Motif ID: PAX4.p2

Z-value: 1.296


Transcription factors associated with PAX4.p2:

Gene SymbolEntrez IDGene Name
PAX4 5078 paired box 4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PAX4chr7_-_127255574-0.263.4e-01Click!


Activity profile for motif PAX4.p2.

activity profile for motif PAX4.p2


Sorted Z-values histogram for motif PAX4.p2

Sorted Z-values for motif PAX4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of PAX4.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_53089722 2.636 NM_001243233
TCF4
transcription factor 4
chr1_+_101702304 2.392 NM_001400
S1PR1
sphingosine-1-phosphate receptor 1
chr1_+_101702561 1.877 S1PR1
sphingosine-1-phosphate receptor 1
chr18_-_53255734 1.860 NM_001083962
NM_001243230
NM_003199
TCF4


transcription factor 4


chr20_-_23062786 1.682 CD93
CD93 molecule
chr11_+_114166534 1.599 NM_006169
NNMT
nicotinamide N-methyltransferase
chr6_-_31697953 1.569 DDAH2
dimethylarginine dimethylaminohydrolase 2
chr6_-_31698033 1.517 NM_013974
DDAH2
dimethylarginine dimethylaminohydrolase 2
chr1_+_151032150 1.337 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_-_90062610 1.314 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr6_+_32407618 1.288 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr1_+_151032683 1.237 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_151032880 1.194 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr18_+_72922725 1.181 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr22_+_23229959 1.164 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr1_+_145524989 1.117 NM_003637
ITGA10
integrin, alpha 10
chr6_-_90062450 1.115 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr4_+_41258941 1.086 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr7_+_93551015 1.005 NM_004126
GNG11
guanine nucleotide binding protein (G protein), gamma 11
chr4_-_84030995 1.002 NM_001130716
PLAC8
placenta-specific 8
chr19_+_14544216 0.965 PKN1
protein kinase N1
chr4_-_186877869 0.946 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr12_+_32112381 0.923 C12orf35
chromosome 12 open reading frame 35
chr11_-_78052925 0.911 NM_012296
GAB2
GRB2-associated binding protein 2
chr4_+_40198526 0.898 NM_004310
RHOH
ras homolog gene family, member H
chr4_+_41258909 0.898 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr6_+_32605182 0.887 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr18_-_53255361 0.854 TCF4
transcription factor 4
chr12_+_32112286 0.851 NM_018169
C12orf35
chromosome 12 open reading frame 35
chr17_+_4854383 0.838 NM_001193503
NM_001976
NM_053013
ENO3


enolase 3 (beta, muscle)


chr1_-_160681552 0.837 NM_001778
CD48
CD48 molecule
chr2_-_136873740 0.824 NM_001008540
CXCR4
chemokine (C-X-C motif) receptor 4
chr9_-_16870719 0.799 NM_017637
BNC2
basonuclin 2
chr19_-_45996470 0.784 NM_206901
RTN2
reticulon 2
chr12_+_56546203 0.753 NM_001199629
NM_002475
MYL6B

myosin, light chain 6B, alkali, smooth muscle and non-muscle

chr1_+_12123433 0.726 NM_001243
TNFRSF8
tumor necrosis factor receptor superfamily, member 8
chr2_+_170550949 0.715 NM_001199290
NM_001008489
NM_001199285
NM_001199286
NM_001199287
NM_001199288
PHOSPHO2-KLHL23
PHOSPHO2




PHOSPHO2-KLHL23 readthrough
phosphatase, orphan 2




chr8_-_82395401 0.714 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr9_-_123676849 0.697 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr12_-_123717645 0.661 MPHOSPH9
M-phase phosphoprotein 9
chrX_+_65384078 0.652 NM_001130860
NM_014799
HEPH

hephaestin

chr11_+_1874199 0.642 NM_002339
LSP1
lymphocyte-specific protein 1
chr2_+_102979096 0.620 NM_003855
IL18R1
interleukin 18 receptor 1
chr1_+_43766565 0.620 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr19_+_14544100 0.601 NM_002741
PKN1
protein kinase N1
chr7_-_23509972 0.599 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr1_-_89591685 0.589 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr9_-_20622476 0.575 NM_004529
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_+_212788359 0.559 NM_001206486
ATF3
activating transcription factor 3
chr2_-_238322770 0.554 COL6A3
collagen, type VI, alpha 3
chr3_+_69134057 0.541 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr8_-_13134028 0.539 DLC1
deleted in liver cancer 1
chrY_+_2709596 0.533 NM_001008
RPS4Y1
ribosomal protein S4, Y-linked 1
chrX_+_99899388 0.529 SRPX2
sushi-repeat containing protein, X-linked 2
chr2_-_21022812 0.527 NM_021925
C2orf43
chromosome 2 open reading frame 43
chr17_-_46622274 0.521 NM_002145
HOXB2
homeobox B2
chr5_-_95158465 0.517 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr4_+_41258895 0.517 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr5_-_126366439 0.514 NM_178450
MARCH3
membrane-associated ring finger (C3HC4) 3
chr9_+_27109138 0.503 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr20_-_4795768 0.502 NM_170774
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr12_+_75874512 0.499 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr8_+_74903563 0.497 NM_001195797
NM_015364
LY96

lymphocyte antigen 96

chr6_-_32557431 0.489 NM_001243965
NM_002124
HLA-DRB1

HLA-DRB4
HLA-DRB5
major histocompatibility complex, class II, DR beta 1

major histocompatibility complex, class II, DR beta 4
major histocompatibility complex, class II, DR beta 5
chrY_+_2709630 0.488 RPS4Y1
ribosomal protein S4, Y-linked 1
chr1_-_150669499 0.482 NM_018178
GOLPH3L
golgi phosphoprotein 3-like
chr7_+_26191732 0.478 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr19_+_50015535 0.472 NM_001136019
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_-_186578122 0.472 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chrX_+_2609224 0.472 NM_001122898
NM_002414
CD99

CD99 molecule

chr9_-_20622433 0.468 MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_-_238322840 0.466 NM_004369
NM_057164
NM_057165
NM_057166
NM_057167
COL6A3




collagen, type VI, alpha 3




chrX_+_99899162 0.462 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr8_+_17434700 0.459 PDGFRL
platelet-derived growth factor receptor-like
chrY_+_2559224 0.446 NM_001122898
NM_002414
CD99

CD99 molecule

chr4_+_86851425 0.427 NM_031305
ARHGAP24
Rho GTPase activating protein 24
chr6_+_57037058 0.423 NM_004282
BAG2
BCL2-associated athanogene 2
chr15_-_48937795 0.418 NM_000138
FBN1
fibrillin 1
chr1_-_1623942 0.417 SLC35E2B
SLC35E2
solute carrier family 35, member E2B
solute carrier family 35, member E2
chr9_-_4742042 0.412 NM_001199853
AK3
adenylate kinase 3
chr7_-_50772997 0.412 NM_001001550
GRB10
growth factor receptor-bound protein 10
chr14_-_106471439 0.409 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr1_-_31230594 0.399 LAPTM5
lysosomal protein transmembrane 5
chr14_-_100842623 0.398 WARS
tryptophanyl-tRNA synthetase
chr17_-_47841517 0.397 NM_030802
FAM117A
family with sequence similarity 117, member A
chr5_+_115420693 0.392 NM_016144
COMMD10
COMM domain containing 10
chr11_-_62472901 0.390


chr17_-_47841468 0.386 FAM117A
family with sequence similarity 117, member A
chr3_+_138066489 0.366 NM_001252091
NM_012219
MRAS

muscle RAS oncogene homolog

chr2_-_191184485 0.364 HIBCH
3-hydroxyisobutyryl-CoA hydrolase
chr2_+_33738941 0.361 NM_015376
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_-_238322815 0.356 COL6A3
collagen, type VI, alpha 3
chr18_+_29671925 0.345 RNF138
ring finger protein 138
chr9_+_116263706 0.342 NM_130795
RGS3
regulator of G-protein signaling 3
chr1_-_150207025 0.334 NM_001136479
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr5_+_68667280 0.331 NM_133339
RAD17
RAD17 homolog (S. pombe)
chr7_-_150329285 0.327 GIMAP6
GTPase, IMAP family member 6
chr5_-_93447237 0.326 NM_001163417
NM_001163418
NM_032042
FAM172A


family with sequence similarity 172, member A


chr11_+_20385230 0.323 NM_006410
NM_001098521
HTATIP2

HIV-1 Tat interactive protein 2, 30kDa

chr12_+_10365415 0.322 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr8_-_145653882 0.322 VPS28
vacuolar protein sorting 28 homolog (S. cerevisiae)
chr15_-_35087748 0.320 NM_005159
ACTC1
actin, alpha, cardiac muscle 1
chr3_+_9975513 0.317 NM_015513
NM_001031717
NM_001077415
CRELD1


cysteine-rich with EGF-like domains 1


chr1_-_38397417 0.317 INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr3_+_186739643 0.316 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr17_-_15164043 0.315 NM_153322
PMP22
peripheral myelin protein 22
chr11_+_20385324 0.315 NM_001098522
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr4_-_120987890 0.313 NM_002358
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
chr5_+_147795459 0.312 FBXO38
F-box protein 38
chr8_-_145653912 0.300 NM_016208
NM_183057
VPS28

vacuolar protein sorting 28 homolog (S. cerevisiae)

chr6_+_25963398 0.299 TRIM38
tripartite motif containing 38
chr9_-_135282164 0.299 NM_001205296
NM_007344
TTF1

transcription termination factor, RNA polymerase I

chr22_-_39640956 0.297 NM_002608
PDGFB
platelet-derived growth factor beta polypeptide
chr9_-_91793681 0.296 NM_016848
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr14_-_100842637 0.294 WARS
tryptophanyl-tRNA synthetase
chr10_+_35484829 0.291 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr16_+_50731049 0.290 NM_022162
NOD2
nucleotide-binding oligomerization domain containing 2
chr7_+_80267922 0.290 CD36
CD36 molecule (thrombospondin receptor)
chr17_-_46682333 0.290 NM_018952
HOXB6
homeobox B6
chr15_+_41625052 0.289 NUSAP1
nucleolar and spindle associated protein 1
chr14_-_100842676 0.289 NM_173701
NM_213645
WARS

tryptophanyl-tRNA synthetase

chr4_-_76439582 0.287 NM_001008925
NM_001009922
NM_015436
RCHY1


ring finger and CHY zinc finger domain containing 1


chr11_-_61584451 0.286 NM_013402
FADS1
fatty acid desaturase 1
chr8_-_145653900 0.284 VPS28
vacuolar protein sorting 28 homolog (S. cerevisiae)
chr5_+_139876504 0.282 ANKHD1
ankyrin repeat and KH domain containing 1
chrX_-_119709618 0.279 NM_003588
CUL4B
cullin 4B
chr1_+_26644380 0.279 NM_001803
CD52
CD52 molecule
chr2_-_85839178 0.277 NM_001013649
C2orf68
chromosome 2 open reading frame 68
chr13_+_76334796 0.274 NM_015842
LMO7
LIM domain 7
chr6_+_33043702 0.273 NM_002121
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr1_-_1624180 0.271 NM_001110781
SLC35E2B
solute carrier family 35, member E2B
chr14_+_101300806 0.269 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_172389827 0.267 NM_139240
C1orf105
chromosome 1 open reading frame 105
chr2_-_191184770 0.267 NM_014362
NM_198047
HIBCH

3-hydroxyisobutyryl-CoA hydrolase

chr9_+_92219926 0.267 NM_006705
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr2_-_136875629 0.266 NM_003467
CXCR4
chemokine (C-X-C motif) receptor 4
chr1_+_46016454 0.263 NM_001202413
NM_001202414
NM_006066
NM_153326
AKR1A1



aldo-keto reductase family 1, member A1 (aldehyde reductase)



chr22_-_17680485 0.262 NM_177405
CECR1
cat eye syndrome chromosome region, candidate 1
chr12_+_16064282 0.262 DERA
deoxyribose-phosphate aldolase (putative)
chr14_+_55738871 0.261 NM_152231
FBXO34
F-box protein 34
chr4_-_186577858 0.261 SORBS2
sorbin and SH3 domain containing 2
chr16_+_53088791 0.261 NM_025134
CHD9
chromodomain helicase DNA binding protein 9
chr10_-_70092648 0.255 NM_001033083
NM_022129
PBLD

phenazine biosynthesis-like protein domain containing

chr12_+_110906203 0.251 NM_013300
C12orf24
chromosome 12 open reading frame 24
chr9_-_136933552 0.250 BRD3
bromodomain containing 3
chr7_-_50800018 0.248 NM_001001549
NM_005311
GRB10

growth factor receptor-bound protein 10

chr11_-_62474869 0.247 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr8_+_41348094 0.246 GOLGA7
golgin A7
chr12_+_56114150 0.246 NM_001199771
NM_002905
RDH5

retinol dehydrogenase 5 (11-cis/9-cis)

chr3_-_17741511 0.245 NM_001134381
TBC1D5
TBC1 domain family, member 5
chr12_+_81110689 0.245 NM_005593
MYF5
myogenic factor 5
chr8_+_41348105 0.244 GOLGA7
golgin A7
chr5_+_162930230 0.243 NM_182796
MAT2B
methionine adenosyltransferase II, beta
chr2_-_218843541 0.241 TNS1
tensin 1
chr11_-_62474666 0.241 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_-_62474810 0.238 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr2_+_47630291 0.238 MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr4_-_119757183 0.237 SEC24D
SEC24 family, member D (S. cerevisiae)
chr6_+_83903031 0.237 NM_033411
RWDD2A
RWD domain containing 2A
chr7_-_37488894 0.237 NM_001206480
ELMO1
engulfment and cell motility 1
chr2_+_202004997 0.237 NM_001202515
CFLAR
CASP8 and FADD-like apoptosis regulator
chr21_+_40759688 0.236 NM_001146218
WRB
tryptophan rich basic protein
chr1_+_46016524 0.236 AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr18_-_52988916 0.232 NM_001243234
NM_001243235
TCF4

transcription factor 4

chr17_-_63822660 0.231 NM_001037325
CEP112
centrosomal protein 112kDa
chr1_+_174843523 0.230 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr11_+_20385259 0.230 NM_001098520
HTATIP2
HIV-1 Tat interactive protein 2, 30kDa
chr6_+_31582978 0.229 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chr8_+_38644754 0.228 TACC1
transforming, acidic coiled-coil containing protein 1
chr11_+_66406087 0.227 NM_001198843
NM_001198844
NM_002896
RBM4


RNA binding motif protein 4


chr11_+_67250595 0.226 AIP
aryl hydrocarbon receptor interacting protein
chr20_-_20036685 0.226 NM_016652
CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr2_+_217498205 0.225 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr14_+_62229062 0.225 NM_003082
SNAPC1
small nuclear RNA activating complex, polypeptide 1, 43kDa
chr5_-_121413906 0.224 LOX
lysyl oxidase
chr15_+_63335086 0.224 TPM1
tropomyosin 1 (alpha)
chr2_+_217498082 0.221 NM_000597
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr1_-_154928564 0.221 NM_020524
PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr5_+_102594406 0.220 NM_033211
C5orf30
chromosome 5 open reading frame 30
chr19_+_17378264 0.220 BABAM1
BRISC and BRCA1 A complex member 1
chr17_-_41116445 0.220 AARSD1
alanyl-tRNA synthetase domain containing 1
chr19_-_49622278 0.218 NM_018111
C19orf73
chromosome 19 open reading frame 73
chr1_-_42965948 0.217 TMSB4XP1
thymosin beta 4, X-linked pseudogene 1
chr8_+_38644721 0.216 NM_001122824
NM_006283
TACC1

transforming, acidic coiled-coil containing protein 1

chr5_-_137071462 0.215 KLHL3
kelch-like 3 (Drosophila)
chr4_-_140060601 0.214 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr4_-_170679027 0.213 NM_017867
C4orf27
chromosome 4 open reading frame 27
chr15_+_41625152 0.212 NUSAP1
nucleolar and spindle associated protein 1
chr6_+_29894105 0.211


chr20_-_44541002 0.205 NM_001242920
NM_006227
NM_182676
PLTP


phospholipid transfer protein


chr2_+_47630246 0.205 NM_000251
MSH2
mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
chr17_+_16284350 0.204 NM_018955
UBB
ubiquitin B
chr5_+_68666861 0.203 NM_133340
NM_133341
RAD17

RAD17 homolog (S. pombe)

chr1_-_1677430 0.201 NM_001199787
NM_182838
SLC35E2B
SLC35E2

solute carrier family 35, member E2B
solute carrier family 35, member E2

chr1_-_154928595 0.201 PBXIP1
pre-B-cell leukemia homeobox interacting protein 1
chr1_+_26644458 0.200 CD52
CD52 molecule
chr1_+_193091057 0.199 NM_024529
CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr13_+_111138079 0.196 COL4A2
collagen, type IV, alpha 2
chr14_+_75229995 0.196 NM_019589
YLPM1
YLP motif containing 1
chr2_+_223916861 0.196 NM_080671
KCNE4
potassium voltage-gated channel, Isk-related family, member 4

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.