Motif ID: NFKB1_REL_RELA.p2

Z-value: 3.287


Transcription factors associated with NFKB1_REL_RELA.p2:

Gene SymbolEntrez IDGene Name
NFKB1 4790 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
REL 5966 v-rel reticuloendotheliosis viral oncogene homolog (avian)
RELA 5970 v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFKB1chr4_+_1034227300.862.1e-05Click!
RELchr2_+_611087020.775.4e-04Click!
RELAchr11_-_654302140.116.8e-01Click!


Activity profile for motif NFKB1_REL_RELA.p2.

activity profile for motif NFKB1_REL_RELA.p2


Sorted Z-values histogram for motif NFKB1_REL_RELA.p2

Sorted Z-values for motif NFKB1_REL_RELA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NFKB1_REL_RELA.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_4229494 9.771 NM_005755
EBI3
Epstein-Barr virus induced 3
chr5_-_149792276 7.089 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_32551993 6.932 HLA-DRB1
HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1
major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chr22_+_22758538 6.696


chr11_+_102188180 6.532 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr19_-_6591012 6.249 CD70
CD70 molecule
chr5_-_149792370 5.950 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr6_+_32605182 5.718 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr2_-_163174816 5.518 NM_022168
IFIH1
interferon induced with helicase C domain 1
chr6_-_31324975 5.470 NM_005514
HLA-B
major histocompatibility complex, class I, B
chr22_-_37545944 5.407 NM_000878
IL2RB
interleukin 2 receptor, beta
chr14_-_35873823 5.397 NM_020529
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr12_+_7055736 5.072 NM_080548
PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr22_+_23134980 5.050


chr6_+_14117486 5.006 NM_001251901
CD83
CD83 molecule
chr20_+_44746889 4.853 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chr1_+_111770280 4.811 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr7_+_69064316 4.808 AUTS2
autism susceptibility candidate 2
chr6_-_31324955 4.774 HLA-B
major histocompatibility complex, class I, B
chr16_+_85932766 4.663 NM_002163
IRF8
interferon regulatory factor 8
chr22_+_23213671 4.446 IGLV4-3
immunoglobulin lambda variable 4-3
chr6_+_116692098 4.430 NM_013352
DSE
dermatan sulfate epimerase
chr16_+_50776012 4.410 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr14_+_103243832 4.345 TRAF3
TNF receptor-associated factor 3
chr12_+_7055753 4.295 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr19_+_42381189 4.204 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr22_-_37640287 4.145 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr11_+_121322848 4.073 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr14_-_96180402 4.063 NM_001098725
NM_021966
TCL1A

T-cell leukemia/lymphoma 1A

chr19_-_6591082 4.054 CD70
CD70 molecule
chr16_+_50775960 4.042 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr22_-_37640187 3.911 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr10_+_12391708 3.903 CAMK1D
calcium/calmodulin-dependent protein kinase ID
chr17_+_65373574 3.895 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_-_31324898 3.772 HLA-B
major histocompatibility complex, class I, B
chr19_+_50922194 3.736 NM_001243998
NM_001243999
NM_001244000
NM_003121
SPIB



Spi-B transcription factor (Spi-1/PU.1 related)



chr14_+_75988765 3.696 NM_006399
BATF
basic leucine zipper transcription factor, ATF-like
chr14_+_75988838 3.685 BATF
basic leucine zipper transcription factor, ATF-like
chr6_+_14118002 3.667 CD83
CD83 molecule
chr6_+_29974352 3.613 HLA-J
major histocompatibility complex, class I, J (pseudogene)
chr19_-_7766978 3.585 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr20_-_4795768 3.550 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr10_+_30722856 3.517 NM_001244134
NM_005204
MAP3K8

mitogen-activated protein kinase kinase kinase 8

chr10_+_104155431 3.472 NM_002502
NFKB2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr13_-_46756326 3.430 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr21_+_27011588 3.375 NM_021219
JAM2
junctional adhesion molecule 2
chr2_+_95691428 3.346 NM_002371
NM_022438
NM_022439
NM_022440
MAL



mal, T-cell differentiation protein



chr14_+_103243813 3.310 NM_001199427
NM_003300
NM_145725
NM_145726
TRAF3



TNF receptor-associated factor 3



chr6_+_29910246 3.271 NM_001242758
NM_002116
HLA-A

major histocompatibility complex, class I, A

chr19_-_11688441 3.228 ACP5
acid phosphatase 5, tartrate resistant
chr15_+_85923739 3.197 NM_006738
NM_007200
AKAP13

A kinase (PRKA) anchor protein 13

chr7_-_24797031 3.162 DFNA5
deafness, autosomal dominant 5
chr17_+_72462521 3.155 NM_007261
CD300A
CD300a molecule
chr22_+_23222897 3.029 CYAT1
immunoglobulin lambda light chain-like
chr5_-_150466696 2.980 NM_001252391
NM_001252392
TNIP1

TNFAIP3 interacting protein 1

chr22_+_22712091 2.978 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr1_-_183560010 2.946 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr6_-_29527701 2.937 NM_006398
UBD
ubiquitin D
chrX_+_12885190 2.934 NM_016562
TLR7
toll-like receptor 7
chr4_+_103422479 2.912 NM_001165412
NM_003998
NFKB1

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

chr4_+_103422822 2.887 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_+_103422730 2.882 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr20_+_44746948 2.851 CD40
CD40 molecule, TNF receptor superfamily member 5
chr15_+_89182038 2.840 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr11_-_57335756 2.836 NM_198183
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr19_+_2476122 2.829 NM_015675
GADD45B
growth arrest and DNA-damage-inducible, beta
chr6_-_29527477 2.742 UBD
ubiquitin D
chr1_-_183559669 2.618 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr6_+_138188352 2.618 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr6_-_31324564 2.615 HLA-B
HLA-C
major histocompatibility complex, class I, B
major histocompatibility complex, class I, C
chr10_+_104154228 2.609 NM_001077493
NM_001077494
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr19_-_6591136 2.590 NM_001252
CD70
CD70 molecule
chr6_+_31539875 2.574 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chrX_+_78200828 2.568 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr2_+_208394692 2.560 CREB1
cAMP responsive element binding protein 1
chr19_+_3136026 2.559 NM_002068
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr1_-_27961623 2.551 NM_005248
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr16_+_81812897 2.478 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr19_-_44285407 2.469 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr6_-_32811773 2.461 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr8_-_70747200 2.455 NM_030958
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr8_-_22550708 2.435 NM_004430
EGR3
early growth response 3
chr21_+_27011766 2.429 JAM2
junctional adhesion molecule 2
chr16_+_50731049 2.418 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr16_+_81812899 2.398 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr1_+_203274646 2.382 NM_006763
BTG2
BTG family, member 2
chr19_-_44285012 2.342 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr13_-_46756295 2.333 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_+_31540092 2.328 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr1_-_184943532 2.290 FAM129A
family with sequence similarity 129, member A
chr4_-_76944585 2.277 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr3_+_121796695 2.272 NM_006889
NM_176892
CD86

CD86 molecule

chr5_-_150460599 2.252 NM_001252385
NM_001252386
NM_001252393
NM_006058
TNIP1



TNFAIP3 interacting protein 1



chr17_-_34207308 2.245 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr10_+_30723050 2.242 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr2_+_237478379 2.241 NM_020311
CXCR7
chemokine (C-X-C motif) receptor 7
chr5_-_150460550 2.231 TNIP1
TNFAIP3 interacting protein 1
chr1_-_25256767 2.228 NM_004350
RUNX3
runt-related transcription factor 3
chr5_-_142782754 2.225 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr19_+_1067536 2.201 HMHA1
histocompatibility (minor) HA-1
chr3_-_58200397 2.168 NM_004944
DNASE1L3
deoxyribonuclease I-like 3
chr2_+_208394756 2.155 CREB1
cAMP responsive element binding protein 1
chr5_-_142783225 2.151 NM_000176
NM_001020825
NM_001024094
NM_001204258
NM_001204259
NM_001204260
NM_001204261
NM_001204262
NM_001204263
NM_001204264
NM_001204265
NR3C1










nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)










chr2_+_208394823 2.122 CREB1
cAMP responsive element binding protein 1
chr1_-_182573393 2.112 NM_002928
RGS16
regulator of G-protein signaling 16
chr14_-_64970319 2.109 NM_006977
ZBTB25
zinc finger and BTB domain containing 25
chr7_+_114562140 2.108 NM_001166345
NM_001166346
NM_199072
MDFIC


MyoD family inhibitor domain containing


chr21_+_27012045 2.094 JAM2
junctional adhesion molecule 2
chr11_-_3862183 2.076 NM_001665
RHOG
ras homolog gene family, member G (rho G)
chr17_+_72462766 2.067 CD300A
CD300a molecule
chr8_+_38758752 2.057 NM_021623
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr19_+_45504686 2.053 NM_006509
RELB
v-rel reticuloendotheliosis viral oncogene homolog B
chr10_+_12391471 2.043 NM_020397
NM_153498
CAMK1D

calcium/calmodulin-dependent protein kinase ID

chr3_+_53195214 2.029 NM_006254
NM_212539
PRKCD

protein kinase C, delta

chr9_+_4490193 2.018 NM_004170
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr15_+_81589240 2.016 NM_004513
IL16
interleukin 16
chr2_+_61108702 2.011 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr11_-_3862137 1.990 RHOG
ras homolog gene family, member G (rho G)
chr2_+_61108775 1.980 REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr2_-_197036262 1.971 STK17B
serine/threonine kinase 17b
chr6_+_29910308 1.947 HLA-A
major histocompatibility complex, class I, A
chr20_+_9495297 1.943 LAMP5
lysosomal-associated membrane protein family, member 5
chr2_+_61108724 1.940 NM_002908
REL
v-rel reticuloendotheliosis viral oncogene homolog (avian)
chr6_+_29855506 1.935


chr1_-_93426998 1.931 NM_001006605
NM_001252269
NM_001252270
NM_001252273
FAM69A



family with sequence similarity 69, member A



chr5_-_171615239 1.918 STK10
serine/threonine kinase 10
chr21_+_27012067 1.899 JAM2
junctional adhesion molecule 2
chr4_+_103422553 1.891 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr17_-_16875388 1.885 NM_012452
TNFRSF13B
tumor necrosis factor receptor superfamily, member 13B
chr5_-_171615320 1.874 NM_005990
STK10
serine/threonine kinase 10
chr5_-_142783200 1.867 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr3_+_52232174 1.859 ALAS1
aminolevulinate, delta-, synthase 1
chr11_+_1889902 1.858 NM_001013253
LSP1
lymphocyte-specific protein 1
chr4_+_142557722 1.853 NM_000585
NM_172175
IL15

interleukin 15

chr5_-_150467220 1.836 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chrX_-_30595883 1.836 NM_025159
CXorf21
chromosome X open reading frame 21
chr5_-_142783059 1.817 NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr6_+_14117857 1.788 NM_001040280
NM_004233
CD83

CD83 molecule

chr3_+_52232076 1.787 NM_199166
NM_000688
ALAS1

aminolevulinate, delta-, synthase 1

chr1_-_209824641 1.768 NM_001017402
LAMB3
laminin, beta 3
chr6_-_32908583 1.755 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr5_-_171615095 1.726 STK10
serine/threonine kinase 10
chr22_+_22764094 1.695


chr7_+_7606549 1.693 NM_019005
MIOS
missing oocyte, meiosis regulator, homolog (Drosophila)
chr12_+_48499655 1.673 NM_001166686
PFKM
phosphofructokinase, muscle
chr6_+_29855349 1.635 HLA-H
major histocompatibility complex, class I, H (pseudogene)
chr11_-_77122877 1.635 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr6_-_132722564 1.633 NM_015529
MOXD1
monooxygenase, DBH-like 1
chr17_+_7461591 1.596 NM_001198622
NM_001198623
NM_001198624
NM_003808
NM_172087
NM_172088
TNFSF13





tumor necrosis factor (ligand) superfamily, member 13





chr6_+_292033 1.590 NM_020185
DUSP22
dual specificity phosphatase 22
chr17_-_7590731 1.576 NM_000546
NM_001126112
NM_001126113
NM_001126114
TP53



tumor protein p53



chr11_+_58910173 1.571 NM_001142519
NM_001142520
NM_001142521
FAM111A


family with sequence similarity 111, member A


chr2_+_233925035 1.563 NM_001017915
NM_005541
INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

chr4_-_71532206 1.534 IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr20_-_57582152 1.511 CTSZ
cathepsin Z
chr1_-_27952591 1.496 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr19_+_14142459 1.491 IL27RA
interleukin 27 receptor, alpha
chr14_+_65878579 1.484 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr1_-_183604885 1.483 NM_005717
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chr4_-_185395616 1.474 NM_002199
IRF2
interferon regulatory factor 2
chr15_-_66084544 1.458 NM_001144823
NM_005848
DENND4A

DENN/MADD domain containing 4A

chr6_+_135502445 1.458 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr19_+_14142611 1.458 IL27RA
interleukin 27 receptor, alpha
chr1_-_209825797 1.454 NM_000228
LAMB3
laminin, beta 3
chr7_+_7606634 1.450 MIOS
missing oocyte, meiosis regulator, homolog (Drosophila)
chr4_-_71532341 1.445 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr1_+_156123321 1.438 NM_001193300
NM_022367
NM_001193302
SEMA4A


sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A


chr2_+_208394615 1.423 NM_004379
NM_134442
CREB1

cAMP responsive element binding protein 1

chr14_+_64971226 1.420 NM_001123329
NM_014950
ZBTB1

zinc finger and BTB domain containing 1

chr1_-_212873306 1.415 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr14_-_106691698 1.410


chr3_+_57261729 1.393 NM_012096
APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr17_+_72462780 1.391 CD300A
CD300a molecule
chr22_-_23922376 1.388 NM_020070
NM_152855
IGLL1

immunoglobulin lambda-like polypeptide 1

chr1_+_26856252 1.363 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_+_90750384 1.354 FAS
Fas (TNF receptor superfamily, member 6)
chr3_+_57261778 1.344 APPL1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr2_-_197036301 1.325 NM_004226
STK17B
serine/threonine kinase 17b
chr14_-_106692107 1.325 IGHV4-31
IGHA1
IGHD
IGHG1
IGHG3
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant delta
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr5_-_131826426 1.324 NM_002198
IRF1
interferon regulatory factor 1
chr14_-_24616429 1.322 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_-_183604793 1.312 ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa
chrX_-_112084006 1.311 NM_133265
AMOT
angiomotin
chr6_+_29894105 1.294


chr1_-_202130677 1.291 NM_001199797
NM_002832
PTPN7

protein tyrosine phosphatase, non-receptor type 7

chr8_+_54793409 1.291 NM_003702
RGS20
regulator of G-protein signaling 20
chr1_+_183605207 1.287 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr1_+_207627614 1.269 NM_001006658
NM_001877
CR2

complement component (3d/Epstein Barr virus) receptor 2

chr12_-_54653317 1.247 NM_001127322
CBX5
chromobox homolog 5
chr16_-_21314371 1.244 NM_001014444
NM_001888
CRYM

crystallin, mu

chr11_-_64570621 1.228 NM_004579
MAP4K2
mitogen-activated protein kinase kinase kinase kinase 2
chr7_-_24797316 1.224 DFNA5
deafness, autosomal dominant 5
chr17_-_61819120 1.219 STRADA
STE20-related kinase adaptor alpha
chr19_+_16187315 1.206 TPM4
tropomyosin 4
chr5_+_96271345 1.205 NM_005575
LNPEP
leucyl/cystinyl aminopeptidase
chr12_-_54653369 1.203 NM_001127321
CBX5
chromobox homolog 5
chr22_-_24059436 1.186


chr6_+_106534210 1.176 PRDM1
PR domain containing 1, with ZNF domain
chr7_-_129592794 1.168 NM_003344
NM_182697
UBE2H

ubiquitin-conjugating enzyme E2H

chr3_+_52232179 1.152 ALAS1
aminolevulinate, delta-, synthase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
6.75 4.46e-25 GO:0006955 immune response
5.03 1.83e-24 GO:0002376 immune system process
6.70 2.34e-13 GO:0002684 positive regulation of immune system process
6.16 2.32e-11 GO:0050776 regulation of immune response
8.11 2.84e-11 GO:0001817 regulation of cytokine production
4.56 4.53e-11 GO:0006952 defense response
4.67 4.03e-10 GO:0002682 regulation of immune system process
8.71 5.17e-10 GO:0051249 regulation of lymphocyte activation
7.21 1.19e-09 GO:0050778 positive regulation of immune response
2.45 2.16e-09 GO:0048518 positive regulation of biological process
7.93 2.80e-09 GO:0002694 regulation of leukocyte activation
9.01 5.48e-09 GO:0002764 immune response-regulating signaling pathway
7.61 5.87e-09 GO:0050865 regulation of cell activation
9.20 1.75e-08 GO:0051251 positive regulation of lymphocyte activation
1.76 2.43e-08 GO:0050896 response to stimulus
8.64 4.58e-08 GO:0002757 immune response-activating signal transduction
8.58 5.03e-08 GO:0002696 positive regulation of leukocyte activation
5.88 5.70e-08 GO:0045087 innate immune response
8.43 6.61e-08 GO:0050867 positive regulation of cell activation
6.94 1.20e-06 GO:0002253 activation of immune response
3.73 1.23e-06 GO:0048584 positive regulation of response to stimulus
7.55 1.29e-06 GO:0019221 cytokine-mediated signaling pathway
2.05 1.69e-06 GO:0007165 signal transduction
8.99 2.01e-06 GO:0050870 positive regulation of T cell activation
2.30 2.45e-06 GO:0006950 response to stress
2.57 2.66e-06 GO:0048583 regulation of response to stimulus
3.23 4.69e-06 GO:0043067 regulation of programmed cell death
1.95 5.03e-06 GO:0023052 signaling
6.81 5.32e-06 GO:0071345 cellular response to cytokine stimulus
3.18 6.53e-06 GO:0010941 regulation of cell death
5.56 1.06e-05 GO:0034097 response to cytokine stimulus
4.41 1.08e-05 GO:0001775 cell activation
6.29 1.55e-05 GO:0045321 leukocyte activation
3.14 1.58e-05 GO:0042981 regulation of apoptosis
9.64 1.77e-05 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.52 1.90e-05 GO:0050789 regulation of biological process
1.55 2.35e-05 GO:0050794 regulation of cellular process
7.33 2.44e-05 GO:0050863 regulation of T cell activation
2.23 4.01e-05 GO:0048519 negative regulation of biological process
3.26 4.34e-05 GO:0051704 multi-organism process
1.81 4.82e-05 GO:0051716 cellular response to stimulus
2.18 5.10e-05 GO:0048522 positive regulation of cellular process
2.44 5.11e-05 GO:0007166 cell surface receptor linked signaling pathway
1.47 6.70e-05 GO:0065007 biological regulation
11.38 8.62e-05 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
11.06 1.11e-04 GO:0002250 adaptive immune response
7.92 1.39e-04 GO:0001819 positive regulation of cytokine production
9.03 1.52e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
23.08 1.64e-04 GO:0002712 regulation of B cell mediated immunity
23.08 1.64e-04 GO:0002889 regulation of immunoglobulin mediated immune response
12.87 1.73e-04 GO:0050864 regulation of B cell activation
10.35 2.00e-04 GO:0034341 response to interferon-gamma
6.68 2.40e-04 GO:0070201 regulation of establishment of protein localization
21.23 2.83e-04 GO:0032655 regulation of interleukin-12 production
11.61 3.96e-04 GO:0060333 interferon-gamma-mediated signaling pathway
6.29 4.65e-04 GO:0046649 lymphocyte activation
2.75 5.15e-04 GO:0010604 positive regulation of macromolecule metabolic process
6.96 5.20e-04 GO:0002697 regulation of immune effector process
14.08 5.59e-04 GO:0032649 regulation of interferon-gamma production
4.42 6.88e-04 GO:0051707 response to other organism
27.65 6.90e-04 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
3.44 7.23e-04 GO:0071310 cellular response to organic substance
8.85 7.73e-04 GO:0050851 antigen receptor-mediated signaling pathway
7.57 8.04e-04 GO:0002521 leukocyte differentiation
10.57 8.27e-04 GO:0071346 cellular response to interferon-gamma
5.87 9.69e-04 GO:0032880 regulation of protein localization
4.92 9.94e-04 GO:0002520 immune system development
6.37 1.26e-03 GO:0031349 positive regulation of defense response
9.70 1.61e-03 GO:0050852 T cell receptor signaling pathway
11.91 1.81e-03 GO:0019882 antigen processing and presentation
6.86 1.98e-03 GO:0002252 immune effector process
3.85 2.00e-03 GO:0009607 response to biotic stimulus
5.45 2.13e-03 GO:0009617 response to bacterium
2.50 2.28e-03 GO:0010033 response to organic substance
4.92 2.47e-03 GO:0048534 hemopoietic or lymphoid organ development
11.26 2.67e-03 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
2.52 3.01e-03 GO:0009893 positive regulation of metabolic process
11.06 3.02e-03 GO:0002819 regulation of adaptive immune response
8.74 3.57e-03 GO:0002224 toll-like receptor signaling pathway
2.08 3.75e-03 GO:0048523 negative regulation of cellular process
8.64 3.92e-03 GO:0001818 negative regulation of cytokine production
10.50 4.32e-03 GO:0031294 lymphocyte costimulation
10.50 4.32e-03 GO:0031295 T cell costimulation
4.34 4.41e-03 GO:0031347 regulation of defense response
8.33 5.14e-03 GO:0002221 pattern recognition receptor signaling pathway
6.93 6.06e-03 GO:0045089 positive regulation of innate immune response
8.05 6.68e-03 GO:0002758 innate immune response-activating signal transduction
7.96 7.27e-03 GO:0002218 activation of innate immune response
7.96 7.27e-03 GO:0030098 lymphocyte differentiation
2.71 7.49e-03 GO:0070887 cellular response to chemical stimulus
3.28 9.27e-03 GO:0050878 regulation of body fluid levels
12.07 9.45e-03 GO:0032479 regulation of type I interferon production
17.02 9.49e-03 GO:0032088 negative regulation of NF-kappaB transcription factor activity
6.48 1.05e-02 GO:0032496 response to lipopolysaccharide
3.39 1.12e-02 GO:0080134 regulation of response to stress
16.39 1.15e-02 GO:0032480 negative regulation of type I interferon production
16.39 1.15e-02 GO:0050830 defense response to Gram-positive bacterium
7.38 1.28e-02 GO:0070663 regulation of leukocyte proliferation
5.50 1.43e-02 GO:0045088 regulation of innate immune response
1.94 1.54e-02 GO:0042221 response to chemical stimulus
8.61 1.65e-02 GO:0042035 regulation of cytokine biosynthetic process
8.49 1.81e-02 GO:0002699 positive regulation of immune effector process
1.76 1.81e-02 GO:0060255 regulation of macromolecule metabolic process
3.82 1.88e-02 GO:0044419 interspecies interaction between organisms
8.37 1.98e-02 GO:0043900 regulation of multi-organism process
10.62 2.01e-02 GO:0042108 positive regulation of cytokine biosynthetic process
5.90 2.23e-02 GO:0002237 response to molecule of bacterial origin
3.34 2.41e-02 GO:0007596 blood coagulation
3.34 2.41e-02 GO:0050817 coagulation
10.21 2.53e-02 GO:0016064 immunoglobulin mediated immune response
3.32 2.62e-02 GO:0007599 hemostasis
4.64 2.63e-02 GO:0030097 hemopoiesis
2.57 2.71e-02 GO:0042127 regulation of cell proliferation
7.94 2.80e-02 GO:0042742 defense response to bacterium
44.23 2.80e-02 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
10.02 2.83e-02 GO:0019724 B cell mediated immunity
2.31 3.44e-02 GO:0051239 regulation of multicellular organismal process
5.57 3.52e-02 GO:0051223 regulation of protein transport
9.48 3.89e-02 GO:0002706 regulation of lymphocyte mediated immunity
19.66 4.30e-02 GO:0046631 alpha-beta T cell activation
3.51 4.68e-02 GO:0060341 regulation of cellular localization
37.91 4.85e-02 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
70.77 1.02e-05 GO:0033256 I-kappaB/NF-kappaB complex
31.60 4.17e-05 GO:0042613 MHC class II protein complex
17.70 1.17e-04 GO:0042611 MHC protein complex
1.76 2.38e-04 GO:0071944 cell periphery
1.72 7.78e-04 GO:0005886 plasma membrane
5.53 1.32e-02 GO:0009897 external side of plasma membrane
88.45 1.67e-02 GO:0033257 Bcl3/NF-kappaB2 complex
7.08 2.62e-02 GO:0009898 internal side of plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.30 3.12e-03 GO:0005125 cytokine activity
11.06 1.32e-02 GO:0003823 antigen binding
1.34 1.69e-02 GO:0005515 protein binding