Motif ID: NFIL3.p2

Z-value: 0.772


Transcription factors associated with NFIL3.p2:

Gene SymbolEntrez IDGene Name
NFIL3 4783 nuclear factor, interleukin 3 regulated

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFIL3chr9_-_941861400.731.5e-03Click!


Activity profile for motif NFIL3.p2.

activity profile for motif NFIL3.p2


Sorted Z-values histogram for motif NFIL3.p2

Sorted Z-values for motif NFIL3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFIL3.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_95360959 6.465 NM_006744
RBP4
retinol binding protein 4, plasma
chr4_+_74269971 6.114 NM_000477
ALB
albumin
chr3_+_133494275 4.363 TF
transferrin
chr10_-_52645430 2.037 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr10_-_82049178 1.633 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr14_+_24563369 1.590 NM_001018073
NM_004563
PCK2

phosphoenolpyruvate carboxykinase 2 (mitochondrial)

chr8_-_17752847 1.541 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr3_+_186330844 1.508 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr17_-_41623246 1.447 NM_001986
ETV4
ets variant 4
chr1_+_207262211 1.414 NM_001017365
NM_001017366
C4BPB

complement component 4 binding protein, beta

chr17_-_41623652 1.381 NM_001079675
ETV4
ets variant 4
chrX_-_131547536 1.334 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr6_-_133035180 1.254 NM_004666
VNN1
vanin 1
chr10_-_69597768 1.218 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr10_+_5005601 1.143 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr4_+_155484131 1.098 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr10_+_5005453 1.006 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr2_-_167005641 0.983 NM_001202435
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr16_-_55866972 0.943 CES1
carboxylesterase 1
chr3_+_186330859 0.920 AHSG
alpha-2-HS-glycoprotein
chr3_-_99833348 0.875 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr14_-_94849552 0.869 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_-_5045967 0.846 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr10_+_5005685 0.786 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_+_57320442 0.748 NM_000562
C8A
complement component 8, alpha polypeptide
chr4_-_186578122 0.743 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr6_+_131894343 0.737 NM_000045
NM_001244438
ARG1

arginase, liver

chr17_-_67240955 0.730 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr19_-_6720585 0.719 NM_000064
C3
complement component 3
chr2_-_88427535 0.715 NM_001443
FABP1
fatty acid binding protein 1, liver
chr1_+_212738675 0.703 NM_001030287
ATF3
activating transcription factor 3
chr9_+_97521930 0.673 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr16_-_55867016 0.655 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr5_-_32388595 0.643 ZFR
zinc finger RNA binding protein
chr3_+_186330711 0.633 AHSG
alpha-2-HS-glycoprotein
chr1_+_24840800 0.613 NM_001251980
NM_001251982
NM_001251985
RCAN3


RCAN family member 3


chr12_-_8043743 0.586 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr17_-_26941178 0.565 NM_001174103
SGK494
uncharacterized serine/threonine-protein kinase SgK494
chr3_-_78666943 0.562 ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr14_+_21156922 0.538 NM_001097577
NM_194431
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr17_-_61850953 0.525 NM_020198
CCDC47
coiled-coil domain containing 47
chr3_-_99594915 0.516 NM_014890
FILIP1L
filamin A interacting protein 1-like
chr2_-_192711923 0.494 NM_004657
SDPR
serum deprivation response
chr7_+_134464161 0.491 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr7_+_45933096 0.483


chr10_-_74283693 0.479 NM_001195519
MICU1
mitochondrial calcium uptake 1
chr2_-_188419049 0.474 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr16_+_31711914 0.461 KIAA0664L3
KIAA0664-like 3
chr17_-_61850890 0.448 CCDC47
coiled-coil domain containing 47
chr4_+_187187342 0.448 F11
coagulation factor XI
chr2_-_239197091 0.445 NM_022817
PER2
period homolog 2 (Drosophila)
chr1_-_203155910 0.413 NM_001276
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr3_+_119501556 0.408 NM_022002
NR1I2
nuclear receptor subfamily 1, group I, member 2
chr16_+_72088507 0.404 NM_001126102
NM_005143
HP

haptoglobin

chr2_-_224903324 0.396 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr4_-_70080448 0.387 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr1_-_203155813 0.383 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chrX_-_33229428 0.383 NM_004006
DMD
dystrophin
chr1_-_203155867 0.375 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr2_-_188419185 0.373 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr13_+_97874540 0.370 NM_144778
NM_207304
MBNL2

muscleblind-like 2 (Drosophila)

chr3_-_148939784 0.369 NM_000096
CP
ceruloplasmin (ferroxidase)
chr4_+_41700736 0.365 LIMCH1
LIM and calponin homology domains 1
chr16_+_3507956 0.364 NM_001083600
NM_024845
NAA60

N(alpha)-acetyltransferase 60, NatF catalytic subunit

chr4_-_69817478 0.360 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_-_203155827 0.359 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr16_+_31711926 0.356 KIAA0664L3
KIAA0664-like 3
chr17_+_40996596 0.351 NM_001158
NM_009590
AOC2

amine oxidase, copper containing 2 (retina-specific)

chr21_-_43786602 0.345 NM_003225
TFF1
trefoil factor 1
chr1_-_203155745 0.343 CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)
chr21_+_45138973 0.327 NM_003681
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr4_-_74088773 0.320 ANKRD17
ankyrin repeat domain 17
chr2_+_148602569 0.319 NM_001616
ACVR2A
activin A receptor, type IIA
chr1_-_247094659 0.303 NM_015446
AHCTF1
AHCTF1P1
AT hook containing transcription factor 1
AT hook containing transcription factor 1 pseudogene 1
chr1_+_25757381 0.302 NM_018202
TMEM57
transmembrane protein 57
chr3_-_123339178 0.294 MYLK
myosin light chain kinase
chr6_-_29527477 0.292 UBD
ubiquitin D
chr11_+_9596233 0.288 NM_001143976
WEE1
WEE1 homolog (S. pombe)
chr13_-_33780142 0.283 NM_001243474
NM_052851
STARD13

StAR-related lipid transfer (START) domain containing 13

chr12_-_123201319 0.279 NM_006018
HCAR3
hydroxycarboxylic acid receptor 3
chr5_-_111091947 0.278 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr11_-_70672644 0.278 SHANK2
SH3 and multiple ankyrin repeat domains 2
chr3_-_185826748 0.277 NM_004454
ETV5
ets variant 5
chr2_+_211421322 0.272 NM_001875
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr16_+_72097124 0.270 NM_020995
HPR
haptoglobin-related protein
chr22_-_50221195 0.268 BRD1
bromodomain containing 1
chr9_+_139871954 0.264 NM_000954
PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr12_-_123187842 0.256 NM_177551
HCAR2
hydroxycarboxylic acid receptor 2
chr7_+_20686965 0.252 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr18_+_32621299 0.244 NM_014268
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr19_-_46389307 0.242 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr3_+_23987514 0.239 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr15_-_56209305 0.239 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr9_+_139872014 0.239 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_-_182354649 0.236 GLUL
glutamate-ammonia ligase
chr5_+_172483285 0.234 NM_001168393
NM_001168394
NM_153607
C5orf41


chromosome 5 open reading frame 41


chr19_-_17414083 0.225 NM_024527
ABHD8
abhydrolase domain containing 8
chr4_+_70146216 0.222 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chr16_+_7382750 0.219 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr17_+_61851557 0.211 NM_007372
NM_203499
DDX42

DEAD (Asp-Glu-Ala-Asp) box polypeptide 42

chr12_-_125002828 0.210


chr21_-_27423423 0.209


chr9_-_95298251 0.207 NM_001197295
NM_001197296
NM_001393
ECM2


extracellular matrix protein 2, female organ and adipocyte specific


chr5_-_140013285 0.201 NM_001040021
NM_001174104
NM_001174105
CD14


CD14 molecule


chr3_+_73110809 0.201 NM_018029
EBLN2
endogenous Bornavirus-like nucleoprotein 2
chr7_+_20655244 0.200 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr2_+_201473942 0.199 AOX1
aldehyde oxidase 1
chr10_+_124151818 0.198 NM_021622
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr19_-_3985343 0.197 EEF2
eukaryotic translation elongation factor 2
chr6_-_2840683 0.194 SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr17_-_39092714 0.193 KRT23
keratin 23 (histone deacetylase inducible)
chr6_+_167525294 0.193 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr14_-_20797532 0.189 NM_182852
NM_182851
CCNB1IP1

cyclin B1 interacting protein 1, E3 ubiquitin protein ligase

chr9_-_73029539 0.186 NM_001206
KLF9
Kruppel-like factor 9
chr1_-_242162364 0.184 NM_001004343
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr11_-_128894008 0.184 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr2_-_99279935 0.181 NM_001160154
MGAT4A
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr1_+_150898814 0.180 NM_001145415
NM_001243491
NM_012432
SETDB1


SET domain, bifurcated 1


chr11_-_62607043 0.179 WDR74
WD repeat domain 74
chr12_-_10282680 0.178 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr8_+_68864341 0.173 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr7_-_143966380 0.171 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr7_+_143880547 0.169 NM_198495
CTAGE4
CTAGE8
CTAGE family, member 4
CTAGE family, member 8
chr3_-_47957475 0.165


chr10_-_116286661 0.164 NM_006720
ABLIM1
actin binding LIM protein 1
chr2_+_131862419 0.162 NM_001100623
NM_017958
PLEKHB2

pleckstrin homology domain containing, family B (evectins) member 2

chr8_+_22210311 0.155 PIWIL2
piwi-like 2 (Drosophila)
chr5_-_32388687 0.152 ZFR
zinc finger RNA binding protein
chr14_-_22005035 0.152 NM_005407
SALL2
sal-like 2 (Drosophila)
chr3_+_12392993 0.142 NM_015869
PPARG
peroxisome proliferator-activated receptor gamma
chr1_-_109935869 0.142 NM_001205228
SORT1
sortilin 1
chr10_-_116418056 0.140 NM_002313
ABLIM1
actin binding LIM protein 1
chr21_-_27512668 0.138 NM_001136016
APP
amyloid beta (A4) precursor protein
chr1_+_178995055 0.136 NM_014864
FAM20B
family with sequence similarity 20, member B
chr10_-_65028825 0.134 NM_004241
JMJD1C
jumonji domain containing 1C
chr10_+_5238756 0.129 NM_001818
AKR1C4
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
chr19_-_3985460 0.128 NM_001961
EEF2
eukaryotic translation elongation factor 2
chr1_+_50575465 0.126 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_-_194188967 0.122 NM_024524
ATP13A3
ATPase type 13A3
chr12_-_10978867 0.122 NM_023921
TAS2R10
taste receptor, type 2, member 10
chr6_+_144612872 0.121 NM_007124
UTRN
utrophin
chr6_+_64231626 0.116 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr20_-_47894591 0.116 NM_021035
ZNFX1
zinc finger, NFX1-type containing 1
chrX_+_118108595 0.116 NM_001031855
NM_024778
LONRF3

LON peptidase N-terminal domain and ring finger 3

chr8_-_17555158 0.110 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr7_-_143599163 0.110 NM_014719
NM_001206938
FAM115A

family with sequence similarity 115, member A

chr17_-_73179093 0.109 NM_001005849
NM_006937
SUMO2

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)

chr16_-_53537112 0.109 NM_001012398
NM_022476
AKTIP

AKT interacting protein

chr2_-_160654736 0.107 NM_001198763
NM_001198764
NM_014880
CD302


CD302 molecule


chr9_-_112191105 0.105 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr16_+_70333058 0.104 NM_001014449
NM_001014451
NM_007242
DDX19B


DEAD (Asp-Glu-Ala-As) box polypeptide 19B


chrM_+_1670 0.103


chr7_-_143454771 0.102 NM_178561
CTAGE6P
CTAGE family, member 6, pseudogene
chr9_+_71819926 0.102 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr3_-_123339423 0.102 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr12_-_16757944 0.100 LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_-_72936538 0.100 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chrX_-_153775002 0.099 G6PD
glucose-6-phosphate dehydrogenase
chr6_+_126307575 0.097 NM_001031712
TRMT11
tRNA methyltransferase 11 homolog (S. cerevisiae)
chr1_+_65613211 0.095 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr5_-_140013034 0.095 NM_000591
CD14
CD14 molecule
chr18_+_22040592 0.093 NM_001143828
NM_001160166
NM_021624
HRH4


histamine receptor H4


chr6_+_24403144 0.092 NM_020662
MRS2
MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
chr7_-_37956515 0.092 NM_003014
SFRP4
secreted frizzled-related protein 4
chr7_+_143268872 0.091 NM_001008747
CTAGE6P
CTAGE15P
CTAGE family, member 6, pseudogene
CTAGE family, member 15, pseudogene
chr12_-_91505215 0.091 LUM
lumican
chr20_-_44455932 0.089 NM_003279
TNNC2
troponin C type 2 (fast)
chr17_-_36956145 0.088 NM_003559
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr2_-_178753464 0.088 NM_001077196
PDE11A
phosphodiesterase 11A
chr9_-_130712866 0.088 NM_203305
FAM102A
family with sequence similarity 102, member A
chr5_+_36606667 0.087 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_-_114790221 0.086 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_71551564 0.085 TSPAN8
tetraspanin 8
chr13_+_97928414 0.084 MBNL2
muscleblind-like 2 (Drosophila)
chr11_-_62607627 0.083 NM_018093
WDR74
WD repeat domain 74
chr2_-_228582698 0.083 NM_025243
SLC19A3
solute carrier family 19, member 3
chr2_+_201756639 0.080 NM_001142356
NIF3L1
NIF3 NGG1 interacting factor 3-like 1 (S. cerevisiae)
chr18_-_55289014 0.079 NARS
asparaginyl-tRNA synthetase
chr8_-_103666018 0.079 NM_001032282
KLF10
Kruppel-like factor 10
chr8_+_17396285 0.077 NM_001164771
NM_003046
SLC7A2

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

chr17_-_38821286 0.077 NM_152349
KRT222
keratin 222
chr6_+_43395285 0.076 NM_001198934
ABCC10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr5_+_154092461 0.076 NM_015315
LARP1
La ribonucleoprotein domain family, member 1
chr3_+_154797910 0.071 NM_007288
MME
membrane metallo-endopeptidase
chr8_-_72274466 0.070 NM_000503
EYA1
eyes absent homolog 1 (Drosophila)
chr19_+_34710327 0.070 LSM14A
LSM14A, SCD6 homolog A (S. cerevisiae)
chr3_+_169684549 0.069 NM_003262
SEC62
SEC62 homolog (S. cerevisiae)
chr14_+_29241989 0.067 C14orf23
chromosome 14 open reading frame 23
chr15_-_83621350 0.067 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr3_-_11623829 0.067 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr2_+_161993465 0.066 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr5_-_137848517 0.066 ETF1
eukaryotic translation termination factor 1
chr1_+_87012758 0.065 NM_012128
CLCA4
chloride channel accessory 4
chr9_-_32550818 0.064 TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr6_-_132032156 0.064 NM_001145659
CTAGE9
CTAGE family, member 9
chr12_-_16758312 0.061 NM_001243611
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_7844713 0.060 NM_016831
PER3
period homolog 3 (Drosophila)
chr10_+_112344076 0.060 SMC3
structural maintenance of chromosomes 3
chr19_+_58513428 0.059 LOC100128398
uncharacterized LOC100128398
chr22_+_42229105 0.059 NM_004599
SREBF2
sterol regulatory element binding transcription factor 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
7.97 7.99e-03 GO:0019752 carboxylic acid metabolic process
7.97 7.99e-03 GO:0043436 oxoacid metabolic process
7.80 9.08e-03 GO:0042180 cellular ketone metabolic process
7.78 9.17e-03 GO:0006082 organic acid metabolic process
30.22 1.91e-02 GO:0002576 platelet degranulation
3.62 2.85e-02 GO:0042221 response to chemical stimulus
93.06 3.31e-02 GO:0015721 bile acid and bile salt transport
5.95 4.13e-02 GO:0009611 response to wounding

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
212.63 1.47e-03 GO:0005577 fibrinogen complex

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
744.06 5.33e-05 GO:0047718 indanol dehydrogenase activity
496.06 1.60e-04 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
372.06 3.19e-04 GO:0047023 androsterone dehydrogenase activity
93.06 6.33e-03 GO:0004033 aldo-keto reductase activity
70.92 1.10e-02 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
67.70 1.21e-02 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
57.29 1.70e-02 GO:0016229 steroid dehydrogenase activity
41.39 3.28e-02 GO:0051087 chaperone binding
8.28 3.29e-02 GO:0008289 lipid binding
34.66 4.67e-02 GO:0043498 cell surface binding