Motif ID: TBX4,5.p2

Z-value: 2.097


Transcription factors associated with TBX4,5.p2:

Gene SymbolEntrez IDGene Name
TBX4 9496 T-box 4
TBX5 6910 T-box 5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TBX5chr12_-_1148417020.224.2e-01Click!
TBX4chr17_+_59533806-0.214.3e-01Click!


Activity profile for motif TBX4,5.p2.

activity profile for motif TBX4,5.p2


Sorted Z-values histogram for motif TBX4,5.p2

Sorted Z-values for motif TBX4,5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TBX4,5.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_4675175 5.515 NM_003963
TM4SF5
transmembrane 4 L six family member 5
chr14_+_95078713 4.471 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr3_+_186330859 4.056 AHSG
alpha-2-HS-glycoprotein
chr6_+_31623668 3.730 NM_019101
APOM
apolipoprotein M
chrY_+_15016698 3.534 NM_004660
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr10_+_114135013 3.348 NM_203380
ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_+_7169192 3.251


chr3_+_186330844 2.989 NM_001622
AHSG
alpha-2-HS-glycoprotein
chr3_+_186330711 2.796 AHSG
alpha-2-HS-glycoprotein
chr14_-_54421269 2.721 NM_130851
BMP4
bone morphogenetic protein 4
chr6_-_11232901 2.669 NM_006403
NM_182966
NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr17_-_7017558 2.633 NM_080914
ASGR2
asialoglycoprotein receptor 2
chrY_+_15016018 2.612 NM_001122665
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr16_-_52581713 2.606 NM_001146188
TOX3
TOX high mobility group box family member 3
chr6_+_31623688 2.569 APOM
apolipoprotein M
chr9_-_123837410 2.495 C5
complement component 5
chr12_+_66218879 2.442 HMGA2
high mobility group AT-hook 2
chr1_-_173174611 2.257 TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr3_+_133465098 2.243 TF
transferrin
chr3_-_49726081 2.200 NM_020998
MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
chr11_-_2159472 2.195 IGF2
insulin-like growth factor 2 (somatomedin A)
chr1_-_161193190 2.176 APOA2
apolipoprotein A-II
chr6_+_132129195 2.130 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr3_-_120400957 2.080 HGD
homogentisate 1,2-dioxygenase
chr12_+_69742130 2.061 NM_000239
LYZ
lysozyme
chr12_-_26985922 2.016 NM_002223
ITPR2
inositol 1,4,5-trisphosphate receptor, type 2
chr16_+_3115638 2.007 NM_001012634
IL32
interleukin 32
chr6_+_31949800 1.976 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr22_+_23229959 1.970 NM_001178126
IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chrX_+_46940235 1.922 RGN
regucalcin (senescence marker protein-30)
chr6_+_31982538 1.901 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr12_+_69742140 1.897 LYZ
lysozyme
chr7_+_94285620 1.808 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr22_+_38201113 1.794 NM_005318
H1F0
H1 histone family, member 0
chr3_+_133464883 1.786 NM_001063
TF
transferrin
chr16_+_3115641 1.774 NM_001012632
NM_001012636
IL32

interleukin 32

chrX_-_130423387 1.764 NM_001170961
NM_001170962
NM_001555
NM_205833
IGSF1



immunoglobulin superfamily, member 1



chr7_+_94285736 1.752 PEG10
paternally expressed 10
chr2_-_61697899 1.744 USP34
ubiquitin specific peptidase 34
chr6_+_26368405 1.716 NM_001197246
BTN3A2
butyrophilin, subfamily 3, member A2
chr7_+_94285676 1.702 NM_001172437
NM_001172438
PEG10

paternally expressed 10

chr7_+_29234111 1.697 NM_004067
CHN2
chimerin (chimaerin) 2
chr21_+_38445562 1.695 NM_001001894
TTC3
tetratricopeptide repeat domain 3
chr16_+_3115312 1.682 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chrX_-_130423199 1.651 IGSF1
immunoglobulin superfamily, member 1
chr3_+_133465204 1.648 TF
transferrin
chr9_-_132805456 1.626 NM_015033
FNBP1
formin binding protein 1
chr9_-_132805256 1.625 FNBP1
formin binding protein 1
chr11_+_73358593 1.622 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr10_+_114135965 1.599 ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_219283809 1.576 NM_007127
VIL1
villin 1
chr2_-_188419049 1.544 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr17_-_74533623 1.534 NM_134268
CYGB
cytoglobin
chr1_+_155100304 1.530 NM_004428
NM_182685
EFNA1

ephrin-A1

chr7_-_103629962 1.529 NM_005045
NM_173054
RELN

reelin

chr11_+_7535000 1.511 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr1_-_173886464 1.506 NM_000488
SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr16_+_3115639 1.503 IL32
interleukin 32
chr3_+_167453431 1.501 NM_001122752
NM_005025
SERPINI1

serpin peptidase inhibitor, clade I (neuroserpin), member 1

chr19_-_39108534 1.483 NM_001042600
NM_007181
MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

chr17_+_34431219 1.483 NM_002984
CCL4
chemokine (C-C motif) ligand 4
chr6_+_28092386 1.482 NM_025231
ZSCAN16
zinc finger and SCAN domain containing 16
chr20_+_8112762 1.481 NM_015192
NM_182734
PLCB1

phospholipase C, beta 1 (phosphoinositide-specific)

chr14_-_107013474 1.449 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr16_+_82068830 1.443 NM_002153
HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr17_+_34538464 1.434 NM_207007
NM_001001435
CCL4L2
CCL4L1
chemokine (C-C motif) ligand 4-like 2
chemokine (C-C motif) ligand 4-like 1
chr11_-_694842 1.424 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr11_-_695069 1.423 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr20_-_22565050 1.416 NM_021784
FOXA2
forkhead box A2
chr1_-_85930610 1.405 DDAH1
dimethylarginine dimethylaminohydrolase 1
chr10_+_114135937 1.398 NM_016234
ACSL5
acyl-CoA synthetase long-chain family member 5
chr2_+_177053306 1.396 NM_024501
HOXD1
homeobox D1
chr2_+_170590241 1.366 NM_144711
KLHL23
kelch-like 23 (Drosophila)
chr11_-_75236418 1.358 NM_030792
GDPD5
glycerophosphodiester phosphodiesterase domain containing 5
chr2_-_216946463 1.350 NM_018441
PECR
peroxisomal trans-2-enoyl-CoA reductase
chr6_+_132129154 1.349 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr6_-_11232883 1.341 NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr16_+_3115611 1.328 NM_001012635
IL32
interleukin 32
chr4_-_155511838 1.319 NM_000508
NM_021871
FGA

fibrinogen alpha chain

chrY_+_15016775 1.313 DDX3Y
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
chr10_+_31608097 1.302 NM_001174093
NM_001174095
NM_001174096
NM_030751
ZEB1



zinc finger E-box binding homeobox 1



chr3_-_182880463 1.291 NM_014398
LAMP3
lysosomal-associated membrane protein 3
chr11_+_60223281 1.282 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chrY_-_2368963 1.273 NM_145177
NM_001171136
NM_004729
DHRSX
ZBED1

dehydrogenase/reductase (SDR family) X-linked
zinc finger, BED-type containing 1

chr17_-_47439326 1.272 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr7_-_94285372 1.267 SGCE
sarcoglycan, epsilon
chr7_-_94285426 1.250 SGCE
sarcoglycan, epsilon
chr10_+_124768401 1.236 NM_001609
ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr17_-_79008372 1.234 FLJ90757
uncharacterized LOC440465
chr10_-_95360959 1.228 NM_006744
RBP4
retinol binding protein 4, plasma
chr1_-_23885916 1.226 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr11_-_695010 1.212 DEAF1
deformed epidermal autoregulatory factor 1 (Drosophila)
chr22_-_37545944 1.198 NM_000878
IL2RB
interleukin 2 receptor, beta
chr7_-_994259 1.198 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr2_-_89165652 1.189


chr6_+_31543340 1.181 NM_000594
TNF
tumor necrosis factor
chr7_-_94285477 1.179 NM_001099400
NM_001099401
NM_003919
SGCE


sarcoglycan, epsilon


chr11_-_115375065 1.171 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr11_-_2170792 1.160 NM_001007139
IGF2
insulin-like growth factor 2 (somatomedin A)
chr4_-_186733372 1.146 NM_003603
NM_001145670
SORBS2

sorbin and SH3 domain containing 2

chr2_+_128176019 1.138 PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr16_+_57406398 1.129 NM_002996
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr19_+_49838700 1.128 CD37
CD37 molecule
chr7_-_994008 1.115 ADAP1
ArfGAP with dual PH domains 1
chr19_+_49838673 1.100 NM_001040031
NM_001774
CD37

CD37 molecule

chr11_-_63381485 1.086 PLA2G16
phospholipase A2, group XVI
chr18_-_47339854 1.083 ACAA2
acetyl-CoA acyltransferase 2
chr12_-_117537090 1.080 NM_001168325
NM_017899
TESC

tescalcin

chr19_+_49838734 1.078 CD37
CD37 molecule
chr20_-_22564893 1.077 FOXA2
forkhead box A2
chrX_+_70443055 1.077 NM_000166
GJB1
gap junction protein, beta 1, 32kDa
chr19_-_9731883 1.049 NM_152289
ZNF561
zinc finger protein 561
chr1_+_17846818 1.033 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chrX_-_2418963 1.028 NM_145177
NM_001171136
NM_004729
DHRSX
ZBED1

dehydrogenase/reductase (SDR family) X-linked
zinc finger, BED-type containing 1

chr18_+_32556891 1.027 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr17_+_67410825 1.026 NM_002758
MAP2K6
mitogen-activated protein kinase kinase 6
chr7_-_22396511 1.024 NM_012294
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr6_-_31619481 1.024


chr16_+_82068910 1.013 HSD17B2
hydroxysteroid (17-beta) dehydrogenase 2
chr11_+_61447816 1.005 NM_006133
DAGLA
diacylglycerol lipase, alpha
chr19_-_51869632 1.002 NM_001985
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr2_+_62932786 1.001 NM_001142616
NM_015252
EHBP1

EH domain binding protein 1

chr1_+_150954498 1.000 NM_003568
ANXA9
annexin A9
chr1_-_173886401 1.000 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr11_-_63381840 1.000 PLA2G16
phospholipase A2, group XVI
chr6_-_31620142 0.999 NM_001098534
BAG6
BCL2-associated athanogene 6
chr2_-_61697846 0.989 NM_014709
USP34
ubiquitin specific peptidase 34
chr19_+_49838646 0.979 CD37
CD37 molecule
chr14_+_74003817 0.975 NM_001037161
ACOT1
acyl-CoA thioesterase 1
chr7_-_77045706 0.968 NM_017439
PION
pigeon homolog (Drosophila)
chr20_-_4804067 0.955 NM_014737
RASSF2
Ras association (RalGDS/AF-6) domain family member 2
chr8_-_124408665 0.952 ATAD2
ATPase family, AAA domain containing 2
chr14_-_107113943 0.950 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_50304989 0.948 NM_001005914
NM_004636
SEMA3B

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B

chr1_-_27240430 0.940 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr8_+_21912327 0.940 NM_001114136
NM_001114139
EPB49

erythrocyte membrane protein band 4.9 (dematin)

chr5_-_42811959 0.936 NM_001085486
NM_001093726
NM_005410
SEPP1


selenoprotein P, plasma, 1


chr10_+_124768498 0.931 ACADSB
acyl-CoA dehydrogenase, short/branched chain
chr10_-_97416367 0.930 ALDH18A1
aldehyde dehydrogenase 18 family, member A1
chr13_+_113760101 0.925 NM_000131
NM_019616
F7

coagulation factor VII (serum prothrombin conversion accelerator)

chr14_+_101193313 0.915 DLK1
delta-like 1 homolog (Drosophila)
chr14_-_106774311 0.911 IGHA1
immunoglobulin heavy constant alpha 1
chr2_-_188419185 0.908 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr7_+_26331493 0.907 NM_001199835
NM_013322
SNX10

sorting nexin 10

chr11_+_61522860 0.903 NM_013279
C11orf9
chromosome 11 open reading frame 9
chr15_+_81071708 0.897 NM_018689
KIAA1199
KIAA1199
chr16_-_55867016 0.893 NM_001025194
NM_001025195
NM_001266
CES1


carboxylesterase 1


chr2_+_69969250 0.892 ANXA4
annexin A4
chrX_+_114795176 0.889 NM_005032
PLS3
plastin 3
chr22_-_50893728 0.883 SBF1
SET binding factor 1
chr17_+_80190107 0.881 NM_001042423
SLC16A3
solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr13_+_31287614 0.881 NM_001204406
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chrX_+_95939851 0.876 DIAPH2
diaphanous homolog 2 (Drosophila)
chr8_-_80993009 0.867 NM_001025252
TPD52
tumor protein D52
chr8_+_56015013 0.863 NM_052898
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr11_+_22696318 0.861 NM_005256
GAS2
growth arrest-specific 2
chr12_+_51318743 0.841 METTL7A
methyltransferase like 7A
chr16_+_58059469 0.838 MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr1_+_151584514 0.832 NM_030918
SNX27
sorting nexin family member 27
chr2_+_30369868 0.828 YPEL5
yippee-like 5 (Drosophila)
chr5_-_95158365 0.818 GLRX
glutaredoxin (thioltransferase)
chr5_-_78282356 0.815 NM_000046
ARSB
arylsulfatase B
chr6_-_16761600 0.815 NM_000332
NM_001128164
ATXN1

ataxin 1

chr7_-_111846384 0.808 NM_014705
DOCK4
dedicator of cytokinesis 4
chr2_+_69969105 0.808 NM_001153
ANXA4
annexin A4
chr16_+_12058963 0.804 NM_001192
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr9_-_75567915 0.801 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr2_+_71295685 0.797 NAGK
N-acetylglucosamine kinase
chr22_+_24823529 0.795 NM_000675
ADORA2A
adenosine A2a receptor
chr10_+_31607419 0.793 ZEB1
zinc finger E-box binding homeobox 1
chr19_-_51869579 0.793 ETFB
electron-transfer-flavoprotein, beta polypeptide
chr4_-_44728518 0.793 NM_138335
GNPDA2
glucosamine-6-phosphate deaminase 2
chr12_-_56211503 0.791 SARNP
SAP domain containing ribonucleoprotein
chr5_-_172755418 0.780 STC2
stanniocalcin 2
chr2_+_30369749 0.778 NM_001127399
NM_001127400
NM_001127401
NM_016061
YPEL5



yippee-like 5 (Drosophila)



chr5_-_95158465 0.777 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr3_+_39851028 0.776 NM_015460
MYRIP
myosin VIIA and Rab interacting protein
chr2_+_30369800 0.772 YPEL5
yippee-like 5 (Drosophila)
chr10_-_97416564 0.772 NM_001017423
NM_002860
ALDH18A1

aldehyde dehydrogenase 18 family, member A1

chr2_-_152955810 0.769 CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr14_+_24605366 0.761 NM_006263
NM_176783
PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr5_-_108745569 0.753 NM_014819
PJA2
praja ring finger 2
chr2_+_109065665 0.751 GCC2
GRIP and coiled-coil domain containing 2
chr10_+_97515408 0.743 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr17_-_42580927 0.741 NM_001002909
GPATCH8
G patch domain containing 8
chr1_+_16090993 0.738 NM_001024215
FBLIM1
filamin binding LIM protein 1
chr19_-_23578226 0.738 NM_003430
ZNF91
zinc finger protein 91
chr20_-_3149070 0.732 NM_014731
ProSAPiP1
ProSAPiP1 protein
chr5_-_130970907 0.726 NM_001164386
NM_001164387
NM_001164388
NM_001164389
NM_001164390
NM_016340
RAPGEF6





Rap guanine nucleotide exchange factor (GEF) 6





chrX_-_70331297 0.726 NM_000206
IL2RG
interleukin 2 receptor, gamma
chr14_+_24605393 0.722 PSME1
proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_+_52828783 0.721 NM_002217
ITIH3
inter-alpha-trypsin inhibitor heavy chain 3
chr9_-_130742803 0.720 NM_001035254
FAM102A
family with sequence similarity 102, member A
chrX_-_48693934 0.717 NM_013271
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr6_+_31913763 0.715 CFB
complement factor B
chr9_-_75568232 0.712 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr17_-_42580745 0.711 GPATCH8
G patch domain containing 8
chr2_+_242127923 0.707 NM_001001666
NM_001001891
ANO7

anoctamin 7

chr6_+_34759816 0.705 UHRF1BP1
UHRF1 binding protein 1
chr19_+_10381763 0.700 ICAM1
intercellular adhesion molecule 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
2.86 2.73e-05 GO:0048583 regulation of response to stimulus
3.53 7.52e-04 GO:0009611 response to wounding
1.66 1.61e-03 GO:0050896 response to stimulus
20.09 3.32e-03 GO:0050707 regulation of cytokine secretion
13.19 4.32e-03 GO:0050708 regulation of protein secretion
5.75 6.35e-03 GO:0006954 inflammatory response
3.51 6.87e-03 GO:0006955 immune response
15.98 1.06e-02 GO:0002700 regulation of production of molecular mediator of immune response
24.45 1.44e-02 GO:0002637 regulation of immunoglobulin production
14.96 1.47e-02 GO:0050714 positive regulation of protein secretion
46.86 2.17e-02 GO:0051023 regulation of immunoglobulin secretion
9.93 2.24e-02 GO:0051222 positive regulation of protein transport
38.34 4.22e-02 GO:0050710 negative regulation of cytokine secretion
18.75 4.30e-02 GO:0006958 complement activation, classical pathway
3.80 4.84e-02 GO:0080134 regulation of response to stress
11.72 4.87e-02 GO:0072376 protein activation cascade

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
4.66 6.71e-08 GO:0005615 extracellular space
3.07 3.27e-07 GO:0005576 extracellular region
3.70 4.58e-06 GO:0044421 extracellular region part

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
11.20 1.10e-05 GO:0004866 endopeptidase inhibitor activity
11.01 1.28e-05 GO:0030414 peptidase inhibitor activity
10.73 1.60e-05 GO:0061135 endopeptidase regulator activity
6.97 4.97e-05 GO:0004857 enzyme inhibitor activity
8.86 8.29e-05 GO:0061134 peptidase regulator activity
3.47 3.13e-04 GO:0030234 enzyme regulator activity
6.74 2.68e-03 GO:0005125 cytokine activity
12.79 3.07e-02 GO:0008009 chemokine activity
11.48 4.66e-02 GO:0042379 chemokine receptor binding