Motif ID: NFE2L1.p2

Z-value: 1.700


Transcription factors associated with NFE2L1.p2:

Gene SymbolEntrez IDGene Name
NFE2L1 4779 nuclear factor (erythroid-derived 2)-like 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2L1chr17_+_461256750.421.0e-01Click!


Activity profile for motif NFE2L1.p2.

activity profile for motif NFE2L1.p2


Sorted Z-values histogram for motif NFE2L1.p2

Sorted Z-values for motif NFE2L1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_10535476 3.658 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr2_-_216259197 3.205 FN1
fibronectin 1
chr16_+_82660390 3.133 NM_001220488
NM_001220489
NM_001220490
NM_001220491
NM_001220492
NM_001257
CDH13





cadherin 13, H-cadherin (heart)





chr3_+_158991035 3.111 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr17_-_39780762 2.963 NM_000422
KRT17
keratin 17
chr21_+_47545896 2.755 COL6A2
collagen, type VI, alpha 2
chr17_-_39743085 2.644 NM_000526
KRT14
keratin 14
chr1_-_68697997 2.597 NM_001002292
NM_001193334
NM_024911
WLS


wntless homolog (Drosophila)


chr12_+_13349720 2.524 EMP1
epithelial membrane protein 1
chr12_+_13349601 2.499 NM_001423
EMP1
epithelial membrane protein 1
chr10_+_75673346 2.411 PLAU
plasminogen activator, urokinase
chr5_+_148206155 2.364 NM_000024
ADRB2
adrenergic, beta-2-, receptor, surface
chr3_-_45267068 2.336 TMEM158
transmembrane protein 158 (gene/pseudogene)
chr12_-_52886971 2.289 NM_005554
KRT6A
keratin 6A
chr16_+_82660573 2.237 CDH13
cadherin 13, H-cadherin (heart)
chr21_+_47545189 2.198 COL6A2
collagen, type VI, alpha 2
chr1_-_59042827 2.153 TACSTD2
tumor-associated calcium signal transducer 2
chr13_-_114566951 2.119 GAS6
growth arrest-specific 6
chr13_-_114567011 2.093 GAS6
growth arrest-specific 6
chr13_-_114567034 2.081 GAS6
growth arrest-specific 6
chr13_-_114567040 2.059 NM_000820
GAS6
growth arrest-specific 6
chr15_-_90349819 2.038 ANPEP
alanyl (membrane) aminopeptidase
chr2_+_201473942 2.013 AOX1
aldehyde oxidase 1
chr21_-_27253197 1.995 APP
amyloid beta (A4) precursor protein
chr5_+_34684611 1.956 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr12_+_78225068 1.911 NM_014903
NAV3
neuron navigator 3
chr10_+_124220990 1.826 NM_002775
HTRA1
HtrA serine peptidase 1
chrX_-_10645726 1.728 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr6_+_7541892 1.687 DSP
desmoplakin
chrX_-_99891690 1.608 NM_003270
TSPAN6
tetraspanin 6
chrX_+_107069459 1.589 MID2
midline 2
chr10_+_5566923 1.554 NM_005185
CALML3
calmodulin-like 3
chr9_-_16727887 1.552 BNC2
basonuclin 2
chr9_+_97521930 1.552 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr6_+_7541837 1.535 DSP
desmoplakin
chr9_-_14313899 1.534 NFIB
nuclear factor I/B
chr6_+_7541863 1.530 NM_001008844
NM_004415
DSP

desmoplakin

chr1_-_59248287 1.502 JUN
jun proto-oncogene
chr5_+_35856990 1.499 NM_002185
IL7R
interleukin 7 receptor
chr7_-_27183225 1.482 NM_019102
HOXA5
homeobox A5
chr17_-_46682333 1.455 NM_018952
HOXB6
homeobox B6
chr2_-_106015423 1.428 NM_001039492
NM_001450
NM_201555
FHL2


four and a half LIM domains 2


chr10_-_92681025 1.426 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr6_-_112575880 1.395 LAMA4
laminin, alpha 4
chr10_-_126849556 1.390 NM_001083914
CTBP2
C-terminal binding protein 2
chrX_+_107069081 1.381 NM_012216
NM_052817
MID2

midline 2

chr17_-_48264039 1.375 COL1A1
collagen, type I, alpha 1
chr3_+_157154579 1.339 NM_002852
PTX3
pentraxin 3, long
chr5_+_36608430 1.304 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_-_112575766 1.278 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr4_-_177713664 1.257 NM_005429
VEGFC
vascular endothelial growth factor C
chr7_+_134464161 1.253 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr10_-_126849066 1.242 NM_001329
CTBP2
C-terminal binding protein 2
chr12_+_54422193 1.219 NM_004503
HOXC6
homeobox C6
chr1_-_154943001 1.216 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr7_+_134464417 1.192 CALD1
caldesmon 1
chr9_-_14313509 1.190 NFIB
nuclear factor I/B
chr3_-_127541160 1.184 NM_007283
MGLL
monoglyceride lipase
chr17_-_40575117 1.169 NM_012232
PTRF
polymerase I and transcript release factor
chr1_+_84609941 1.167 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_-_175843360 1.165 CLTB
clathrin, light chain B
chr8_-_42065037 1.147 PLAT
plasminogen activator, tissue
chr5_+_140868721 1.143 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr8_-_42065193 1.141 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chrX_+_99899162 1.130 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr18_+_56530677 1.128 ZNF532
zinc finger protein 532
chr7_+_129932973 1.120 NM_001163446
NM_016352
CPA4

carboxypeptidase A4

chr6_-_10419786 1.115 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_-_95392449 1.115 CNN3
calponin 3, acidic
chr1_+_44064509 1.108 PTPRF
protein tyrosine phosphatase, receptor type, F
chr10_+_86131546 1.093 FAM190B
family with sequence similarity 190, member B
chr5_+_138211084 1.088 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr10_-_92680784 1.073 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr11_-_27743604 1.057 NM_170731
BDNF
brain-derived neurotrophic factor
chr5_+_140810181 1.054 PCDHGA12
protocadherin gamma subfamily A, 12
chr2_+_36583369 1.052 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr8_-_145018904 1.046 NM_201381
PLEC
plectin
chr4_-_40936640 1.038 APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr20_+_9458460 1.024 PLCB4
phospholipase C, beta 4
chrX_+_99899388 1.002 SRPX2
sushi-repeat containing protein, X-linked 2
chr21_-_36421586 1.000 NM_001754
RUNX1
runt-related transcription factor 1
chr12_-_91576805 0.996 NM_001920
DCN
decorin
chr6_-_134495944 0.994 SGK1
serum/glucocorticoid regulated kinase 1
chr5_-_54281345 0.989 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr4_+_169418167 0.989 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr8_+_95653399 0.989 ESRP1
epithelial splicing regulatory protein 1
chr21_-_36421630 0.987 RUNX1
runt-related transcription factor 1
chr6_-_110501164 0.975 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr17_-_39768939 0.971 NM_005557
KRT16
keratin 16
chr11_+_12695851 0.964 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr2_+_46524448 0.964 NM_001430
EPAS1
endothelial PAS domain protein 1
chr5_+_140810126 0.957 NM_003735
NM_032094
PCDHGA12

protocadherin gamma subfamily A, 12

chr12_-_58160823 0.946 NM_000785
CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr13_+_111154013 0.945 COL4A2
collagen, type IV, alpha 2
chr1_-_95392501 0.941 NM_001839
CNN3
calponin 3, acidic
chr14_-_75078669 0.940 NM_000428
LTBP2
latent transforming growth factor beta binding protein 2
chr2_-_165551178 0.938 COBLL1
COBL-like 1
chr1_-_59043165 0.933 NM_002353
TACSTD2
tumor-associated calcium signal transducer 2
chr22_+_38597938 0.931 NM_001161572
NM_001161574
NM_012323
MAFF


v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)


chr5_+_102201526 0.919 NM_000919
NM_001177306
NM_138766
NM_138821
NM_138822
PAM




peptidylglycine alpha-amidating monooxygenase




chrX_-_10588458 0.916 NM_000381
NM_033289
MID1

midline 1 (Opitz/BBB syndrome)

chr6_-_169654047 0.908 NM_003247
THBS2
thrombospondin 2
chr12_+_53491417 0.897 NM_002178
IGFBP6
insulin-like growth factor binding protein 6
chr2_-_175712276 0.894 NM_001206602
CHN1
chimerin (chimaerin) 1
chrX_+_114827818 0.892 NM_001136025
NM_001172335
PLS3

plastin 3

chr11_-_8832189 0.889 NM_213618
ST5
suppression of tumorigenicity 5
chr12_-_105322056 0.888 NM_032148
SLC41A2
solute carrier family 41, member 2
chr18_+_61554938 0.876 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr1_+_32050510 0.868 TINAGL1
tubulointerstitial nephritis antigen-like 1
chr5_-_39424930 0.863 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_+_158787040 0.860 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr9_-_14086901 0.856 NFIB
nuclear factor I/B
chr16_+_86544104 0.851 NM_001451
FOXF1
forkhead box F1
chr5_+_140753480 0.840 NM_018919
NM_032086
PCDHGA6

protocadherin gamma subfamily A, 6

chr5_+_125800786 0.832 NM_001146322
GRAMD3
GRAM domain containing 3
chr10_+_17271341 0.830 VIM
vimentin
chr15_+_74218962 0.829 LOXL1
lysyl oxidase-like 1
chr11_+_35160385 0.829 NM_000610
NM_001001389
NM_001001390
NM_001001391
NM_001001392
NM_001202555
NM_001202556
NM_001202557
CD44







CD44 molecule (Indian blood group)







chr7_-_41742666 0.829 NM_002192
INHBA
inhibin, beta A
chr18_-_21891469 0.829 NM_001242508
OSBPL1A
oxysterol binding protein-like 1A
chr3_-_149095517 0.828 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr22_+_38598065 0.827 MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr5_-_39425297 0.826 NM_001244871
NM_001343
DAB2

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

chr10_+_17271276 0.824 VIM
vimentin
chr13_-_45048436 0.823 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr7_+_75931829 0.819 NM_001540
HSPB1
heat shock 27kDa protein 1
chr10_+_17271277 0.819 VIM
vimentin
chr12_+_53491448 0.818 IGFBP6
insulin-like growth factor binding protein 6
chrX_+_135251795 0.817 NM_001167819
FHL1
four and a half LIM domains 1
chr16_+_15596122 0.813 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr2_-_225266710 0.812 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr10_+_17271302 0.805 VIM
vimentin
chr8_-_93029864 0.800 NM_175636
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr13_-_38172862 0.800 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr10_+_17271859 0.800 VIM
vimentin
chr7_-_129592794 0.800 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr16_+_56598960 0.797 NM_032935
MT4
metallothionein 4
chr17_-_15168590 0.790 NM_000304
PMP22
peripheral myelin protein 22
chr6_-_134496006 0.790 NM_005627
SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_91572328 0.789 NM_133504
NM_133505
NM_133506
NM_133507
DCN



decorin



chr8_+_94929991 0.779 NM_001161778
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chrX_+_135278912 0.777 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr5_-_150948504 0.771 NM_001447
FAT2
FAT tumor suppressor homolog 2 (Drosophila)
chr7_+_75931991 0.762 HSPB1
heat shock 27kDa protein 1
chr1_+_114522029 0.762 NM_020190
OLFML3
olfactomedin-like 3
chr18_+_47088400 0.757 NM_006033
LIPG
lipase, endothelial
chr8_-_126104007 0.755 KIAA0196
KIAA0196
chrX_+_107069502 0.754 MID2
midline 2
chrX_-_48931645 0.753 NM_007213
PRAF2
PRA1 domain family, member 2
chr5_+_125758818 0.752 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr1_-_155210887 0.752 GBA
glucosidase, beta, acid
chr5_+_140810326 0.751 PCDHGA12
protocadherin gamma subfamily A, 12
chr8_+_95653272 0.748 ESRP1
epithelial splicing regulatory protein 1
chr10_+_121410751 0.747 NM_004281
BAG3
BCL2-associated athanogene 3
chr5_+_125759076 0.746 GRAMD3
GRAM domain containing 3
chr5_+_140729723 0.745 NM_018922
NM_032095
PCDHGB1

protocadherin gamma subfamily B, 1

chr8_+_95653340 0.745 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr12_-_95611023 0.743 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr6_-_46825942 0.742 GPR116
G protein-coupled receptor 116
chr8_-_126103926 0.742 KIAA0196
KIAA0196
chr2_-_175869910 0.738 NM_001822
NM_001025201
CHN1

chimerin (chimaerin) 1

chr15_+_74218794 0.737 LOXL1
lysyl oxidase-like 1
chr14_+_65007418 0.736 HSPA2
heat shock 70kDa protein 2
chr15_+_74218786 0.734 NM_005576
LOXL1
lysyl oxidase-like 1
chr2_+_189839132 0.731 COL3A1
collagen, type III, alpha 1
chr10_+_8096772 0.729 GATA3
GATA binding protein 3
chr4_-_74964996 0.729 NM_002089
CXCL2
chemokine (C-X-C motif) ligand 2
chr3_-_123411185 0.722 MYLK
myosin light chain kinase
chr10_+_121410891 0.720 BAG3
BCL2-associated athanogene 3
chr8_-_126104004 0.717 KIAA0196
KIAA0196
chr6_-_138428477 0.717 NM_022121
PERP
PERP, TP53 apoptosis effector
chr20_-_23030141 0.714 NM_000361
THBD
thrombomodulin
chr10_-_17659365 0.711 NM_014241
PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr3_-_149095413 0.707 TM4SF1
transmembrane 4 L six family member 1
chr1_-_151966713 0.707 NM_002966
S100A10
S100 calcium binding protein A10
chr9_+_120466625 0.704 TLR4
toll-like receptor 4
chr10_-_3827205 0.703 KLF6
Kruppel-like factor 6
chr10_+_17271956 0.700 VIM
vimentin
chr7_+_107221203 0.699 NM_001008405
BCAP29
B-cell receptor-associated protein 29
chr10_+_124134206 0.699 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr15_-_63674074 0.697 NM_001218
NM_206925
CA12

carbonic anhydrase XII

chrX_-_13835187 0.696 GPM6B
glycoprotein M6B
chrX_+_73641084 0.695 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr2_-_55199894 0.694


chr1_+_203596222 0.694 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr6_-_169653922 0.691 THBS2
thrombospondin 2
chr3_-_149095458 0.691 TM4SF1
transmembrane 4 L six family member 1
chr1_+_86889768 0.687 NM_006536
CLCA2
chloride channel accessory 2
chr10_+_128593994 0.684 NM_001380
DOCK1
dedicator of cytokinesis 1
chr5_+_102201713 0.684 PAM
peptidylglycine alpha-amidating monooxygenase
chr4_+_74735107 0.683 NM_001511
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chrX_-_140271275 0.678 LDOC1
leucine zipper, down-regulated in cancer 1
chr7_-_129592711 0.676 NM_001202498
UBE2H
ubiquitin-conjugating enzyme E2H
chr10_-_33623771 0.674 NM_001024628
NM_001024629
NM_001244972
NM_001244973
NM_003873
NRP1




neuropilin 1




chr1_-_209824641 0.674 NM_001017402
LAMB3
laminin, beta 3
chr5_-_39425030 0.674 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr15_+_74218811 0.673 LOXL1
lysyl oxidase-like 1
chr17_-_79478956 0.672 ACTG1
actin, gamma 1
chrX_-_140271293 0.670 NM_012317
LDOC1
leucine zipper, down-regulated in cancer 1
chr6_-_46293628 0.669 NM_005822
RCAN2
regulator of calcineurin 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
1.92 3.21e-03 GO:0032501 multicellular organismal process
3.85 4.92e-03 GO:0009611 response to wounding
5.46 5.77e-03 GO:0051094 positive regulation of developmental process
7.17 6.78e-03 GO:0001568 blood vessel development
3.21 9.83e-03 GO:0051239 regulation of multicellular organismal process
4.55 1.11e-02 GO:0042060 wound healing
6.68 1.13e-02 GO:0001944 vasculature development
4.91 1.45e-02 GO:0007596 blood coagulation
4.91 1.45e-02 GO:0050817 coagulation
4.87 1.54e-02 GO:0007599 hemostasis
2.00 2.89e-02 GO:0032502 developmental process
8.54 3.35e-02 GO:0001525 angiogenesis
4.28 4.58e-02 GO:0050878 regulation of body fluid levels
16.60 4.63e-02 GO:0042058 regulation of epidermal growth factor receptor signaling pathway

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
19.95 5.39e-04 GO:0031983 vesicle lumen
17.66 8.45e-03 GO:0031093 platelet alpha granule lumen
17.30 9.18e-03 GO:0034774 secretory granule lumen
16.60 1.08e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
14.83 1.68e-02 GO:0031091 platelet alpha granule
2.49 3.04e-02 GO:0005576 extracellular region
7.87 4.79e-02 GO:0005912 adherens junction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.52 2.25e-03 GO:0005198 structural molecule activity
12.21 2.94e-02 GO:0005201 extracellular matrix structural constituent
11.86 3.28e-02 GO:0005200 structural constituent of cytoskeleton