Motif ID: PRDM1.p3

Z-value: 2.016


Transcription factors associated with PRDM1.p3:

Gene SymbolEntrez IDGene Name
PRDM1 639 PR domain containing 1, with ZNF domain

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRDM1chr6_+_1065467360.292.7e-01Click!


Activity profile for motif PRDM1.p3.

activity profile for motif PRDM1.p3


Sorted Z-values histogram for motif PRDM1.p3

Sorted Z-values for motif PRDM1.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM1.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_112575766 5.212 NM_001105206
NM_001105207
NM_001105208
NM_001105209
NM_002290
LAMA4




laminin, alpha 4




chr1_+_212781969 4.497 NM_001040619
NM_001206484
NM_001206488
NM_001674
ATF3



activating transcription factor 3



chr6_+_32821924 4.375 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr6_-_112575880 4.315 LAMA4
laminin, alpha 4
chr11_+_32112607 4.241 RCN1
reticulocalbin 1, EF-hand calcium binding domain
chr2_-_190044330 4.159 NM_000393
COL5A2
collagen, type V, alpha 2
chr9_-_16727887 4.024 BNC2
basonuclin 2
chr1_+_212782103 3.988 ATF3
activating transcription factor 3
chr6_-_112575708 3.861 LAMA4
laminin, alpha 4
chr1_-_111746917 3.726 DENND2D
DENN/MADD domain containing 2D
chr3_+_8543508 3.645 NM_014583
LMCD1
LIM and cysteine-rich domains 1
chr10_-_44880452 3.271 NM_000609
NM_001033886
NM_001178134
NM_199168
CXCL12



chemokine (C-X-C motif) ligand 12



chr4_+_142557722 3.100 NM_000585
NM_172175
IL15

interleukin 15

chr8_+_97506020 2.799 SDC2
syndecan 2
chr10_+_63808968 2.758 NM_001244638
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_+_8543539 2.741 LMCD1
LIM and cysteine-rich domains 1
chr3_-_114343052 2.576 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr6_-_32811773 2.511 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr14_+_24605366 2.321 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr3_-_49851356 2.166 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr14_+_24605393 2.151 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr5_-_142815076 2.125 NM_001018074
NM_001018075
NM_001018077
NR3C1


nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


chr8_+_97506071 2.117 SDC2
syndecan 2
chrX_+_102883647 2.079 NM_001006640
TCEAL1
transcription elongation factor A (SII)-like 1
chr6_-_29527701 2.050 NM_006398
UBD
ubiquitin D
chr6_-_29527477 2.041 UBD
ubiquitin D
chr6_-_112575345 2.025 LAMA4
laminin, alpha 4
chr12_+_25205180 2.021 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr2_+_231280906 1.937 SP100
SP100 nuclear antigen
chr10_+_114135965 1.923 ACSL5
acyl-CoA synthetase long-chain family member 5
chr1_+_162602308 1.895 DDR2
discoidin domain receptor tyrosine kinase 2
chr10_+_114135937 1.858 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr22_-_36556781 1.832 NM_145640
APOL3
apolipoprotein L, 3
chr8_+_144640476 1.816 NM_024736
GSDMD
gasdermin D
chr4_+_37892698 1.811 NM_015173
TBC1D1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr12_+_6561176 1.780 NM_018009
TAPBPL
TAP binding protein-like
chr4_-_100242487 1.715 NM_000668
ADH1A
ADH1B
alcohol dehydrogenase 1A (class I), alpha polypeptide
alcohol dehydrogenase 1B (class I), beta polypeptide
chr11_+_63304272 1.710 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr11_+_65190272 1.690


chr18_-_53071225 1.656 NM_001243232
TCF4
transcription factor 4
chr12_+_25205488 1.633 LRMP
lymphoid-restricted membrane protein
chr20_+_388963 1.600 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr9_+_137533643 1.580 NM_000093
COL5A1
collagen, type V, alpha 1
chr10_+_114136014 1.541 ACSL5
acyl-CoA synthetase long-chain family member 5
chr3_-_49851217 1.486 UBA7
ubiquitin-like modifier activating enzyme 7
chr4_+_146403955 1.475 NM_001003688
SMAD1
SMAD family member 1
chr20_+_389346 1.434 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_-_221915393 1.410 DUSP10
dual specificity phosphatase 10
chr11_-_104839263 1.342 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr8_+_97505876 1.335 NM_002998
SDC2
syndecan 2
chr8_-_29120571 1.321 NM_015254
KIF13B
kinesin family member 13B
chr8_-_79717540 1.314 NM_000880
NM_001199886
NM_001199887
NM_001199888
IL7



interleukin 7



chr12_-_57505176 1.307 NM_001178078
NM_001178080
NM_001178081
NM_003153
STAT6



signal transducer and activator of transcription 6, interleukin-4 induced



chr20_+_388693 1.301 NM_006462
NM_031229
RBCK1

RanBP-type and C3HC4-type zinc finger containing 1

chr17_+_6659155 1.266 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chr11_+_5646206 1.240 NM_021616
TRIM34
tripartite motif containing 34
chr1_-_221915458 1.232 NM_007207
NM_144729
DUSP10

dual specificity phosphatase 10

chr10_+_91061705 1.225 NM_001547
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr8_+_97505895 1.220 SDC2
syndecan 2
chr13_-_110802708 1.202 COL4A1
collagen, type IV, alpha 1
chr17_+_6659356 1.171 XAF1
XIAP associated factor 1
chr22_+_22550159 1.151 IGLV6-57
immunoglobulin lambda variable 6-57
chrX_-_118827060 1.125 SEPT6
septin 6
chrX_-_118827322 1.118 NM_015129
NM_145799
NM_145800
NM_145802
SEPT6



septin 6



chr2_-_231084600 1.108 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr22_+_22550112 1.054


chr19_-_23578226 1.053 NM_003430
ZNF91
zinc finger protein 91
chr5_-_96143573 1.007 ERAP1
endoplasmic reticulum aminopeptidase 1
chr14_-_69262959 1.006 NM_001244701
ZFP36L1
zinc finger protein 36, C3H type-like 1
chr17_+_41158741 1.001 NM_005533
IFI35
interferon-induced protein 35
chr1_+_162602198 0.995 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chrX_+_102883891 0.983 NM_001006639
NM_004780
TCEAL1

transcription elongation factor A (SII)-like 1

chr1_-_244006471 0.974 NM_005465
NM_181690
AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

chr2_+_231280870 0.969 NM_001080391
NM_001206701
NM_001206702
NM_001206703
NM_003113
SP100




SP100 nuclear antigen




chr6_-_32812189 0.942 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr7_-_86848818 0.910 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr12_+_102271349 0.907 DRAM1
DNA-damage regulated autophagy modulator 1
chr2_-_191878883 0.904 STAT1
signal transducer and activator of transcription 1, 91kDa
chr12_-_57505121 0.899 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr5_-_96143689 0.897 NM_001040458
NM_016442
ERAP1

endoplasmic reticulum aminopeptidase 1

chr1_-_57045235 0.875 NM_003713
PPAP2B
phosphatidic acid phosphatase type 2B
chr12_+_102271082 0.869 NM_018370
DRAM1
DNA-damage regulated autophagy modulator 1
chr2_+_231280933 0.869 SP100
SP100 nuclear antigen
chr9_+_112542496 0.854 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr3_+_51976274 0.844 NM_001003931
NM_005485
PARP3

poly (ADP-ribose) polymerase family, member 3

chr7_+_134832765 0.843 NM_018295
TMEM140
transmembrane protein 140
chr1_+_19971865 0.827 NM_001204085
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr14_+_24701624 0.823 NM_001002000
NM_001002001
GMPR2

guanosine monophosphate reductase 2

chr16_-_67970734 0.802 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr3_+_51977286 0.775 PARP3
poly (ADP-ribose) polymerase family, member 3
chr2_-_127864505 0.765 NM_004305
NM_139343
NM_139344
NM_139345
NM_139346
NM_139347
NM_139348
NM_139349
NM_139350
NM_139351
BIN1









bridging integrator 1









chr19_+_49838700 0.759 CD37
CD37 molecule
chr16_+_50776012 0.754 NM_001042412
CYLD
cylindromatosis (turban tumor syndrome)
chr15_-_80263460 0.754 NM_001114735
NM_004049
BCL2A1

BCL2-related protein A1

chr10_+_123754141 0.726 TACC2
transforming, acidic coiled-coil containing protein 2
chr4_-_185395616 0.709 NM_002199
IRF2
interferon regulatory factor 2
chr16_+_50775960 0.709 NM_001042355
NM_015247
CYLD

cylindromatosis (turban tumor syndrome)

chr5_+_49962920 0.663 PARP8
poly (ADP-ribose) polymerase family, member 8
chr4_-_186578122 0.661 NM_001145674
NM_001145675
SORBS2

sorbin and SH3 domain containing 2

chr19_+_36239445 0.637 LIN37
lin-37 homolog (C. elegans)
chr7_+_128580725 0.616 NM_001098627
IRF5
interferon regulatory factor 5
chr11_-_5706186 0.614 NM_033034
NM_033092
NM_033093
TRIM5


tripartite motif containing 5


chr1_-_150780705 0.613 NM_000396
CTSK
cathepsin K
chr22_-_30642683 0.610 NM_002309
LIF
leukemia inhibitory factor (cholinergic differentiation factor)
chr6_+_26440699 0.607 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr12_-_57824787 0.606 R3HDM2
R3H domain containing 2
chr19_+_36239261 0.605 NM_019104
LIN37
lin-37 homolog (C. elegans)
chr13_+_31309690 0.594 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr12_-_57504935 0.563 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr19_+_49838734 0.549 CD37
CD37 molecule
chr13_+_31309644 0.528 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr10_-_13749622 0.525 FRMD4A
FERM domain containing 4A
chr11_-_104905849 0.520 CASP1
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr12_-_49319211 0.496 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr1_-_221915426 0.461 DUSP10
dual specificity phosphatase 10
chr22_+_39473009 0.452 NM_021822
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr1_-_159046555 0.451 NM_004833
AIM2
absent in melanoma 2
chr17_-_80407601 0.443 NM_001193655
C17orf62
chromosome 17 open reading frame 62
chr1_-_9129666 0.438 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr8_-_93075190 0.421 NM_004349
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr15_+_83098709 0.415 NM_198181
GOLGA6L9
golgin A6 family-like 9
chr9_-_123676849 0.414 NM_001190947
TRAF1
TNF receptor-associated factor 1
chr2_+_231090443 0.410 NM_001005176
NM_007237
SP140

SP140 nuclear body protein

chr16_-_67970651 0.410 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr1_+_19972259 0.406 NM_001204086
NBL1
neuroblastoma, suppression of tumorigenicity 1
chr20_+_57470200 0.391 GNAS
GNAS complex locus
chr10_+_122610853 0.389 WDR11
WD repeat domain 11
chr15_-_37393364 0.370 NM_001220482
NM_002399
MEIS2

Meis homeobox 2

chr10_+_91092238 0.363 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr1_-_150738255 0.351 CTSS
cathepsin S
chr7_+_134464161 0.347 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr9_+_110045551 0.346 RAD23B
RAD23 homolog B (S. cerevisiae)
chr9_+_123850573 0.346 NM_007018
CNTRL
centriolin
chr7_+_5253816 0.344 NM_001033520
WIPI2
WD repeat domain, phosphoinositide interacting 2
chr3_-_11623829 0.329 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr2_+_231191877 0.326 NM_138402
SP140L
SP140 nuclear body protein-like
chr4_-_186577858 0.322 SORBS2
sorbin and SH3 domain containing 2
chr1_-_150738232 0.314 CTSS
cathepsin S
chrX_-_13835187 0.309 GPM6B
glycoprotein M6B
chr19_+_49977465 0.305 NM_001204502
NM_001459
FLT3LG

fms-related tyrosine kinase 3 ligand

chr17_+_3379295 0.288 NM_000049
ASPA
aspartoacylase
chr14_-_24701561 0.267 NM_001199823
NM_006156
NEDD8-MDP1
NEDD8
NEDD8-MDP1 readthrough
neural precursor cell expressed, developmentally down-regulated 8
chr6_+_25962978 0.264 NM_006355
TRIM38
tripartite motif containing 38
chr21_+_43933983 0.257 SLC37A1
solute carrier family 37 (glycerol-3-phosphate transporter), member 1
chr3_+_187871473 0.255 NM_001167672
LPP
LIM domain containing preferred translocation partner in lipoma
chr22_+_39436608 0.254 NM_001006666
NM_145298
APOBEC3F

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

chr2_-_175260349 0.247 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr22_-_36562224 0.244 NM_145641
NM_145642
APOL3

apolipoprotein L, 3

chr14_-_24615794 0.242 NM_002818
PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_-_231090443 0.241 NM_001185015
SP110
SP110 nuclear body protein
chr14_-_69260630 0.235 NM_001244698
NM_004926
ZFP36L1

zinc finger protein 36, C3H type-like 1

chr17_-_15973760 0.231 NCOR1
nuclear receptor corepressor 1
chr1_+_221052845 0.225 HLX
H2.0-like homeobox
chr15_+_71184781 0.220 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr14_-_69259654 0.218 ZFP36L1
zinc finger protein 36, C3H type-like 1
chr5_+_32710742 0.216 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr11_-_58343308 0.213 NM_004811
LPXN
leupaxin
chr11_+_77532159 0.207 NM_024684
C11orf67
chromosome 11 open reading frame 67
chr1_+_110453232 0.203 NM_000757
NM_172210
NM_172212
CSF1


colony stimulating factor 1 (macrophage)


chr3_-_69129502 0.199 NM_003968
NM_198195
UBA3

ubiquitin-like modifier activating enzyme 3

chr2_+_238969730 0.195 SCLY
selenocysteine lyase
chr3_+_9834778 0.192 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr1_-_8483701 0.188 NM_001042682
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr3_+_113616317 0.187 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr1_+_222817634 0.185 MIA3
melanoma inhibitory activity family, member 3
chr1_-_144521169 0.184 FAM91A2
family with sequence similarity 91, member A2
chr1_+_17906941 0.182 NM_001011722
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr2_-_144994905 0.178 NM_024659
GTDC1
glycosyltransferase-like domain containing 1
chr1_-_154580632 0.177 ADAR
adenosine deaminase, RNA-specific
chr9_+_110045565 0.171 RAD23B
RAD23 homolog B (S. cerevisiae)
chr4_+_152020732 0.170 NM_001006
RPS3A
ribosomal protein S3A
chr8_+_97657581 0.169 PGCP
plasma glutamate carboxypeptidase
chr1_+_226012974 0.165 NM_000120
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr8_-_23712297 0.161 NM_003155
STC1
stanniocalcin 1
chr3_-_8543327 0.157 LOC100288428
uncharacterized LOC100288428
chrX_-_13835012 0.156 GPM6B
glycoprotein M6B
chr22_-_31688329 0.151 NM_001135911
NM_052880
PIK3IP1

phosphoinositide-3-kinase interacting protein 1

chr3_+_107241782 0.147 NM_001142568
NM_020235
BBX

bobby sox homolog (Drosophila)

chr4_+_76649826 0.147 NM_003715
USO1
USO1 vesicle docking protein homolog (yeast)
chr1_-_44497028 0.144 SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr4_+_76649806 0.140 USO1
USO1 vesicle docking protein homolog (yeast)
chr14_-_24615772 0.137 PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr12_-_9913415 0.131 NM_001781
CD69
CD69 molecule
chr14_-_24701472 0.130 NEDD8
neural precursor cell expressed, developmentally down-regulated 8
chr11_+_65190267 0.121 NEAT1
nuclear paraspeckle assembly transcript 1 (non-protein coding)
chr9_+_110045516 0.119 NM_002874
RAD23B
RAD23 homolog B (S. cerevisiae)
chr1_-_148176392 0.118


chr4_+_76649739 0.115 USO1
USO1 vesicle docking protein homolog (yeast)
chr20_-_18447622 0.111 NM_001099407
DZANK1
double zinc ribbon and ankyrin repeat domains 1
chr1_-_143744355 0.111 LOC100286793
FLJ39739
uncharacterized LOC100286793
uncharacterized FLJ39739
chr19_+_13105970 0.109 NM_002501
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr10_+_91087601 0.105 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chrX_-_118827155 0.096 SEPT6
septin 6
chr19_-_47735858 0.092 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr11_-_77531750 0.086 NM_016578
RSF1
remodeling and spacing factor 1
chr7_+_134464372 0.084 CALD1
caldesmon 1
chr11_-_78052925 0.083 NM_012296
GAB2
GRB2-associated binding protein 2
chr1_-_13390747 0.083 NM_001012276
PRAMEF8
PRAMEF7
PRAME family member 8
PRAME family member 7
chr22_-_36635999 0.082 NM_145637
APOL2
apolipoprotein L, 2
chr6_-_24936177 0.081 FAM65B
family with sequence similarity 65, member B

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
21.27 1.37e-03 GO:0060337 type I interferon-mediated signaling pathway
21.27 1.37e-03 GO:0071357 cellular response to type I interferon
20.93 1.49e-03 GO:0034340 response to type I interferon
9.00 1.96e-02 GO:0019221 cytokine-mediated signaling pathway
6.83 2.56e-02 GO:0034097 response to cytokine stimulus
3.32 3.25e-02 GO:0002376 immune system process
8.13 3.46e-02 GO:0071345 cellular response to cytokine stimulus
10.56 4.18e-02 GO:0010565 regulation of cellular ketone metabolic process
3.71 4.96e-02 GO:0070887 cellular response to chemical stimulus

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
175.69 2.79e-03 GO:0005588 collagen type V

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
175.69 2.71e-03 GO:0004024 alcohol dehydrogenase activity, zinc-dependent