
GP6

glycoprotein VI (platelet)

chr1_-_190446701 0.510 NM_199051
FAM5C
family with sequence similarity 5, member C
chr11_+_61102035 0.509 DAK
dihydroxyacetone kinase 2 homolog (S. cerevisiae)
chr11_-_47374221 0.504 NM_000256
MYBPC3
myosin binding protein C, cardiac
chr17_-_17480325 0.504 PEMT
phosphatidylethanolamine N-methyltransferase
chr20_+_56136136 0.502 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr7_-_44180911 0.498 NM_021223
MYL7
myosin, light chain 7, regulatory
chr10_+_118350470 0.496 NM_006229
PNLIPRP1
pancreatic lipase-related protein 1
chr10_+_7745341 0.495 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_-_57195052 0.495 NM_017611
SLC43A3
solute carrier family 43, member 3
chr13_-_46756291 0.494 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_-_21270537 0.492 NM_198232
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr6_-_123957941 0.492 NM_001251987
NM_006073
TRDN

triadin

chr11_+_92085261 0.484 NM_001008781
FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr1_+_50574601 0.477 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr21_-_35899046 0.466 NM_203418
RCAN1
regulator of calcineurin 1
chr14_+_102276125 0.465 NM_002719
NM_178586
NM_178587
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chr3_+_69812620 0.464 NM_001184967
MITF
microphthalmia-associated transcription factor
chr5_-_141338626 0.450 NM_016580
PCDH12
protocadherin 12
chr19_-_54692132 0.447 MBOAT7
membrane bound O-acyltransferase domain containing 7
chr16_-_67977956 0.441 NM_000229
LCAT
lecithin-cholesterol acyltransferase
chr10_-_94257470 0.441 NM_001165946
IDE
insulin-degrading enzyme
chr9_+_35673852 0.439 NM_001216
CA9
carbonic anhydrase IX
chr5_+_59784004 0.437 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr4_-_76957139 0.435 NM_005409
CXCL11
chemokine (C-X-C motif) ligand 11
chr8_-_41655139 0.432 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chr2_-_208994408 0.431 NM_020989
CRYGC
crystallin, gamma C
chr3_-_168864325 0.429 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr1_+_198608136 0.429 NM_002838
NM_080921
NM_080923
PTPRC


protein tyrosine phosphatase, receptor type, C


chr8_+_12803150 0.427 NM_020844
KIAA1456
KIAA1456
chr4_+_74269971 0.424 NM_000477
ALB
albumin
chr6_-_30128688 0.424 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr4_-_23891608 0.422 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr18_+_19749403 0.419 NM_005257
GATA6
GATA binding protein 6
chr2_+_220378891 0.416 NM_018674
NM_182847
ACCN4

amiloride-sensitive cation channel 4, pituitary

chr2_+_109204904 0.416 NM_001193488
LIMS1
LIM and senescent cell antigen-like domains 1
chr20_+_43029865 0.414 NM_000457
NM_178849
NM_178850
HNF4A


hepatocyte nuclear factor 4, alpha


chr10_+_18689512 0.404 NM_201570
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr4_-_16077740 0.402 NM_001145849
NM_001145850
NM_001145851
NM_001145852
NM_006017
PROM1




prominin 1




chr15_-_43513024 0.397 EPB42
erythrocyte membrane protein band 4.2
chr12_-_23737507 0.394 NM_178010
SOX5
SRY (sex determining region Y)-box 5
chr7_+_106505876 0.393 NM_002649
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide
chrX_+_49593905 0.392 NM_007003
PAGE4
P antigen family, member 4 (prostate associated)
chr3_-_120401401 0.390 NM_000187
HGD
homogentisate 1,2-dioxygenase
chr2_+_90077732 0.388


chr7_+_28475233 0.388 NM_004904
CREB5
cAMP responsive element binding protein 5
chr4_-_123377471 0.387 NM_000586
IL2
interleukin 2
chr11_-_129762903 0.383 NM_006165
NFRKB
nuclear factor related to kappaB binding protein
chr8_+_124194751 0.382 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr3_-_168864066 0.376 NM_001105077
NM_001163999
NM_005241
MECOM


MDS1 and EVI1 complex locus


chr1_-_43736600 0.376 EBNA1BP2
EBNA1 binding protein 2
chr19_-_47217576 0.373 NM_001079882
PRKD2
protein kinase D2
chr1_+_35851101 0.373 ZMYM4
zinc finger, MYM-type 4
chr1_+_15272414 0.370 NM_001017999
KAZN
kazrin, periplakin interacting protein
chr10_+_70847817 0.366 NM_002727
SRGN
serglycin
chr22_+_35462125 0.364 NM_001008494
ISX
intestine-specific homeobox
chr17_+_26369617 0.358 NM_016231
NLK
nemo-like kinase
chr2_-_188419185 0.356 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.78 6.81e-04 GO:0065008 regulation of biological quality
22.21 1.13e-02 GO:0031100 organ regeneration
45.19 1.35e-02 GO:0015669 gas transport
7.04 2.12e-02 GO:0030097 hemopoiesis
6.32 4.18e-02 GO:0048534 hemopoietic or lymphoid organ development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
76.67 1.36e-05 GO:0005833 hemoglobin complex
35.15 7.35e-03 GO:0034361 very-low-density lipoprotein particle
35.15 7.35e-03 GO:0034385 triglyceride-rich lipoprotein particle
19.78 4.26e-02 GO:0032994 protein-lipid complex
19.78 4.26e-02 GO:0034358 plasma lipoprotein particle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
126.50 9.90e-05 GO:0008519 ammonium transmembrane transporter activity
18.51 6.77e-04 GO:0005319 lipid transporter activity
63.26 1.17e-03 GO:0017127 cholesterol transporter activity
52.72 2.13e-03 GO:0005344 oxygen transporter activity
52.72 2.13e-03 GO:0015248 sterol transporter activity
45.19 3.50e-03 GO:0015101 organic cation transmembrane transporter activity
13.62 2.02e-02 GO:0004867 serine-type endopeptidase inhibitor activity
3.23 2.49e-02 GO:0022892 substrate-specific transporter activity