Motif ID: GTF2A1,2.p2

Z-value: 1.577


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
GTF2A2chr15_-_59949536-0.421.0e-01Click!
GTF2A1chr14_-_81687574-0.136.3e-01Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_145878775 3.143 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr7_+_100770378 3.131 NM_000602
NM_001165413
SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr12_+_53491417 2.892 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr3_-_145878936 2.803 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr19_+_41725098 2.656 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr21_+_42540054 2.387 BACE2
beta-site APP-cleaving enzyme 2
chr12_+_53491448 2.371 IGFBP6
insulin-like growth factor binding protein 6
chr21_+_42540092 2.341 BACE2
beta-site APP-cleaving enzyme 2
chr21_-_28217692 2.295 NM_006988
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr1_-_57045129 2.254 PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_13349601 2.235 NM_001423
EMP1
epithelial membrane protein 1
chr1_-_57045214 2.220 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_57045235 2.189 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chrX_-_3264680 2.185 NM_015419
MXRA5
matrix-remodelling associated 5
chr3_+_62304667 2.136 C3orf14
chromosome 3 open reading frame 14
chr1_-_57044980 2.130 PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_145879222 2.103 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr15_+_81071708 2.081 NM_018689
KIAA1199
KIAA1199
chr11_-_111782447 2.070 NM_001885
CRYAB
crystallin, alpha B
chr21_+_42539727 2.041 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr7_-_41742666 1.997 NM_002192
INHBA
inhibin, beta A
chr8_-_18541441 1.833 PSD3
pleckstrin and Sec7 domain containing 3
chr13_-_45150601 1.796 NM_001243799
NM_183422
TSC22D1

TSC22 domain family, member 1

chr3_-_78666943 1.782 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr12_-_76425207 1.763 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr11_-_119294242 1.758 NM_006288
THY1
Thy-1 cell surface antigen
chr12_+_81110689 1.738 NM_005593
MYF5
myogenic factor 5
chr17_+_1665233 1.726 NM_002615
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_48133331 1.718 NM_002204
NM_005501
ITGA3

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)

chr17_+_48133357 1.705 ITGA3
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
chr3_-_149086884 1.682 TM4SF1
transmembrane 4 L six family member 1
chr11_-_117166247 1.681 NM_001207048
NM_001207049
BACE1

beta-site APP-cleaving enzyme 1

chr1_+_86046434 1.657 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr17_-_48278874 1.656 COL1A1
collagen, type I, alpha 1
chr21_-_28217272 1.634 ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr3_-_99594915 1.577 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr17_+_1665342 1.537 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr16_+_55515468 1.524 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr10_-_17659365 1.514 NM_014241
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr11_+_131240370 1.508 NM_001048209
NTM
neurotrimin
chr17_+_80193649 1.432 NM_001206952
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr19_-_45909566 1.375 NM_001142502
PPP1R13L
protein phosphatase 1, regulatory subunit 13 like
chr8_-_23177481 1.365 LOXL2
lysyl oxidase-like 2
chrX_-_106243442 1.316 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr17_-_48278987 1.301 NM_000088
COL1A1
collagen, type I, alpha 1
chr9_+_124043719 1.298 GSN
gelsolin
chr2_-_161349874 1.282 RBMS1
RNA binding motif, single stranded interacting protein 1
chr22_+_33196801 1.265 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr3_+_100211408 1.211 NM_018004
TMEM45A
transmembrane protein 45A
chr11_+_13299376 1.211 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr2_+_30369749 1.209 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr1_-_68697997 1.170 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr12_-_7245048 1.158 C1R
complement component 1, r subcomponent
chr11_+_13299372 1.150 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr2_+_30369800 1.139 YPEL5
yippee-like 5 (Drosophila)
chr11_-_119293848 1.129 THY1
Thy-1 cell surface antigen
chr16_+_56716378 1.128 NM_005952
MT1X
metallothionein 1X
chr2_+_28616346 1.111 FOSL2
FOS-like antigen 2
chr19_-_44031310 1.103 NM_014297
ETHE1
ethylmalonic encephalopathy 1
chr15_+_39873276 1.102 NM_003246
THBS1
thrombospondin 1
chrX_-_128657453 1.099 NM_003069
NM_139035
SMARCA1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

chrX_-_114252132 1.085 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr8_-_42065037 1.077 PLAT
plasminogen activator, tissue
chr16_+_22825806 1.073 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr6_-_46293628 1.070 NM_005822
RCAN2
regulator of calcineurin 2
chr13_-_114567034 1.061 GAS6
growth arrest-specific 6
chr13_-_114567040 1.048 NM_000820
GAS6
growth arrest-specific 6
chr1_-_209824641 1.047 NM_001017402
LAMB3
laminin, beta 3
chr3_+_100211554 1.046 TMEM45A
transmembrane protein 45A
chr19_+_35607218 1.044 FXYD3
FXYD domain containing ion transport regulator 3
chr16_+_22825481 1.032 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr2_+_28615695 1.031 FOSL2
FOS-like antigen 2
chr17_+_1665306 1.031 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr12_-_7245006 1.024 NM_001733
C1R
complement component 1, r subcomponent
chr3_-_48130283 1.018 MAP4
microtubule-associated protein 4
chr2_-_175712276 1.012 NM_001206602
CHN1
chimerin (chimaerin) 1
chr22_+_35777051 1.003 NM_002133
HMOX1
heme oxygenase (decycling) 1
chr11_+_13299260 1.002 NM_001030272
NM_001030273
NM_001178
ARNTL


aryl hydrocarbon receptor nuclear translocator-like


chr8_-_134309448 1.000 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr12_-_46766019 0.999 SLC38A2
solute carrier family 38, member 2
chr15_+_32933869 0.991 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr1_+_156084565 0.980 LMNA
lamin A/C
chr22_+_35777087 0.978 HMOX1
heme oxygenase (decycling) 1
chr11_-_35547144 0.949 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr1_+_156084541 0.943 LMNA
lamin A/C
chr13_-_38172862 0.940 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr3_-_48130633 0.936 NM_001134364
NM_002375
NM_030885
MAP4


microtubule-associated protein 4


chr14_+_75745480 0.932 NM_005252
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr1_+_205473768 0.927 CDK18
cyclin-dependent kinase 18
chr3_-_149375584 0.926 NM_001168280
NM_015472
WWTR1

WW domain containing transcription regulator 1

chr1_+_164818083 0.916 PBX1
pre-B-cell leukemia homeobox 1
chr13_-_45150391 0.911 TSC22D1
TSC22 domain family, member 1
chr1_+_156084579 0.894 LMNA
lamin A/C
chr11_+_67070987 0.891 SSH3
slingshot homolog 3 (Drosophila)
chr22_+_30792929 0.890 NM_001204204
NM_012429
NM_033382
SEC14L2


SEC14-like 2 (S. cerevisiae)


chr12_+_13349720 0.886 EMP1
epithelial membrane protein 1
chr4_+_74281884 0.885 ALB
albumin
chr1_-_16482426 0.883 NM_004431
EPHA2
EPH receptor A2
chr17_-_1389013 0.881 NM_001080950
MYO1C
myosin IC
chr3_+_50304989 0.875 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr13_-_114567011 0.873 GAS6
growth arrest-specific 6
chr17_+_4854383 0.853 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr7_+_94292737 0.843 PEG10
paternally expressed 10
chr11_+_13299349 0.837 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr22_-_43042976 0.837 NM_001129819
NM_001171661
NM_007326
CYB5R3


cytochrome b5 reductase 3


chr2_+_30369868 0.826 YPEL5
yippee-like 5 (Drosophila)
chr12_-_46766563 0.823 NM_018976
SLC38A2
solute carrier family 38, member 2
chr7_+_94292816 0.823 PEG10
paternally expressed 10
chr1_+_163038564 0.814 NM_005613
RGS4
regulator of G-protein signaling 4
chr1_+_21766559 0.813 NM_032264
NBPF3
neuroblastoma breakpoint family, member 3
chr10_-_91102430 0.808 LIPA
lipase A, lysosomal acid, cholesterol esterase
chrX_-_128657440 0.802 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr5_+_34687663 0.798 NM_001145523
RAI14
retinoic acid induced 14
chr1_+_201979747 0.792 ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chrX_-_128657381 0.791 SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr13_-_40177200 0.791 LHFP
lipoma HMGIC fusion partner
chr19_+_36239445 0.788 LIN37
lin-37 homolog (C. elegans)
chr1_+_163038934 0.784 NM_001113381
RGS4
regulator of G-protein signaling 4
chr2_+_201171411 0.783 SPATS2L
spermatogenesis associated, serine-rich 2-like
chr19_+_41725259 0.778 AXL
AXL receptor tyrosine kinase
chr2_-_211168315 0.777 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr11_+_13299391 0.771 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr1_+_64058891 0.765 NM_002633
PGM1
phosphoglucomutase 1
chr1_+_205473683 0.763 NM_002596
NM_212502
NM_212503
CDK18


cyclin-dependent kinase 18


chr11_+_13299329 0.757 ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr1_+_183114214 0.751 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr6_-_46293404 0.747 RCAN2
regulator of calcineurin 2
chr22_-_38668943 0.745 TMEM184B
transmembrane protein 184B
chr15_+_67458492 0.744 NM_001145104
SMAD3
SMAD family member 3
chr2_+_74120132 0.742 ACTG2
actin, gamma 2, smooth muscle, enteric
chr2_-_9563584 0.737 ITGB1BP1
integrin beta 1 binding protein 1
chr19_+_41725135 0.736 AXL
AXL receptor tyrosine kinase
chr19_-_57336373 0.735 NM_001146186
PEG3
paternally expressed 3
chr21_-_27253197 0.733 APP
amyloid beta (A4) precursor protein
chr10_-_125851850 0.730 NM_014863
NM_015892
CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

chr19_+_41725131 0.729 AXL
AXL receptor tyrosine kinase
chr2_-_190927321 0.727 NM_005259
MSTN
myostatin
chr20_-_56285576 0.724 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr9_+_139872014 0.724 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr12_-_6451156 0.719 NM_001065
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr15_-_77363122 0.717 TSPAN3
tetraspanin 3
chr10_+_54074037 0.715 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr22_-_38668966 0.710 NM_001195072
NM_012264
TMEM184B

transmembrane protein 184B

chr1_-_221915458 0.703 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr22_+_29702950 0.698 NM_006478
NM_152236
NM_152237
GAS2L1


growth arrest-specific 2 like 1


chr2_+_74120092 0.697 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chr2_-_218808705 0.693 NM_022648
TNS1
tensin 1
chr10_+_7745325 0.693 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_52967608 0.686 NM_175053
KRT74
keratin 74
chr13_+_111154013 0.669 COL4A2
collagen, type IV, alpha 2
chr1_+_46646199 0.663 TSPAN1
tetraspanin 1
chr7_-_559479 0.654 NM_002607
NM_033023
PDGFA

platelet-derived growth factor alpha polypeptide

chr9_+_2622134 0.654 VLDLR
very low density lipoprotein receptor
chr1_-_32169555 0.653 COL16A1
collagen, type XVI, alpha 1
chr15_+_63340314 0.651 NM_001018008
TPM1
tropomyosin 1 (alpha)
chr10_+_7745229 0.651 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr7_-_150974179 0.649 NM_003078
SMARCD3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr17_+_41006094 0.648 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr22_-_38668669 0.644 NM_001195071
TMEM184B
transmembrane protein 184B
chr22_+_31487315 0.641 SMTN
smoothelin
chr13_+_37006408 0.639 NM_001111045
NM_003914
CCNA1

cyclin A1

chr20_-_56284945 0.639 NM_020182
PMEPA1
prostate transmembrane protein, androgen induced 1
chr3_+_61547179 0.632 NM_002841
PTPRG
protein tyrosine phosphatase, receptor type, G
chr7_+_99699129 0.631 NM_004722
AP4M1
adaptor-related protein complex 4, mu 1 subunit
chr2_-_9563587 0.627 NM_004763
NM_022334
ITGB1BP1

integrin beta 1 binding protein 1

chr13_-_114566951 0.616 GAS6
growth arrest-specific 6
chr21_+_47545896 0.612 COL6A2
collagen, type VI, alpha 2
chr20_-_43977023 0.610 NM_002999
SDC4
syndecan 4
chr12_-_56106061 0.609 NM_001144997
ITGA7
integrin, alpha 7
chr12_-_76425375 0.609 NM_007350
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr10_+_114710785 0.609 TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr7_-_6523689 0.605 NM_001100603
NM_006854
KDELR2

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2

chr1_+_209859524 0.605 NM_001206741
NM_181755
HSD11B1

hydroxysteroid (11-beta) dehydrogenase 1

chr4_+_41614911 0.603 NM_001112719
NM_001112720
LIMCH1

LIM and calponin homology domains 1

chr20_+_11898536 0.602 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr3_-_149095517 0.595 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr11_+_114166534 0.594 NM_006169
NNMT
nicotinamide N-methyltransferase
chrX_+_70521627 0.592 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chrX_+_135251454 0.581 NM_001159704
FHL1
four and a half LIM domains 1
chr14_-_54955664 0.580 GMFB
glia maturation factor, beta
chr10_+_101542460 0.577 NM_000392
ABCC2
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr20_+_44441671 0.570 NM_181801
UBE2C
ubiquitin-conjugating enzyme E2C
chr3_+_133464883 0.569 NM_001063
TF
transferrin
chr15_-_76005179 0.569 NM_001897
CSPG4
chondroitin sulfate proteoglycan 4
chr17_-_80009237 0.568 RFNG
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr9_+_2621740 0.564 NM_001018056
NM_003383
VLDLR

very low density lipoprotein receptor

chrX_-_106960268 0.562 NM_004089
TSC22D3
TSC22 domain family, member 3
chr20_-_44455932 0.561 NM_003279
TNNC2
troponin C type 2 (fast)
chr1_+_78470593 0.561 NM_007034
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr19_-_39264144 0.557 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr10_+_7745284 0.554 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr15_-_90349819 0.554 ANPEP
alanyl (membrane) aminopeptidase
chr2_-_21225640 0.553 APOB
apolipoprotein B (including Ag(x) antigen)
chr20_+_59827452 0.552 NM_001794
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr7_-_137028275 0.546 PTN
pleiotrophin
chr15_-_77363519 0.546 NM_001168412
NM_005724
NM_198902
TSPAN3


tetraspanin 3


chr17_-_26697293 0.545 VTN
vitronectin
chr9_-_75568232 0.545 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr4_+_41700736 0.545 LIMCH1
LIM and calponin homology domains 1
chr6_+_129204285 0.540 NM_000426
NM_001079823
LAMA2

laminin, alpha 2


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
21.35 1.66e-03 GO:0010810 regulation of cell-substrate adhesion
6.10 2.10e-03 GO:0048646 anatomical structure formation involved in morphogenesis
30.62 3.95e-03 GO:0045861 negative regulation of proteolysis
7.67 4.07e-03 GO:0001568 blood vessel development
7.15 6.81e-03 GO:0001944 vasculature development
13.55 1.58e-02 GO:0040013 negative regulation of locomotion
9.14 2.29e-02 GO:0001525 angiogenesis
9.01 2.47e-02 GO:0030155 regulation of cell adhesion
18.90 2.80e-02 GO:0061041 regulation of wound healing
5.06 2.93e-02 GO:0072358 cardiovascular system development
5.06 2.93e-02 GO:0072359 circulatory system development
147.95 2.98e-02 GO:0010757 negative regulation of plasminogen activation
37.00 3.33e-02 GO:0010812 negative regulation of cell-substrate adhesion

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
3.99 2.01e-04 GO:0044421 extracellular region part
2.97 5.50e-04 GO:0005576 extracellular region
4.02 2.33e-03 GO:0005615 extracellular space
6.01 3.75e-03 GO:0031012 extracellular matrix

Nothing significant found in function category.