Motif ID: SPI1.p2

Z-value: 2.853


Transcription factors associated with SPI1.p2:

Gene SymbolEntrez IDGene Name
SPI1 6688 spleen focus forming virus (SFFV) proviral integration oncogene spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPI1chr11_-_474000960.693.4e-03Click!


Activity profile for motif SPI1.p2.

activity profile for motif SPI1.p2


Sorted Z-values histogram for motif SPI1.p2

Sorted Z-values for motif SPI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPI1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_26644458 5.016 CD52
CD52 molecule
chr1_-_111743297 4.854 DENND2D
DENN/MADD domain containing 2D
chr1_-_31230673 4.784 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr12_+_25205488 4.686 LRMP
lymphoid-restricted membrane protein
chr5_-_88179278 4.504 NM_001193350
NM_002397
MEF2C

myocyte enhancer factor 2C

chr22_+_37257004 4.018 NM_000631
NM_013416
NCF4

neutrophil cytosolic factor 4, 40kDa

chrX_+_48542159 3.914 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr17_-_29641094 3.899 NM_006495
EVI2B
ecotropic viral integration site 2B
chr12_+_25205180 3.853 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr11_+_65190272 3.756


chr17_-_29641087 3.709 EVI2B
ecotropic viral integration site 2B
chr19_-_7764283 3.606 NM_001207019
FCER2
Fc fragment of IgE, low affinity II, receptor for (CD23)
chr14_-_23288912 3.506 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_-_53600999 3.465 NM_000889
ITGB7
integrin, beta 7
chr1_+_111415791 3.463 CD53
CD53 molecule
chr17_-_29641068 3.452 EVI2B
ecotropic viral integration site 2B
chr5_+_118691692 3.447 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr14_-_23285011 3.360 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_+_111415721 3.350 NM_000560
CD53
CD53 molecule
chr2_+_143886969 3.311 ARHGAP15
Rho GTPase activating protein 15
chr6_-_32160289 3.246 GPSM3
G-protein signaling modulator 3
chr17_-_34417386 2.943 NM_002983
CCL3
chemokine (C-C motif) ligand 3
chr1_+_161632904 2.919 NM_001002273
NM_001002274
NM_001002275
NM_001190828
NM_004001
FCGR2B




FCGR2C
Fc fragment of IgG, low affinity IIb, receptor (CD32)




Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
chrX_-_118827060 2.872 SEPT6
septin 6
chr19_+_49838700 2.864 CD37
CD37 molecule
chr16_+_81812925 2.828 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr16_+_81812899 2.803 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr6_-_32908583 2.791 NM_002118
HLA-DMB
major histocompatibility complex, class II, DM beta
chr7_+_69064316 2.724 AUTS2
autism susceptibility candidate 2
chr16_+_81812897 2.721 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr1_-_31230594 2.714 LAPTM5
lysosomal protein transmembrane 5
chr11_-_46142955 2.691 NM_001101802
NM_016621
PHF21A

PHD finger protein 21A

chr3_+_16926451 2.690 NM_001144382
PLCL2
phospholipase C-like 2
chr3_-_16555128 2.670 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr11_-_60719116 2.599 NM_016582
SLC15A3
solute carrier family 15, member 3
chr12_-_53601051 2.583 ITGB7
integrin, beta 7
chr19_-_7766978 2.558 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr12_+_7060554 2.552 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr6_+_31540092 2.539 NM_000595
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr10_-_98031154 2.525 NM_001114094
NM_013314
BLNK

B-cell linker

chr14_+_21249209 2.484 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr11_+_128563772 2.478 NM_001167681
NM_002017
FLI1

Friend leukemia virus integration 1

chr2_+_68592317 2.461 NM_002664
PLEK
pleckstrin
chr7_-_86848818 2.447 NM_024315
C7orf23
chromosome 7 open reading frame 23
chr7_+_114562908 2.378 MDFIC
MyoD family inhibitor domain containing
chr14_-_23284617 2.329 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_-_184943673 2.279 NM_052966
FAM129A
family with sequence similarity 129, member A
chr19_-_39108534 2.255 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr1_+_26644380 2.248 NM_001803
CD52
CD52 molecule
chr15_+_81517639 2.236 NM_172217
IL16
interleukin 16
chr21_-_46340821 2.234 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_143886898 2.225 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr6_-_31550065 2.219 NM_002341
NM_009588
LTB

lymphotoxin beta (TNF superfamily, member 3)

chr15_+_75074714 2.212 CSK
c-src tyrosine kinase
chr6_-_32497925 2.197 NM_002125
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr16_+_30194730 2.170 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr2_+_68592432 2.170 PLEK
pleckstrin
chr17_+_65373574 2.160 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr6_+_31539875 2.146 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr7_+_69063768 2.109 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr17_-_38721701 2.105 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr7_+_101928417 2.101 SH2B2
SH2B adaptor protein 2
chr1_-_184943532 2.100 FAM129A
family with sequence similarity 129, member A
chr7_+_101928390 2.093 NM_020979
SH2B2
SH2B adaptor protein 2
chr5_-_88178964 2.066 MEF2C
myocyte enhancer factor 2C
chr1_+_174128547 2.055 NM_014857
RABGAP1L
RAB GTPase activating protein 1-like
chr15_+_75074417 2.039 NM_001127190
NM_004383
CSK

c-src tyrosine kinase

chr19_+_49838673 2.033 NM_001040031
NM_001774
CD37

CD37 molecule

chr12_+_7055753 2.006 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr16_-_88717395 1.997 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr19_+_42381189 1.994 NM_001783
NM_021601
CD79A

CD79a molecule, immunoglobulin-associated alpha

chr5_+_49962920 1.960 PARP8
poly (ADP-ribose) polymerase family, member 8
chr2_-_60780767 1.948 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr5_+_49962771 1.945 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chrX_-_47489243 1.930 NM_001145252
CFP
complement factor properdin
chr17_+_34431219 1.915 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr1_-_160617042 1.911 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr6_+_31543340 1.909 NM_000594
TNF
tumor necrosis factor
chrX_-_47489703 1.898 NM_002621
CFP
complement factor properdin
chr3_-_15373807 1.896 SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr19_-_10450262 1.890 NM_002162
ICAM3
intercellular adhesion molecule 3
chrX_-_15872882 1.882 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr19_+_49838646 1.880 CD37
CD37 molecule
chr1_+_183605207 1.877 NM_015149
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr16_-_89043215 1.875 NM_005187
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr1_-_111743261 1.869 NM_024901
DENND2D
DENN/MADD domain containing 2D
chr6_+_31582978 1.840 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chrX_-_15872905 1.821


chr1_+_111770280 1.819 NM_001025197
NM_004000
CHI3L2

chitinase 3-like 2

chr1_-_183559669 1.807 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chrX_-_15873094 1.804 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr1_+_174128654 1.790 RABGAP1L
RAB GTPase activating protein 1-like
chr3_-_121379757 1.780 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr10_-_27149791 1.770 ABI1
abl-interactor 1
chr13_-_46756291 1.766 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_+_34538464 1.754 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chrX_+_48542193 1.748 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr12_+_7060433 1.732 NM_002831
NM_080549
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr1_-_183560010 1.710 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr2_-_96811138 1.696 NM_004418
DUSP2
dual specificity phosphatase 2
chr12_+_54891539 1.694 NCKAP1L
NCK-associated protein 1-like
chr11_+_121322848 1.686 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr1_-_25256364 1.675 RUNX3
runt-related transcription factor 3
chr17_+_34640030 1.673 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr10_-_27149892 1.637 ABI1
abl-interactor 1
chr12_-_51717905 1.623 NM_016293
BIN2
bridging integrator 2
chr2_-_214016332 1.614 NM_001079526
IKZF2
IKAROS family zinc finger 2 (Helios)
chr4_-_185395616 1.612 NM_002199
IRF2
interferon regulatory factor 2
chr8_+_56792345 1.594 NM_001111097
NM_002350
LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

chr7_+_74188308 1.584 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr19_+_49838734 1.583 CD37
CD37 molecule
chr13_+_31287614 1.569 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr17_+_7155371 1.566 NM_203415
NM_015362
NM_203413
NM_203414
C17orf81



chromosome 17 open reading frame 81



chr1_+_32739711 1.565 NM_001042771
LCK
lymphocyte-specific protein tyrosine kinase
chr8_+_56792399 1.558 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr12_+_54891491 1.558 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr12_+_54891522 1.557 NCKAP1L
NCK-associated protein 1-like
chr12_-_51717835 1.551 BIN2
bridging integrator 2
chr6_-_32812409 1.547 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chrX_-_135749436 1.546 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr10_+_35484829 1.539 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr8_+_56792392 1.529 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr6_-_32812711 1.528 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr3_-_121379701 1.522 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_-_183559463 1.517 NCF2
neutrophil cytosolic factor 2
chr9_-_132805256 1.512 FNBP1
formin binding protein 1
chr6_-_137113166 1.507


chr18_+_56338818 1.497 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr2_-_89442551 1.492 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr21_-_46340874 1.483 NM_000211
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr6_-_29595746 1.468 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr7_-_37488554 1.466 NM_014800
ELMO1
engulfment and cell motility 1
chr19_-_6481765 1.462 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr8_+_38758752 1.451 NM_021623
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr11_-_58343308 1.451 NM_004811
LPXN
leupaxin
chr2_-_175499275 1.427 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr13_-_49107250 1.419 NM_001268
RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr21_-_46340776 1.416 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr10_+_26727692 1.403 APBB1IP
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr7_-_37488408 1.386 ELMO1
engulfment and cell motility 1
chr4_+_154387450 1.383 NM_001131007
NM_015196
KIAA0922

KIAA0922

chr4_-_105412466 1.368 NM_025212
CXXC4
CXXC finger protein 4
chr6_-_154677868 1.352 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr13_-_49107185 1.348 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr1_-_207095198 1.347 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chrX_-_15872921 1.339 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr22_+_37309618 1.335 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr6_-_32812189 1.318 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr16_+_30675777 1.302 NM_001105079
FBRS
fibrosin
chr3_+_48507621 1.302 TREX1
three prime repair exonuclease 1
chr12_+_7060543 1.294 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr14_-_106471439 1.283 IGHA1
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr9_+_128509616 1.281 NM_006195
PBX3
pre-B-cell leukemia homeobox 3
chr5_-_169724734 1.273 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_-_49319211 1.271 NM_001143782
NM_016594
FKBP11

FK506 binding protein 11, 19 kDa

chr1_-_27952591 1.270 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr6_+_42896859 1.259 NM_006586
CNPY3
canopy 3 homolog (zebrafish)
chr4_-_76944585 1.258 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr6_-_137113602 1.255 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr5_-_169724817 1.243 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr6_+_31583766 1.238 NM_032955
AIF1
allograft inflammatory factor 1
chr5_-_169724782 1.232 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr17_+_25958257 1.232 LGALS9
lectin, galactoside-binding, soluble, 9
chr14_-_23284565 1.228 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr6_-_137113529 1.228 MAP3K5
mitogen-activated protein kinase kinase kinase 5
chr16_+_27413482 1.224 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr12_-_51717941 1.205 BIN2
bridging integrator 2
chr6_-_32811773 1.204 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr9_-_35650852 1.199 NM_014450
SIT1
signaling threshold regulating transmembrane adaptor 1
chr10_+_30723050 1.186 MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr22_+_22569155 1.183


chr6_-_32160637 1.182 GPSM3
G-protein signaling modulator 3
chrX_-_15872938 1.164 AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr1_-_32801606 1.164 NM_023009
MARCKSL1
MARCKS-like 1
chr3_-_125094003 1.161 NM_021964
ZNF148
zinc finger protein 148
chr7_+_150264457 1.160 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr18_+_56338678 1.159 MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
chr19_+_36203829 1.158 NM_014383
ZBTB32
zinc finger and BTB domain containing 32
chr5_+_156693051 1.154 NM_001037333
NM_001037332
CYFIP2

cytoplasmic FMR1 interacting protein 2

chr1_+_209929378 1.152 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr1_-_9129583 1.145 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr7_+_150434435 1.140 NM_018384
GIMAP5
GTPase, IMAP family member 5
chr17_+_43299277 1.138 NM_005892
FMNL1
formin-like 1
chr22_-_18257194 1.134 BID
BH3 interacting domain death agonist
chr6_-_26056647 1.134 NM_005319
HIST1H1C
histone cluster 1, H1c
chr5_+_110559647 1.133 NM_001744
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr22_-_18257221 1.132 BID
BH3 interacting domain death agonist
chr22_-_18257160 1.112 BID
BH3 interacting domain death agonist
chr1_-_9129620 1.108 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr17_+_25958245 1.107 LGALS9
lectin, galactoside-binding, soluble, 9
chr6_-_6320897 1.106 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr11_-_67120943 1.103 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr19_-_8642297 1.103 MYO1F
myosin IF
chr17_+_25958217 1.096 LGALS9
lectin, galactoside-binding, soluble, 9
chr22_-_37882214 1.096 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr10_-_88281486 1.093 WAPAL
wings apart-like homolog (Drosophila)
chr3_+_9834778 1.089 NM_001198780
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr1_-_9129666 1.088 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr7_+_21467572 1.082 NM_003112
SP4
Sp4 transcription factor
chr2_-_24149899 1.067 NM_001242338
NM_017552
ATAD2B

ATPase family, AAA domain containing 2B


Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.50 6.36e-19 GO:0002376 immune system process
5.03 1.95e-13 GO:0006955 immune response
5.79 6.52e-10 GO:0050776 regulation of immune response
4.58 1.06e-09 GO:0002682 regulation of immune system process
5.63 3.59e-09 GO:0002684 positive regulation of immune system process
4.08 1.96e-08 GO:0006952 defense response
6.61 4.82e-08 GO:0050778 positive regulation of immune response
11.97 2.24e-07 GO:0050851 antigen receptor-mediated signaling pathway
10.99 6.15e-07 GO:0002429 immune response-activating cell surface receptor signaling pathway
10.66 8.77e-07 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.29 2.64e-06 GO:0006950 response to stress
2.55 3.49e-06 GO:0048583 regulation of response to stimulus
6.60 5.86e-06 GO:0002253 activation of immune response
1.65 7.29e-06 GO:0050896 response to stimulus
6.38 9.27e-06 GO:0045321 leukocyte activation
7.12 2.55e-05 GO:0002757 immune response-activating signal transduction
4.26 3.13e-05 GO:0001775 cell activation
6.99 3.17e-05 GO:0002764 immune response-regulating signaling pathway
6.95 3.40e-05 GO:0050867 positive regulation of cell activation
6.91 3.65e-05 GO:0046649 lymphocyte activation
5.76 3.71e-05 GO:0048534 hemopoietic or lymphoid organ development
5.35 9.85e-05 GO:0002520 immune system development
7.00 1.07e-04 GO:0051251 positive regulation of lymphocyte activation
7.72 1.35e-04 GO:0050870 positive regulation of T cell activation
3.08 1.68e-04 GO:0009611 response to wounding
59.81 1.72e-04 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
2.03 1.96e-04 GO:0048518 positive regulation of biological process
3.24 2.12e-04 GO:0048584 positive regulation of response to stimulus
6.53 2.27e-04 GO:0002696 positive regulation of leukocyte activation
29.91 3.44e-04 GO:0002920 regulation of humoral immune response
51.27 3.98e-04 GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin
5.56 4.59e-04 GO:0030097 hemopoiesis
26.39 6.97e-04 GO:0050853 B cell receptor signaling pathway
5.28 8.19e-04 GO:0050865 regulation of cell activation
6.29 1.05e-03 GO:0050863 regulation of T cell activation
5.58 1.22e-03 GO:0051249 regulation of lymphocyte activation
1.70 1.37e-03 GO:0051716 cellular response to stimulus
39.87 1.41e-03 GO:0002922 positive regulation of humoral immune response
35.89 2.32e-03 GO:0002714 positive regulation of B cell mediated immunity
35.89 2.32e-03 GO:0002891 positive regulation of immunoglobulin mediated immune response
5.23 2.41e-03 GO:0030036 actin cytoskeleton organization
10.65 3.00e-03 GO:0031294 lymphocyte costimulation
10.65 3.00e-03 GO:0031295 T cell costimulation
5.08 3.25e-03 GO:0002694 regulation of leukocyte activation
1.78 3.45e-03 GO:0007165 signal transduction
3.58 3.90e-03 GO:0007599 hemostasis
1.42 4.30e-03 GO:0050789 regulation of biological process
1.38 5.38e-03 GO:0065007 biological regulation
29.91 5.39e-03 GO:0045730 respiratory burst
3.33 5.48e-03 GO:0050878 regulation of body fluid levels
9.24 7.84e-03 GO:0007015 actin filament organization
8.61 1.26e-02 GO:0050852 T cell receptor signaling pathway
4.44 1.30e-02 GO:0030029 actin filament-based process
4.40 1.41e-02 GO:0006954 inflammatory response
3.39 1.47e-02 GO:0007596 blood coagulation
3.39 1.47e-02 GO:0050817 coagulation
5.77 2.01e-02 GO:0002697 regulation of immune effector process
44.86 2.10e-02 GO:0045586 regulation of gamma-delta T cell differentiation
44.86 2.10e-02 GO:0045588 positive regulation of gamma-delta T cell differentiation
5.65 2.38e-02 GO:0050900 leukocyte migration
9.79 2.49e-02 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
13.20 2.69e-02 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
9.62 2.76e-02 GO:0002819 regulation of adaptive immune response
12.82 3.12e-02 GO:0002821 positive regulation of adaptive immune response
38.45 3.64e-02 GO:0046643 regulation of gamma-delta T cell activation
38.45 3.64e-02 GO:0046645 positive regulation of gamma-delta T cell activation
6.14 3.70e-02 GO:0002521 leukocyte differentiation
3.70 3.90e-02 GO:0045087 innate immune response
18.89 3.97e-02 GO:0008154 actin polymerization or depolymerization
7.06 4.60e-02 GO:0030098 lymphocyte differentiation
11.81 4.69e-02 GO:0002705 positive regulation of leukocyte mediated immunity
11.81 4.69e-02 GO:0002708 positive regulation of lymphocyte mediated immunity
11.81 4.69e-02 GO:0030183 B cell differentiation
1.39 4.85e-02 GO:0050794 regulation of cellular process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
51.27 6.78e-05 GO:0043020 NADPH oxidase complex
14.02 3.39e-03 GO:0005884 actin filament
44.86 3.58e-03 GO:0001891 phagocytic cup
1.60 1.38e-02 GO:0071944 cell periphery
1.60 1.88e-02 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
44.86 1.53e-04 GO:0016175 superoxide-generating NADPH oxidase activity
13.46 7.32e-04 GO:0003823 antigen binding
27.61 1.50e-03 GO:0050664 oxidoreductase activity, acting on NADH or NADPH, oxygen as acceptor
4.84 1.55e-02 GO:0005125 cytokine activity
1.33 2.08e-02 GO:0005515 protein binding
12.38 4.33e-02 GO:0032813 tumor necrosis factor receptor superfamily binding