Motif ID: HIC1.p2

Z-value: 3.904


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512
0.185.0e-01Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_101980736 11.385 NM_001130145
NM_001195044
NM_006106
YAP1


Yes-associated protein 1


chr2_-_224903933 11.121 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr1_-_85930610 10.105 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr2_-_224903324 9.698 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr2_+_235860616 8.583 NM_014521
SH3BP4
SH3-domain binding protein 4
chr1_-_85930733 7.605 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_-_95392449 7.471 CNN3
calponin 3, acidic
chr13_-_110959441 7.397 NM_001845
COL4A1
collagen, type IV, alpha 1
chr13_+_98795710 6.811 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr8_+_26435339 6.665 NM_001386
DPYSL2
dihydropyrimidinase-like 2
chr10_+_124134206 6.530 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr11_-_12030838 6.510 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr1_-_94702916 6.484 ARHGAP29
Rho GTPase activating protein 29
chr13_+_110959592 6.477 NM_001846
COL4A2
collagen, type IV, alpha 2
chr16_-_4166021 6.347 ADCY9
adenylate cyclase 9
chr11_-_12030882 6.287 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr2_-_1748240 5.898 PXDN
peroxidasin homolog (Drosophila)
chr13_+_98795468 5.864 FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr2_-_161349874 5.688 RBMS1
RNA binding motif, single stranded interacting protein 1
chr16_+_31483066 5.470 NM_001042454
NM_001164719
TGFB1I1

transforming growth factor beta 1 induced transcript 1

chr2_+_9346909 5.426 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr11_-_12030539 5.387 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr14_+_55595966 5.286 LGALS3
lectin, galactoside-binding, soluble, 3
chr4_-_177713664 5.274 NM_005429
VEGFC
vascular endothelial growth factor C
chr11_-_12030622 5.223 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr8_-_119123804 5.190 NM_000127
EXT1
exostosin 1
chr10_-_15413054 5.185 NM_001010924
FAM171A1
family with sequence similarity 171, member A1
chr13_+_27131799 5.122 NM_006646
WASF3
WAS protein family, member 3
chr3_-_185542807 5.099 NM_001007225
NM_006548
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr17_-_76921205 4.994 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_-_20812727 4.919 NM_018584
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chrX_+_135229536 4.904 NM_001159702
NM_001159703
NM_001449
FHL1


four and a half LIM domains 1


chr14_+_55595932 4.902 NM_001177388
NM_002306
LGALS3

lectin, galactoside-binding, soluble, 3

chr4_-_22517339 4.836 NM_145290
GPR125
G protein-coupled receptor 125
chr17_-_76921453 4.711 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr2_+_102314162 4.709 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr21_+_42540054 4.694 BACE2
beta-site APP-cleaving enzyme 2
chr2_+_9346876 4.619 NM_001135191
NM_003887
ASAP2

ArfGAP with SH3 domain, ankyrin repeat and PH domain 2

chr7_+_130131921 4.515 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr8_-_41166931 4.470 NM_003012
SFRP1
secreted frizzled-related protein 1
chr3_-_149688638 4.459 NM_002628
NM_053024
PFN2

profilin 2

chr2_+_46524448 4.298 NM_001430
EPAS1
endothelial PAS domain protein 1
chr12_-_106641675 4.260 NM_006825
CKAP4
cytoskeleton-associated protein 4
chr17_-_76921076 4.253 TIMP2
TIMP metallopeptidase inhibitor 2
chr3_-_145878936 4.250 PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chrX_+_9983793 4.205 NM_015691
WWC3
WWC family member 3
chr1_+_182992329 4.177 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr13_-_40177304 4.175 LHFP
lipoma HMGIC fusion partner
chr1_-_225840660 4.128 NM_001008493
NM_018212
ENAH

enabled homolog (Drosophila)

chr15_+_101420032 4.128 ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr10_-_13341745 4.114 NM_001037537
PHYH
phytanoyl-CoA 2-hydroxylase
chr9_-_88714486 4.104 NM_016548
GOLM1
golgi membrane protein 1
chr9_-_88714395 4.067 GOLM1
golgi membrane protein 1
chr11_+_86511490 4.052 NM_007173
PRSS23
protease, serine, 23
chr7_-_24797031 4.049 DFNA5
deafness, autosomal dominant 5
chr9_-_13279562 4.045 MPDZ
multiple PDZ domain protein
chr5_+_92920592 4.031 NR2F1
NR2F2
nuclear receptor subfamily 2, group F, member 1
nuclear receptor subfamily 2, group F, member 2
chr14_+_105941061 4.027 NM_001312
CRIP2
cysteine-rich protein 2
chr8_+_22436641 4.007 PDLIM2
PDZ and LIM domain 2 (mystique)
chr1_-_94703252 3.994 NM_004815
ARHGAP29
Rho GTPase activating protein 29
chr2_-_1748285 3.933 NM_012293
PXDN
peroxidasin homolog (Drosophila)
chr12_-_124457099 3.884 NM_025140
CCDC92
coiled-coil domain containing 92
chr1_+_19970674 3.848 NM_005380
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr7_-_24797052 3.796 NM_001127453
DFNA5
deafness, autosomal dominant 5
chr8_-_11725595 3.701 CTSB
cathepsin B
chr10_+_124220990 3.683 NM_002775
HTRA1
HtrA serine peptidase 1
chr5_-_16936371 3.650 NM_012334
MYO10
myosin X
chr15_+_101420004 3.620 NM_000693
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr21_+_46825291 3.605


chr10_+_124134093 3.530 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr5_+_76114832 3.507 NM_005242
F2RL1
coagulation factor II (thrombin) receptor-like 1
chr6_+_71998514 3.453 OGFRL1
opioid growth factor receptor-like 1
chr9_+_124030413 3.448 GSN
gelsolin
chr20_+_4666796 3.443 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr17_-_74707066 3.440 MXRA7
matrix-remodelling associated 7
chr21_+_46825001 3.437 NM_130445
COL18A1
collagen, type XVIII, alpha 1
chr3_-_124605840 3.437 ITGB5
integrin, beta 5
chr6_+_7541837 3.421 DSP
desmoplakin
chr12_+_66218141 3.416 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr2_-_113191106 3.361 NM_001164463
NM_005054
RGPD8
RGPD5
RANBP2-like and GRIP domain containing 8
RANBP2-like and GRIP domain containing 5
chr2_-_235405692 3.323 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr9_+_124030455 3.318 GSN
gelsolin
chr21_+_42540092 3.308 BACE2
beta-site APP-cleaving enzyme 2
chr13_+_48807492 3.305 ITM2B
integral membrane protein 2B
chr9_+_123963728 3.283 GSN
gelsolin
chr4_-_52904424 3.270 NM_000232
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr18_-_21977711 3.252 OSBPL1A
oxysterol binding protein-like 1A
chr16_-_4166185 3.221 NM_001116
ADCY9
adenylate cyclase 9
chr7_-_24797316 3.219 DFNA5
deafness, autosomal dominant 5
chr7_-_151329153 3.199 NM_024429
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr6_+_7541863 3.199 NM_001008844
NM_004415
DSP

desmoplakin

chr5_-_57755787 3.190 NM_001252226
NM_006622
PLK2

polo-like kinase 2

chr8_+_26435466 3.180 DPYSL2
dihydropyrimidinase-like 2
chr6_+_71998476 3.148 NM_024576
OGFRL1
opioid growth factor receptor-like 1
chr22_+_33197678 3.137 TIMP3
TIMP metallopeptidase inhibitor 3
chr9_+_124030370 3.123 NM_001127662
NM_001127663
NM_001127664
NM_001127665
NM_001127666
NM_001127667
NM_198252
GSN






gelsolin






chr10_-_126849010 3.122 CTBP2
C-terminal binding protein 2
chr22_+_33197744 3.113 TIMP3
TIMP metallopeptidase inhibitor 3
chr21_+_18885104 3.113 NM_001207063
NM_001207064
NM_001207065
NM_001207066
NM_001338
CXADR




coxsackie virus and adenovirus receptor




chr6_-_132272311 3.080 NM_001901
CTGF
connective tissue growth factor
chr14_+_105331581 3.023 NM_001112726
NM_015005
KIAA0284

KIAA0284

chr2_-_56150862 3.021 EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr1_+_99127146 3.016 NM_015976
NM_152238
SNX7

sorting nexin 7

chr17_-_62657997 3.004 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr5_-_122372413 2.981 NM_000943
PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr7_+_130131172 2.943 NM_177525
MEST
mesoderm specific transcript homolog (mouse)
chr18_-_25757351 2.942 NM_001792
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr4_-_57976355 2.938 IGFBP7
insulin-like growth factor binding protein 7
chr9_-_88714460 2.933 GOLM1
golgi membrane protein 1
chr13_-_114566951 2.893 GAS6
growth arrest-specific 6
chr20_-_50384899 2.892 NM_006045
ATP9A
ATPase, class II, type 9A
chr8_-_27472188 2.870 CLU
clusterin
chr5_-_122372320 2.865 PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr19_+_33685489 2.831 NM_002333
LRP3
low density lipoprotein receptor-related protein 3
chr13_+_27131879 2.829 WASF3
WAS protein family, member 3
chr21_+_18885296 2.827 CXADR
coxsackie virus and adenovirus receptor
chr2_-_1748317 2.826 PXDN
peroxidasin homolog (Drosophila)
chr3_+_50192420 2.825 SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr5_+_76011780 2.808 NM_001992
F2R
coagulation factor II (thrombin) receptor
chr7_-_30029284 2.749 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr8_-_27472298 2.744 NM_001831
CLU
clusterin
chr8_-_48650683 2.736 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr8_-_48650703 2.713 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr12_+_6309475 2.700 NM_001769
CD9
CD9 molecule
chr20_+_48807365 2.695 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr1_-_57044980 2.691 PPAP2B
phosphatidic acid phosphatase type 2B
chr3_-_145968819 2.678 PLSCR4
phospholipid scramblase 4
chr1_+_86046434 2.677 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr6_+_71998508 2.669 OGFRL1
opioid growth factor receptor-like 1
chr11_+_129939807 2.656 APLP2
amyloid beta (A4) precursor-like protein 2
chr3_-_127541975 2.644 NM_001003794
MGLL
monoglyceride lipase
chr1_-_236228382 2.617 NID1
nidogen 1
chr2_-_99347430 2.593 MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr18_+_21269528 2.589 NM_001127717
NM_198129
LAMA3

laminin, alpha 3

chr15_-_23086290 2.588 NM_144599
NIPA1
non imprinted in Prader-Willi/Angelman syndrome 1
chr3_-_149688886 2.585 PFN2
profilin 2
chr21_+_42539727 2.558 NM_012105
NM_138991
NM_138992
BACE2


beta-site APP-cleaving enzyme 2


chr22_+_38598065 2.543 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr19_+_33685140 2.537 LRP3
low density lipoprotein receptor-related protein 3
chr15_-_83953465 2.527 NM_001717
BNC1
basonuclin 1
chr5_-_146889618 2.523 NM_001197294
DPYSL3
dihydropyrimidinase-like 3
chr14_-_105444693 2.521 NM_138420
AHNAK2
AHNAK nucleoprotein 2
chr3_-_145879222 2.519 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr3_-_129325175 2.518 NM_015103
PLXND1
plexin D1
chr2_-_165697927 2.511 NM_014900
COBLL1
COBL-like 1
chr13_+_98795410 2.487 NM_001001715
NM_005766
FARP1

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

chr13_-_114567040 2.467 NM_000820
GAS6
growth arrest-specific 6
chr5_+_76114881 2.460 F2RL1
coagulation factor II (thrombin) receptor-like 1
chr1_-_95392501 2.459 NM_001839
CNN3
calponin 3, acidic
chr13_-_40177200 2.449 LHFP
lipoma HMGIC fusion partner
chr12_+_66218879 2.447 HMGA2
high mobility group AT-hook 2
chr19_-_4400470 2.446 NM_001199943
NM_003025
SH3GL1

SH3-domain GRB2-like 1

chr3_-_185542744 2.446 IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr7_+_79764087 2.422 NM_002069
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr16_-_15149827 2.417 NM_173474
NTAN1
N-terminal asparagine amidase
chr5_+_52776408 2.413 FST
follistatin
chr12_-_110318178 2.395 NM_016433
GLTP
glycolipid transfer protein
chr9_-_139940556 2.394 NPDC1
neural proliferation, differentiation and control, 1
chr14_+_65171149 2.385 NM_015549
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr15_+_96873845 2.383 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr11_+_129939792 2.372 APLP2
amyloid beta (A4) precursor-like protein 2
chr4_-_7941092 2.357 NM_001134647
NM_198595
AFAP1

actin filament associated protein 1

chr19_+_15218141 2.352 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr3_-_145968958 2.348 NM_001128306
NM_001177304
NM_020353
PLSCR4


phospholipid scramblase 4


chr1_+_182992694 2.340


chr13_-_40177355 2.335 NM_005780
LHFP
lipoma HMGIC fusion partner
chr11_+_69455978 2.327 CCND1
cyclin D1
chr6_+_107811272 2.326 NM_018013
SOBP
sine oculis binding protein homolog (Drosophila)
chr19_+_16187306 2.324 TPM4
tropomyosin 4
chr11_-_2950593 2.319 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr10_+_120863626 2.315 FAM45A
FAM45B
family with sequence similarity 45, member A
family with sequence similarity 45, member A pseudogene
chr10_-_17659365 2.313 NM_014241
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr7_-_122526781 2.298 NM_001009571
NM_001167940
NM_017954
CADPS2


Ca++-dependent secretion activator 2


chr12_-_80084023 2.290 PAWR
PRKC, apoptosis, WT1, regulator
chr3_+_57994087 2.290 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr17_-_882905 2.283 NM_022463
NXN
nucleoredoxin
chr18_-_5630629 2.280 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr20_+_11871364 2.280 NM_181443
BTBD3
BTB (POZ) domain containing 3
chr2_-_242447449 2.239 STK25
serine/threonine kinase 25
chr11_+_129940462 2.223 NM_001243299
APLP2
amyloid beta (A4) precursor-like protein 2
chr1_-_43919345 2.220 HYI
hydroxypyruvate isomerase (putative)
chr8_-_11725587 2.220 CTSB
cathepsin B
chr5_-_55290601 2.196 NM_001190981
NM_002184
NM_175767
IL6ST


interleukin 6 signal transducer (gp130, oncostatin M receptor)


chr1_+_223900212 2.192 CAPN2
calpain 2, (m/II) large subunit
chr10_+_126150340 2.183 NM_001167880
NM_022126
LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr16_-_10674443 2.180 NM_001424
EMP2
epithelial membrane protein 2
chr5_+_52776479 2.178 FST
follistatin
chr15_-_23378217 2.174 HERC2P2
hect domain and RLD 2 pseudogene 2
chr8_+_27491460 2.171 NM_016240
NM_182826
SCARA3

scavenger receptor class A, member 3

chr19_+_16187315 2.163 TPM4
tropomyosin 4
chr1_-_236228476 2.138 NM_002508
NID1
nidogen 1
chr1_+_223900226 2.126 CAPN2
calpain 2, (m/II) large subunit
chr13_-_114567011 2.117 GAS6
growth arrest-specific 6
chr14_-_52535711 2.116 NID2
nidogen 2 (osteonidogen)
chr10_-_91011586 2.114 NM_000235
NM_001127605
LIPA

lipase A, lysosomal acid, cholesterol esterase

chr14_+_85999464 2.107


chr10_+_120863610 2.102 NM_207009
FAM45A
family with sequence similarity 45, member A
chr8_-_11725509 2.102 CTSB
cathepsin B
chr18_-_21977785 2.090 NM_080597
OSBPL1A
oxysterol binding protein-like 1A
chr14_+_105155724 2.077 NM_001031714
NM_022489
NM_032714
INF2


inverted formin, FH2 and WH2 domain containing



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.54 4.52e-13 GO:0009653 anatomical structure morphogenesis
1.92 7.37e-11 GO:0048731 system development
1.81 8.54e-10 GO:0048856 anatomical structure development
1.68 1.32e-08 GO:0032502 developmental process
1.72 2.39e-08 GO:0007275 multicellular organismal development
3.07 4.33e-08 GO:0032989 cellular component morphogenesis
2.63 7.34e-08 GO:0022008 neurogenesis
2.69 7.75e-08 GO:0048699 generation of neurons
1.99 7.99e-08 GO:0048869 cellular developmental process
3.09 1.04e-07 GO:0000902 cell morphogenesis
2.00 1.12e-07 GO:0030154 cell differentiation
3.27 1.66e-07 GO:0000904 cell morphogenesis involved in differentiation
3.70 9.18e-07 GO:0007411 axon guidance
2.54 1.03e-06 GO:0040011 locomotion
3.11 2.19e-06 GO:0048858 cell projection morphogenesis
3.32 2.20e-06 GO:0007409 axonogenesis
3.08 2.86e-06 GO:0032990 cell part morphogenesis
2.09 3.51e-06 GO:0007399 nervous system development
1.48 4.17e-06 GO:0032501 multicellular organismal process
3.20 5.55e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
3.15 7.83e-06 GO:0048812 neuron projection morphogenesis
2.70 2.33e-05 GO:0030030 cell projection organization
2.04 3.55e-05 GO:0009966 regulation of signal transduction
2.85 3.66e-05 GO:0006935 chemotaxis
2.85 3.66e-05 GO:0042330 taxis
1.94 5.76e-05 GO:0023051 regulation of signaling
5.34 6.73e-05 GO:0010769 regulation of cell morphogenesis involved in differentiation
2.89 6.86e-05 GO:0031175 neuron projection development
5.29 7.73e-05 GO:0022604 regulation of cell morphogenesis
3.46 9.93e-05 GO:0060284 regulation of cell development
1.82 1.40e-04 GO:0048583 regulation of response to stimulus
3.38 2.93e-04 GO:0001944 vasculature development
3.48 3.19e-04 GO:0001568 blood vessel development
2.23 3.62e-04 GO:0048468 cell development
1.79 3.71e-04 GO:0048513 organ development
3.68 4.18e-04 GO:0050767 regulation of neurogenesis
2.75 5.46e-04 GO:0072358 cardiovascular system development
2.75 5.46e-04 GO:0072359 circulatory system development
2.27 6.00e-04 GO:0051128 regulation of cellular component organization
1.96 7.40e-04 GO:0051239 regulation of multicellular organismal process
3.43 7.50e-04 GO:0051960 regulation of nervous system development
2.31 1.06e-03 GO:2000026 regulation of multicellular organismal development
4.25 1.68e-03 GO:0043062 extracellular structure organization
2.50 1.90e-03 GO:0048666 neuron development
1.33 2.85e-03 GO:0050896 response to stimulus
4.95 3.06e-03 GO:0010720 positive regulation of cell development
2.33 3.20e-03 GO:0045595 regulation of cell differentiation
3.11 3.88e-03 GO:0040012 regulation of locomotion
2.46 4.05e-03 GO:0006928 cellular component movement
2.24 4.37e-03 GO:0007155 cell adhesion
2.24 4.37e-03 GO:0022610 biological adhesion
2.02 4.48e-03 GO:0009605 response to external stimulus
2.15 4.66e-03 GO:0009888 tissue development
2.29 4.67e-03 GO:0030182 neuron differentiation
3.61 7.55e-03 GO:0045664 regulation of neuron differentiation
4.89 8.69e-03 GO:0030198 extracellular matrix organization
2.05 9.24e-03 GO:0050793 regulation of developmental process
1.59 9.62e-03 GO:0042221 response to chemical stimulus
2.83 1.13e-02 GO:0045597 positive regulation of cell differentiation
3.30 1.40e-02 GO:0048514 blood vessel morphogenesis
2.59 1.42e-02 GO:0016477 cell migration
1.45 1.46e-02 GO:0007165 signal transduction
3.04 1.61e-02 GO:0061061 muscle structure development
2.92 1.74e-02 GO:0051270 regulation of cellular component movement
4.22 1.87e-02 GO:0010975 regulation of neuron projection development
2.30 2.21e-02 GO:0009887 organ morphogenesis
1.95 2.45e-02 GO:0032879 regulation of localization
2.23 2.91e-02 GO:0042060 wound healing
2.91 4.85e-02 GO:0030334 regulation of cell migration

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
1.40 2.51e-08 GO:0016020 membrane
5.05 1.45e-06 GO:0005912 adherens junction
4.77 1.56e-06 GO:0070161 anchoring junction
1.53 1.02e-05 GO:0071944 cell periphery
7.25 1.58e-05 GO:0005604 basement membrane
3.20 2.35e-05 GO:0031012 extracellular matrix
1.52 2.74e-05 GO:0005886 plasma membrane
5.01 1.64e-04 GO:0044420 extracellular matrix part
4.85 5.97e-04 GO:0005924 cell-substrate adherens junction
1.62 8.87e-04 GO:0044459 plasma membrane part
4.65 9.61e-04 GO:0030055 cell-substrate junction
1.34 1.16e-03 GO:0044425 membrane part
2.98 1.20e-03 GO:0015629 actin cytoskeleton
2.40 1.42e-03 GO:0030054 cell junction
4.67 2.14e-03 GO:0005925 focal adhesion
2.86 5.80e-03 GO:0005578 proteinaceous extracellular matrix
1.89 6.70e-03 GO:0044421 extracellular region part
3.31 1.18e-02 GO:0031252 cell leading edge
4.24 1.29e-02 GO:0019898 extrinsic to membrane
2.48 1.40e-02 GO:0009986 cell surface
1.69 1.77e-02 GO:0005856 cytoskeleton
26.28 2.16e-02 GO:0005862 muscle thin filament tropomyosin
7.25 3.38e-02 GO:0005913 cell-cell adherens junction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
3.01 3.92e-07 GO:0008092 cytoskeletal protein binding
3.62 1.19e-06 GO:0003779 actin binding
1.23 4.56e-03 GO:0005515 protein binding
1.78 4.97e-02 GO:0005102 receptor binding