Motif ID: ZNF423.p2

Z-value: 1.337


Transcription factors associated with ZNF423.p2:

Gene SymbolEntrez IDGene Name
ZNF423 23090 zinc finger protein 423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ZNF423chr16_-_498609170.078.1e-01Click!


Activity profile for motif ZNF423.p2.

activity profile for motif ZNF423.p2


Sorted Z-values histogram for motif ZNF423.p2

Sorted Z-values for motif ZNF423.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF423.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_26644458 2.130 CD52
CD52 molecule
chr16_+_57392694 1.588 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr9_+_93564099 1.492 SYK
spleen tyrosine kinase
chr1_+_26644380 1.481 NM_001803
CD52
CD52 molecule
chr1_-_27952591 1.414 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr3_-_16555128 1.356 NM_015150
RFTN1
raftlin, lipid raft linker 1
chr19_+_14544100 1.328 NM_002741
PKN1
protein kinase N1
chr3_-_16554992 1.301 RFTN1
raftlin, lipid raft linker 1
chr9_+_93564063 1.279 SYK
spleen tyrosine kinase
chr17_+_76164624 1.220 NM_004710
SYNGR2
synaptogyrin 2
chr10_-_121296044 1.219 NM_002925
RGS10
regulator of G-protein signaling 10
chr9_+_93564073 1.213 SYK
spleen tyrosine kinase
chr19_-_49314177 1.205 NM_001164773
NM_001190
BCAT2

branched chain amino-acid transaminase 2, mitochondrial

chr16_+_23847359 1.162 PRKCB
protein kinase C, beta
chr16_+_23847321 1.095 PRKCB
protein kinase C, beta
chr6_-_90062610 1.021 NM_016021
UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr16_+_23847271 0.979 NM_002738
NM_212535
PRKCB

protein kinase C, beta

chr3_+_52529351 0.968 NM_015136
STAB1
stabilin 1
chr20_-_23066828 0.952 NM_012072
CD93
CD93 molecule
chr22_+_22786283 0.946


chr11_-_33891485 0.916 NM_001142315
LMO2
LIM domain only 2 (rhombotin-like 1)
chr19_-_11689765 0.914 NM_001111035
NM_001111036
ACP5

acid phosphatase 5, tartrate resistant

chr1_-_184943532 0.905 FAM129A
family with sequence similarity 129, member A
chr9_+_93564204 0.900 NM_001174168
SYK
spleen tyrosine kinase
chr22_+_37309618 0.898 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr19_+_14544216 0.890 PKN1
protein kinase N1
chr16_+_2867163 0.871 NM_006799
NM_144956
NM_144957
PRSS21


protease, serine, 21 (testisin)


chr3_+_52529370 0.860 STAB1
stabilin 1
chr1_-_212873197 0.815 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr19_-_11689591 0.800 NM_001111034
ACP5
acid phosphatase 5, tartrate resistant
chr15_-_83876165 0.768 NM_016073
HDGFRP3
hepatoma-derived growth factor, related protein 3
chr5_+_118406721 0.745 DMXL1
Dmx-like 1
chr22_+_22735134 0.741 CYAT1
immunoglobulin lambda light chain-like
chr9_+_101569933 0.729 NM_024642
GALNT12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
chr20_-_57582303 0.728 NM_001336
CTSZ
cathepsin Z
chr1_-_212873306 0.718 NM_018664
BATF3
basic leucine zipper transcription factor, ATF-like 3
chr2_+_74776146 0.715 NM_001197260
DOK1
docking protein 1, 62kDa (downstream of tyrosine kinase 1)
chr10_+_3109708 0.711 NM_002627
PFKP
phosphofructokinase, platelet
chr20_+_30639981 0.694 NM_001172129
NM_001172130
NM_001172131
NM_001172132
NM_001172133
NM_002110
HCK





hemopoietic cell kinase





chr3_-_127541975 0.656 NM_001003794
MGLL
monoglyceride lipase
chr5_+_153570270 0.654 NM_198321
GALNT10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr1_+_76190371 0.649 ACADM
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
chr21_+_27011766 0.638 JAM2
junctional adhesion molecule 2
chr1_-_9129666 0.631 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr9_+_93564011 0.624 NM_001135052
NM_003177
SYK

spleen tyrosine kinase

chr5_+_118407067 0.620 NM_005509
DMXL1
Dmx-like 1
chr7_+_26191732 0.617 NM_004289
NFE2L3
nuclear factor (erythroid-derived 2)-like 3
chr21_-_46962281 0.616 NM_001205206
NM_194255
SLC19A1

solute carrier family 19 (folate transporter), member 1

chr1_+_76190442 0.595 ACADM
acyl-CoA dehydrogenase, C-4 to C-12 straight chain
chr11_+_1892098 0.588 NM_001013254
NM_001013255
LSP1

lymphocyte-specific protein 1

chr19_-_18548971 0.580 NM_001170938
NM_016368
ISYNA1

inositol-3-phosphate synthase 1

chr9_-_130742803 0.577 NM_001035254
FAM102A
family with sequence similarity 102, member A
chr6_+_33244916 0.576 NM_003782
B3GALT4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr21_+_27012045 0.566 JAM2
junctional adhesion molecule 2
chr6_-_90062450 0.565 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr19_-_18548788 0.564 NM_001170939
ISYNA1
inositol-3-phosphate synthase 1
chr6_+_31543340 0.559 NM_000594
TNF
tumor necrosis factor
chr20_-_57582152 0.549 CTSZ
cathepsin Z
chr6_-_32160289 0.548 GPSM3
G-protein signaling modulator 3
chr8_-_80679897 0.544 NM_001040708
NM_012258
HEY1

hairy/enhancer-of-split related with YRPW motif 1

chr18_-_5543967 0.542 NM_012307
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr6_-_90062349 0.540 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr9_-_135230358 0.535 NM_015046
SETX
senataxin
chr19_-_41858948 0.531 TGFB1
transforming growth factor, beta 1
chr15_-_83316621 0.525 NM_030594
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr6_-_90062439 0.522 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr1_-_193028389 0.519 UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr1_+_110230417 0.510 NM_000561
NM_146421
GSTM1

glutathione S-transferase mu 1

chr11_-_67120943 0.510 NM_021173
POLD4
polymerase (DNA-directed), delta 4
chr16_+_2867227 0.506 PRSS21
protease, serine, 21 (testisin)
chr9_-_135230129 0.505 SETX
senataxin
chr1_+_110198873 0.503 GSTM2
GSTM4
glutathione S-transferase mu 2 (muscle)
glutathione S-transferase mu 4
chr3_-_195808958 0.500 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr12_+_65218351 0.495 NM_015279
TBC1D30
TBC1 domain family, member 30
chr3_-_121553907 0.494 NM_001023570
NM_001023571
IQCB1

IQ motif containing B1

chr11_+_61560108 0.490 NM_004111
FEN1
flap structure-specific endonuclease 1
chr7_+_2443164 0.487 NM_001243794
NM_001243795
NM_018641
CHST12


carbohydrate (chondroitin 4) sulfotransferase 12


chr10_+_124914279 0.487 BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast)
chr9_+_4985243 0.485 NM_004972
JAK2
Janus kinase 2
chr3_-_128207366 0.482 NM_001145661
GATA2
GATA binding protein 2
chr10_+_17271276 0.481 VIM
vimentin
chr9_-_16870719 0.480 NM_017637
BNC2
basonuclin 2
chr8_-_70745624 0.471 NM_001146008
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr11_+_61560401 0.467 FEN1
flap structure-specific endonuclease 1
chr17_-_40428391 0.467 NM_012448
STAT5B
signal transducer and activator of transcription 5B
chr3_-_195808997 0.463 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chrX_-_118827060 0.462 SEPT6
septin 6
chr11_+_1968586 0.461 MRPL23
mitochondrial ribosomal protein L23
chr14_+_92790151 0.458 NM_153646
SLC24A4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr19_-_48673559 0.456 NM_000234
LIG1
ligase I, DNA, ATP-dependent
chr19_+_50180492 0.456 PRMT1
protein arginine methyltransferase 1
chr14_+_66975205 0.450 GPHN
gephyrin
chr22_-_37882214 0.449 NM_001166343
NM_002405
MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr11_+_61560352 0.448 FEN1
flap structure-specific endonuclease 1
chr19_+_20011700 0.448 NM_031218
ZNF93
zinc finger protein 93
chr3_-_127541160 0.447 NM_007283
MGLL
monoglyceride lipase
chr16_-_56459371 0.445 NM_001144
AMFR
autocrine motility factor receptor
chr11_-_107729492 0.441 SLC35F2
solute carrier family 35, member F2
chr21_+_27012067 0.441 JAM2
junctional adhesion molecule 2
chrX_+_64887534 0.440 MSN
moesin
chr19_-_2038937 0.439 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr1_+_10459084 0.438 NM_002631
PGD
phosphogluconate dehydrogenase
chr19_+_50180408 0.436 NM_001207042
NM_001536
NM_198318
PRMT1


protein arginine methyltransferase 1


chr8_+_17433941 0.434 NM_006207
PDGFRL
platelet-derived growth factor receptor-like
chr7_+_142985307 0.432 NM_032982
NM_032983
CASP2

caspase 2, apoptosis-related cysteine peptidase

chr7_-_1595746 0.431 NM_001097620
TMEM184A
transmembrane protein 184A
chr10_+_17271341 0.431 VIM
vimentin
chr11_+_1968499 0.429 NM_021134
MRPL23
mitochondrial ribosomal protein L23
chr6_+_42896859 0.427 NM_006586
CNPY3
canopy 3 homolog (zebrafish)
chr10_+_17271277 0.427 VIM
vimentin
chr1_-_182573393 0.424 NM_002928
RGS16
regulator of G-protein signaling 16
chr1_-_183559463 0.423 NCF2
neutrophil cytosolic factor 2
chr9_-_135230340 0.419 SETX
senataxin
chr6_+_42897184 0.418 CNPY3
canopy 3 homolog (zebrafish)
chr20_-_44539542 0.418 PLTP
phospholipid transfer protein
chr9_+_4985082 0.418 JAK2
Janus kinase 2
chr6_+_42897236 0.413 CNPY3
canopy 3 homolog (zebrafish)
chr19_-_3028901 0.412 NM_003260
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr6_-_18264638 0.411 NM_001134709
NM_003472
DEK

DEK oncogene

chrX_+_30265270 0.406 NM_177404
MAGEB1
melanoma antigen family B, 1
chr22_+_22735207 0.405 IGLJ3
immunoglobulin lambda joining 3
chr11_-_107729523 0.405 SLC35F2
solute carrier family 35, member F2
chrY_-_1522648 0.403 NM_001173473
ASMTL
acetylserotonin O-methyltransferase-like
chr11_+_46403279 0.402 MDK
midkine (neurite growth-promoting factor 2)
chr19_+_12273866 0.400 NM_003437
ZNF136
zinc finger protein 136
chr2_+_46769892 0.400 RHOQ
ras homolog gene family, member Q
chr3_-_128212027 0.395 NM_032638
GATA2
GATA binding protein 2
chr12_-_53601051 0.394 ITGB7
integrin, beta 7
chr9_-_6645564 0.394 NM_000170
GLDC
glycine dehydrogenase (decarboxylating)
chr6_-_3227776 0.393 NM_178012
TUBB2B
tubulin, beta 2B class IIb
chr1_-_151299822 0.393 PI4KB
phosphatidylinositol 4-kinase, catalytic, beta
chrX_+_48542159 0.392 NM_000377
WAS
Wiskott-Aldrich syndrome (eczema-thrombocytopenia)
chr3_-_195808934 0.390 TFRC
transferrin receptor (p90, CD71)
chr1_-_32801606 0.389 NM_023009
MARCKSL1
MARCKS-like 1
chr15_-_66648991 0.389 NM_017858
TIPIN
TIMELESS interacting protein
chr2_+_46769821 0.380 NM_012249
RHOQ
ras homolog gene family, member Q
chr19_-_6591012 0.379 CD70
CD70 molecule
chr3_-_52931341 0.379 TMEM110
transmembrane protein 110
chr7_+_50344255 0.377 NM_001220765
NM_001220766
NM_001220767
NM_001220768
NM_001220769
NM_001220770
NM_001220771
NM_001220772
NM_001220773
NM_001220774
NM_001220775
NM_001220776
NM_006060
IKZF1












IKAROS family zinc finger 1 (Ikaros)












chr7_+_6629658 0.372 NM_024067
C7orf26
chromosome 7 open reading frame 26
chr10_+_17271302 0.371 VIM
vimentin
chr20_-_44539597 0.369 NM_001242921
PLTP
phospholipid transfer protein
chr11_+_61595633 0.366 NM_004265
FADS2
fatty acid desaturase 2
chr1_-_212873104 0.366 BATF3
basic leucine zipper transcription factor, ATF-like 3
chr11_+_46403302 0.365 NM_001012333
MDK
midkine (neurite growth-promoting factor 2)
chr11_+_95523608 0.361 NM_001243776
NM_001243777
NM_014679
CEP57


centrosomal protein 57kDa


chr16_+_30675777 0.360 NM_001105079
FBRS
fibrosin
chr16_-_46782104 0.359 NM_182493
MYLK3
myosin light chain kinase 3
chr16_+_58498216 0.359 NDRG4
NDRG family member 4
chr1_-_27953046 0.359 NM_001042729
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr19_-_3786279 0.355 MATK
megakaryocyte-associated tyrosine kinase
chrX_+_64887510 0.355 NM_002444
MSN
moesin
chr7_+_2443205 0.355 CHST12
carbohydrate (chondroitin 4) sulfotransferase 12
chr1_-_117113640 0.354 NM_001144822
NM_001779
CD58

CD58 molecule

chr11_+_117049838 0.348 NM_001040455
SIDT2
SID1 transmembrane family, member 2
chr19_-_6591136 0.347 NM_001252
CD70
CD70 molecule
chr5_+_43603216 0.346 NM_182977
NNT
nicotinamide nucleotide transhydrogenase
chr12_+_113344738 0.345 NM_001032409
NM_002534
NM_016816
OAS1


2'-5'-oligoadenylate synthetase 1, 40/46kDa


chr10_-_94333721 0.345 IDE
insulin-degrading enzyme
chr1_-_33366838 0.344 NM_033504
TMEM54
transmembrane protein 54
chr6_+_292033 0.343 NM_020185
DUSP22
dual specificity phosphatase 22
chr5_+_96271345 0.341 NM_005575
LNPEP
leucyl/cystinyl aminopeptidase
chr1_-_206785842 0.341 NM_001201478
NM_006893
EIF2D

eukaryotic translation initiation factor 2D

chr11_+_43333603 0.341 API5
apoptosis inhibitor 5
chr1_+_32666201 0.339 NM_024296
CCDC28B
coiled-coil domain containing 28B
chr7_-_55640198 0.337 NM_030796
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr3_-_52567809 0.336 NT5DC2
5'-nucleotidase domain containing 2
chr11_+_43333535 0.336 API5
apoptosis inhibitor 5
chr1_-_206785694 0.335 EIF2D
eukaryotic translation initiation factor 2D
chr7_+_64126481 0.335 NM_001013746
NM_016220
ZNF107

zinc finger protein 107

chr12_+_111471827 0.335 NM_015267
CUX2
cut-like homeobox 2
chr19_-_6591082 0.335 CD70
CD70 molecule
chr9_-_16870664 0.333 BNC2
basonuclin 2
chr21_+_45432202 0.328 NM_003274
TRAPPC10
trafficking protein particle complex 10
chr3_-_13461802 0.327 NM_024923
NUP210
nucleoporin 210kDa
chr20_-_52199635 0.327 NM_006526
ZNF217
zinc finger protein 217
chrX_+_9432980 0.326 NM_005647
TBL1X
transducin (beta)-like 1X-linked
chr10_-_94333828 0.326 IDE
insulin-degrading enzyme
chr11_-_61560052 0.326 NM_014206
C11orf10
chromosome 11 open reading frame 10
chr16_-_1821503 0.326 NME3
non-metastatic cells 3, protein expressed in
chr19_-_2042022 0.325 MKNK2
MAP kinase interacting serine/threonine kinase 2
chr13_+_33160537 0.322 NM_015032
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr15_+_64443909 0.322 NM_024798
SNX22
sorting nexin 22
chr18_+_77160243 0.320 NM_172387
NM_172389
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr17_-_58603291 0.320 APPBP2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr11_+_43333502 0.318 NM_001142930
NM_001142931
NM_001243747
NM_006595
API5



apoptosis inhibitor 5



chr15_-_59225766 0.318 SLTM
SAFB-like, transcription modulator
chr11_-_57194591 0.317 NM_199329
SLC43A3
solute carrier family 43, member 3
chr5_+_68788387 0.316 NM_001205254
OCLN
occludin
chr12_+_7342269 0.314 NM_001131023
NM_001131024
NM_001131025
PEX5


peroxisomal biogenesis factor 5


chr6_+_31430955 0.313 HCP5
HLA complex P5 (non-protein coding)
chr12_+_7342956 0.313 NM_000319
PEX5
peroxisomal biogenesis factor 5
chr1_+_99730067 0.313 LPPR4
lipid phosphate phosphatase-related protein type 4
chr1_-_156023488 0.311 NM_020131
UBQLN4
ubiquilin 4
chr5_-_175964223 0.311 NM_014901
RNF44
ring finger protein 44
chr14_-_106209380 0.311 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr7_+_99775346 0.310 STAG3
stromal antigen 3
chr2_+_65283485 0.310 NM_015147
CEP68
centrosomal protein 68kDa
chr21_+_45719921 0.309 NM_002626
PFKL
phosphofructokinase, liver
chr8_-_133493003 0.305 NM_004519
KCNQ3
potassium voltage-gated channel, KQT-like subfamily, member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
702.75 3.41e-04 GO:0035405 histone-threonine phosphorylation
263.58 3.18e-03 GO:0016572 histone phosphorylation
124.08 1.54e-02 GO:0050853 B cell receptor signaling pathway
111.03 1.93e-02 GO:0018107 peptidyl-threonine phosphorylation
95.90 2.60e-02 GO:0018210 peptidyl-threonine modification
81.16 3.66e-02 GO:0007257 activation of JUN kinase activity

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
702.75 8.59e-05 GO:0035184 histone threonine kinase activity
301.23 6.00e-04 GO:0035173 histone kinase activity
150.65 2.59e-03 GO:0004697 protein kinase C activity
70.35 1.23e-02 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
68.08 1.31e-02 GO:0005080 protein kinase C binding
62.08 1.58e-02 GO:0050681 androgen receptor binding
58.64 1.77e-02 GO:0004715 non-membrane spanning protein tyrosine kinase activity
8.48 2.73e-02 GO:0004672 protein kinase activity
44.00 3.16e-02 GO:0035258 steroid hormone receptor binding