Motif ID: HLF.p2

Z-value: 1.693


Transcription factors associated with HLF.p2:

Gene SymbolEntrez IDGene Name
HLF 3131 hepatic leukemia factor

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HLFchr17_+_533423200.923.2e-07Click!


Activity profile for motif HLF.p2.

activity profile for motif HLF.p2


Sorted Z-values histogram for motif HLF.p2

Sorted Z-values for motif HLF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HLF.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_117085302 7.285 NM_000607
ORM1
orosomucoid 1
chr9_+_117092068 7.198 NM_000608
ORM2
orosomucoid 2
chr7_+_45933096 6.985


chr10_-_52645430 6.879 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr1_-_230849863 6.067 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_+_133494275 5.888 TF
transferrin
chr16_+_72088507 5.413 NM_001126102
NM_005143
HP

haptoglobin

chr1_-_230849847 5.032 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_88427535 5.000 NM_001443
FABP1
fatty acid binding protein 1, liver
chr16_-_55866972 4.821 CES1
carboxylesterase 1
chr3_+_186330844 4.740 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr16_-_55867016 4.603 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr2_+_113885137 4.497 NM_173842
IL1RN
interleukin 1 receptor antagonist
chr3_-_49726081 4.245 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr2_-_99279935 3.883 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_+_207262211 3.636 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr19_+_35773409 3.563 NM_021175
HAMP
hepcidin antimicrobial peptide
chr10_-_95360959 3.274 NM_006744
RBP4
retinol binding protein 4, plasma
chr3_+_186330859 3.214 AHSG
alpha-2-HS-glycoprotein
chr13_-_46679143 3.160 NM_001872
NM_016413
CPB2

carboxypeptidase B2 (plasma)

chr4_+_100485239 3.111 NM_000253
MTTP
microsomal triglyceride transfer protein
chr16_+_72097124 2.954 NM_020995
HPR
haptoglobin-related protein
chr4_+_155484131 2.748 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr2_+_113885145 2.716 IL1RN
interleukin 1 receptor antagonist
chr16_+_57406398 2.715 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr6_+_131894343 2.608 NM_000045
NM_001244438
ARG1

arginase, liver

chr18_+_55888799 2.568 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr17_-_41623246 2.457 NM_001986
ETV4
ets variant 4
chr3_-_120400957 2.442 HGD
homogentisate 1,2-dioxygenase
chr18_+_55888750 2.421 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr6_+_31895201 2.368 NM_000063
NM_001145903
C2

complement component 2

chr10_-_116444374 2.357 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr3_+_186330711 2.206 AHSG
alpha-2-HS-glycoprotein
chr17_-_34328607 2.194 CCL14-CCL15
CCL14-CCL15 readthrough
chr10_-_116444112 2.151 ABLIM1
actin binding LIM protein 1
chr3_-_12586962 2.085 NM_001195279
LOC100129480
uncharacterized LOC100129480
chr4_+_74269971 2.029 NM_000477
ALB
albumin
chr9_+_103947316 2.012 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr18_+_55816546 1.976 NM_001144965
NM_001144968
NM_001144969
NM_001144971
NEDD4L



neural precursor cell expressed, developmentally down-regulated 4-like



chr17_-_34328530 1.963 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr17_-_34329083 1.959 NM_032965
CCL15
chemokine (C-C motif) ligand 15
chr17_-_64225496 1.951 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr14_+_24563369 1.894 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr11_-_18258383 1.839 NM_006512
SAA4
serum amyloid A4, constitutive
chr15_-_42840910 1.836 LRRC57
leucine rich repeat containing 57
chr17_-_39092714 1.796 KRT23
keratin 23 (histone deacetylase inducible)
chr8_+_40010986 1.760 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr4_+_69962191 1.742 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr5_+_150399980 1.688 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr10_+_114133775 1.675 ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_+_31895401 1.650 C2
complement component 2
chr10_-_82049178 1.648 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr1_-_230850335 1.593 NM_000029
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr20_+_36011936 1.559 SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
chr22_+_24979717 1.553 NM_013430
GGT1
gamma-glutamyltransferase 1
chr10_+_124151818 1.537 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr18_+_55888838 1.503 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr8_+_124194751 1.440 NM_032899
NM_207006
FAM83A

family with sequence similarity 83, member A

chr2_-_114514196 1.373 NM_025181
SLC35F5
solute carrier family 35, member F5
chr7_+_129847699 1.351 NM_145268
C7orf45
chromosome 7 open reading frame 45
chr12_-_123201319 1.325 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr4_+_71062241 1.292 NM_017855
ODAM
odontogenic, ameloblast asssociated
chr16_-_4588738 1.269 NM_001199055
NM_001199056
NM_013399
C16orf5


chromosome 16 open reading frame 5


chr2_+_228678556 1.268 NM_001130046
NM_004591
CCL20

chemokine (C-C motif) ligand 20

chr9_-_94186140 1.259 NM_005384
NFIL3
nuclear factor, interleukin 3 regulated
chr22_+_25003610 1.251 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr19_+_45417920 1.236 NM_001645
APOC1
apolipoprotein C-I
chr4_-_110723334 1.189 NM_000204
CFI
complement factor I
chr12_-_8043743 1.185 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr1_+_150954498 1.182 NM_003568
ANXA9
annexin A9
chr3_+_142342265 1.176 NM_002670
PLS1
plastin 1
chr6_+_144612872 1.161 NM_007124
UTRN
utrophin
chr19_+_45418063 1.154 APOC1
apolipoprotein C-I
chr4_+_187187342 1.147 F11
coagulation factor XI
chr3_-_170744458 1.119 SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr9_-_130712866 1.115 NM_203305
FAM102A
family with sequence similarity 102, member A
chr20_-_3154169 1.060 ProSAPiP1
ProSAPiP1 protein
chr1_+_229440128 1.042 NM_006542
SPHAR
S-phase response (cyclin related)
chr3_-_99594915 1.041 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr9_+_71819926 1.036 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr7_+_94297448 1.029 PEG10
paternally expressed 10
chr18_+_77866914 1.022 NM_014913
ADNP2
ADNP homeobox 2
chr15_+_42840991 1.019 NM_001130447
NM_018097
HAUS2

HAUS augmin-like complex, subunit 2

chr15_-_42840992 0.980 NM_153260
LRRC57
leucine rich repeat containing 57
chr11_-_66675334 0.969 NM_022172
PC
pyruvate carboxylase
chr4_-_23891608 0.930 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr3_+_122044010 0.928 NM_005213
CSTA
cystatin A (stefin A)
chr3_+_119501556 0.926 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr19_-_460995 0.913 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr14_-_20801427 0.882 NM_021178
NM_182849
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr19_+_45971249 0.881 NM_001114171
NM_006732
FOSB

FBJ murine osteosarcoma viral oncogene homolog B

chr12_-_123187842 0.864 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr16_+_3507956 0.843 NM_001083600
NM_024845
NAA60

N(alpha)-acetyltransferase 60, NatF catalytic subunit

chr10_+_114133838 0.836 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr6_-_133035180 0.814 NM_004666
VNN1
vanin 1
chrX_-_131547536 0.804 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr10_-_101190201 0.798 NM_002079
GOT1
glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)
chr9_-_99382073 0.795 NM_003671
NM_033331
CDC14B

CDC14 cell division cycle 14 homolog B (S. cerevisiae)

chr8_+_117778741 0.794 NM_032334
UTP23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr19_+_33864574 0.791 NM_001806
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr7_+_20655244 0.787 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr3_+_124303505 0.783 NM_007064
KALRN
kalirin, RhoGEF kinase
chr11_-_70672644 0.774 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr5_+_150400132 0.770 GPX3
glutathione peroxidase 3 (plasma)
chr4_-_74088773 0.768 ANKRD17
ankyrin repeat domain 17
chr17_-_56494930 0.767 NM_017763
RNF43
ring finger protein 43
chr3_-_148939784 0.757 NM_000096
CP
ceruloplasmin (ferroxidase)
chr16_+_31711914 0.744 KIAA0664L3
KIAA0664-like 3
chr3_+_169684549 0.731 NM_003262
SEC62
SEC62 homolog (S. cerevisiae)
chr8_-_145115565 0.727 NM_017570
OPLAH
5-oxoprolinase (ATP-hydrolysing)
chr17_-_71308118 0.727 NM_012121
CDC42EP4
CDC42 effector protein (Rho GTPase binding) 4
chr7_+_143880547 0.721 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr18_+_77867145 0.714 ADNP2
ADNP homeobox 2
chr5_-_147211141 0.713 SPINK1
serine peptidase inhibitor, Kazal type 1
chr19_-_2042022 0.703 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr11_-_70507911 0.683 NM_133266
SHANK2
SH3 and multiple ankyrin repeat domains 2
chr1_+_168148215 0.682 TIPRL
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr4_-_110723127 0.669 CFI
complement factor I
chr2_-_73869493 0.669 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr17_-_7155258 0.657 NM_015343
CTDNEP1
CTD nuclear envelope phosphatase 1
chr6_-_41702734 0.656 NM_007162
TFEB
transcription factor EB
chr6_-_30043547 0.655 NM_170769
NM_025236
RNF39

ring finger protein 39

chrM_+_1670 0.644


chrX_+_43514157 0.643 MAOA
monoamine oxidase A
chr7_-_143966380 0.630 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr10_+_5238756 0.629 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr21_-_43187197 0.602 NM_020639
RIPK4
receptor-interacting serine-threonine kinase 4
chr2_+_201756639 0.599 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr14_+_68086655 0.599 ARG2
arginase, type II
chr6_-_132032156 0.599 NM_001145659
CTAGE9
CTAGE family, member 9
chr5_-_32388595 0.598 ZFR
zinc finger RNA binding protein
chr16_+_31128973 0.596 NM_032188
NM_182958
KAT8

K(lysine) acetyltransferase 8

chr13_-_75901897 0.588 TBC1D4
TBC1 domain family, member 4
chr16_+_31711926 0.587 KIAA0664L3
KIAA0664-like 3
chr21_-_43786602 0.587 NM_003225
TFF1
trefoil factor 1
chr19_-_4540078 0.585 LRG1
leucine-rich alpha-2-glycoprotein 1
chr19_+_13056671 0.578 RAD23A
RAD23 homolog A (S. cerevisiae)
chr21_+_45079375 0.575 NM_015056
RRP1B
ribosomal RNA processing 1 homolog B (S. cerevisiae)
chr12_+_57623355 0.573 NM_001166356
NM_005412
SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

chr1_+_241695433 0.573 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr2_-_239197091 0.569 NM_022817
PER2
period homolog 2 (Drosophila)
chr14_+_103388992 0.565 NM_030943
AMN
amnionless homolog (mouse)
chr17_-_26941178 0.552 NM_001174103
SGK494
uncharacterized serine/threonine-protein kinase SgK494
chr12_-_28124915 0.546 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr11_+_43665772 0.546


chr19_-_47617008 0.544 NM_015168
ZC3H4
zinc finger CCCH-type containing 4
chr19_+_13056607 0.538 NM_005053
RAD23A
RAD23 homolog A (S. cerevisiae)
chr3_+_142375738 0.537 NM_001172312
PLS1
plastin 1
chr1_+_212738675 0.532 NM_001030287
ATF3
activating transcription factor 3
chr17_-_61850953 0.525 NM_020198
CCDC47
coiled-coil domain containing 47
chr11_+_62104773 0.523 NM_001083926
NM_025080
ASRGL1

asparaginase like 1

chr5_+_6746100 0.515 NM_001171806
PAPD7
PAP associated domain containing 7
chr6_+_32939974 0.515 BRD2
bromodomain containing 2
chr5_-_42811959 0.515 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr17_+_41322413 0.514 NM_031862
NM_031858
NBR1

neighbor of BRCA1 gene 1

chr16_-_30457197 0.511 NM_012248
SEPHS2
selenophosphate synthetase 2
chr12_+_57623827 0.503 NM_001166358
NM_001166359
NM_001166357
SHMT2


serine hydroxymethyltransferase 2 (mitochondrial)


chr17_-_4607414 0.497 PELP1
proline, glutamate and leucine rich protein 1
chr4_-_153273683 0.491 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr6_-_2840683 0.489 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr3_+_186435097 0.484 NM_000893
NM_001102416
NM_001166451
KNG1


kininogen 1


chr20_-_44600939 0.484 ZNF335
zinc finger protein 335
chr20_+_32150139 0.482 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr2_-_68694389 0.480 NM_001024680
FBXO48
F-box protein 48
chr17_-_76836852 0.472 NM_025090
USP36
ubiquitin specific peptidase 36
chr14_+_29241989 0.470 C14orf23
chromosome 14 open reading frame 23
chr7_-_15601574 0.468 NM_001004320
AGMO
alkylglycerol monooxygenase
chr7_+_143268872 0.462 NM_001008747
CTAGE6P
CTAGE15P
CTAGE family, member 6, pseudogene
CTAGE family, member 15, pseudogene
chr3_+_42132707 0.458 NM_001042646
TRAK1
trafficking protein, kinesin binding 1
chr1_-_154600383 0.457 ADAR
adenosine deaminase, RNA-specific
chr1_+_179965756 0.455 CEP350
centrosomal protein 350kDa
chr5_+_156696351 0.454 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr22_+_35462125 0.450 NM_001008494
ISX
intestine-specific homeobox
chr17_-_4607198 0.445 PELP1
proline, glutamate and leucine rich protein 1
chr20_+_62372436 0.445 SLC2A4RG
SLC2A4 regulator
chrX_+_9431314 0.445 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr1_-_247054277 0.439 AHCTF1
AT hook containing transcription factor 1
chr1_-_247094659 0.436 NM_015446
AHCTF1
AHCTF1P1
AT hook containing transcription factor 1
AT hook containing transcription factor 1 pseudogene 1
chr6_-_47254143 0.433 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr17_-_61850890 0.428 CCDC47
coiled-coil domain containing 47
chr1_-_154600446 0.427 NM_001025107
ADAR
adenosine deaminase, RNA-specific
chr2_-_214015053 0.425 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr10_+_71812536 0.421 H2AFY2
H2A histone family, member Y2
chr8_+_21916685 0.414 NM_001114138
NM_001978
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr2_-_216300770 0.412 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr3_+_9975513 0.412 NM_015513
NM_001031717
NM_001077415
CRELD1


cysteine-rich with EGF-like domains 1


chr19_-_4540035 0.412 NM_052972
LRG1
leucine-rich alpha-2-glycoprotein 1
chr2_-_31637598 0.410 NM_000379
XDH
xanthine dehydrogenase
chr1_-_200638996 0.407 DDX59
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
chr8_-_101315457 0.405 NM_015435
RNF19A
ring finger protein 19A
chr2_-_65593866 0.403 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr12_-_7261788 0.403 NM_016546
C1RL
complement component 1, r subcomponent-like
chr10_+_103911932 0.399 NM_004741
NOLC1
nucleolar and coiled-body phosphoprotein 1
chr19_+_13056656 0.399 RAD23A
RAD23 homolog A (S. cerevisiae)
chr19_-_6459735 0.399 NM_024103
SLC25A23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr4_+_1894508 0.398 NM_007331
NM_133330
NM_133331
NM_133335
WHSC1



Wolf-Hirschhorn syndrome candidate 1



chr5_+_126112314 0.392 NM_005573
LMNB1
lamin B1
chr9_-_112191105 0.385 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr10_-_45474210 0.383 NM_007021
C10orf10
chromosome 10 open reading frame 10
chr16_-_70323343 0.378 AARS
alanyl-tRNA synthetase

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.12 1.00e-03 GO:0009611 response to wounding
2.55 2.56e-03 GO:0006950 response to stress
17.30 5.04e-03 GO:0072376 protein activation cascade
56.56 8.94e-03 GO:0051917 regulation of fibrinolysis
23.71 1.19e-02 GO:0006953 acute-phase response
207.36 1.20e-02 GO:0006883 cellular sodium ion homeostasis
3.79 2.96e-02 GO:0006952 defense response

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
6.25 1.17e-09 GO:0005615 extracellular space
5.22 9.41e-09 GO:0044421 extracellular region part
3.80 2.97e-08 GO:0005576 extracellular region
37.72 2.91e-04 GO:0034364 high-density lipoprotein particle
25.93 1.38e-03 GO:0032994 protein-lipid complex
25.93 1.38e-03 GO:0034358 plasma lipoprotein particle
82.95 2.00e-02 GO:0045179 apical cortex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
9.36 1.78e-02 GO:0004252 serine-type endopeptidase activity
4.60 2.97e-02 GO:0008289 lipid binding
69.13 3.23e-02 GO:0030492 hemoglobin binding
8.05 3.58e-02 GO:0008236 serine-type peptidase activity
7.93 3.84e-02 GO:0017171 serine hydrolase activity
19.45 4.53e-02 GO:0005504 fatty acid binding