Motif ID: HES1.p2

Z-value: 2.227


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HES1chr3_+_1938539300.107.2e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_58358120 3.679 NM_001206897
NM_003888
NM_170696
ALDH1A2


aldehyde dehydrogenase 1 family, member A2


chr16_+_29817810 2.813 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr15_-_58357848 2.729 ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr7_+_155089614 2.673 INSIG1
insulin induced gene 1
chr3_-_47823419 2.545 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr7_+_106685007 2.536 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr7_-_148581379 2.229 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr21_-_46962281 2.153 NM_001205206
NM_194255
SLC19A1

solute carrier family 19 (folate transporter), member 1

chr1_-_32801606 2.051 NM_023009
MARCKSL1
MARCKS-like 1
chr21_+_35445808 2.034 NM_032476
NM_006933
MRPS6
SLC5A3
mitochondrial ribosomal protein S6
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr2_-_96811138 1.991 NM_004418
DUSP2
dual specificity phosphatase 2
chr7_+_155089483 1.960 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr5_+_612404 1.872 NM_018140
CEP72
centrosomal protein 72kDa
chr5_+_612454 1.757 CEP72
centrosomal protein 72kDa
chr15_+_50474357 1.744 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr10_-_23003443 1.676 NM_005028
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr5_+_131630065 1.643 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr22_+_19711065 1.643 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr6_+_135502477 1.642 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_-_38273852 1.598 NM_024640
YRDC
yrdC domain containing (E. coli)
chr19_+_30302861 1.594 NM_001238
CCNE1
cyclin E1
chr3_-_47823368 1.585 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chrX_-_154033729 1.565 NM_001166460
NM_001166461
NM_001166462
NM_002436
MPP1



membrane protein, palmitoylated 1, 55kDa



chr6_-_13711643 1.510 NM_005493
RANBP9
RAN binding protein 9
chr7_-_148581297 1.491 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_148581403 1.478 NM_001203247
NM_001203248
NM_004456
NM_152998
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr3_-_47823337 1.470 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr6_+_57037333 1.468 BAG2
BCL2-associated athanogene 2
chr6_-_13711484 1.437 RANBP9
RAN binding protein 9
chr5_+_75699003 1.419 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr7_-_100230676 1.415 TFR2
transferrin receptor 2
chr21_-_44495894 1.403 NM_000071
CBS
cystathionine-beta-synthase
chr7_-_148581377 1.393 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr16_+_222845 1.387 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chrX_-_109561314 1.375 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr19_-_1652327 1.364 NM_003200
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr16_+_84733606 1.357 USP10
ubiquitin specific peptidase 10
chr6_+_37137882 1.347 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr19_+_35759880 1.343 NM_003367
NM_207291
USF2

upstream transcription factor 2, c-fos interacting

chr9_+_131451519 1.331 SET
SET nuclear oncogene
chr16_+_30194730 1.321 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr19_+_1071208 1.313 HMHA1
histocompatibility (minor) HA-1
chr14_+_103243813 1.309 NM_001199427
NM_003300
NM_145725
NM_145726
TRAF3



TNF receptor-associated factor 3



chr18_+_12948010 1.290 SEH1L
SEH1-like (S. cerevisiae)
chr1_-_11120081 1.274 NM_003132
SRM
spermidine synthase
chr16_+_84733596 1.270 USP10
ubiquitin specific peptidase 10
chr1_-_38273846 1.266 YRDC
yrdC domain containing (E. coli)
chr6_+_157802479 1.265 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr7_+_100027404 1.252 MEPCE
methylphosphate capping enzyme
chr6_-_13814546 1.248 NM_001031713
CCDC90A
coiled-coil domain containing 90A
chr1_+_46713385 1.243 RAD54L
RAD54-like (S. cerevisiae)
chr7_+_100027253 1.238 NM_019606
MEPCE
methylphosphate capping enzyme
chr14_+_101193190 1.236 NM_003836
DLK1
delta-like 1 homolog (Drosophila)
chr16_+_84733611 1.227 USP10
ubiquitin specific peptidase 10
chr1_+_167189948 1.222 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr17_-_76124767 1.194 TMC6
transmembrane channel-like 6
chr16_+_2039945 1.173 NM_004209
SYNGR3
synaptogyrin 3
chr16_+_84733554 1.169 NM_005153
USP10
ubiquitin specific peptidase 10
chr14_+_101193275 1.169 DLK1
delta-like 1 homolog (Drosophila)
chr21_+_45285026 1.169 AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr19_+_35759967 1.160 USF2
upstream transcription factor 2, c-fos interacting
chr17_+_79989485 1.158 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr22_-_22221937 1.151 MAPK1
mitogen-activated protein kinase 1
chr10_-_99094427 1.148 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr3_-_47823275 1.148 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr4_+_57774035 1.144 NM_005612
REST
RE1-silencing transcription factor
chr6_-_13711952 1.136 RANBP9
RAN binding protein 9
chr17_-_40428311 1.132 STAT5B
signal transducer and activator of transcription 5B
chr1_-_53793743 1.132 NM_001018054
NM_004631
NM_017522
NM_033300
LRP8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr16_-_88717395 1.131 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr17_+_30813928 1.127 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr19_+_49622480 1.123 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr3_-_47823377 1.120 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr3_-_47823343 1.117 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr1_+_2985730 1.113 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr7_-_87505640 1.103 SLC25A40
solute carrier family 25, member 40
chr17_+_40440481 1.099 STAT5A
signal transducer and activator of transcription 5A
chrX_-_154033647 1.099 MPP1
membrane protein, palmitoylated 1, 55kDa
chr19_+_4402658 1.099 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr16_+_226678 1.095 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr11_+_65029312 1.085 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr11_+_14665268 1.075 NM_000922
PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr3_-_47823333 1.064 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr7_+_75677402 1.063 MDH2
malate dehydrogenase 2, NAD (mitochondrial)
chr3_-_47823386 1.061 NM_003074
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chrX_-_109561298 1.054 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr2_-_101034049 1.042 NM_004854
CHST10
carbohydrate sulfotransferase 10
chr4_+_57774090 1.038 REST
RE1-silencing transcription factor
chr3_-_13008959 1.037 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr22_+_29876180 1.035 NM_021076
NEFH
neurofilament, heavy polypeptide
chr1_+_23345928 1.035 NM_001009999
NM_015013
KDM1A

lysine (K)-specific demethylase 1A

chr1_-_39338976 1.033 NM_012333
MYCBP
c-myc binding protein
chr12_-_6716475 1.032 CHD4
chromodomain helicase DNA binding protein 4
chr7_+_87505543 1.024 NM_006716
DBF4
DBF4 homolog (S. cerevisiae)
chr14_+_103243832 1.014 TRAF3
TNF receptor-associated factor 3
chrX_+_102470003 1.007 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr1_+_212458867 1.004 NM_006243
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr6_+_135502521 1.001 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_+_65991357 0.999 NM_001198687
NM_001198688
NM_001198689
LEPR


leptin receptor


chr21_+_45285101 0.996 NM_020132
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr5_+_118691549 0.996 NM_014350
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chrX_-_48776282 0.995 NM_006875
PIM2
pim-2 oncogene
chr16_+_85646923 0.985 NM_014615
KIAA0182
KIAA0182
chr1_+_65991390 0.983 LEPR
leptin receptor
chrX_-_3631654 0.980 NM_005044
PRKX
protein kinase, X-linked
chr16_+_15489586 0.975 NM_001128423
NM_173803
MPV17L

MPV17 mitochondrial membrane protein-like

chr1_+_227127937 0.974 NM_020247
ADCK3
aarF domain containing kinase 3
chr6_+_36410800 0.973 KCTD20
potassium channel tetramerisation domain containing 20
chr19_-_10613767 0.973 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chrX_-_154033696 0.972 MPP1
membrane protein, palmitoylated 1, 55kDa
chr3_-_50649080 0.967 CISH
cytokine inducible SH2-containing protein
chr5_-_79950783 0.967 NM_000791
DHFR
dihydrofolate reductase
chr1_+_23345985 0.966 KDM1A
lysine (K)-specific demethylase 1A
chr3_-_50540853 0.958 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr15_+_41786055 0.953 NM_002220
ITPKA
inositol-trisphosphate 3-kinase A
chr21_+_33031932 0.943 NM_000454
SOD1
superoxide dismutase 1, soluble
chr19_-_55972935 0.941 ISOC2
isochorismatase domain containing 2
chr8_+_61591239 0.939 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr19_+_33072087 0.937 NM_004708
PDCD5
programmed cell death 5
chr1_+_25757381 0.933 NM_018202
TMEM57
transmembrane protein 57
chr7_-_994259 0.931 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr5_+_149546340 0.928 NM_001804
CDX1
caudal type homeobox 1
chr2_-_10588451 0.928 NM_002539
ODC1
ornithine decarboxylase 1
chr19_-_13068008 0.926 GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr8_+_56792399 0.924 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr1_+_10092990 0.924 NM_001105562
NM_006048
UBE4B

ubiquitination factor E4B

chr17_-_3867585 0.923 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr19_-_13068033 0.922 NM_052850
GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr9_+_131451847 0.913 SET
SET nuclear oncogene
chr1_+_227127959 0.913 ADCK3
aarF domain containing kinase 3
chr17_-_79980685 0.912 NM_144998
STRA13
stimulated by retinoic acid 13 homolog (mouse)
chr5_+_68665123 0.908 NM_133343
RAD17
RAD17 homolog (S. pombe)
chr22_+_21771661 0.908 NM_015094
HIC2
hypermethylated in cancer 2
chr5_+_95067511 0.906


chr18_-_12377248 0.906 NM_006796
AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr9_+_135545389 0.901 GTF3C4
general transcription factor IIIC, polypeptide 4, 90kDa
chr1_+_91966653 0.895 NM_001134420
CDC7
cell division cycle 7 homolog (S. cerevisiae)
chrX_-_137793826 0.879 NM_004114
FGF13
fibroblast growth factor 13
chr15_-_38856830 0.879 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

chr16_-_4401265 0.879 NM_016069
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr1_+_91966365 0.879 NM_001134419
NM_003503
CDC7

cell division cycle 7 homolog (S. cerevisiae)

chr10_-_23003036 0.879 PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr20_+_55966440 0.874 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr12_-_108954952 0.873 SART3
squamous cell carcinoma antigen recognized by T cells 3
chr10_-_43892697 0.873 NM_001098207
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr16_+_81040515 0.872 CENPN
centromere protein N
chr5_+_70883179 0.872 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr16_+_15489619 0.872 MPV17L
MPV17 mitochondrial membrane protein-like
chr22_-_20104428 0.868 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr20_-_30795346 0.867 NM_002657
PLAGL2
pleiomorphic adenoma gene-like 2
chr6_+_36410543 0.864 NM_173562
KCTD20
potassium channel tetramerisation domain containing 20
chr9_+_4985082 0.864 JAK2
Janus kinase 2
chr1_+_227127993 0.860 ADCK3
aarF domain containing kinase 3
chr3_-_38071030 0.856 NM_006225
PLCD1
phospholipase C, delta 1
chr22_+_19701968 0.856 NM_002688
SEPT5
septin 5
chr19_-_9731883 0.851 NM_152289
ZNF561
zinc finger protein 561
chr12_-_108954942 0.844 SART3
squamous cell carcinoma antigen recognized by T cells 3
chr12_+_93771607 0.837 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr7_+_99775346 0.836 STAG3
stromal antigen 3
chr1_-_53793583 0.835 LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr6_+_135502445 0.832 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr12_-_6716550 0.831 NM_001273
CHD4
chromodomain helicase DNA binding protein 4
chr1_+_182808481 0.826 DHX9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr2_-_172750724 0.824 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr7_-_65447233 0.820 NM_000181
GUSB
glucuronidase, beta
chr1_-_161147209 0.819 B4GALT3
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr18_-_23670533 0.812 NM_001007559
NM_005637
SS18

synovial sarcoma translocation, chromosome 18

chr17_+_73257992 0.812 MRPS7
mitochondrial ribosomal protein S7
chr1_-_11120047 0.812 SRM
spermidine synthase
chr2_-_27435014 0.811 NM_021095
SLC5A6
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
chr17_+_73257944 0.807 MRPS7
mitochondrial ribosomal protein S7
chr11_-_32452358 0.805 NM_001198551
NM_001198552
WT1

Wilms tumor 1

chr1_-_220101925 0.805 NM_018713
SLC30A10
solute carrier family 30, member 10
chr10_+_30722856 0.804 NM_001244134
NM_005204
MAP3K8

mitogen-activated protein kinase kinase kinase 8

chr17_+_73257745 0.800 NM_015971
MRPS7
mitochondrial ribosomal protein S7
chr18_+_2655885 0.800 NM_015295
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr19_-_8373157 0.798 NM_001165895
NM_016579
CD320

CD320 molecule

chr7_-_87505667 0.797 NM_018843
SLC25A40
solute carrier family 25, member 40
chr7_-_99698278 0.796 NM_182776
MCM7
minichromosome maintenance complex component 7
chr1_+_227127999 0.796 ADCK3
aarF domain containing kinase 3
chr7_-_148581359 0.795 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr9_-_131790434 0.794 NM_020145
SH3GLB2
SH3-domain GRB2-like endophilin B2
chr5_+_118691692 0.794 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr12_-_108954929 0.793 SART3
squamous cell carcinoma antigen recognized by T cells 3
chr3_-_13461802 0.792 NM_024923
NUP210
nucleoporin 210kDa
chr6_+_20404033 0.788 NM_001243076
E2F3
E2F transcription factor 3
chr6_+_57037058 0.785 NM_004282
BAG2
BCL2-associated athanogene 2
chr1_-_38273683 0.785 YRDC
yrdC domain containing (E. coli)
chr10_+_16478941 0.783 NM_001001484
NM_030664
PTER

phosphotriesterase related

chr1_+_11751778 0.782 NM_198545
C1orf187
chromosome 1 open reading frame 187
chr6_+_10747991 0.782 NM_001127711
NM_030969
TMEM14B

transmembrane protein 14B

chr4_+_108910869 0.778 NM_001184705
NM_005327
HADH

hydroxyacyl-CoA dehydrogenase

chrX_+_49326599 0.778 NM_001098405
GAGE12F
GAGE4
GAGE5
GAGE7
GAGE12E
G antigen 12F
G antigen 4
G antigen 5
G antigen 7
G antigen 12E
chr1_+_12040475 0.777 MFN2
mitofusin 2
chr4_-_2965147 0.776 NOP14
NOP14 nucleolar protein homolog (yeast)
chr16_-_47007567 0.775 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr9_-_139981102 0.775 LOC100289341
uncharacterized LOC100289341
chr18_-_12377168 0.774 AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr11_+_747428 0.772 NM_006755
TALDO1
transaldolase 1
chr19_+_10982244 0.771 NM_199141
CARM1
coactivator-associated arginine methyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.61 4.50e-03 GO:0050878 regulation of body fluid levels
186.01 1.69e-02 GO:0046544 development of secondary male sexual characteristics
37.21 3.74e-02 GO:0043029 T cell homeostasis

Nothing significant found in compartment category.

Nothing significant found in function category.