Motif ID: NFE2.p2

Z-value: 1.299


Transcription factors associated with NFE2.p2:

Gene SymbolEntrez IDGene Name
NFE2 4778 nuclear factor (erythroid-derived 2), 45kDa

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2chr12_-_54694717,
chr12_-_54689536,
chr12_-_54694647
0.165.6e-01Click!


Activity profile for motif NFE2.p2.

activity profile for motif NFE2.p2


Sorted Z-values histogram for motif NFE2.p2

Sorted Z-values for motif NFE2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_38721701 6.680 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr22_+_23040394 5.202 IGL@
immunoglobulin lambda locus
chr22_+_23010757 5.033


chr22_+_22723972 3.709


chr22_+_23165273 3.351


chr12_-_15114495 3.313 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr13_-_99959649 3.237 NM_004951
GPR183
G protein-coupled receptor 183
chr1_+_174844655 3.181 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr22_+_22569155 3.161


chr4_+_41258941 2.923 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chrX_-_154563735 2.863 NM_001289
CLIC2
chloride intracellular channel 2
chr5_+_150020201 2.786 NM_001109974
NM_007286
SYNPO

synaptopodin

chrX_+_12993224 2.752 NM_021109
TMSB4X
thymosin beta 4, X-linked
chr6_+_33043702 2.609 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr11_+_20385324 2.397 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr11_+_20385230 2.261 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr11_+_20385259 2.255 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr22_+_22758538 2.161


chr10_-_6019880 2.109 NM_001243539
IL15RA
interleukin 15 receptor, alpha
chr9_-_123688352 2.100 TRAF1
TNF receptor-associated factor 1
chrX_-_100641143 2.094 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr11_+_67351276 2.094 GSTP1
glutathione S-transferase pi 1
chr11_+_67351065 2.092 NM_000852
GSTP1
glutathione S-transferase pi 1
chr17_-_28618836 1.975 BLMH
bleomycin hydrolase
chr17_-_29641087 1.973 EVI2B
ecotropic viral integration site 2B
chr16_+_57392694 1.967 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr1_+_150122246 1.965 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr22_+_22712091 1.959 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr22_+_23134980 1.950


chr1_+_150122415 1.949 PLEKHO1
pleckstrin homology domain containing, family O member 1
chr5_-_141061798 1.888 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr10_-_6019454 1.853 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr6_-_84140758 1.837 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr22_+_22697538 1.828


chr3_-_98241357 1.815 CLDND1
claudin domain containing 1
chr17_-_29641068 1.801 EVI2B
ecotropic viral integration site 2B
chr1_+_150122095 1.791 NM_016274
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr10_+_30723050 1.779 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr19_-_7764283 1.769 NM_001207019
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr10_+_17270257 1.744 NM_003380
VIM
vimentin
chr6_-_84140744 1.691 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr22_+_22735134 1.630 CYAT1
immunoglobulin lambda light chain-like
chr3_+_183894736 1.619 AP2M1
adaptor-related protein complex 2, mu 1 subunit
chr17_+_30771520 1.569 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chrX_+_99899162 1.560 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr11_-_102668892 1.554 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr10_+_30722856 1.545 NM_001244134
NM_005204
MAP3K8

mitogen-activated protein kinase kinase kinase 8

chr5_-_141061749 1.539 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr22_+_22786283 1.518


chr17_-_29641094 1.516 NM_006495
EVI2B
ecotropic viral integration site 2B
chr17_+_32582295 1.514 NM_002982
CCL2
chemokine (C-C motif) ligand 2
chr11_+_20385686 1.507 NM_001098523
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr6_-_84140854 1.492 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr8_-_82395401 1.486 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr7_+_90339146 1.482 CDK14
cyclin-dependent kinase 14
chr11_-_102668822 1.463 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr15_+_89182038 1.461 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chrX_+_99899388 1.461 SRPX2
sushi-repeat containing protein, X-linked 2
chr18_-_53068755 1.423 TCF4
transcription factor 4
chr3_+_49027281 1.387 NM_177938
NM_177939
P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr11_+_128563772 1.371 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr10_+_17270469 1.359 VIM
vimentin
chr11_-_9025531 1.306 NM_020645
NRIP3
nuclear receptor interacting protein 3
chr3_+_48507209 1.306 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr19_+_4229494 1.295 NM_005755
EBI3
Epstein-Barr virus induced 3
chrX_-_15511710 1.292 NM_001018109
NM_003662
PIR

pirin (iron-binding nuclear protein)

chr3_+_48507621 1.270 TREX1
three prime repair exonuclease 1
chr22_+_22676814 1.250


chr4_-_76944585 1.250 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr17_-_28619183 1.222 NM_000386
BLMH
bleomycin hydrolase
chrX_+_65382627 1.214 HEPH
hephaestin
chr3_-_58200397 1.202 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chrX_+_65382432 1.180 NM_138737
HEPH
hephaestin
chr5_-_169724734 1.180 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr3_-_98241683 1.177 CLDND1
claudin domain containing 1
chr12_+_7060433 1.161 NM_002831
NM_080549
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr18_-_53303129 1.147 NM_001243226
TCF4
transcription factor 4
chr19_+_36203829 1.145 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr5_-_169724817 1.135 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_24877453 1.124 NM_015864
FAM65B
family with sequence similarity 65, member B
chr2_-_89292396 1.101 IGKC
immunoglobulin kappa constant
chr5_-_169724782 1.101 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chrX_+_9431314 1.069 NM_001139466
NM_001139467
NM_001139468
TBL1X


transducin (beta)-like 1X-linked


chr18_-_53177999 1.063 NM_001243231
TCF4
transcription factor 4
chr4_-_16900348 1.057 NM_001130834
NM_001290
LDB2

LIM domain binding 2

chr7_+_150434435 1.055 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr1_+_155853546 1.054 SYT11
synaptotagmin XI
chr12_-_91573264 1.050 NM_133503
DCN
decorin
chr9_+_4985082 1.026 JAK2
Janus kinase 2
chr12_-_8765438 1.019 NM_020661
AICDA
activation-induced cytidine deaminase
chr17_-_45899133 1.019 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr11_-_3862137 1.014 RHOG
ras homolog gene family, member G (rho G)
chr22_-_37545944 1.011 NM_000878
IL2RB
interleukin 2 receptor, beta
chr22_+_22735207 1.003 IGLJ3
immunoglobulin lambda joining 3
chr11_+_128563993 1.000 FLI1
Friend leukemia virus integration 1
chr6_+_44195008 0.996 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr8_-_42623928 0.995 NM_001199279
NM_004198
CHRNA6

cholinergic receptor, nicotinic, alpha 6

chr3_+_69915374 0.969 NM_198177
MITF
microphthalmia-associated transcription factor
chr3_-_98241748 0.953 CLDND1
claudin domain containing 1
chr2_+_152214105 0.933 NM_007115
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr1_-_225616556 0.927 NM_194442
LBR
lamin B receptor
chr19_-_56348127 0.923 NM_145007
NLRP11
NLR family, pyrin domain containing 11
chrX_-_15511358 0.914 PIR
pirin (iron-binding nuclear protein)
chr16_-_89043215 0.905 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr7_+_23286390 0.904 GPNMB
glycoprotein (transmembrane) nmb
chr1_-_159046555 0.896 NM_004833
AIM2
absent in melanoma 2
chr3_+_50284325 0.895 NM_001166425
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
chr15_+_44829373 0.882 EIF3J
eukaryotic translation initiation factor 3, subunit J
chr1_-_246580710 0.859 NM_022743
SMYD3
SET and MYND domain containing 3
chr5_-_137071462 0.853 KLHL3
kelch-like 3 (Drosophila)
chr7_+_23286386 0.846 GPNMB
glycoprotein (transmembrane) nmb
chr11_+_10476665 0.833 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr7_+_23286277 0.830 NM_001005340
NM_002510
GPNMB

glycoprotein (transmembrane) nmb

chr6_-_31550065 0.821 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr7_+_22766765 0.821 NM_000600
IL6
interleukin 6 (interferon, beta 2)
chrX_-_129244422 0.817 ELF4
E74-like factor 4 (ets domain transcription factor)
chr19_-_10450262 0.813 NM_002162
ICAM3
intercellular adhesion molecule 3
chr14_+_103801160 0.810 NM_183004
EIF5
eukaryotic translation initiation factor 5
chr17_-_45899118 0.808 OSBPL7
oxysterol binding protein-like 7
chr1_+_12123433 0.804 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr11_-_62474666 0.796 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chrX_-_129244471 0.794 NM_001421
ELF4
E74-like factor 4 (ets domain transcription factor)
chr17_-_34207308 0.794 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr3_+_119316694 0.790 NM_001206960
NM_001206961
NM_015900
PLA1A


phospholipase A1 member A


chr22_+_23222897 0.790 CYAT1
immunoglobulin lambda light chain-like
chr7_+_150688143 0.785 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr11_-_3862183 0.781 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chrX_-_135749436 0.763 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr22_-_39268214 0.755 CBX6
chromobox homolog 6
chr2_-_175462428 0.739 WIPF1
WAS/WASL interacting protein family, member 1
chr10_-_94333721 0.738 IDE
insulin-degrading enzyme
chr16_-_1429612 0.733 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr6_-_84140651 0.729 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr11_-_6676851 0.714 NM_003737
DCHS1
dachsous 1 (Drosophila)
chr10_+_71075609 0.710 NM_033496
HK1
hexokinase 1
chr3_-_98241722 0.709 CLDND1
claudin domain containing 1
chr10_-_94333828 0.696 IDE
insulin-degrading enzyme
chr17_-_73150769 0.684 NM_001002032
NM_001002033
NM_016185
HN1


hematological and neurological expressed 1


chr1_+_14075861 0.682 NM_001007257
PRDM2
PR domain containing 2, with ZNF domain
chr11_-_102714240 0.682 NM_002422
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr3_+_141043054 0.681 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr12_-_102591547 0.681 NM_002674
PMCH
pro-melanin-concentrating hormone
chr9_+_4985243 0.677 NM_004972
JAK2
Janus kinase 2
chr10_-_21462987 0.671 NEBL
nebulette
chr1_-_183559463 0.667 NCF2
neutrophil cytosolic factor 2
chr9_-_34662629 0.664 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr6_+_106546736 0.664 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr6_-_32908583 0.662 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr3_+_11178778 0.661 NM_001098213
HRH1
histamine receptor H1
chr12_+_10365415 0.660 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr5_-_137071703 0.656 NM_017415
KLHL3
kelch-like 3 (Drosophila)
chr8_-_70745624 0.655 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr11_+_10477480 0.627 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr11_-_62474869 0.624 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr17_+_30771494 0.620 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_-_115880851 0.612 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr2_+_33359607 0.610 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr16_+_58534045 0.605 NM_001242833
NM_001242834
NM_001242835
NM_001242836
NDRG4



NDRG family member 4



chr15_+_101459459 0.604 NM_024652
LRRK1
leucine-rich repeat kinase 1
chr9_+_2015218 0.604 NM_003070
NM_139045
SMARCA2

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

chr1_-_109969058 0.599 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr14_-_106691698 0.597


chr19_-_41859253 0.586 TGFB1
transforming growth factor, beta 1
chr14_-_106092256 0.585 IGHG4
immunoglobulin heavy constant gamma 4 (G4m marker)
chr10_-_101769640 0.581 NM_015221
DNMBP
dynamin binding protein
chr10_-_94333847 0.579 NM_004969
IDE
insulin-degrading enzyme
chrX_-_16730669 0.579 NM_175859
NM_019857
CTPS2

CTP synthase II

chr7_-_134854225 0.578 NM_001243753
NM_001243755
C7orf49

chromosome 7 open reading frame 49

chr4_-_159092509 0.575 FAM198B
family with sequence similarity 198, member B
chr4_+_170581212 0.574 NM_001243374
CLCN3
chloride channel 3
chr17_+_30771532 0.574 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr10_+_35484829 0.560 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chrX_-_72434623 0.559 NAP1L2
nucleosome assembly protein 1-like 2
chr1_+_40735749 0.556 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr1_-_109969044 0.554 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr3_-_93782066 0.553 NM_001195643
DHFRL1
dihydrofolate reductase-like 1
chr5_-_169724614 0.552 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_-_46293404 0.551 RCAN2
regulator of calcineurin 2
chr14_-_106111114 0.548 IGHG2
immunoglobulin heavy constant gamma 2 (G2m marker)
chr7_+_23286420 0.547 GPNMB
glycoprotein (transmembrane) nmb
chr15_+_86220267 0.535 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr12_+_69202796 0.533 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr17_+_30771522 0.529 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr1_+_154966061 0.525 NM_018655
LENEP
lens epithelial protein
chr1_-_160832466 0.524 NM_001166663
NM_001166664
NM_016382
CD244


CD244 molecule, natural killer cell receptor 2B4


chrX_-_72434656 0.521 NAP1L2
nucleosome assembly protein 1-like 2
chr5_+_72143929 0.520 NM_153188
TNPO1
transportin 1
chr18_+_21572736 0.518 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr17_+_30771485 0.518 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr21_+_30517897 0.513 C21orf7
chromosome 21 open reading frame 7
chr3_+_132373289 0.510 NM_198329
UBA5
ubiquitin-like modifier activating enzyme 5
chr7_+_150434679 0.503 GIMAP5
GTPase, IMAP family member 5
chr14_-_106237675 0.495 IGHM
immunoglobulin heavy constant mu
chr7_+_130794854 0.493 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr22_+_22764094 0.490


chr1_-_183559669 0.486 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr6_-_159239269 0.485 NM_003379
EZR
ezrin
chr6_-_159239198 0.484 EZR
ezrin
chr1_-_109968951 0.484 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr6_+_34206567 0.484 NM_145905
HMGA1
high mobility group AT-hook 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.08 2.72e-05 GO:0002376 immune system process
4.85 3.12e-04 GO:0006955 immune response
10.10 5.45e-04 GO:0019221 cytokine-mediated signaling pathway
9.12 1.18e-03 GO:0071345 cellular response to cytokine stimulus
9.26 4.85e-03 GO:0050867 positive regulation of cell activation
10.42 1.14e-02 GO:0050870 positive regulation of T cell activation
1.75 1.27e-02 GO:0050896 response to stimulus
6.57 1.32e-02 GO:0034097 response to cytokine stimulus
5.23 2.37e-02 GO:0002684 positive regulation of immune system process
4.17 2.52e-02 GO:0002682 regulation of immune system process
7.05 2.84e-02 GO:0050865 regulation of cell activation
147.95 3.12e-02 GO:0051772 regulation of nitric-oxide synthase 2 biosynthetic process
8.66 3.24e-02 GO:0051251 positive regulation of lymphocyte activation
8.50 3.60e-02 GO:0050863 regulation of T cell activation
2.27 4.21e-02 GO:0048518 positive regulation of biological process
8.09 4.74e-02 GO:0002696 positive regulation of leukocyte activation

Nothing significant found in compartment category.

Nothing significant found in function category.