Motif ID: NFE2L2.p2

Z-value: 1.467


Transcription factors associated with NFE2L2.p2:

Gene SymbolEntrez IDGene Name
NFE2L2 4780 nuclear factor (erythroid-derived 2)-like 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFE2L2chr2_-_178129294-0.774.9e-04Click!


Activity profile for motif NFE2L2.p2.

activity profile for motif NFE2L2.p2


Sorted Z-values histogram for motif NFE2L2.p2

Sorted Z-values for motif NFE2L2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFE2L2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_+_23010757 8.990


chrX_-_154563735 5.274 NM_001289
CLIC2
chloride intracellular channel 2
chr22_+_22569155 5.209


chr22_+_23040394 4.274 IGL@
immunoglobulin lambda locus
chrX_-_100641143 4.102 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr22_+_22735134 3.992 CYAT1
immunoglobulin lambda light chain-like
chr22_+_22723972 3.675


chr19_-_7764283 3.126 NM_001207019
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr22_+_23229959 3.121 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_22735207 3.090 IGLJ3
immunoglobulin lambda joining 3
chr22_+_22758538 3.082


chr22_+_22712091 3.079 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr22_+_23165273 3.045


chr9_-_123688352 3.015 TRAF1
TNF receptor-associated factor 1
chr17_+_30771520 2.967 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr11_+_67351276 2.645 GSTP1
glutathione S-transferase pi 1
chr11_+_67351065 2.617 NM_000852
GSTP1
glutathione S-transferase pi 1
chrX_+_12993224 2.417 NM_021109
TMSB4X
thymosin beta 4, X-linked
chr22_+_22786283 2.415


chr13_-_99959649 2.332 NM_004951
GPR183
G protein-coupled receptor 183
chr17_-_38721701 2.180 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr17_+_30771494 2.097 NM_002815
PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr7_-_134854225 2.021 NM_001243753
NM_001243755
C7orf49

chromosome 7 open reading frame 49

chr14_-_106733392 2.001 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr12_-_15114495 1.988 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_+_30771522 1.977 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_+_30771532 1.959 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_28618836 1.953 BLMH
bleomycin hydrolase
chr17_+_30771485 1.941 PSMD11
proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr6_+_84569427 1.915 CYB5R4
cytochrome b5 reductase 4
chr22_+_22676814 1.901


chr14_-_106967528 1.868 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr6_-_24877453 1.860 NM_015864
FAM65B
family with sequence similarity 65, member B
chr6_+_84569394 1.843 CYB5R4
cytochrome b5 reductase 4
chr12_-_8765438 1.819 NM_020661
AICDA
activation-induced cytidine deaminase
chr14_-_106539099 1.713 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr11_+_10476665 1.696 NM_001025389
AMPD3
adenosine monophosphate deaminase 3
chr14_-_106641585 1.685 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_-_29641087 1.683 EVI2B
ecotropic viral integration site 2B
chr22_+_23222897 1.676 CYAT1
immunoglobulin lambda light chain-like
chr11_+_118958696 1.659 NM_001024382
HMBS
hydroxymethylbilane synthase
chrX_-_109683457 1.645 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr1_-_158656487 1.595 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr6_+_84569364 1.500 NM_016230
CYB5R4
cytochrome b5 reductase 4
chr10_-_6019880 1.488 NM_001243539
IL15RA
interleukin 15 receptor, alpha
chr3_-_98241357 1.488 CLDND1
claudin domain containing 1
chr1_-_225616556 1.480 NM_194442
LBR
lamin B receptor
chr12_-_102591547 1.479 NM_002674
PMCH
pro-melanin-concentrating hormone
chr6_+_44195008 1.469 SLC29A1
solute carrier family 29 (nucleoside transporters), member 1
chr3_-_58200397 1.444 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr16_+_27438578 1.438 NM_021798
IL21R
interleukin 21 receptor
chr22_+_23154240 1.427


chr22_+_23134980 1.408


chr17_-_73150769 1.363 NM_001002032
NM_001002033
NM_016185
HN1


hematological and neurological expressed 1


chr15_+_89182038 1.357 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr12_-_71182699 1.333 NM_001207015
PTPRR
protein tyrosine phosphatase, receptor type, R
chr1_+_154966061 1.308 NM_018655
LENEP
lens epithelial protein
chr9_+_130922471 1.306 NM_024112
C9orf16
chromosome 9 open reading frame 16
chr17_-_28619183 1.296 NM_000386
BLMH
bleomycin hydrolase
chr14_-_107170400 1.284 IGHV4-31
IGHV1-69
IGHA1
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 1-69
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr14_-_106926393 1.280 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chrX_+_119738542 1.269 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr7_+_150688143 1.252 NM_000603
NOS3
nitric oxide synthase 3 (endothelial cell)
chr22_+_22764094 1.237


chr10_-_6019454 1.233 NM_002189
NM_172200
IL15RA

interleukin 15 receptor, alpha

chr8_-_42623928 1.230 NM_001199279
NM_004198
CHRNA6

cholinergic receptor, nicotinic, alpha 6

chr7_+_150434435 1.204 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr6_+_33043702 1.173 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr6_-_35696359 1.146 NM_001145775
FKBP5
FK506 binding protein 5
chr4_-_40517913 1.142 NM_019027
RBM47
RNA binding motif protein 47
chrX_-_119445306 1.126 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr19_-_56348127 1.125 NM_145007
NLRP11
NLR family, pyrin domain containing 11
chr7_+_130794854 1.119 NM_001145354
MKLN1
muskelin 1, intracellular mediator containing kelch motifs
chr21_+_33031932 1.112 NM_000454
SOD1
superoxide dismutase 1, soluble
chr6_+_36410800 1.112 KCTD20
potassium channel tetramerisation domain containing 20
chr14_-_107122358 1.109


chr6_+_36410543 1.089 NM_173562
KCTD20
potassium channel tetramerisation domain containing 20
chr6_-_84140758 1.079 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_-_84140744 1.077 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr1_+_12123433 1.036 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr3_+_48507209 1.030 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr16_+_30077120 1.024 ALDOA
aldolase A, fructose-bisphosphate
chr6_-_35888816 1.018 SRPK1
SRSF protein kinase 1
chr15_+_44829373 1.017 EIF3J
eukaryotic translation initiation factor 3, subunit J
chr6_-_154677868 1.014 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr8_-_30585220 0.987 GSR
glutathione reductase
chr15_-_83240499 0.980 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr21_-_46237882 0.977 SUMO3
SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)
chr17_-_29641094 0.955 NM_006495
EVI2B
ecotropic viral integration site 2B
chr13_-_41593405 0.939 ELF1
E74-like factor 1 (ets domain transcription factor)
chr2_-_142889269 0.934 NM_018557
LRP1B
low density lipoprotein receptor-related protein 1B
chr16_+_30077146 0.930 ALDOA
aldolase A, fructose-bisphosphate
chr15_+_44829332 0.929 EIF3J
eukaryotic translation initiation factor 3, subunit J
chr16_-_1429612 0.915 NM_001193389
NM_023076
UNKL

unkempt homolog (Drosophila)-like

chr3_-_98241748 0.909 CLDND1
claudin domain containing 1
chrX_-_110513750 0.908 NM_014289
CAPN6
calpain 6
chr19_-_6670598 0.891 NM_003807
NM_172014
TNFSF14

tumor necrosis factor (ligand) superfamily, member 14

chr15_+_44829265 0.883 NM_003758
EIF3J
eukaryotic translation initiation factor 3, subunit J
chr17_-_29641068 0.878 EVI2B
ecotropic viral integration site 2B
chr14_-_106774311 0.873 IGHA1
immunoglobulin heavy constant alpha 1
chr6_+_106546736 0.863 NM_182907
PRDM1
PR domain containing 1, with ZNF domain
chr19_-_6670078 0.854 TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr16_+_30076993 0.847 NM_001243177
NM_184041
ALDOA

aldolase A, fructose-bisphosphate

chr6_+_150070844 0.846 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr22_-_19466725 0.844 NM_001035247
NM_005659
UFD1L

ubiquitin fusion degradation 1 like (yeast)

chr2_+_231921625 0.843 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr10_-_76868853 0.843 NM_001007271
NM_001007272
NM_001007273
DUSP13


dual specificity phosphatase 13


chr3_+_48507621 0.832 TREX1
three prime repair exonuclease 1
chr11_-_3862183 0.824 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr6_+_150070818 0.809 NM_001252049
NM_001252050
NM_001252051
NM_001252052
NM_001252053
NM_005389
PCMT1





protein-L-isoaspartate (D-aspartate) O-methyltransferase





chr22_-_19466621 0.805 UFD1L
ubiquitin fusion degradation 1 like (yeast)
chr6_+_32121228 0.802 NM_138717
PPT2
palmitoyl-protein thioesterase 2
chr19_-_2038937 0.801 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr22_+_22735202 0.801


chr5_-_176936857 0.801 NM_024872
DOK3
docking protein 3
chr7_+_107204402 0.795 NM_181581
DUS4L
dihydrouridine synthase 4-like (S. cerevisiae)
chr6_-_35888889 0.793 SRPK1
SRSF protein kinase 1
chr19_-_6591012 0.792 CD70
CD70 molecule
chr22_+_23063107 0.788 IGLJ3
immunoglobulin lambda joining 3
chrX_-_119445279 0.783 FAM70A
family with sequence similarity 70, member A
chr7_+_139528951 0.781 NM_001061
NM_001166253
NM_030984
TBXAS1


thromboxane A synthase 1 (platelet)


chr11_-_3862137 0.780 RHOG
ras homolog gene family, member G (rho G)
chr6_-_35888937 0.771 NM_003137
SRPK1
SRSF protein kinase 1
chr1_-_150208441 0.770 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_-_246580710 0.761 NM_022743
SMYD3
SET and MYND domain containing 3
chrX_-_64754594 0.754 LAS1L
LAS1-like (S. cerevisiae)
chr10_+_85899184 0.750 NM_014394
GHITM
growth hormone inducible transmembrane protein
chr17_+_43299277 0.749 NM_005892
FMNL1
formin-like 1
chr6_+_44214853 0.739 HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr12_-_57030083 0.733 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr10_+_121411086 0.730 BAG3
BCL2-associated athanogene 3
chrX_-_53350521 0.728 NM_001111125
IQSEC2
IQ motif and Sec7 domain 2
chr6_+_150070856 0.725 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr12_+_64845839 0.724 NM_013254
TBK1
TANK-binding kinase 1
chr15_+_81517639 0.723 NM_172217
IL16
interleukin 16
chr2_-_233641225 0.722 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr7_+_148395886 0.716 NM_003592
CUL1
cullin 1
chr11_+_10477480 0.704 NM_001025390
AMPD3
adenosine monophosphate deaminase 3
chr1_+_233749749 0.701 NM_002245
KCNK1
potassium channel, subfamily K, member 1
chr1_-_109969044 0.701 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr7_+_148396016 0.698 CUL1
cullin 1
chr8_-_59571920 0.696 NM_001144772
NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr15_+_40733302 0.695 NM_014952
BAHD1
bromo adjacent homology domain containing 1
chr10_-_99052429 0.691 NM_001204300
NM_032900
ARHGAP19

Rho GTPase activating protein 19

chr6_+_44214786 0.689 NM_007355
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr8_-_59572403 0.687 NM_003580
NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr1_-_150208462 0.681 NM_001136478
NM_030920
ANP32E

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr1_-_109969058 0.676 NM_001199772
NM_002790
NM_001199773
NM_001199774
PSMA5



proteasome (prosome, macropain) subunit, alpha type, 5



chr17_+_73598139 0.676 MYO15B
myosin XVB pseudogene
chr22_+_23029175 0.673 IGLV3-25
immunoglobulin lambda variable 3-25
chr2_-_220173693 0.667 NM_001199764
PTPRN
protein tyrosine phosphatase, receptor type, N
chrX_-_72434623 0.660 NAP1L2
nucleosome assembly protein 1-like 2
chr17_-_45899133 0.654 NM_145798
OSBPL7
oxysterol binding protein-like 7
chr11_-_14541867 0.642 PSMA1
proteasome (prosome, macropain) subunit, alpha type, 1
chrX_-_64754637 0.636 NM_001170649
NM_001170650
NM_031206
LAS1L


LAS1-like (S. cerevisiae)


chr22_-_39268214 0.636 CBX6
chromobox homolog 6
chr11_-_47447457 0.635 PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr4_-_76944585 0.627 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr21_-_33651324 0.617 NM_018944
MIS18A
MIS18 kinetochore protein homolog A (S. pombe)
chr14_+_103800678 0.614 EIF5
eukaryotic translation initiation factor 5
chr1_+_14075861 0.614 NM_001007257
PRDM2
PR domain containing 2, with ZNF domain
chr6_+_34206567 0.613 NM_145905
HMGA1
high mobility group AT-hook 1
chr12_-_76478737 0.607 NM_004537
NM_139207
NAP1L1

nucleosome assembly protein 1-like 1

chr16_+_90168671 0.607 FAM157C
family with sequence similarity 157, member C
chr7_+_148395995 0.605 CUL1
cullin 1
chr7_+_150434679 0.598 GIMAP5
GTPase, IMAP family member 5
chr2_-_89292396 0.595 IGKC
immunoglobulin kappa constant
chr1_-_109968951 0.594 PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr18_-_267987 0.592 NM_005131
THOC1
THO complex 1
chr3_+_133118789 0.587 NM_003571
BFSP2
beaded filament structural protein 2, phakinin
chr3_+_132373289 0.586 NM_198329
UBA5
ubiquitin-like modifier activating enzyme 5
chr12_+_56137063 0.580 NM_005811
GDF11
growth differentiation factor 11
chr8_-_59572385 0.575 NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr3_+_184038050 0.568 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr16_-_67517715 0.567 NM_001138
AGRP
agouti related protein homolog (mouse)
chrX_-_129244422 0.566 ELF4
E74-like factor 4 (ets domain transcription factor)
chr1_-_150208134 0.562 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr17_-_45899118 0.561 OSBPL7
oxysterol binding protein-like 7
chr3_+_141043054 0.557 NM_001080412
ZBTB38
zinc finger and BTB domain containing 38
chr18_+_158480 0.554 NM_001037334
NM_005151
USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

chr2_-_214016332 0.551 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr17_-_65362635 0.547 PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chr10_+_115312777 0.544 NM_004132
HABP2
hyaluronan binding protein 2
chr10_+_131934674 0.544 GLRX3
glutaredoxin 3
chrX_-_72434656 0.536 NAP1L2
nucleosome assembly protein 1-like 2
chr7_+_112063131 0.536 NM_001007245
NM_001197080
IFRD1

interferon-related developmental regulator 1

chr3_-_98241722 0.536 CLDND1
claudin domain containing 1
chr10_-_94333721 0.531 IDE
insulin-degrading enzyme
chr5_+_179125362 0.530 CANX
calnexin
chr6_-_84140651 0.530 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_+_18699494 0.529 NM_001100418
NM_001100419
C19orf60

chromosome 19 open reading frame 60

chr2_+_231921608 0.528 PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr3_+_184038445 0.527 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr1_+_114493766 0.525 NM_198269
HIPK1
homeodomain interacting protein kinase 1
chr17_+_45286427 0.522 NM_001002841
MYL4
myosin, light chain 4, alkali; atrial, embryonic
chr14_-_23284565 0.520 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_+_14075931 0.517 PRDM2
PR domain containing 2, with ZNF domain
chr6_-_33548017 0.515 NM_001188
BAK1
BCL2-antagonist/killer 1
chr12_+_50794591 0.513 NM_001170803
NM_001170804
NM_001170808
NM_052879
NM_199188
NM_199190
LARP4





La ribonucleoprotein domain family, member 4





chr11_-_14541886 0.512 NM_001143937
NM_002786
PSMA1

proteasome (prosome, macropain) subunit, alpha type, 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.38 4.56e-03 GO:0002376 immune system process
4.09 1.18e-02 GO:0006955 immune response
145.40 2.88e-02 GO:0051772 regulation of nitric-oxide synthase 2 biosynthetic process

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
32.73 1.96e-06 GO:0003823 antigen binding
109.05 1.04e-02 GO:0008296 3'-5'-exodeoxyribonuclease activity
21.12 3.14e-02 GO:0004536 deoxyribonuclease activity