Motif ID: IKZF2.p2

Z-value: 1.712


Transcription factors associated with IKZF2.p2:

Gene SymbolEntrez IDGene Name
IKZF2 22807 IKAROS family zinc finger 2 (Helios)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IKZF2chr2_-_214015053-0.243.7e-01Click!


Activity profile for motif IKZF2.p2.

activity profile for motif IKZF2.p2


Sorted Z-values histogram for motif IKZF2.p2

Sorted Z-values for motif IKZF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of IKZF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_38172862 6.980 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr2_+_189839132 6.246 COL3A1
collagen, type III, alpha 1
chr2_+_189839113 5.701 COL3A1
collagen, type III, alpha 1
chr1_-_57045235 5.658 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr2_+_189839078 5.631 NM_000090
COL3A1
collagen, type III, alpha 1
chr1_-_57045214 4.752 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_-_238322770 4.170 COL6A3
collagen, type VI, alpha 3
chr2_-_238322840 3.902 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chr7_+_102553343 3.717 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr2_-_238322815 3.350 COL6A3
collagen, type VI, alpha 3
chr7_+_94024201 3.201 COL1A2
collagen, type I, alpha 2
chr19_-_43709692 3.076 NM_002780
NM_213633
PSG4

pregnancy specific beta-1-glycoprotein 4

chr12_-_91573264 3.051 NM_133503
DCN
decorin
chr7_+_93551015 2.982 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chrX_-_135863104 2.972 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chrX_+_135251454 2.955 NM_001159704
FHL1
four and a half LIM domains 1
chr3_+_157154579 2.722 NM_002852
PTX3
pentraxin 3, long
chr12_-_91576579 2.687 DCN
decorin
chr12_-_91505215 2.686 LUM
lumican
chr17_-_48262900 2.671 COL1A1
collagen, type I, alpha 1
chr5_-_42811959 2.638 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr12_-_91505541 2.456 NM_002345
LUM
lumican
chr2_-_175712276 2.315 NM_001206602
CHN1
chimerin (chimaerin) 1
chr21_-_28339405 2.310 NM_007038
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr1_-_57045129 2.284 PPAP2B
phosphatidic acid phosphatase type 2B
chrX_-_135863033 2.217 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_153518265 2.214 NM_002961
NM_019554
S100A4

S100 calcium binding protein A4

chr1_-_57044980 2.128 PPAP2B
phosphatidic acid phosphatase type 2B
chr2_-_190927321 2.115 NM_005259
MSTN
myostatin
chrX_-_114252132 2.065 NM_000640
IL13RA2
interleukin 13 receptor, alpha 2
chr5_-_111091947 1.967 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr1_+_155853546 1.871 SYT11
synaptotagmin XI
chr1_-_193155723 1.852 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr7_-_137028275 1.773 PTN
pleiotrophin
chr2_-_190044330 1.756 NM_000393
COL5A2
collagen, type V, alpha 2
chr1_+_101185195 1.723 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chrX_+_135251795 1.668 NM_001167819
FHL1
four and a half LIM domains 1
chr20_+_9198036 1.663 NM_182797
PLCB4
phospholipase C, beta 4
chr13_-_34250899 1.662 NM_001243476
STARD13
StAR-related lipid transfer (START) domain containing 13
chr5_-_121412805 1.657 NM_001178102
LOX
lysyl oxidase
chr7_-_137028433 1.641 PTN
pleiotrophin
chr7_-_137028533 1.611 NM_002825
PTN
pleiotrophin
chr4_+_55095263 1.596 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr18_-_53089722 1.540 NM_001243233
TCF4
transcription factor 4
chr12_+_119616594 1.536 NM_014365
HSPB8
heat shock 22kDa protein 8
chr2_-_151344145 1.518 NM_005168
RND3
Rho family GTPase 3
chr2_-_217540722 1.501 IGFBP5
insulin-like growth factor binding protein 5
chr1_+_162602198 1.491 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chrX_+_100805415 1.489 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr17_-_46687925 1.485 HOXB7
homeobox B7
chr1_-_150780705 1.461 NM_000396
CTSK
cathepsin K
chr2_-_211179765 1.453 NM_079420
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr8_-_18541441 1.441 PSD3
pleckstrin and Sec7 domain containing 3
chr4_-_157892545 1.424 NM_016205
PDGFC
platelet derived growth factor C
chr15_+_74218794 1.424 LOXL1
lysyl oxidase-like 1
chr7_-_137028370 1.422 PTN
pleiotrophin
chr5_-_111093792 1.421 NM_001142477
NM_001142476
C5orf13

chromosome 5 open reading frame 13

chr1_+_162602308 1.390 DDR2
discoidin domain receptor tyrosine kinase 2
chr3_+_69812620 1.374 NM_001184967
MITF
microphthalmia-associated transcription factor
chr16_-_65155965 1.339 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr1_+_171154387 1.335 NM_001460
FMO2
flavin containing monooxygenase 2 (non-functional)
chr5_+_92918924 1.318 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr2_-_217560247 1.311 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chrX_+_100333835 1.306 NM_021637
TMEM35
transmembrane protein 35
chr11_+_114167197 1.304 NNMT
nicotinamide N-methyltransferase
chr11_+_114167168 1.297 NNMT
nicotinamide N-methyltransferase
chr2_+_74120092 1.289 NM_001199893
NM_001615
ACTG2

actin, gamma 2, smooth muscle, enteric

chrX_+_135230736 1.289 NM_001159700
FHL1
four and a half LIM domains 1
chr15_+_74218811 1.289 LOXL1
lysyl oxidase-like 1
chr19_-_43441249 1.282 NM_001206650
NM_002783
PSG7

pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)

chr5_-_151066445 1.280 SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr12_+_7167979 1.277 NM_001734
NM_201442
C1S

complement component 1, s subcomponent

chr16_-_65155984 1.273 CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_+_74120132 1.270 ACTG2
actin, gamma 2, smooth muscle, enteric
chr6_+_129204285 1.270 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr12_+_26348268 1.267 NM_001135823
SSPN
sarcospan (Kras oncogene-associated gene)
chr1_-_79472360 1.260 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr15_+_74218786 1.259 NM_005576
LOXL1
lysyl oxidase-like 1
chr2_-_231989755 1.253 NM_000867
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B
chr2_-_175869910 1.236 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr2_-_163099877 1.234 NM_004460
FAP
fibroblast activation protein, alpha
chrX_+_135278912 1.228 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr4_+_169418167 1.223 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr17_-_66951381 1.205 NM_007168
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr4_-_114900802 1.204 NM_024590
ARSJ
arylsulfatase family, member J
chr1_+_171060017 1.176 NM_001002294
NM_006894
FMO3

flavin containing monooxygenase 3

chr1_+_163038564 1.171 NM_005613
RGS4
regulator of G-protein signaling 4
chrX_-_135863502 1.150 NM_004840
ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr8_+_70378858 1.127 NM_001128204
NM_015170
SULF1

sulfatase 1

chr4_-_157892054 1.121 PDGFC
platelet derived growth factor C
chrX_+_102632108 1.113 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr14_-_35591151 1.082 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr18_-_53071225 1.076 NM_001243232
TCF4
transcription factor 4
chr12_+_78225068 1.069 NM_014903
NAV3
neuron navigator 3
chr8_+_17433941 1.058 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr2_-_216259197 1.051 FN1
fibronectin 1
chrX_+_149613719 1.041 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr7_+_134576150 1.039 NM_033139
NM_033140
CALD1

caldesmon 1

chr1_+_163038934 1.036 NM_001113381
RGS4
regulator of G-protein signaling 4
chr11_+_114166534 1.031 NM_006169
NNMT
nicotinamide N-methyltransferase
chr13_+_102104941 1.002 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr12_+_75874512 0.987 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr13_-_33780142 0.978 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr14_-_35591652 0.968 PPP2R3C
protein phosphatase 2, regulatory subunit B'', gamma
chr1_+_196621007 0.961 NM_000186
NM_001014975
CFH

complement factor H

chr7_+_134576187 0.961 CALD1
caldesmon 1
chr8_-_108510094 0.957 NM_001146
NM_001199859
ANGPT1

angiopoietin 1

chr4_+_124317884 0.947 NM_199327
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr2_+_207406815 0.940 ADAM23
ADAM metallopeptidase domain 23
chrX_-_10544852 0.937 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr3_-_123339178 0.925 MYLK
myosin light chain kinase
chr1_-_68697997 0.923 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr22_+_33196801 0.921 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr16_-_65155881 0.918 NM_001797
CDH11
cadherin 11, type 2, OB-cadherin (osteoblast)
chr2_-_145277879 0.917 NM_001171653
NM_014795
ZEB2

zinc finger E-box binding homeobox 2

chr15_+_32933869 0.916 NM_001144757
NM_003020
SCG5

secretogranin V (7B2 protein)

chr17_+_32582295 0.916 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr1_+_180124013 0.908 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr4_+_26322184 0.897 NM_015874
NM_203284
RBPJ

recombination signal binding protein for immunoglobulin kappa J region

chr17_-_46682333 0.895 NM_018952
HOXB6
homeobox B6
chrX_-_135749436 0.886 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr11_-_102668822 0.884 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr9_-_88715024 0.884 NM_177937
GOLM1
golgi membrane protein 1
chr12_+_26348488 0.878 NM_005086
SSPN
sarcospan (Kras oncogene-associated gene)
chr19_-_43269818 0.875 NM_001130167
NM_001130168
NM_182707
PSG8


pregnancy specific beta-1-glycoprotein 8


chr8_-_13134028 0.872 DLC1
deleted in liver cancer 1
chr16_+_82660573 0.868 CDH13
cadherin 13, H-cadherin (heart)
chr11_-_102668892 0.867 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr6_+_123109970 0.862 NM_006714
SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr16_+_82660390 0.858 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr1_+_180124023 0.857 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr2_-_179672056 0.857 NM_003319
NM_133378
NM_133379
NM_133432
NM_133437
TTN




titin




chr10_+_11047253 0.856 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr6_-_131384321 0.853 EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr1_+_100111430 0.852 NM_017734
PALMD
palmdelphin
chr2_-_162929928 0.844 DPP4
dipeptidyl-peptidase 4
chr6_-_131384387 0.844 NM_001135554
NM_001135555
NM_001199388
NM_001431
EPB41L2



erythrocyte membrane protein band 4.1-like 2



chr6_-_128841432 0.831 NM_002844
NM_001135648
PTPRK

protein tyrosine phosphatase, receptor type, K

chr1_+_180124031 0.820 QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr12_-_105322056 0.794 NM_032148
SLC41A2
solute carrier family 41, member 2
chr5_+_32710742 0.793 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr5_+_32711437 0.792 NM_000908
NM_001204375
NPR3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

chr2_+_30454396 0.785 NM_030915
LBH
limb bud and heart development homolog (mouse)
chr4_+_55095433 0.784 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr3_+_69915374 0.783 NM_198177
MITF
microphthalmia-associated transcription factor
chr3_+_12392993 0.780 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr18_+_8717368 0.779 NM_015210
CCDC165
coiled-coil domain containing 165
chr4_+_26322647 0.778 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr4_+_26322627 0.771 RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr5_-_150537335 0.765 NM_001155
ANXA6
annexin A6
chr7_+_94297448 0.763 PEG10
paternally expressed 10
chr1_-_173176314 0.761 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr1_+_203444955 0.749 PRELP
proline/arginine-rich end leucine-rich repeat protein
chr1_+_158979681 0.744 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr4_+_124320664 0.738 NM_005841
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr5_-_95158465 0.735 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr11_+_133938819 0.731 NM_001205329
NM_032801
JAM3

junctional adhesion molecule 3

chr17_-_46688362 0.731 NM_004502
HOXB7
homeobox B7
chr6_-_46825942 0.724 GPR116
G protein-coupled receptor 116
chr15_+_25101697 0.721 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr1_+_86046434 0.714 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr5_-_111312522 0.714 NM_001142474
NM_001142475
C5orf13

chromosome 5 open reading frame 13

chr6_-_169654047 0.712 NM_003247
THBS2
thrombospondin 2
chr8_-_95274540 0.707 NM_005261
NM_181702
GEM

GTP binding protein overexpressed in skeletal muscle

chr6_+_123110345 0.704 SMPDL3A
sphingomyelin phosphodiesterase, acid-like 3A
chr3_-_145879222 0.693 NM_000935
NM_182943
PLOD2

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

chr17_+_1665281 0.691 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_7506599 0.688 NM_198474
OLFML1
olfactomedin-like 1
chr2_+_223916861 0.683 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4
chr1_+_53480573 0.683 NM_001007099
NM_001007100
NM_001007250
SCP2


sterol carrier protein 2


chr20_-_34025955 0.676 NM_000557
GDF5
growth differentiation factor 5
chr11_+_86511490 0.671 NM_007173
PRSS23
protease, serine, 23
chr1_+_183114214 0.670 LAMC1
laminin, gamma 1 (formerly LAMB2)
chr8_-_95274520 0.666 GEM
GTP binding protein overexpressed in skeletal muscle
chr17_-_55980749 0.661 NM_017949
CUEDC1
CUE domain containing 1
chr13_-_73356070 0.658 NM_001128226
NM_014953
DIS3

DIS3 mitotic control homolog (S. cerevisiae)

chr5_-_95158365 0.655 GLRX
glutaredoxin (thioltransferase)
chr22_-_37164073 0.655 NM_001177702
IFT27
intraflagellar transport 27 homolog (Chlamydomonas)
chr1_+_150245182 0.654 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr9_-_95244634 0.645 ASPN
asporin
chr11_-_62472901 0.644


chr5_+_140718353 0.642 NM_018915
NM_032009
PCDHGA2

protocadherin gamma subfamily A, 2

chr1_+_53480616 0.641 SCP2
sterol carrier protein 2
chr9_-_13250313 0.637 NM_003829
MPDZ
multiple PDZ domain protein
chr5_+_155754172 0.636 SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr10_-_74283693 0.634 NM_001195519
MICU1
mitochondrial calcium uptake 1
chr3_+_69812961 0.629 NM_006722
MITF
microphthalmia-associated transcription factor
chr11_+_63304272 0.628 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr1_-_93342706 0.628 NM_001252271
FAM69A
family with sequence similarity 69, member A
chr9_-_79520878 0.625 NM_015225
PRUNE2
prune homolog 2 (Drosophila)
chr1_-_110933683 0.610 NM_001201546
NM_001201547
NM_001201548
NM_001201549
NM_004696
SLC16A4




solute carrier family 16, member 4 (monocarboxylic acid transporter 5)




chr1_+_64088886 0.608 NM_001172818
PGM1
phosphoglucomutase 1
chr10_-_29754478 0.607 SVIL
supervillin
chr11_-_27741192 0.598 NM_001143807
BDNF
brain-derived neurotrophic factor
chr6_+_134210247 0.589 NM_198392
NM_003206
TCF21

transcription factor 21

chr5_-_146833150 0.589 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr12_+_60083125 0.579 NM_004731
SLC16A7
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
chr1_-_116311330 0.578 CASQ2
calsequestrin 2 (cardiac muscle)
chr9_+_112887780 0.575 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr12_+_5603297 0.574 NM_002527
NTF3
neurotrophin 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
45.84 1.06e-06 GO:0030199 collagen fibril organization
17.07 7.81e-06 GO:0030198 extracellular matrix organization
7.74 5.79e-05 GO:0001501 skeletal system development
2.48 1.78e-04 GO:0048731 system development
11.12 2.23e-04 GO:0043062 extracellular structure organization
2.23 6.70e-04 GO:0007275 multicellular organismal development
2.84 7.28e-04 GO:0048513 organ development
2.23 1.71e-03 GO:0048856 anatomical structure development
31.89 2.73e-03 GO:0043588 skin development
2.02 5.95e-03 GO:0032502 developmental process
7.89 1.15e-02 GO:0007517 muscle organ development
1.74 3.56e-02 GO:0032501 multicellular organismal process
122.22 3.66e-02 GO:0043589 skin morphogenesis

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
44.45 5.57e-10 GO:0005581 collagen
3.74 4.67e-09 GO:0005576 extracellular region
18.72 9.70e-09 GO:0044420 extracellular matrix part
4.83 2.00e-08 GO:0044421 extracellular region part
8.68 4.38e-08 GO:0031012 extracellular matrix
9.74 4.84e-08 GO:0005578 proteinaceous extracellular matrix
83.33 1.67e-07 GO:0005583 fibrillar collagen
4.98 8.34e-07 GO:0005615 extracellular space
183.32 2.66e-03 GO:0005584 collagen type I
122.22 7.96e-03 GO:0005589 collagen type VI

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
66.67 2.63e-05 GO:0048407 platelet-derived growth factor binding
26.20 1.20e-04 GO:0005518 collagen binding
16.19 1.77e-04 GO:0005201 extracellular matrix structural constituent
122.22 8.99e-03 GO:0005017 platelet-derived growth factor receptor activity
9.09 2.22e-02 GO:0019838 growth factor binding