Motif ID: ZBTB6.p2

Z-value: 1.150


Transcription factors associated with ZBTB6.p2:

Gene SymbolEntrez IDGene Name
ZBTB6 10773 zinc finger and BTB domain containing 6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZBTB6chr9_-_125675571-0.146.2e-01Click!


Activity profile for motif ZBTB6.p2.

activity profile for motif ZBTB6.p2


Sorted Z-values histogram for motif ZBTB6.p2

Sorted Z-values for motif ZBTB6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB6.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_52914080 5.652 NM_000424
KRT5
keratin 5
chr12_-_52845862 3.800 NM_005555
KRT6B
keratin 6B
chr12_-_52886971 2.953 NM_005554
KRT6A
keratin 6A
chr11_-_12030882 1.851 NM_013253
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr12_+_53342842 1.535 NM_000224
KRT18
keratin 18
chr11_-_12030539 1.504 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr11_-_12030622 1.491 NM_015881
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr11_-_12030838 1.467 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr1_+_43996478 1.341 NM_002840
NM_130440
PTPRF

protein tyrosine phosphatase, receptor type, F

chr5_-_72744351 1.329 NM_004472
FOXD1
forkhead box D1
chr1_-_153538305 1.287 NM_005978
S100A2
S100 calcium binding protein A2
chr10_+_48255223 1.268 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr2_-_20425166 1.265 NM_001006946
SDC1
syndecan 1
chr10_+_88728187 1.239 NM_006829
C10orf116
chromosome 10 open reading frame 116
chr10_+_75673346 1.239 PLAU
plasminogen activator, urokinase
chr12_+_53342899 1.221 KRT18
keratin 18
chr12_-_53012332 1.200 NM_175068
KRT73
keratin 73
chr10_+_47746919 1.178 NM_001630
ANXA8L2
ANXA8
annexin A8-like 2
annexin A8
chr10_-_47173917 1.158 NM_001040084
NM_001098845
ANXA8L2
ANXA8
ANXA8L1
annexin A8-like 2
annexin A8
annexin A8-like 1
chr7_+_144052432 1.138 NM_005435
ARHGEF5
Rho guanine nucleotide exchange factor (GEF) 5
chr19_+_38755422 1.137 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr22_+_33197678 1.120 TIMP3
TIMP metallopeptidase inhibitor 3
chr12_-_52967608 1.086 NM_175053
KRT74
keratin 74
chr16_+_22825481 1.073 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr22_+_33197744 1.068 TIMP3
TIMP metallopeptidase inhibitor 3
chr16_+_22825806 1.018 NM_006043
HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr5_+_52776479 1.013 FST
follistatin
chr12_+_56325788 1.003 NM_201444
NM_201445
NM_201554
DGKA


diacylglycerol kinase, alpha 80kDa


chr8_+_104512975 0.968 NM_001100117
RIMS2
regulating synaptic membrane exocytosis 2
chr6_-_10412606 0.954 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr11_-_79151694 0.939 NM_001098816
ODZ4
odz, odd Oz/ten-m homolog 4 (Drosophila)
chr11_-_12030128 0.928 NM_001018057
DKK3
dickkopf 3 homolog (Xenopus laevis)
chr2_-_20424627 0.906 NM_002997
SDC1
syndecan 1
chr5_+_52776408 0.904 FST
follistatin
chr10_-_95241943 0.879 NM_013451
NM_133337
MYOF

myoferlin

chr10_-_125853102 0.830 CHST15
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
chr2_-_235405692 0.827 NM_005737
ARL4C
ADP-ribosylation factor-like 4C
chr17_-_39743085 0.814 NM_000526
KRT14
keratin 14
chr18_+_29078026 0.804 NM_001943
DSG2
desmoglein 2
chr22_+_31489343 0.792 SMTN
smoothelin
chrX_+_73641084 0.787 NM_006517
SLC16A2
solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
chr17_-_62657997 0.776 SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chr16_+_56716378 0.770 NM_005952
MT1X
metallothionein 1X
chr16_+_56659584 0.755 NM_175617
MT1E
metallothionein 1E
chr20_-_56285576 0.735 NM_199169
NM_199170
PMEPA1

prostate transmembrane protein, androgen induced 1

chr17_+_48610045 0.725 NM_017957
EPN3
epsin 3
chr2_-_224903933 0.720 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr12_-_28124915 0.711 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr3_-_189838673 0.696 LEPREL1
leprecan-like 1
chr17_+_15848230 0.691 NM_000676
ADORA2B
adenosine A2b receptor
chr8_-_49833823 0.687 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr6_-_2971981 0.667 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr10_+_54074037 0.664 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr6_-_2971787 0.663 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr4_+_30721865 0.661 NM_032456
NM_001173523
NM_002589
NM_032457
PCDH7



protocadherin 7



chr7_+_116139619 0.654 NM_001206747
NM_001233
NM_198212
CAV2


caveolin 2


chr17_+_15848422 0.652 ADORA2B
adenosine A2b receptor
chr1_+_13910251 0.641 NM_006474
NM_198389
PDPN

podoplanin

chr8_-_48650703 0.612 NM_005195
CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr17_+_48610077 0.586 EPN3
epsin 3
chr4_-_187644983 0.579 NM_005245
FAT1
FAT tumor suppressor homolog 1 (Drosophila)
chr5_-_57755787 0.572 NM_001252226
NM_006622
PLK2

polo-like kinase 2

chr11_+_63753827 0.568 OTUB1
OTU domain, ubiquitin aldehyde binding 1
chr4_-_177713664 0.567 NM_005429
VEGFC
vascular endothelial growth factor C
chr8_-_48650683 0.561 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr21_+_39644428 0.560 NM_170737
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr18_-_28622624 0.555 NM_001941
NM_024423
DSC3

desmocollin 3

chr4_-_99579540 0.547 NM_005723
TSPAN5
tetraspanin 5
chr19_+_41223282 0.546 ITPKC
inositol-trisphosphate 3-kinase C
chr1_+_162531349 0.544 UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr12_-_52867521 0.537 NM_173086
KRT6C
keratin 6C
chr1_-_6662681 0.533 KLHL21
kelch-like 21 (Drosophila)
chr1_+_162531229 0.521 NM_003115
UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr6_+_30850693 0.515 DDR1
discoidin domain receptor tyrosine kinase 1
chr3_-_189838907 0.514 NM_018192
LEPREL1
leprecan-like 1
chr15_+_71184781 0.511 NM_001199017
NM_017691
NM_001199018
LRRC49


leucine rich repeat containing 49


chr3_-_52090090 0.508 NM_001947
DUSP7
dual specificity phosphatase 7
chr5_+_131593388 0.501 PDLIM4
PDZ and LIM domain 4
chr20_-_56286540 0.495 NM_199171
PMEPA1
prostate transmembrane protein, androgen induced 1
chr11_-_35547144 0.495 NM_001001991
NM_015430
PAMR1

peptidase domain containing associated with muscle regeneration 1

chr3_-_38066277 0.494 NM_001130964
PLCD1
phospholipase C, delta 1
chrX_-_51239295 0.488 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr10_-_79686279 0.474 NM_004747
DLG5
discs, large homolog 5 (Drosophila)
chr12_+_53342654 0.472 NM_199187
KRT18
keratin 18
chr2_+_9346909 0.471 ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr6_-_2971281 0.469 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr15_+_45422130 0.459 NM_017434
NM_175940
DUOX1

dual oxidase 1

chr4_+_30722191 0.453 PCDH7
protocadherin 7
chr8_+_15397761 0.453 TUSC3
tumor suppressor candidate 3
chr4_+_1795004 0.452 NM_000142
NM_001163213
NM_022965
FGFR3


fibroblast growth factor receptor 3


chr8_-_145018057 0.451 NM_201382
PLEC
plectin
chr22_+_31478845 0.445 NM_001207017
SMTN
smoothelin
chrX_-_51239426 0.445 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr17_-_39768939 0.436 NM_005557
KRT16
keratin 16
chr3_-_45187897 0.435 NM_022842
NM_178181
CDCP1

CUB domain containing protein 1

chr19_-_55658310 0.431 TNNT1
troponin T type 1 (skeletal, slow)
chr17_-_1619473 0.426 MIR22HG
MIR22 host gene (non-protein coding)
chrX_+_102632108 0.424 NM_014380
NGFRAP1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr3_-_45187861 0.417 CDCP1
CUB domain containing protein 1
chr17_+_2680349 0.416 RAP1GAP2
RAP1 GTPase activating protein 2
chr1_+_86046434 0.414 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr5_-_131563481 0.410 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr1_-_93426998 0.408 NM_001006605
NM_001252269
NM_001252270
NM_001252273
FAM69A



family with sequence similarity 69, member A



chr19_+_38755238 0.406 SPINT2
serine peptidase inhibitor, Kunitz type, 2
chr5_+_131593377 0.404 PDLIM4
PDZ and LIM domain 4
chr11_-_61735108 0.403 NM_002032
FTH1
ferritin, heavy polypeptide 1
chr2_-_55277421 0.399 RTN4
reticulon 4
chr8_-_145027975 0.399 NM_201379
PLEC
plectin
chr5_+_131593331 0.398 NM_001131027
NM_003687
PDLIM4

PDZ and LIM domain 4

chr1_-_59248287 0.397 JUN
jun proto-oncogene
chr6_-_53409897 0.393 NM_001197115
NM_001498
GCLC

glutamate-cysteine ligase, catalytic subunit

chr15_+_74218962 0.393 LOXL1
lysyl oxidase-like 1
chr15_-_83953465 0.391 NM_001717
BNC1
basonuclin 1
chr9_-_100954883 0.389 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr12_+_56211718 0.388 NM_014182
ORMDL2
ORM1-like 2 (S. cerevisiae)
chr14_-_69445772 0.386 ACTN1
actinin, alpha 1
chr16_-_31214054 0.377 NM_013258
NM_145182
PYCARD

PYD and CARD domain containing

chr3_-_45187843 0.376 CDCP1
CUB domain containing protein 1
chr12_+_56211862 0.376 ORMDL2
ORM1-like 2 (S. cerevisiae)
chr22_+_43547526 0.369 NM_000714
NM_007311
TSPO

translocator protein (18kDa)

chr16_-_122573 0.369 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr19_-_4400470 0.367 NM_001199943
NM_003025
SH3GL1

SH3-domain GRB2-like 1

chr8_+_61429551 0.366 RAB2A
RAB2A, member RAS oncogene family
chr1_+_158150678 0.361 CD1D
CD1d molecule
chr1_-_205290756 0.361 NM_030952
NUAK2
NUAK family, SNF1-like kinase, 2
chr12_-_6484389 0.357 NM_001159576
SCNN1A
sodium channel, nonvoltage-gated 1 alpha
chr5_+_17217474 0.355 NM_006317
BASP1
brain abundant, membrane attached signal protein 1
chr3_-_13921617 0.354 NM_004625
WNT7A
wingless-type MMTV integration site family, member 7A
chr20_+_44035203 0.352 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chrX_+_131157231 0.350 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chr22_+_43547558 0.349 TSPO
translocator protein (18kDa)
chr3_+_159557649 0.347 NM_001197109
SCHIP1
schwannomin interacting protein 1
chr16_-_4987056 0.344 NM_002705
PPL
periplakin
chr12_+_4430346 0.343 NM_020375
C12orf5
chromosome 12 open reading frame 5
chr1_-_214724565 0.341 PTPN14
protein tyrosine phosphatase, non-receptor type 14
chr16_-_31214003 0.339 PYCARD
PYD and CARD domain containing
chr2_+_219082119 0.339 NM_005731
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr19_+_38755097 0.336 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr17_-_1359410 0.334 NM_005206
NM_016823
CRK

v-crk sarcoma virus CT10 oncogene homolog (avian)

chr17_+_48712115 0.333 NM_001144070
NM_003786
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr1_+_26856252 0.332 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr19_-_50143350 0.331 NM_006270
RRAS
related RAS viral (r-ras) oncogene homolog
chr2_+_187454724 0.329 NM_001145000
NM_002210
ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

chrX_-_54521866 0.329 FGD1
FYVE, RhoGEF and PH domain containing 1
chr3_-_190040192 0.328 NM_021101
CLDN1
claudin 1
chr7_+_116140097 0.327 NM_001206748
CAV2
caveolin 2
chr3_-_120169493 0.326 NM_007085
FSTL1
follistatin-like 1
chr3_+_142315205 0.324 NM_001145319
PLS1
plastin 1
chr11_+_65686727 0.323 NM_006442
DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)
chr7_+_55086922 0.319 EGFR
epidermal growth factor receptor
chr8_+_30241943 0.318 NM_001008710
NM_001008711
NM_001008712
NM_006867
RBPMS



RNA binding protein with multiple splicing



chr11_+_63753902 0.317 OTUB1
OTU domain, ubiquitin aldehyde binding 1
chr20_+_6748744 0.315 NM_001200
BMP2
bone morphogenetic protein 2
chr16_-_4166021 0.313 ADCY9
adenylate cyclase 9
chr5_+_86564044 0.311 NM_002890
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr2_-_55277653 0.311 RTN4
reticulon 4
chr1_-_108507474 0.304 NM_006113
VAV3
vav 3 guanine nucleotide exchange factor
chr10_+_72575724 0.304 SGPL1
sphingosine-1-phosphate lyase 1
chr11_+_69455938 0.304 CCND1
cyclin D1
chr8_+_61429390 0.303 NM_001242644
NM_002865
RAB2A

RAB2A, member RAS oncogene family

chr16_+_31044881 0.301 NM_004604
STX4
syntaxin 4
chr11_+_12695851 0.299 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr5_+_17217781 0.298 BASP1
brain abundant, membrane attached signal protein 1
chr1_-_153588789 0.298 NM_020672
S100A14
S100 calcium binding protein A14
chr1_-_94374986 0.297 NM_002061
GCLM
glutamate-cysteine ligase, modifier subunit
chr2_+_36583369 0.296 NM_016441
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr1_-_59042827 0.295 TACSTD2
tumor-associated calcium signal transducer 2
chr5_+_141488385 0.295 NDFIP1
Nedd4 family interacting protein 1
chr17_+_65373574 0.294 PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr15_+_39873276 0.291 NM_003246
THBS1
thrombospondin 1
chr17_+_41476351 0.290 NM_001661
ARL4D
ADP-ribosylation factor-like 4D
chr5_+_141488384 0.289 NDFIP1
Nedd4 family interacting protein 1
chr16_+_68679229 0.289 CDH3
cadherin 3, type 1, P-cadherin (placental)
chr1_+_109792640 0.289 NM_001408
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
chr1_+_44444986 0.287 B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr3_-_45267804 0.287 NM_015444
TMEM158
transmembrane protein 158 (gene/pseudogene)
chr1_-_94374949 0.285 GCLM
glutamate-cysteine ligase, modifier subunit
chr5_+_52776263 0.284 NM_006350
NM_013409
FST

follistatin

chr8_+_25042379 0.283 DOCK5
dedicator of cytokinesis 5
chr19_+_41222915 0.282 NM_025194
ITPKC
inositol-trisphosphate 3-kinase C
chr2_-_55277459 0.279 RTN4
reticulon 4
chr1_+_26856240 0.279 NM_002953
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr5_+_141488314 0.279 NM_030571
NDFIP1
Nedd4 family interacting protein 1
chr3_-_43663467 0.278 NM_001204831
NM_001204832
NM_001204833
NM_001204834
NM_018075
ANO10




anoctamin 10




chr16_+_56642477 0.278 NM_005953
MT2A
metallothionein 2A
chr5_+_50678957 0.278 NM_002202
ISL1
ISL LIM homeobox 1
chr3_-_43663421 0.278 ANO10
anoctamin 10
chr10_-_33623771 0.277 NM_001024628
NM_001024629
NM_001244972
NM_001244973
NM_003873
NRP1




neuropilin 1




chr11_-_115375065 0.275 NM_001098517
NM_014333
CADM1

cell adhesion molecule 1

chr5_+_86564146 0.274 RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr1_+_26856259 0.273 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr4_-_102268333 0.270 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_+_57994087 0.268 NM_001164317
NM_001164318
NM_001164319
NM_001457
FLNB



filamin B, beta



chr6_-_108395854 0.267 OSTM1
osteopetrosis associated transmembrane protein 1
chr2_-_55277698 0.266 NM_020532
NM_153828
NM_207520
RTN4


reticulon 4


chr5_+_50679239 0.265 ISL1
ISL LIM homeobox 1
chr5_-_151066492 0.265 NM_003118
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr5_+_86564727 0.263 NM_022650
RASA1
RAS p21 protein activator (GTPase activating protein) 1
chr2_+_192109879 0.263 NM_001130158
NM_012223
NM_001161819
MYO1B


myosin IB


chr12_-_95611023 0.262 NM_018351
FGD6
FYVE, RhoGEF and PH domain containing 6

Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
100.03 5.77e-10 GO:0045095 keratin filament
41.29 1.49e-07 GO:0005882 intermediate filament
32.71 6.13e-07 GO:0045111 intermediate filament cytoskeleton

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
66.03 3.25e-04 GO:0005544 calcium-dependent phospholipid binding
6.56 5.55e-03 GO:0005198 structural molecule activity
13.06 5.95e-03 GO:0005543 phospholipid binding
23.61 7.35e-03 GO:0005200 structural constituent of cytoskeleton