Motif ID: RXRG_dimer.p3

Z-value: 1.213


Transcription factors associated with RXRG_dimer.p3:

Gene SymbolEntrez IDGene Name
NR1H2 7376 nuclear receptor subfamily 1, group H, member 2
PPARA 5465 peroxisome proliferator-activated receptor alpha
PPARG 5468 peroxisome proliferator-activated receptor gamma
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR1H2chr19_+_50879681-0.674.9e-03Click!
RXRBchr6_-_331683690.552.7e-02Click!
PPARGchr3_+_12329332,
chr3_+_12392993,
chr3_+_12330336
0.439.9e-02Click!
RXRGchr1_-_165414499-0.421.1e-01Click!
RXRAchr9_+_1372183240.361.7e-01Click!
PPARAchr22_+_46546690-0.341.9e-01Click!


Activity profile for motif RXRG_dimer.p3.

activity profile for motif RXRG_dimer.p3


Sorted Z-values histogram for motif RXRG_dimer.p3

Sorted Z-values for motif RXRG_dimer.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRG_dimer.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_116708334 3.908 NM_000039
APOA1
apolipoprotein A-I
chr11_+_116700620 3.409 NM_000040
APOC3
apolipoprotein C-III
chr6_+_31623688 2.867 APOM
apolipoprotein M
chr6_+_31623668 2.744 NM_019101
APOM
apolipoprotein M
chr20_+_56136136 2.321 NM_002591
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr10_-_52645384 2.093 A1CF
APOBEC1 complementation factor
chr2_+_219283809 2.075 NM_007127
VIL1
villin 1
chr19_+_50016490 2.069 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_+_50016500 2.015 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_-_42811959 1.997 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr10_-_52645430 1.697 NM_001198818
NM_001198819
NM_001198820
NM_014576
NM_138932
NM_138933
A1CF





APOBEC1 complementation factor





chr2_+_109065665 1.694 GCC2
GRIP and coiled-coil domain containing 2
chr12_-_6665220 1.579 NM_001039670
NM_001193457
NM_080730
IFFO1


intermediate filament family orphan 1


chr1_-_173886464 1.519 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr2_+_109065576 1.422 NM_181453
GCC2
GRIP and coiled-coil domain containing 2
chr19_+_50016435 1.404 NM_004107
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr5_+_92918924 1.390 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_+_145727665 1.270 NM_001201325
NM_001201326
NM_002614
PDZK1


PDZ domain containing 1


chr10_+_102732285 1.263 NM_001203244
NM_017893
SEMA4G

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

chr2_+_178257488 1.218 AGPS
alkylglycerone phosphate synthase
chr13_+_100741268 1.185 NM_000282
NM_001127692
NM_001178004
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr1_+_145727712 1.169 PDZK1
PDZ domain containing 1
chr20_-_20033005 1.162 CRNKL1
crooked neck pre-mRNA splicing factor-like 1 (Drosophila)
chr7_-_65447233 1.148 NM_000181
GUSB
glucuronidase, beta
chr16_+_4714709 1.103 MGRN1
mahogunin, ring finger 1
chr2_+_178257371 1.074 NM_003659
AGPS
alkylglycerone phosphate synthase
chr2_+_138721807 1.074 NM_001024074
NM_001024075
NM_006895
HNMT


histamine N-methyltransferase


chr2_-_64246431 1.034 VPS54
vacuolar protein sorting 54 homolog (S. cerevisiae)
chr20_+_30945988 1.024 NM_001164603
NM_015338
ASXL1

additional sex combs like 1 (Drosophila)

chr7_-_65447162 0.988 GUSB
glucuronidase, beta
chr16_-_87970107 0.962 NM_001739
CA5A
carbonic anhydrase VA, mitochondrial
chr7_-_65447187 0.915 GUSB
glucuronidase, beta
chr7_-_72936538 0.913 BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr6_+_30524662 0.868 PRR3
proline rich 3
chr7_-_65447206 0.864 GUSB
glucuronidase, beta
chr4_+_140587086 0.837 MGST2
microsomal glutathione S-transferase 2
chr2_+_219646448 0.828 NM_000784
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chrX_-_122866888 0.817 NM_001081550
THOC2
THO complex 2
chr19_+_50016606 0.797 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_-_173886401 0.788 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr14_-_95623665 0.776 NM_177438
DICER1
dicer 1, ribonuclease type III
chr20_+_37590969 0.763 NM_001190809
NM_021931
DHX35

DEAH (Asp-Glu-Ala-His) box polypeptide 35

chr2_-_28113211 0.719 NM_022128
RBKS
ribokinase
chr7_-_74489636 0.699 WBSCR16
Williams-Beuren syndrome chromosome region 16
chr1_-_15911461 0.644 NM_024758
AGMAT
agmatine ureohydrolase (agmatinase)
chr1_+_43855599 0.644 SZT2
seizure threshold 2 homolog (mouse)
chr2_+_159313407 0.624 PKP4
plakophilin 4
chr6_+_143999058 0.613 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr2_-_207024103 0.573 NM_001199981
NM_001199982
NM_001199983
NM_005006
NDUFS1



NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)



chrX_-_122866881 0.571 THOC2
THO complex 2
chr2_+_73441344 0.570 NM_006062
SMYD5
SMYD family member 5
chr20_-_36661822 0.552 NM_014657
TTI1
TELO2 interacting protein 1
chr12_-_51422012 0.527 NM_001174125
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr22_+_41865112 0.503 NM_001098
ACO2
aconitase 2, mitochondrial
chr3_-_52312257 0.499 WDR82
WD repeat domain 82
chr17_-_36105005 0.468 NM_000458
NM_001165923
HNF1B

HNF1 homeobox B

chr22_-_24059524 0.463 GUSBP11
glucuronidase, beta pseudogene 11
chr19_-_41196419 0.457 NM_004756
NUMBL
numb homolog (Drosophila)-like
chr7_-_74489572 0.438 WBSCR16
Williams-Beuren syndrome chromosome region 16
chr18_-_47339854 0.408 ACAA2
acetyl-CoA acyltransferase 2
chr2_+_162016926 0.401 NM_001199135
TANK
TRAF family member-associated NFKB activator
chr11_+_118230292 0.392 NM_001204077
NM_004788
UBE4A

ubiquitination factor E4A

chrX_+_38420690 0.387 NM_004615
TSPAN7
tetraspanin 7
chr7_+_137761177 0.385 NM_001190906
NM_001190907
NM_005989
AKR1D1


aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)


chr1_-_160313029 0.364 COPA
coatomer protein complex, subunit alpha
chr18_-_51750460 0.354 MBD2
methyl-CpG binding domain protein 2
chr1_+_160313061 0.347 NM_015331
NCSTN
nicastrin
chr7_-_74489686 0.343 NM_030798
WBSCR16
Williams-Beuren syndrome chromosome region 16
chr19_+_11546485 0.341 PRKCSH
protein kinase C substrate 80K-H
chr9_+_115142395 0.339 HSDL2
hydroxysteroid dehydrogenase like 2
chr16_-_47007567 0.325 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr2_+_86668270 0.323 NM_018433
KDM3A
lysine (K)-specific demethylase 3A
chr9_+_115142188 0.320 NM_001195822
NM_032303
HSDL2

hydroxysteroid dehydrogenase like 2

chr7_-_72936592 0.316 NM_032408
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr22_-_24059436 0.311


chr2_-_198364997 0.305 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr3_+_150264514 0.303 NM_032025
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr11_+_118230348 0.285 UBE4A
ubiquitination factor E4A
chr2_-_198364522 0.285 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr22_+_25003610 0.283 NM_001032365
GGT1
gamma-glutamyltransferase 1
chr22_-_24059502 0.280 GUSBP11
glucuronidase, beta pseudogene 11
chr19_+_11546085 0.278 NM_001001329
NM_002743
PRKCSH

protein kinase C substrate 80K-H

chr20_+_43160435 0.277 NM_007066
NM_181804
NM_181805
PKIG


protein kinase (cAMP-dependent, catalytic) inhibitor gamma


chr1_-_43855448 0.274 MED8
mediator complex subunit 8
chr10_+_114133838 0.257 NM_203379
ACSL5
acyl-CoA synthetase long-chain family member 5
chr4_-_4543690 0.251 STX18
syntaxin 18
chr20_-_34542205 0.251 SCAND1
SCAN domain containing 1
chr22_+_38201113 0.244 NM_005318
H1F0
H1 histone family, member 0
chr4_+_90816002 0.244 NM_007351
MMRN1
multimerin 1
chr12_-_51419923 0.244 NM_001174129
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
chr11_+_86748870 0.240 NM_001168724
NM_022918
TMEM135

transmembrane protein 135

chr16_-_21436657 0.238 NM_130464
NPIPL3
nuclear pore complex interacting protein-like 3
chr2_-_198364560 0.235 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr12_-_51420097 0.228 NM_000617
NM_001174126
NM_001174127
NM_001174128
SLC11A2



solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2



chr1_+_78354199 0.221 NM_001172309
NM_144573
NEXN

nexilin (F actin binding protein)

chr3_-_150264264 0.219 SERP1
stress-associated endoplasmic reticulum protein 1
chr1_-_32860014 0.204 NM_001143888
NM_001143889
NM_001143890
NM_018045
BSDC1



BSD domain containing 1



chr2_+_109237679 0.203 NM_001193484
LIMS1
LIM and senescent cell antigen-like domains 1
chr2_-_198364623 0.201 NM_002156
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr19_+_11546938 0.200 PRKCSH
protein kinase C substrate 80K-H
chr3_-_150264280 0.181 NM_014445
SERP1
stress-associated endoplasmic reticulum protein 1
chr18_-_46477080 0.178 NM_001190821
NM_005904
SMAD7

SMAD family member 7

chr12_-_54121203 0.171 NM_001143682
NM_020898
CALCOCO1

calcium binding and coiled-coil domain 1

chr1_+_45097669 0.170 RNF220
ring finger protein 220
chr9_+_91933384 0.165 NM_024077
SECISBP2
SECIS binding protein 2
chrX_-_64254592 0.162 NM_001178032
NM_001243804
ZC4H2

zinc finger, C4H2 domain containing

chr8_-_145550300 0.160 DGAT1
diacylglycerol O-acyltransferase 1
chr17_+_7123246 0.159 ACADVL
acyl-CoA dehydrogenase, very long chain
chr22_+_47158517 0.159 NM_014346
TBC1D22A
TBC1 domain family, member 22A
chr16_-_47007483 0.158 DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr3_-_49314281 0.158 NM_198562
C3orf62
chromosome 3 open reading frame 62
chr1_-_19578015 0.154 KIAA0090
KIAA0090
chr20_-_34542385 0.152 NM_033630
SCAND1
SCAN domain containing 1
chr15_+_96873845 0.151 NM_021005
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr7_+_120628722 0.150 NM_024913
C7orf58
chromosome 7 open reading frame 58
chr12_+_107168336 0.149 NM_018157
RIC8B
resistance to inhibitors of cholinesterase 8 homolog B (C. elegans)
chr1_-_79472360 0.149 NM_022159
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr12_+_121416548 0.148 NM_000545
HNF1A
HNF1 homeobox A
chr15_+_57210852 0.146 TCF12
transcription factor 12
chrX_-_1510901 0.145 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr22_+_24115035 0.145 NM_005940
MMP11
matrix metallopeptidase 11 (stromelysin 3)
chr22_-_31742329 0.142 PATZ1
POZ (BTB) and AT hook containing zinc finger 1
chr20_+_44509847 0.142 NM_080603
ZSWIM1
zinc finger, SWIM-type containing 1
chr11_+_117049838 0.139 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr18_-_47340208 0.137 NM_006111
ACAA2
acetyl-CoA acyltransferase 2
chr11_-_62414063 0.136 GANAB
glucosidase, alpha; neutral AB
chr11_+_118443091 0.129 NM_001142281
NM_001655
ARCN1

archain 1

chr1_+_150337145 0.123 RPRD2
regulation of nuclear pre-mRNA domain containing 2
chr3_+_184056304 0.122 FAM131A
family with sequence similarity 131, member A
chr1_-_226374400 0.120 ACBD3
acyl-CoA binding domain containing 3
chr1_-_226374401 0.120 NM_022735
ACBD3
acyl-CoA binding domain containing 3
chr11_+_118443140 0.117 ARCN1
archain 1
chr2_+_207024317 0.117 NM_001037663
NM_001959
NM_021121
EEF1B2


eukaryotic translation elongation factor 1 beta 2


chr19_+_1205773 0.112 NM_000455
STK11
serine/threonine kinase 11
chr1_+_36396673 0.109 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr20_-_54967221 0.108 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr16_-_30596808 0.108 NM_152458
ZNF785
zinc finger protein 785
chr12_+_96252705 0.107 NM_003095
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr12_-_7079616 0.107 PHB2
prohibitin 2
chr2_+_198365113 0.106 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr2_+_207024614 0.104 EEF1B2
eukaryotic translation elongation factor 1 beta 2
chrY_-_1460901 0.101 NM_001636
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr1_-_19578030 0.101 KIAA0090
KIAA0090
chr19_+_11546447 0.101 PRKCSH
protein kinase C substrate 80K-H
chr11_-_62414086 0.100 GANAB
glucosidase, alpha; neutral AB
chr14_+_24867926 0.097 NM_025081
NYNRIN
NYN domain and retroviral integrase containing
chr2_+_28113612 0.097 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr19_+_11546467 0.097 PRKCSH
protein kinase C substrate 80K-H
chr1_-_111970354 0.096 NM_002557
OVGP1
oviductal glycoprotein 1, 120kDa
chr14_-_106174914 0.095 IGHA1
immunoglobulin heavy constant alpha 1
chr6_-_30523933 0.094 GNL1
guanine nucleotide binding protein-like 1
chr2_+_28113655 0.091 BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr1_-_19578045 0.091 NM_015047
KIAA0090
KIAA0090
chr5_-_32444729 0.089 ZFR
zinc finger RNA binding protein
chr10_+_120967094 0.087 NM_005308
GRK5
G protein-coupled receptor kinase 5
chr2_+_198365012 0.085 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr3_+_139654001 0.084 NM_022131
CLSTN2
calsyntenin 2
chr8_-_145550516 0.082 DGAT1
diacylglycerol O-acyltransferase 1
chr12_+_121416294 0.082 HNF1A
HNF1 homeobox A
chr17_+_7123149 0.076 NM_000018
NM_001033859
ACADVL

acyl-CoA dehydrogenase, very long chain

chr19_-_36303724 0.073 PRODH2
proline dehydrogenase (oxidase) 2
chr20_+_42187634 0.071 NM_170693
SGK2
serum/glucocorticoid regulated kinase 2
chr2_+_28113481 0.069 NM_199193
NM_199194
NM_004899
NM_199191
NM_199192
BRE




brain and reproductive organ-expressed (TNFRSF1A modulator)




chr20_+_54967572 0.069 NM_001324
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chr19_+_39390570 0.068 NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr17_+_7533452 0.067 NM_001040
NM_001146279
NM_001146280
NM_001146281
SHBG



sex hormone-binding globulin



chr12_+_49716970 0.066 NM_001100620
NM_005480
TROAP

trophinin associated protein (tastin)

chr15_+_57210823 0.065 NM_003205
NM_207036
NM_207037
NM_207038
TCF12



transcription factor 12



chr7_+_100318422 0.063 NM_000799
EPO
erythropoietin
chr17_+_45973515 0.061 NM_003110
SP2
Sp2 transcription factor
chr16_+_30710461 0.058 NM_006662
SRCAP
Snf2-related CREBBP activator protein
chr2_-_220034706 0.058 NM_001144889
NM_001144890
NM_144712
SLC23A3


solute carrier family 23 (nucleobase transporters), member 3


chr8_-_145550536 0.051 NM_012079
DGAT1
diacylglycerol O-acyltransferase 1
chrX_+_105937067 0.051 NM_024539
RNF128
ring finger protein 128
chr15_+_57210972 0.051 TCF12
transcription factor 12
chr20_+_55108265 0.050 NM_001013646
FAM209B
family with sequence similarity 209, member B
chr4_+_156680603 0.049 GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr10_+_75504145 0.049 SEC24C
SEC24 family, member C (S. cerevisiae)
chr10_+_75504119 0.045 NM_004922
NM_198597
SEC24C

SEC24 family, member C (S. cerevisiae)

chr16_-_30546145 0.045 NM_023931
ZNF747
zinc finger protein 747
chr8_+_67624652 0.044 NM_001033578
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr2_-_74756824 0.044 AUP1
ancient ubiquitous protein 1
chr2_-_74756823 0.043 AUP1
ancient ubiquitous protein 1
chr7_-_74306672 0.043 STAG3L2
stromal antigen 3-like 2
chr5_-_176981537 0.041 NM_001190946
FAM193B
family with sequence similarity 193, member B
chr1_-_211848820 0.041 NM_001204182
NM_001204183
NM_002497
NEK2


NIMA (never in mitosis gene a)-related kinase 2


chr4_-_4543747 0.041 NM_016930
STX18
syntaxin 18
chr13_+_21714709 0.041 SAP18
Sin3A-associated protein, 18kDa
chr2_-_74756815 0.037 AUP1
ancient ubiquitous protein 1
chr2_-_74756838 0.034 AUP1
ancient ubiquitous protein 1
chr12_+_69202796 0.031 MDM2
Mdm2 p53 binding protein homolog (mouse)
chr2_+_74756986 0.030 HTRA2
HtrA serine peptidase 2
chr6_+_96025343 0.028 NM_024641
MANEA
mannosidase, endo-alpha
chr12_+_67663147 0.028 CAND1
cullin-associated and neddylation-dissociated 1
chr15_-_83680369 0.028 NM_001160113
NM_001160114
NM_001160115
NM_001160116
NM_144597
C15orf40




chromosome 15 open reading frame 40




chr8_+_67624941 0.028 SGK3
serum/glucocorticoid regulated kinase family, member 3
chr9_+_140513451 0.026 EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr2_+_74757243 0.025 HTRA2
HtrA serine peptidase 2
chr2_+_74757127 0.025 HTRA2
HtrA serine peptidase 2
chr1_-_160312959 0.025



Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
137.52 2.00e-04 GO:0034377 plasma lipoprotein particle assembly
137.52 2.00e-04 GO:0065005 protein-lipid complex assembly
117.88 3.29e-04 GO:0034375 high-density lipoprotein particle remodeling
97.09 6.13e-04 GO:0043691 reverse cholesterol transport
86.87 8.72e-04 GO:0034381 plasma lipoprotein particle clearance
82.53 1.02e-03 GO:0033344 cholesterol efflux
78.60 1.19e-03 GO:0034367 macromolecular complex remodeling
78.60 1.19e-03 GO:0034368 protein-lipid complex remodeling
78.60 1.19e-03 GO:0034369 plasma lipoprotein particle remodeling
366.65 1.72e-03 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
66.03 2.06e-03 GO:0071825 protein-lipid complex subunit organization
66.03 2.06e-03 GO:0071827 plasma lipoprotein particle organization
275.00 3.44e-03 GO:0010901 regulation of very-low-density lipoprotein particle remodeling
275.00 3.44e-03 GO:0032488 Cdc42 protein signal transduction
48.57 5.29e-03 GO:0097006 regulation of plasma lipoprotein particle levels
220.01 5.73e-03 GO:0034380 high-density lipoprotein particle assembly
43.46 7.43e-03 GO:0030301 cholesterol transport
42.34 8.04e-03 GO:0015918 sterol transport
183.35 8.59e-03 GO:0034384 high-density lipoprotein particle clearance
38.41 1.08e-02 GO:0042632 cholesterol homeostasis
38.41 1.08e-02 GO:0055092 sterol homeostasis
122.25 2.05e-02 GO:0033700 phospholipid efflux
28.49 2.66e-02 GO:0055088 lipid homeostasis
13.22 3.60e-02 GO:0046486 glycerolipid metabolic process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
206.26 1.22e-05 GO:0034366 spherical high-density lipoprotein particle
91.70 1.76e-04 GO:0034361 very-low-density lipoprotein particle
91.70 1.76e-04 GO:0034385 triglyceride-rich lipoprotein particle
75.03 3.31e-04 GO:0034364 high-density lipoprotein particle
51.60 1.05e-03 GO:0032994 protein-lipid complex
51.60 1.05e-03 GO:0034358 plasma lipoprotein particle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
366.65 3.78e-04 GO:0070653 high-density lipoprotein particle receptor binding