Motif ID: NKX3-1.p2

Z-value: 1.797


Transcription factors associated with NKX3-1.p2:

Gene SymbolEntrez IDGene Name
NKX3-1 4824 NK3 homeobox 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX3-1chr8_-_235404010.322.2e-01Click!


Activity profile for motif NKX3-1.p2.

activity profile for motif NKX3-1.p2


Sorted Z-values histogram for motif NKX3-1.p2

Sorted Z-values for motif NKX3-1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX3-1.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_64225496 9.630 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr7_+_45933096 9.326


chr4_+_74301932 7.676 NM_001134
AFP
alpha-fetoprotein
chr4_+_88896838 7.187 SPP1
secreted phosphoprotein 1
chr4_+_88896899 7.086 SPP1
secreted phosphoprotein 1
chr4_+_88896868 7.059 SPP1
secreted phosphoprotein 1
chr4_+_88896801 7.055 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr4_+_74269971 6.234 NM_000477
ALB
albumin
chrX_-_131573638 5.156 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr20_+_30697291 4.906 NM_014742
TM9SF4
transmembrane 9 superfamily protein member 4
chr17_-_56492938 4.329 RNF43
ring finger protein 43
chr8_-_17743062 3.935 FGL1
fibrinogen-like 1
chr7_+_94539209 3.392 NM_001166161
NM_001166162
NM_001166163
PPP1R9A


protein phosphatase 1, regulatory subunit 9A


chr12_-_103311380 3.071 NM_000277
PAH
phenylalanine hydroxylase
chrX_+_107683015 3.056 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr6_+_31895201 2.907 NM_000063
NM_001145903
C2

complement component 2

chr8_-_17752847 2.884 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr5_+_156696351 2.722 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chrX_+_105937067 2.634 NM_024539
RNF128
ring finger protein 128
chr3_-_149086884 2.612 TM4SF1
transmembrane 4 L six family member 1
chr10_-_69597768 2.590 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr20_+_30697512 2.418 TM9SF4
transmembrane 9 superfamily protein member 4
chr16_+_82068958 2.300 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr14_+_95078713 2.263 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr17_+_53342356 2.190 HLF
hepatic leukemia factor
chr10_-_52645430 2.185 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr16_+_82068830 2.173 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr20_-_52199635 2.158 NM_006526
ZNF217
zinc finger protein 217
chr6_+_30130982 2.142 NM_033229
TRIM15
tripartite motif containing 15
chr1_+_207262583 2.100 NM_000716
NM_001017364
NM_001017367
C4BPB


complement component 4 binding protein, beta


chr15_+_66585632 2.081 NM_133375
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr5_-_98262217 2.068 NM_001270
CHD1
chromodomain helicase DNA binding protein 1
chr10_-_118680978 2.064 KIAA1598
KIAA1598
chr4_+_74270832 2.053 ALB
albumin
chrX_-_32430370 2.010 NM_004011
NM_004012
DMD

dystrophin

chrX_-_2882288 1.922 NM_000047
ARSE
arylsulfatase E (chondrodysplasia punctata 1)
chr16_+_82068910 1.839 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr3_-_183273407 1.732 NM_130446
KLHL6
kelch-like 6 (Drosophila)
chr14_+_39734475 1.705 NM_203354
CTAGE5
CTAGE family, member 5
chr4_-_84035908 1.691 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr4_-_84035888 1.688 PLAC8
placenta-specific 8
chr15_+_59904090 1.668 GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr10_-_7682741 1.532 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr2_+_64681270 1.516 NM_014181
LGALSL
lectin, galactoside-binding-like
chr2_-_20512016 1.474 PUM2
pumilio homolog 2 (Drosophila)
chr6_+_31895401 1.471 C2
complement component 2
chr3_-_50340979 1.467 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr2_-_188419049 1.455 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr4_-_69886112 1.453 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr6_-_79675672 1.422 PHIP
pleckstrin homology domain interacting protein
chr12_-_80084742 1.418 NM_002583
PAWR
PRKC, apoptosis, WT1, regulator
chr17_+_37844325 1.403 NM_001005862
ERBB2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr10_-_11574273 1.355 NM_001080491
USP6NL
USP6 N-terminal like
chr10_+_57358749 1.340 NM_001190478
MTRNR2L5
MT-RNR2-like 5
chr3_+_142375738 1.333 NM_001172312
PLS1
plastin 1
chr18_-_52625278 1.326 NM_001143829
CCDC68
coiled-coil domain containing 68
chr6_+_64286348 1.306 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr15_-_60919642 1.294 NM_002943
NM_134260
RORA

RAR-related orphan receptor A

chr2_+_17721806 1.288 NM_003385
VSNL1
visinin-like 1
chr10_+_5488521 1.268 NM_005863
NET1
neuroepithelial cell transforming 1
chr6_+_144612872 1.250 NM_007124
UTRN
utrophin
chrX_-_130423387 1.239 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr3_-_197300193 1.236 NM_203315
BDH1
3-hydroxybutyrate dehydrogenase, type 1
chr16_-_21314371 1.235 NM_001014444
NM_001888
CRYM

crystallin, mu

chrM_+_1670 1.199


chr4_+_166299942 1.199 NM_001873
CPE
carboxypeptidase E
chr10_+_7745354 1.195 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_15911461 1.155 NM_024758
AGMAT
agmatine ureohydrolase (agmatinase)
chr10_-_116444374 1.154 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr15_+_59903980 1.125 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type
chr10_-_52645384 1.106 A1CF
APOBEC1 complementation factor
chr2_-_165551178 1.101 COBLL1
COBL-like 1
chr10_+_7745229 1.093 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745284 1.041 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_+_15990300 1.038


chr4_-_186697065 1.036 NM_001145673
SORBS2
sorbin and SH3 domain containing 2
chr11_+_73358593 1.035 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr21_-_43786602 1.023 NM_003225
TFF1
trefoil factor 1
chr4_+_1902352 1.017 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chrX_-_130423199 1.017 IGSF1
immunoglobulin superfamily, member 1
chr4_-_10686314 1.004 NM_052964
CLNK
cytokine-dependent hematopoietic cell linker
chr21_-_27253197 1.001 APP
amyloid beta (A4) precursor protein
chr1_-_231560789 1.001 NM_022051
EGLN1
egl nine homolog 1 (C. elegans)
chrX_+_99839789 1.000 NM_022144
TNMD
tenomodulin
chr10_+_7745325 0.995 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_112344076 0.994 SMC3
structural maintenance of chromosomes 3
chr14_+_88471467 0.991 NM_003608
GPR65
G protein-coupled receptor 65
chr5_+_92918924 0.990 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_+_167298382 0.975 POU2F1
POU class 2 homeobox 1
chr2_+_17721983 0.972 VSNL1
visinin-like 1
chr4_-_69817478 0.955 NM_024743
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_+_160709038 0.929 NM_021181
SLAMF7
SLAM family member 7
chr10_+_102121371 0.916 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr11_+_22688156 0.906 NM_001143830
GAS2
growth arrest-specific 2
chr6_+_134758840 0.892 LOC154092
uncharacterized LOC154092
chr7_+_115863004 0.877 NM_152829
TES
testis derived transcript (3 LIM domains)
chr3_-_120400957 0.870 HGD
homogentisate 1,2-dioxygenase
chrX_-_131547536 0.854 NM_001170701
NM_001170702
NM_001170703
MBNL3


muscleblind-like 3 (Drosophila)


chr12_-_51403028 0.847 NM_001174130
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr4_+_155484131 0.847 NM_001184741
NM_005141
FGB

fibrinogen beta chain

chr15_+_94899163 0.829 NM_001159644
MCTP2
multiple C2 domains, transmembrane 2
chr3_-_12941547 0.829 IQSEC1
IQ motif and Sec7 domain 1
chr10_-_98031154 0.826 NM_001114094
NM_013314
BLNK

B-cell linker

chr3_-_194072004 0.825 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr18_+_55888838 0.821 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr14_-_106610338 0.820 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr9_+_79968344 0.818 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr9_+_71819926 0.816 NM_001170415
NM_001170416
TJP2

tight junction protein 2 (zona occludens 2)

chr4_-_153303663 0.808 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr2_+_211458078 0.792 NM_001122634
CPS1
carbamoyl-phosphate synthase 1, mitochondrial
chr13_-_75901897 0.784 TBC1D4
TBC1 domain family, member 4
chr6_-_32908583 0.783 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_+_167525294 0.777 NM_004367
CCR6
chemokine (C-C motif) receptor 6
chr11_-_128894008 0.777 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr15_-_56388662 0.766 RFX7
regulatory factor X, 7
chr8_+_40010986 0.759 NM_020130
C8orf4
chromosome 8 open reading frame 4
chr6_-_2176224 0.753 NM_001253846
GMDS
GDP-mannose 4,6-dehydratase
chr15_-_77176191 0.753 NM_020843
SCAPER
S-phase cyclin A-associated protein in the ER
chr13_-_48987652 0.749 NM_001162498
LPAR6
lysophosphatidic acid receptor 6
chr12_+_69742140 0.732 LYZ
lysozyme
chr19_+_50015535 0.730 NM_001136019
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_+_26365397 0.720 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chrX_-_107682600 0.718 NM_001847
COL4A6
collagen, type IV, alpha 6
chr17_+_27369917 0.714 NM_016518
PIPOX
pipecolic acid oxidase
chr4_-_186732047 0.713 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr9_-_75567915 0.703 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chrX_+_107288199 0.696 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr1_+_57320442 0.694 NM_000562
C8A
complement component 8, alpha polypeptide
chr4_+_140587086 0.693 MGST2
microsomal glutathione S-transferase 2
chr17_+_48821106 0.691 LUC7L3
LUC7-like 3 (S. cerevisiae)
chrX_+_91090459 0.662 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr1_+_54359859 0.658 NM_000792
NM_001039715
NM_001039716
NM_213593
DIO1



deiodinase, iodothyronine, type I



chr13_-_41706587 0.648 NM_152903
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr2_+_234826042 0.638 NM_024080
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr5_+_126859157 0.636 PRRC1
proline-rich coiled-coil 1
chr15_+_25068793 0.635 NM_022806
NM_022807
NM_022808
SNRPN


small nuclear ribonucleoprotein polypeptide N


chr2_+_75059781 0.635 NM_000189
HK2
hexokinase 2
chr4_-_110723334 0.632 NM_000204
CFI
complement factor I
chr17_-_42144986 0.626 NM_152344
LSM12
LSM12 homolog (S. cerevisiae)
chr17_-_16097882 0.623 NM_001190438
NM_001190440
NCOR1

nuclear receptor corepressor 1

chr11_+_57529233 0.616 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001206883
NM_001206884
NM_001206885
NM_001206886
NM_001206887
NM_001206888
NM_001206889
NM_001206890
NM_001206891
NM_001331
CTNND1





















catenin (cadherin-associated protein), delta 1





















chrX_-_131623994 0.616 NM_001170704
MBNL3
muscleblind-like 3 (Drosophila)
chr12_+_53845884 0.614 NM_001098620
NM_001128911
NM_001128912
NM_001128913
NM_001128914
NM_005016
NM_031989
PCBP2






poly(rC) binding protein 2






chr7_+_20686965 0.614 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr11_+_87032428 0.611 TMEM135
transmembrane protein 135
chr4_-_151770611 0.611 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr8_-_110693233 0.610 NM_001099745
NM_001099746
SYBU

syntabulin (syntaxin-interacting)

chr14_+_21152735 0.601 ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr12_-_81763127 0.584 NM_001220479
NM_001220480
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr4_-_70080448 0.582 NM_001073
UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr18_+_33234532 0.580 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr10_-_101841593 0.578 NM_001308
CPN1
carboxypeptidase N, polypeptide 1
chr2_-_128100673 0.574 NM_006609
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr12_+_121132677 0.572


chr3_-_105421044 0.572 CBLB
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
chr21_-_43816123 0.571 NM_024022
NM_032405
TMPRSS3

transmembrane protease, serine 3

chr16_+_69796237 0.564 NM_007014
NM_199423
WWP2

WW domain containing E3 ubiquitin protein ligase 2

chr16_+_10522724 0.561 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr6_+_27777713 0.550 NM_003536
HIST1H3H
histone cluster 1, H3h
chr17_-_56494930 0.534 NM_017763
RNF43
ring finger protein 43
chr20_-_3149070 0.534 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr17_-_67240955 0.529 NM_080282
ABCA10
ATP-binding cassette, sub-family A (ABC1), member 10
chr13_-_48987017 0.526 LPAR6
lysophosphatidic acid receptor 6
chr10_-_116444112 0.525 ABLIM1
actin binding LIM protein 1
chr5_+_139889635 0.525


chr10_-_99094427 0.522 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr6_-_25874439 0.511 NM_001098486
NM_006632
SLC17A3

solute carrier family 17 (sodium phosphate), member 3

chr15_-_77154284 0.506 NM_001145923
SCAPER
S-phase cyclin A-associated protein in the ER
chr2_-_233641225 0.505 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr12_-_14996381 0.500 NM_021071
ART4
ADP-ribosyltransferase 4 (Dombrock blood group)
chrY_-_2655478 0.498 NM_003140
SRY
sex determining region Y
chr3_-_57234279 0.495 NM_003865
HESX1
HESX homeobox 1
chr20_+_30102237 0.494 NM_030789
NM_178580
NM_178581
NM_178582
HM13



histocompatibility (minor) 13



chr7_+_99816870 0.488 NM_024070
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr14_-_106471439 0.487 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr1_-_41627045 0.484 NM_001031694
SCMH1
sex comb on midleg homolog 1 (Drosophila)
chr14_+_23789396 0.482 NM_004643
PABPN1
poly(A) binding protein, nuclear 1
chr1_+_50575465 0.473 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr19_-_15236465 0.470 NM_006844
ILVBL
ilvB (bacterial acetolactate synthase)-like
chr2_+_74057969 0.464 STAMBP
STAM binding protein
chr16_+_4845265 0.464 NM_001253793
NM_001253794
LOC440335

uncharacterized LOC440335

chr9_+_90112754 0.455 NM_004938
DAPK1
death-associated protein kinase 1
chr4_-_140060601 0.455 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr20_+_30102261 0.454 HM13
histocompatibility (minor) 13
chr1_-_160549226 0.452 CD84
CD84 molecule
chr1_+_212475147 0.450 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr2_-_165424993 0.447 GRB14
growth factor receptor-bound protein 14
chr19_-_51858041 0.436 NM_001014763
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr15_-_80263460 0.430 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr9_+_90112419 0.430 DAPK1
death-associated protein kinase 1
chr6_+_14117486 0.429 NM_001251901
CD83
CD83 molecule
chr9_-_35665204 0.427 NM_032818
C9orf100
chromosome 9 open reading frame 100
chr6_+_42896859 0.419 NM_006586
CNPY3
canopy 3 homolog (zebrafish)
chr2_+_120770606 0.415 NM_001184938
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr2_-_10942642 0.411 PDIA6
protein disulfide isomerase family A, member 6
chr15_+_66585822 0.409 NM_001143688
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr22_+_40322609 0.408 GRAP2
GRB2-related adaptor protein 2
chr6_+_131958441 0.401 NM_005021
ENPP3
ectonucleotide pyrophosphatase/phosphodiesterase 3
chr12_-_53994783 0.398 NM_001130059
ATF7
activating transcription factor 7
chr1_-_160001723 0.398 NM_145167
PIGM
phosphatidylinositol glycan anchor biosynthesis, class M

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
75.30 2.43e-03 GO:0030212 hyaluronan metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
2.55 1.12e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
16.21 1.08e-03 GO:0004867 serine-type endopeptidase inhibitor activity
8.90 1.93e-02 GO:0004866 endopeptidase inhibitor activity
8.74 2.10e-02 GO:0030414 peptidase inhibitor activity
8.52 2.36e-02 GO:0061135 endopeptidase regulator activity