Motif ID: SPIB.p2

Z-value: 1.959


Transcription factors associated with SPIB.p2:

Gene SymbolEntrez IDGene Name
SPIB 6689 Spi-B transcription factor (Spi-1/PU.1 related)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SPIBchr19_+_509221940.852.6e-05Click!


Activity profile for motif SPIB.p2.

activity profile for motif SPIB.p2


Sorted Z-values histogram for motif SPIB.p2

Sorted Z-values for motif SPIB.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SPIB.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_15114495 7.815 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chrX_+_48542159 4.573 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr18_-_53068755 3.695 TCF4
transcription factor 4
chr2_-_175499275 3.128 NM_003387
WIPF1
WAS/WASL interacting protein family, member 1
chr17_+_34431219 2.884 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr12_+_25205180 2.811 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr12_+_25205488 2.769 LRMP
lymphoid-restricted membrane protein
chr17_+_34640030 2.695 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr22_+_23222897 2.668 CYAT1
immunoglobulin lambda light chain-like
chr3_-_121379757 2.618 NM_005335
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_+_49838673 2.462 NM_001040031
NM_001774
CD37

CD37 molecule

chr19_+_49838700 2.406 CD37
CD37 molecule
chr6_-_32160289 2.391 GPSM3
G-protein signaling modulator 3
chr17_+_67410825 2.389 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr1_-_25256364 2.330 RUNX3
runt-related transcription factor 3
chr3_-_121379701 2.324 HCLS1
hematopoietic cell-specific Lyn substrate 1
chr19_+_49838646 2.320 CD37
CD37 molecule
chr10_+_70847857 2.295 SRGN
serglycin
chr1_-_183560010 2.284 NM_001127651
NCF2
neutrophil cytosolic factor 2
chr4_+_40198526 2.241 NM_004310
RHOH
ras homolog gene family, member H
chr2_-_96811138 2.223 NM_004418
DUSP2
dual specificity phosphatase 2
chr1_-_183559669 2.192 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr12_+_54891539 2.148 NCKAP1L
NCK-associated protein 1-like
chr10_+_70847817 2.139 NM_002727
SRGN
serglycin
chr16_+_30194925 2.089 CORO1A
coronin, actin binding protein, 1A
chr11_-_33890931 1.986 LMO2
LIM domain only 2 (rhombotin-like 1)
chr14_+_88471467 1.968 NM_003608
GPR65
G protein-coupled receptor 65
chr12_+_54891522 1.949 NCKAP1L
NCK-associated protein 1-like
chr19_-_36233311 1.933 NM_024660
IGFLR1
IGF-like family receptor 1
chr17_+_34538464 1.885 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr12_+_54891491 1.883 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr18_-_53177999 1.851 NM_001243231
TCF4
transcription factor 4
chr19_+_49838734 1.843 CD37
CD37 molecule
chrX_-_70331297 1.839 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr12_+_7060517 1.836 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr12_+_7060538 1.820 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr1_-_183559463 1.813 NCF2
neutrophil cytosolic factor 2
chr12_+_7060543 1.803 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr5_-_169724734 1.794 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr3_+_48507209 1.790 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr12_+_7060531 1.778 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr17_-_29641094 1.776 NM_006495
EVI2B
ecotropic viral integration site 2B
chr5_-_169724817 1.744 NM_005565
LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr5_-_169724782 1.736 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr12_+_7060433 1.703 NM_002831
NM_080549
PTPN6

protein tyrosine phosphatase, non-receptor type 6

chr17_-_29641087 1.701 EVI2B
ecotropic viral integration site 2B
chrX_-_100641143 1.696 NM_000061
BTK
Bruton agammaglobulinemia tyrosine kinase
chr12_+_7060554 1.681 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chrX_-_112066353 1.655 NM_001113490
AMOT
angiomotin
chr6_-_32634287 1.651 NM_001243961
NM_002123
HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

chr11_-_33891361 1.643 NM_001142316
LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_-_25864430 1.619 NM_015187
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chrX_+_48542193 1.609 WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr11_-_33891258 1.580 LMO2
LIM domain only 2 (rhombotin-like 1)
chr5_+_169064274 1.566 DOCK2
dedicator of cytokinesis 2
chr17_-_29641068 1.557 EVI2B
ecotropic viral integration site 2B
chr1_-_207095198 1.557 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr4_+_68424444 1.554 NM_012108
STAP1
signal transducing adaptor family member 1
chr3_-_119278402 1.545 NM_005191
CD80
CD80 molecule
chr12_+_4382882 1.544 NM_001759
CCND2
cyclin D2
chr17_-_29648631 1.495 NM_001003927
NM_014210
EVI2A

ecotropic viral integration site 2A

chr17_-_62084282 1.466 NM_000873
ICAM2
intercellular adhesion molecule 2
chr17_+_40439564 1.422 NM_003152
STAT5A
signal transducer and activator of transcription 5A
chr12_+_48499655 1.404 NM_001166686
PFKM
phosphofructokinase, muscle
chr4_+_103422822 1.392 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chrX_-_135863104 1.384 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr1_-_25291474 1.377 NM_001031680
RUNX3
runt-related transcription factor 3
chrX_-_135863033 1.370 ARHGEF6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr7_-_37488554 1.364 NM_014800
ELMO1
engulfment and cell motility 1
chr6_-_154677868 1.354 NM_001130700
NM_015553
IPCEF1

interaction protein for cytohesin exchange factors 1

chr11_+_102188180 1.353 NM_001165
NM_182962
BIRC3

baculoviral IAP repeat containing 3

chr7_-_37488408 1.302 ELMO1
engulfment and cell motility 1
chr7_-_37488894 1.297 NM_001206480
ELMO1
engulfment and cell motility 1
chr13_-_49110117 1.293 RCBTB2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr1_-_23886284 1.292 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr1_+_209929378 1.289 NM_025228
TRAF3IP3
TRAF3 interacting protein 3
chr18_-_60986508 1.273 NM_000633
NM_000657
BCL2

B-cell CLL/lymphoma 2

chr12_-_110434057 1.273 GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr4_-_105412466 1.268 NM_025212
CXXC4
CXXC finger protein 4
chr18_-_53303129 1.267 NM_001243226
TCF4
transcription factor 4
chr14_+_100531764 1.253 EVL
Enah/Vasp-like
chr10_-_64576123 1.219 NM_000399
NM_001136177
NM_001136179
EGR2


early growth response 2


chr2_+_68592317 1.211 NM_002664
PLEK
pleckstrin
chr6_+_31582978 1.210 NM_004847
NM_001623
AIF1

allograft inflammatory factor 1

chr2_-_214015053 1.202 NM_016260
IKZF2
IKAROS family zinc finger 2 (Helios)
chr5_+_118691692 1.190 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr6_+_31539875 1.182 NM_001159740
LTA
lymphotoxin alpha (TNF superfamily, member 1)
chr16_+_28943259 1.179 NM_001178098
NM_001770
CD19

CD19 molecule

chr11_-_67205151 1.146 NM_005608
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr11_-_58343308 1.146 NM_004811
LPXN
leupaxin
chrX_-_15873094 1.142 NM_003916
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr10_-_64576074 1.123 EGR2
early growth response 2
chr11_-_33891485 1.121 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr19_-_6481765 1.110 NM_024898
DENND1C
DENN/MADD domain containing 1C
chr1_-_31230594 1.098 LAPTM5
lysosomal protein transmembrane 5
chr1_+_183774214 1.090 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr14_+_100531745 1.084 NM_016337
EVL
Enah/Vasp-like
chr17_+_76164624 1.082 NM_004710
SYNGR2
synaptogyrin 2
chr14_+_64971504 1.058 ZBTB1
zinc finger and BTB domain containing 1
chr7_+_150264457 1.056 NM_018326
GIMAP4
GTPase, IMAP family member 4
chr7_+_69063768 1.041 NM_001127231
NM_001127232
NM_015570
AUTS2


autism susceptibility candidate 2


chr13_-_46756326 1.037 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr5_-_169724614 1.036 LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr1_-_25256767 1.035 NM_004350
RUNX3
runt-related transcription factor 3
chr21_-_39870303 1.034 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr13_-_46756295 1.025 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_95449131 1.018 NM_001205263
RAD54B
RAD54 homolog B (S. cerevisiae)
chr4_+_103422730 1.017 NFKB1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr8_-_6420454 1.013 NM_001118887
NM_001118888
NM_001147
ANGPT2


angiopoietin 2


chr15_+_81589240 1.008 NM_004513
IL16
interleukin 16
chr1_-_31230673 1.004 NM_006762
LAPTM5
lysosomal protein transmembrane 5
chr17_-_38721701 1.001 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chr6_+_32407618 0.996 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr17_+_25958192 0.995 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_173174611 0.994 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr16_+_81812899 0.994 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr17_+_25958151 0.982 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr16_+_81812925 0.981 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr19_-_39826676 0.975 NM_004877
GMFG
glia maturation factor, gamma
chr12_-_102874373 0.971 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr6_+_31543340 0.961 NM_000594
TNF
tumor necrosis factor
chr12_-_102874158 0.958 IGF1
insulin-like growth factor 1 (somatomedin C)
chr10_+_35484829 0.957 NM_182721
NM_182722
NM_182723
NM_182724
NM_182725
CREM




cAMP responsive element modulator




chr17_+_25958245 0.938 LGALS9
lectin, galactoside-binding, soluble, 9
chr17_+_25958217 0.934 LGALS9
lectin, galactoside-binding, soluble, 9
chr19_-_39826625 0.930 GMFG
glia maturation factor, gamma
chrX_+_12994286 0.925 TMSB4X
thymosin beta 4, X-linked
chr22_-_37545944 0.924 NM_000878
IL2RB
interleukin 2 receptor, beta
chrX_-_74376075 0.922 NM_004299
ABCB7
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr1_+_26644458 0.918 CD52
CD52 molecule
chr8_-_22550708 0.914 NM_004430
EGR3
early growth response 3
chr5_+_169064238 0.907 NM_004946
DOCK2
dedicator of cytokinesis 2
chr19_-_41859253 0.907 TGFB1
transforming growth factor, beta 1
chr16_+_30194730 0.896 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr17_+_18380097 0.896 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr11_+_5646206 0.895 NM_021616
TRIM34
tripartite motif containing 34
chr1_-_160617042 0.895 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr22_+_22723972 0.892


chr20_+_44746889 0.891 NM_001250
NM_152854
CD40

CD40 molecule, TNF receptor superfamily member 5

chrX_+_37639246 0.885 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr8_-_22550057 0.879 NM_001199881
EGR3
early growth response 3
chr17_+_25958257 0.878 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_-_23885916 0.878 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr1_+_26644380 0.871 NM_001803
CD52
CD52 molecule
chr7_+_128580725 0.870 NM_001098627
IRF5
interferon regulatory factor 5
chr22_+_23165273 0.870


chr9_+_71320105 0.849 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr3_+_48507621 0.849 TREX1
three prime repair exonuclease 1
chr14_-_107131217 0.845 IGHA1
immunoglobulin heavy constant alpha 1
chrX_-_129244652 0.839 NM_001127197
ELF4
E74-like factor 4 (ets domain transcription factor)
chr16_+_81812897 0.837 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr19_-_13213973 0.836 NM_005583
LYL1
lymphoblastic leukemia derived sequence 1
chr11_+_61560352 0.833 FEN1
flap structure-specific endonuclease 1
chr18_-_53089722 0.832 NM_001243233
TCF4
transcription factor 4
chr14_-_106967528 0.828 IGHA1
IGHA2
IGHG1
IGHM
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr17_-_40833840 0.826 NM_016602
CCR10
chemokine (C-C motif) receptor 10
chr1_-_111743297 0.820 DENND2D
DENN/MADD domain containing 2D
chr11_+_7618416 0.819 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_-_60780404 0.818 NM_018014
NM_022893
NM_138559
BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr16_+_30483959 0.803 NM_001114380
NM_002209
ITGAL

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

chr22_-_37640287 0.800 NM_002872
RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr11_-_62472901 0.799


chr3_-_16555128 0.797 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr15_-_43785266 0.791 NM_001141979
NM_001141980
TP53BP1

tumor protein p53 binding protein 1

chr3_-_16554992 0.789 RFTN1
raftlin, lipid raft linker 1
chr6_-_6320897 0.788 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr12_+_120105656 0.777 NM_006253
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr3_+_69134057 0.767 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr10_-_98031154 0.767 NM_001114094
NM_013314
BLNK

B-cell linker

chr1_+_150245182 0.766 NM_024579
C1orf54
chromosome 1 open reading frame 54
chr22_+_23213671 0.765 IGLV4-3
immunoglobulin lambda variable 4-3
chr3_+_152017193 0.764 NM_207293
NM_207294
NM_207295
NM_207296
NM_207297
MBNL1




muscleblind-like (Drosophila)




chr12_-_102874299 0.763 IGF1
insulin-like growth factor 1 (somatomedin C)
chr10_-_27149892 0.762 ABI1
abl-interactor 1
chr2_-_89165652 0.760


chr1_-_226926875 0.757 NM_002221
ITPKB
inositol-trisphosphate 3-kinase B
chr7_+_116660291 0.756 ST7
suppression of tumorigenicity 7
chrX_+_78200828 0.753 NM_014499
NM_198333
P2RY10

purinergic receptor P2Y, G-protein coupled, 10

chr3_+_16926451 0.751 NM_001144382
PLCL2
phospholipase C-like 2
chrX_+_119737743 0.750 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr11_+_61560401 0.750 FEN1
flap structure-specific endonuclease 1
chr3_+_4535030 0.747 NM_001099952
NM_001168272
NM_002222
ITPR1


inositol 1,4,5-trisphosphate receptor, type 1


chr3_+_4535160 0.746 ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr10_+_97515408 0.745 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr14_-_106573348 0.745 IGHV4-31
IGHA1
IGHA2
IGHG1
IGHG3
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
immunoglobulin heavy constant mu
chr7_+_99971132 0.744 PILRA
paired immunoglobin-like type 2 receptor alpha
chr8_+_98703361 0.740 MTDH
metadherin
chrX_+_119737984 0.735 MCTS1
malignant T cell amplified sequence 1
chr22_-_37640187 0.732 RAC2
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr8_+_38585703 0.731 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr2_+_143886969 0.730 ARHGAP15
Rho GTPase activating protein 15
chrX_+_37639306 0.724 CYBB
cytochrome b-245, beta polypeptide
chr20_+_44746948 0.723 CD40
CD40 molecule, TNF receptor superfamily member 5
chr19_+_35645614 0.720 NM_014164
FXYD5
FXYD domain containing ion transport regulator 5
chr2_-_74405800 0.719 NM_018221
MOB1A
MOB kinase activator 1A
chr2_+_143886898 0.717 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr13_-_46756291 0.712 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr14_+_50087400 0.707 NM_002408
MGAT2
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr15_+_75074714 0.705 CSK
c-src tyrosine kinase
chr19_-_41859519 0.700 TGFB1
transforming growth factor, beta 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.52 2.37e-09 GO:0002376 immune system process
11.79 4.58e-09 GO:0030036 actin cytoskeleton organization
10.00 4.23e-08 GO:0030029 actin filament-based process
5.61 2.41e-07 GO:0002682 regulation of immune system process
3.40 2.97e-07 GO:0048583 regulation of response to stimulus
4.86 7.40e-06 GO:0006955 immune response
6.35 1.55e-05 GO:0002684 positive regulation of immune system process
6.27 1.83e-05 GO:0050776 regulation of immune response
6.19 2.15e-05 GO:0007010 cytoskeleton organization
17.85 6.61e-05 GO:0007015 actin filament organization
1.66 7.07e-05 GO:0050789 regulation of biological process
1.82 7.14e-05 GO:0050896 response to stimulus
4.21 3.98e-04 GO:0006952 defense response
13.49 4.62e-04 GO:0050851 antigen receptor-mediated signaling pathway
46.22 8.02e-04 GO:0043029 T cell homeostasis
12.39 8.25e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
12.02 1.01e-03 GO:0002768 immune response-regulating cell surface receptor signaling pathway
1.56 1.04e-03 GO:0065007 biological regulation
6.73 1.14e-03 GO:0050778 positive regulation of immune response
2.33 1.58e-03 GO:0048518 positive regulation of biological process
1.97 1.68e-03 GO:0051716 cellular response to stimulus
11.04 1.80e-03 GO:0042110 T cell activation
8.47 2.48e-03 GO:0002757 immune response-activating signal transduction
8.31 2.84e-03 GO:0002764 immune response-regulating signaling pathway
8.26 2.97e-03 GO:0050867 positive regulation of cell activation
1.61 3.54e-03 GO:0050794 regulation of cellular process
31.52 4.17e-03 GO:0001776 leukocyte homeostasis
31.52 4.17e-03 GO:0002260 lymphocyte homeostasis
8.68 8.88e-03 GO:0002697 regulation of immune effector process
3.66 1.14e-02 GO:0048584 positive regulation of response to stimulus
6.81 1.23e-02 GO:0002253 activation of immune response
2.02 1.26e-02 GO:0007165 signal transduction
4.53 1.48e-02 GO:0001775 cell activation
6.58 1.57e-02 GO:0045321 leukocyte activation
7.89 1.65e-02 GO:0051251 positive regulation of lymphocyte activation
6.29 2.19e-02 GO:0050865 regulation of cell activation
12.94 2.42e-02 GO:0050671 positive regulation of lymphocyte proliferation
7.36 2.57e-02 GO:0002696 positive regulation of leukocyte activation
12.75 2.60e-02 GO:0032946 positive regulation of mononuclear cell proliferation
2.22 2.70e-02 GO:0006950 response to stress
12.57 2.79e-02 GO:0070665 positive regulation of leukocyte proliferation
7.19 2.99e-02 GO:0046649 lymphocyte activation
5.94 3.28e-02 GO:0048534 hemopoietic or lymphoid organ development
1.88 3.67e-02 GO:0023052 signaling
11.72 3.91e-02 GO:0048872 homeostasis of number of cells
3.09 4.04e-02 GO:0042981 regulation of apoptosis
3.06 4.38e-02 GO:0043067 regulation of programmed cell death

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
27.09 7.81e-05 GO:0005884 actin filament
6.55 2.38e-02 GO:0031252 cell leading edge
3.19 2.38e-02 GO:0031982 vesicle
57.77 4.06e-02 GO:0001891 phagocytic cup
3.16 4.82e-02 GO:0031988 membrane-bounded vesicle

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
5.31 4.83e-04 GO:0030695 GTPase regulator activity
5.16 6.27e-04 GO:0060589 nucleoside-triphosphatase regulator activity
5.91 4.91e-03 GO:0005083 small GTPase regulator activity
1.43 2.01e-02 GO:0005515 protein binding