Motif ID: SRY.p2

Z-value: 1.068


Transcription factors associated with SRY.p2:

Gene SymbolEntrez IDGene Name
SRY 6736 sex determining region Y

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
SRYchrY_-_2655478-0.126.6e-01Click!


Activity profile for motif SRY.p2.

activity profile for motif SRY.p2


Sorted Z-values histogram for motif SRY.p2

Sorted Z-values for motif SRY.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SRY.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_75766794 4.855 ANXA1
annexin A1
chr9_+_75766777 3.293 NM_000700
ANXA1
annexin A1
chr2_-_56151273 3.257 NM_001039348
NM_001039349
EFEMP1

EGF containing fibulin-like extracellular matrix protein 1

chr7_+_134464417 2.866 CALD1
caldesmon 1
chrX_-_99891690 2.803 NM_003270
TSPAN6
tetraspanin 6
chr12_-_28124915 2.319 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr2_-_216259197 2.115 FN1
fibronectin 1
chr2_+_102508333 2.083 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr21_+_35190586 1.767 ITSN1
intersectin 1 (SH3 domain protein)
chr8_+_32504250 1.731 NM_013959
NRG1
neuregulin 1
chr20_+_19915716 1.693 RIN2
Ras and Rab interactor 2
chrX_+_107683015 1.641 NM_000495
NM_033380
COL4A5

collagen, type IV, alpha 5

chr6_-_134498973 1.616 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr5_+_140739589 1.606 NM_018923
NM_032096
PCDHGB2

protocadherin gamma subfamily B, 2

chr10_-_105845619 1.564 NM_000494
COL17A1
collagen, type XVII, alpha 1
chr13_-_45048436 1.561 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr3_-_149086884 1.558 TM4SF1
transmembrane 4 L six family member 1
chr2_+_102508377 1.545 MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr8_-_82395401 1.524 NM_001442
FABP4
fatty acid binding protein 4, adipocyte
chr13_-_110802708 1.502 COL4A1
collagen, type IV, alpha 1
chr20_+_19870209 1.501 NM_018993
RIN2
Ras and Rab interactor 2
chr12_+_13349720 1.433 EMP1
epithelial membrane protein 1
chr2_-_190044330 1.418 NM_000393
COL5A2
collagen, type V, alpha 2
chr12_-_89746244 1.396 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr12_-_8815266 1.390 MFAP5
microfibrillar associated protein 5
chr10_-_105845556 1.381 COL17A1
collagen, type XVII, alpha 1
chr9_-_14314036 1.380 NM_001190737
NM_005596
NFIB

nuclear factor I/B

chr4_+_169418167 1.356 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr5_+_34687663 1.353 NM_001145523
RAI14
retinoic acid induced 14
chr12_-_52886971 1.346 NM_005554
KRT6A
keratin 6A
chr18_+_3451589 1.313 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chrX_-_10544852 1.306 NM_001193277
MID1
midline 1 (Opitz/BBB syndrome)
chr18_-_21852189 1.274 NM_018030
OSBPL1A
oxysterol binding protein-like 1A
chr4_-_101439071 1.248 NM_001159694
NM_016242
EMCN

endomucin

chrX_+_135251454 1.245 NM_001159704
FHL1
four and a half LIM domains 1
chr9_-_107690526 1.244 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr18_+_72922725 1.220 NM_005786
TSHZ1
teashirt zinc finger homeobox 1
chr1_+_81771844 1.219 LPHN2
latrophilin 2
chr2_+_102314162 1.205 NM_001242560
NM_004834
NM_145686
NM_001242559
NM_145687
MAP4K4




mitogen-activated protein kinase kinase kinase kinase 4




chr4_-_90759446 1.184 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr1_+_84609941 1.181 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr5_+_71502700 1.164 MAP1B
microtubule-associated protein 1B
chr2_-_151344145 1.163 NM_005168
RND3
Rho family GTPase 3
chr12_-_6233684 1.155 NM_000552
VWF
von Willebrand factor
chr11_+_101983170 1.154 NM_001195045
YAP1
Yes-associated protein 1
chr1_-_153606567 1.150 NM_001024210
S100A13
S100 calcium binding protein A13
chr6_+_139456240 1.149 NM_016217
HECA
headcase homolog (Drosophila)
chr11_+_129979330 1.145 APLP2
amyloid beta (A4) precursor-like protein 2
chr6_+_151561508 1.136 AKAP12
A kinase (PRKA) anchor protein 12
chr22_-_36236330 1.116 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr10_-_126849010 1.115 CTBP2
C-terminal binding protein 2
chr1_+_151032683 1.110 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_-_85930610 1.109 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr1_+_155099935 1.101 EFNA1
ephrin-A1
chr2_-_225266710 1.094 NM_001122779
NM_024785
FAM124B

family with sequence similarity 124B

chr22_-_36236421 1.091 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr6_+_151561094 1.077 NM_005100
AKAP12
A kinase (PRKA) anchor protein 12
chr22_-_36236264 1.076 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr10_-_126849066 1.054 NM_001329
CTBP2
C-terminal binding protein 2
chr7_-_27205123 1.052 HOXA9
homeobox A9
chrX_+_135251795 1.045 NM_001167819
FHL1
four and a half LIM domains 1
chr11_-_102668892 1.044 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr5_+_36606667 1.035 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr1_+_151032866 1.032 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr5_+_36606456 1.030 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr7_-_107643330 1.024 NM_002291
LAMB1
laminin, beta 1
chr10_-_91102430 1.023 LIPA
lipase A, lysosomal acid, cholesterol esterase
chr3_-_123339178 1.020 MYLK
myosin light chain kinase
chr6_-_47277354 1.014 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_-_163113938 1.006 RGS5
regulator of G-protein signaling 5
chr6_-_134639195 0.994 NM_001143676
SGK1
serum/glucocorticoid regulated kinase 1
chr1_+_151032880 0.991 MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr7_-_27205148 0.989 NM_152739
HOXA9
homeobox A9
chr1_+_43766565 0.962 NM_001253357
NM_005424
TIE1

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

chr18_+_47088400 0.950 NM_006033
LIPG
lipase, endothelial
chr1_+_84630575 0.940 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr5_+_34684611 0.917 NM_001145521
NM_001145525
RAI14

retinoic acid induced 14

chr11_+_129991582 0.910 APLP2
amyloid beta (A4) precursor-like protein 2
chr12_+_79439432 0.909 NM_001135806
SYT1
synaptotagmin I
chr21_+_39628869 0.906 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr11_-_102668822 0.899 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr7_-_41742666 0.897 NM_002192
INHBA
inhibin, beta A
chr7_+_134464372 0.886 CALD1
caldesmon 1
chr14_+_94577078 0.876 NM_001130080
NM_005532
IFI27

interferon, alpha-inducible protein 27

chr16_+_55515468 0.871 NM_001127891
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr18_+_3447607 0.854 NM_173207
TGIF1
TGFB-induced factor homeobox 1
chrX_+_102611379 0.845 NM_001006612
NM_001006613
NM_001006614
NM_016303
WBP5



WW domain binding protein 5



chr12_-_95611023 0.843 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6
chr9_+_27109138 0.836 NM_000459
TEK
TEK tyrosine kinase, endothelial
chr10_+_124134206 0.833 PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr10_+_124134093 0.831 NM_001001974
PLEKHA1
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr2_-_165424993 0.824 GRB14
growth factor receptor-bound protein 14
chr18_+_56530060 0.823 NM_018181
ZNF532
zinc finger protein 532
chr5_+_140743755 0.813 NM_018918
NM_032054
PCDHGA5

protocadherin gamma subfamily A, 5

chr3_-_69037498 0.804 C3orf64
chromosome 3 open reading frame 64
chr12_-_71031174 0.804 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_+_78225068 0.800 NM_014903
NAV3
neuron navigator 3
chrX_+_15525430 0.789 NM_001721
BMX
BMX non-receptor tyrosine kinase
chr11_+_19372270 0.787 NM_001111018
NAV2
neuron navigator 2
chr12_-_52845862 0.780 NM_005555
KRT6B
keratin 6B
chr1_+_66458389 0.776 NM_001037340
PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_-_39424930 0.772 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr8_-_13134028 0.763 DLC1
deleted in liver cancer 1
chrX_-_38079980 0.761 NM_001170750
NM_001170751
NM_001170752
NM_006307
SRPX



sushi-repeat containing protein, X-linked



chr15_+_43885251 0.754 NM_020990
CKMT1B
CKMT1A
creatine kinase, mitochondrial 1B
creatine kinase, mitochondrial 1A
chr3_+_62305395 0.752 NM_020685
C3orf14
chromosome 3 open reading frame 14
chr3_-_99833348 0.748 NM_001042459
NM_182909
FILIP1L

filamin A interacting protein 1-like

chr2_-_192711923 0.744 NM_004657
SDPR
serum deprivation response
chr17_-_39743085 0.741 NM_000526
KRT14
keratin 14
chr6_-_105627857 0.723 NM_022361
POPDC3
popeye domain containing 3
chr12_-_8815479 0.719 MFAP5
microfibrillar associated protein 5
chr22_-_19512859 0.716 NM_001130861
NM_003277
CLDN5

claudin 5

chr9_-_74383301 0.713 NM_001135820
NM_013390
TMEM2

transmembrane protein 2

chr8_+_79428335 0.710 NM_006823
NM_181839
PKIA

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

chr9_-_14086901 0.707 NFIB
nuclear factor I/B
chr12_-_10251520 0.704 NM_016511
CLEC1A
C-type lectin domain family 1, member A
chr9_-_16727887 0.694 BNC2
basonuclin 2
chr22_+_38599026 0.692 NM_001161573
MAFF
v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chr2_-_55237255 0.683 NM_007008
RTN4
reticulon 4
chr9_+_116343169 0.672 RGS3
regulator of G-protein signaling 3
chr7_+_102553343 0.671 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr4_+_146403955 0.661 NM_001003688
SMAD1
SMAD family member 1
chr9_-_14398981 0.660 NM_001190738
NFIB
nuclear factor I/B
chrX_-_100914816 0.655 NM_014782
NM_177949
ARMCX2

armadillo repeat containing, X-linked 2

chr18_+_29027731 0.653 NM_001944
DSG3
desmoglein 3
chr2_+_234621637 0.649 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr4_-_186732047 0.649 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr4_+_86699846 0.646 NM_001042669
ARHGAP24
Rho GTPase activating protein 24
chr5_-_168271852 0.644


chr19_-_19049790 0.638 NM_001145724
HOMER3
homer homolog 3 (Drosophila)
chr20_+_11898536 0.633 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr2_+_183582667 0.628 DNAJC10
DnaJ (Hsp40) homolog, subfamily C, member 10
chr4_-_159093523 0.628 FAM198B
family with sequence similarity 198, member B
chrX_+_114827818 0.621 NM_001136025
NM_001172335
PLS3

plastin 3

chr3_-_195310770 0.620 APOD
apolipoprotein D
chr11_-_72380107 0.618 NM_001146209
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr9_+_97521930 0.617 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr18_+_61254533 0.616 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chr1_-_173020011 0.614 NM_005092
TNFSF18
tumor necrosis factor (ligand) superfamily, member 18
chr11_-_17191287 0.612 NM_002645
PIK3C2A
phosphoinositide-3-kinase, class 2, alpha polypeptide
chr1_+_84647342 0.604 NM_001242862
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr10_-_123356158 0.598 NM_001144915
FGFR2
fibroblast growth factor receptor 2
chr2_-_55199894 0.594


chr13_+_111134933 0.594 COL4A2
collagen, type IV, alpha 2
chr5_+_73109342 0.593 NM_001244364
RGNEF
190 kDa guanine nucleotide exchange factor
chr1_-_95392501 0.586 NM_001839
CNN3
calponin 3, acidic
chr3_-_111314181 0.575 NM_024508
ZBED2
zinc finger, BED-type containing 2
chr13_-_99630243 0.574 NM_001130048
NM_001130050
DOCK9

dedicator of cytokinesis 9

chr9_+_116342939 0.573 NM_021106
RGS3
regulator of G-protein signaling 3
chr4_-_16900028 0.572 LDB2
LIM domain binding 2
chr11_-_89322778 0.571 NM_001143837
NOX4
NADPH oxidase 4
chr6_+_12290528 0.568 NM_001168319
NM_001955
EDN1

endothelin 1

chr5_+_125758818 0.564 NM_001146320
NM_001146321
NM_023927
GRAMD3


GRAM domain containing 3


chr1_+_84630014 0.563 NM_001242857
NM_001242858
NM_001242859
PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr2_-_113594325 0.559 NM_000576
IL1B
interleukin 1, beta
chr8_-_18666295 0.558 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr8_-_62602285 0.555 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr14_+_85996512 0.555 FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_+_20915440 0.552 NM_001785
CDA
cytidine deaminase
chr2_-_188312872 0.551 NM_005795
CALCRL
calcitonin receptor-like
chr20_+_9288446 0.533 NM_000933
PLCB4
phospholipase C, beta 4
chr11_+_113931228 0.529 NM_001018011
ZBTB16
zinc finger and BTB domain containing 16
chr6_+_158733691 0.527 NM_001007466
NM_020245
TULP4

tubby like protein 4

chr4_-_186732208 0.522 NM_001145671
SORBS2
sorbin and SH3 domain containing 2
chr8_-_17580024 0.515 NM_001166393
MTUS1
microtubule associated tumor suppressor 1
chr4_+_169552752 0.515 NM_001166109
PALLD
palladin, cytoskeletal associated protein
chrX_+_15518899 0.512 NM_203281
BMX
BMX non-receptor tyrosine kinase
chr2_+_102953716 0.510 NM_003856
IL1RL1
interleukin 1 receptor-like 1
chr6_-_46889620 0.509 NM_001098518
GPR116
G protein-coupled receptor 116
chr15_+_99191671 0.506 IGF1R
insulin-like growth factor 1 receptor
chr10_-_118680978 0.504 KIAA1598
KIAA1598
chr12_-_50616425 0.503 NM_001113547
LIMA1
LIM domain and actin binding 1
chr16_+_57673206 0.500 NM_001145774
GPR56
G protein-coupled receptor 56
chr1_+_155100304 0.500 NM_004428
NM_182685
EFNA1

ephrin-A1

chr14_-_69354900 0.498 ACTN1
actinin, alpha 1
chr12_+_13043955 0.498 NM_003979
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr1_+_84630374 0.498 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_66797775 0.497 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr13_-_45011059 0.497 NM_006022
TSC22D1
TSC22 domain family, member 1
chr7_+_134576150 0.495 NM_033139
NM_033140
CALD1

caldesmon 1

chr13_-_38172862 0.494 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr15_-_50411405 0.489 NM_024837
ATP8B4
ATPase, class I, type 8B, member 4
chr9_+_706744 0.488 NM_153186
KANK1
KN motif and ankyrin repeat domains 1
chr8_-_134309448 0.488 NM_001135242
NM_006096
NDRG1

N-myc downstream regulated 1

chr2_-_113542970 0.487 NM_000575
IL1A
interleukin 1, alpha
chr5_+_140771482 0.486 NM_014004
NM_032088
PCDHGA8

protocadherin gamma subfamily A, 8

chr12_+_56915587 0.485 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr2_-_219157207 0.484 NM_022152
TMBIM1
transmembrane BAX inhibitor motif containing 1
chr2_-_31352489 0.479 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chrX_-_107682600 0.478 NM_001847
COL4A6
collagen, type IV, alpha 6
chr17_-_15554809 0.475 TRIM16
tripartite motif containing 16
chr11_+_123986103 0.474 NM_001130142
NM_014622
NM_198315
VWA5A


von Willebrand factor A domain containing 5A


chrX_+_100805415 0.470 NM_016608
ARMCX1
armadillo repeat containing, X-linked 1
chr1_-_152297678 0.469 NM_002016
FLG
filaggrin
chr4_+_90816002 0.468 NM_007351
MMRN1
multimerin 1
chr4_-_139163222 0.466 NM_014331
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr11_+_69467210 0.463 CCND1
cyclin D1
chr12_-_8815370 0.452 NM_003480
MFAP5
microfibrillar associated protein 5
chr12_-_10151689 0.450 NM_001099431
NM_016509
CLEC1B

C-type lectin domain family 1, member B

chr3_+_122044010 0.450 NM_005213
CSTA
cystatin A (stefin A)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
218.09 9.79e-03 GO:0050701 interleukin-1 secretion
1.85 2.21e-02 GO:0032501 multicellular organismal process
19.40 2.39e-02 GO:0001816 cytokine production
145.40 2.93e-02 GO:0032612 interleukin-1 production

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
10.70 7.15e-08 GO:0005578 proteinaceous extracellular matrix
8.86 6.11e-07 GO:0031012 extracellular matrix
17.82 1.17e-06 GO:0044420 extracellular matrix part
3.93 2.98e-04 GO:0044421 extracellular region part
65.44 9.79e-04 GO:0043205 fibril
2.77 3.37e-03 GO:0005576 extracellular region
15.06 1.27e-02 GO:0005604 basement membrane
72.71 2.82e-02 GO:0005587 collagen type IV
62.32 3.94e-02 GO:0030935 sheet-forming collagen
19.84 4.13e-02 GO:0005581 collagen

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
19.26 5.25e-05 GO:0005201 extracellular matrix structural constituent
4.33 7.23e-03 GO:0005198 structural molecule activity