Motif ID: bHLH_family.p2

Z-value: 1.992


Transcription factors associated with bHLH_family.p2:

Gene SymbolEntrez IDGene Name
ARNTL 406 aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 56938 aryl hydrocarbon receptor nuclear translocator-like 2
CLOCK 9575 clock homolog (mouse)
HES6 55502 hairy and enhancer of split 6 (Drosophila)
HEY1 23462 hairy/enhancer-of-split related with YRPW motif 1
HEY2 23493 hairy/enhancer-of-split related with YRPW motif 2
HEYL 26508 hairy/enhancer-of-split related with YRPW motif-like
ID1 3397 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
MITF 4286 microphthalmia-associated transcription factor
MLXIPL 51085 MLX interacting protein-like
MNT 4335 MAX binding protein
MXD3 83463 MAX dimerization protein 3
MXD4 10608 MAX dimerization protein 4
MXI1 4601 MAX interactor 1
NPAS2 4862 neuronal PAS domain protein 2
OLIG1 116448 oligodendrocyte transcription factor 1
OLIG2 10215 oligodendrocyte lineage transcription factor 2
TFE3 7030 transcription factor binding to IGHM enhancer 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
MLXIPLchr7_-_730388140.621.0e-02Click!
MXD4chr4_-_2263706-0.611.2e-02Click!
TFE3chrX_-_48900932-0.581.9e-02Click!
NPAS2chr2_+_1014364910.448.6e-02Click!
MITFchr3_+_69812961-0.439.7e-02Click!
HEY1chr8_-_806798970.421.1e-01Click!
ID1chr20_+_301930830.381.5e-01Click!
OLIG2chr21_+_34398210-0.351.9e-01Click!
ARNTLchr11_+_13299260-0.243.8e-01Click!
MXI1chr10_+_111969988,
chr10_+_111985628
0.233.8e-01Click!
HEY2chr6_+_126070724,
chr6_+_126070813
0.204.5e-01Click!
ARNTL2chr12_+_27485767-0.185.0e-01Click!
HEYLchr1_-_40105341,
chr1_-_40098639,
chr1_-_40105296
0.126.7e-01Click!
MXD3chr5_-_176738831-0.087.6e-01Click!
MNTchr17_-_23042170.048.7e-01Click!
CLOCKchr4_-_56412968-0.029.5e-01Click!


Activity profile for motif bHLH_family.p2.

activity profile for motif bHLH_family.p2


Sorted Z-values histogram for motif bHLH_family.p2

Sorted Z-values for motif bHLH_family.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of bHLH_family.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_10765106 3.556 ILF3
interleukin enhancer binding factor 3, 90kDa
chrX_+_152908819 3.428 DUSP9
dual specificity phosphatase 9
chrX_+_131157635 3.217 NM_001042452
MST4
serine/threonine protein kinase MST4
chr14_-_55369163 3.152 NM_000161
NM_001024024
NM_001024070
NM_001024071
GCH1



GTP cyclohydrolase 1



chr19_+_18284578 3.106 NM_006332
IFI30
interferon, gamma-inducible protein 30
chr1_-_113498615 3.046 NM_001166496
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr1_-_161193375 3.045 NM_001643
APOA2
apolipoprotein A-II
chr11_+_121322848 2.801 NM_003105
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr6_+_87865261 2.757 NM_015021
ZNF292
zinc finger protein 292
chr12_-_63328857 2.684 PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr14_-_94849552 2.624 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_+_76164624 2.614 NM_004710
SYNGR2
synaptogyrin 2
chr19_-_10764449 2.612 LOC147727
uncharacterized LOC147727
chr17_+_55163077 2.592 NM_001242903
NM_001242902
AKAP1

A kinase (PRKA) anchor protein 1

chrX_-_133119475 2.543 GPC3
glypican 3
chrX_+_131157231 2.542 NM_001042453
NM_016542
MST4

serine/threonine protein kinase MST4

chrX_-_133119624 2.423 NM_001164617
NM_001164618
NM_001164619
NM_004484
GPC3



glypican 3



chr2_-_208634051 2.418 NM_003468
FZD5
frizzled family receptor 5
chr20_+_61273823 2.414 SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr11_+_68079999 2.404 NM_002335
LRP5
low density lipoprotein receptor-related protein 5
chr2_+_219283809 2.401 NM_007127
VIL1
villin 1
chr12_-_63328663 2.370 NM_020700
PPM1H
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr19_+_18284619 2.329 IFI30
interferon, gamma-inducible protein 30
chr6_+_138188352 2.311 NM_006290
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr1_+_40627066 2.300 RLF
rearranged L-myc fusion
chr6_+_37137882 2.290 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr16_-_68269948 2.250 NM_024939
ESRP2
epithelial splicing regulatory protein 2
chr19_+_10764987 2.206 ILF3
interleukin enhancer binding factor 3, 90kDa
chr17_-_76124791 2.160 NM_001127198
TMC6
transmembrane channel-like 6
chr11_-_66725790 2.153 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr1_+_1981902 2.150 NM_002744
PRKCZ
protein kinase C, zeta
chr4_-_16085309 2.142 PROM1
prominin 1
chr1_-_113498828 2.126 NM_003051
SLC16A1
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
chr19_+_35739282 2.108 LSR
lipolysis stimulated lipoprotein receptor
chr12_-_58146118 2.031 NM_000075
CDK4
cyclin-dependent kinase 4
chr12_-_58146025 2.011 CDK4
cyclin-dependent kinase 4
chr2_+_216176808 1.980 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr4_-_16085593 1.971 NM_001145847
NM_001145848
PROM1

prominin 1

chr1_+_40627031 1.963 NM_012421
RLF
rearranged L-myc fusion
chr2_+_216176818 1.928 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr1_+_65613211 1.910 NM_203464
NM_001005353
AK4

adenylate kinase 4

chr17_+_78075390 1.886 GAA
glucosidase, alpha; acid
chr19_+_18284631 1.864 IFI30
interferon, gamma-inducible protein 30
chr2_-_172291227 1.857 NM_024770
METTL8
methyltransferase like 8
chr14_-_24036532 1.844 AP1G2
adaptor-related protein complex 1, gamma 2 subunit
chr11_+_67159421 1.844 NM_004584
RAD9A
RAD9 homolog A (S. pombe)
chr19_+_10764896 1.819 NM_001137673
NM_004516
NM_012218
NM_017620
NM_153464
ILF3




interleukin enhancer binding factor 3, 90kDa




chr6_+_31982538 1.814 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr1_+_150255228 1.812 NM_144697
C1orf51
chromosome 1 open reading frame 51
chr16_+_85646923 1.795 NM_014615
KIAA0182
KIAA0182
chr6_+_160390128 1.794 NM_000876
IGF2R
insulin-like growth factor 2 receptor
chr12_-_58146110 1.787 CDK4
cyclin-dependent kinase 4
chr17_+_79935493 1.785 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr8_-_8750739 1.746 NM_004225
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr20_+_47538211 1.738 NM_006420
ARFGEF2
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr14_+_31343642 1.732 NM_001135058
NM_004086
COCH

coagulation factor C homolog, cochlin (Limulus polyphemus)

chr2_+_216176678 1.719 NM_004044
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr19_-_41903226 1.716 NM_020158
EXOSC5
exosome component 5
chr3_+_50654600 1.712 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr1_+_40627055 1.701 RLF
rearranged L-myc fusion
chr17_-_7137722 1.699 NM_004422
DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr19_-_41256371 1.686 C19orf54
chromosome 19 open reading frame 54
chr15_+_50474357 1.655 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr12_-_58146108 1.651 CDK4
cyclin-dependent kinase 4
chr3_+_52017299 1.577 NM_000666
NM_001198895
NM_001198896
NM_001198897
NM_001198898
ACY1




aminoacylase 1




chr15_+_89182038 1.542 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr1_-_161193190 1.539 APOA2
apolipoprotein A-II
chr7_+_94536926 1.536 NM_001166160
NM_017650
PPP1R9A

protein phosphatase 1, regulatory subunit 9A

chr17_-_41623652 1.468 NM_001079675
ETV4
ets variant 4
chr3_+_50654558 1.464 NM_001243925
NM_004635
MAPKAPK3

mitogen-activated protein kinase-activated protein kinase 3

chr2_+_220042986 1.464 FAM134A
family with sequence similarity 134, member A
chr5_-_150603615 1.452 CCDC69
coiled-coil domain containing 69
chr2_+_220042948 1.445 FAM134A
family with sequence similarity 134, member A
chr6_-_33385814 1.444


chr17_+_79935410 1.443 NM_001251888
NM_024083
ASPSCR1

alveolar soft part sarcoma chromosome region, candidate 1

chr4_-_40631846 1.441 NM_001098634
RBM47
RNA binding motif protein 47
chr9_-_100954883 1.430 NM_052820
CORO2A
coronin, actin binding protein, 2A
chr19_-_33793429 1.422 NM_004364
CEBPA
CCAAT/enhancer binding protein (C/EBP), alpha
chr7_-_1595746 1.407 NM_001097620
TMEM184A
transmembrane protein 184A
chr1_-_154193044 1.372 C1orf43
chromosome 1 open reading frame 43
chr2_+_42396392 1.360 NM_001145076
NM_019063
EML4

echinoderm microtubule associated protein like 4

chr1_-_27240430 1.360 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr12_-_110939877 1.357 NM_016226
NM_057180
VPS29

vacuolar protein sorting 29 homolog (S. cerevisiae)

chr17_-_7137675 1.351 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr17_+_72744802 1.348 SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr2_+_169312793 1.343 NM_203463
CERS6
ceramide synthase 6
chr17_-_76124767 1.328 TMC6
transmembrane channel-like 6
chr11_+_7535213 1.309 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr6_+_7107986 1.297 NM_001003698
NM_001003699
NM_001003700
RREB1


ras responsive element binding protein 1


chr2_+_74756531 1.296 NM_013247
NM_145074
HTRA2

HtrA serine peptidase 2

chr6_+_7541863 1.289 NM_001008844
NM_004415
DSP

desmoplakin

chr9_+_131709991 1.279 NUP188
nucleoporin 188kDa
chr19_+_35739519 1.272 NM_015925
NM_205834
NM_205835
LSR


lipolysis stimulated lipoprotein receptor


chr22_-_36903033 1.260 FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr22_-_36903086 1.258 NM_024955
NM_001102371
FOXRED2

FAD-dependent oxidoreductase domain containing 2

chr20_+_48552902 1.258 NM_018683
RNF114
ring finger protein 114
chrX_-_131573638 1.236 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr19_+_7702010 1.221 STXBP2
syntaxin binding protein 2
chr8_+_22224997 1.218 NM_001135153
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr17_+_2680349 1.215 RAP1GAP2
RAP1 GTPase activating protein 2
chr1_-_12677347 1.211 NM_004753
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr9_-_133454818 1.211 LOC100272217
uncharacterized LOC100272217
chr9_+_131709970 1.209 NM_015354
NUP188
nucleoporin 188kDa
chr8_+_22224758 1.190 NM_001128431
NM_001135154
NM_015359
SLC39A14


solute carrier family 39 (zinc transporter), member 14


chr7_+_150759633 1.182 NM_001199693
NM_001199694
SLC4A2

solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)

chr11_-_118972529 1.180 DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr2_+_47596286 1.165 NM_002354
EPCAM
epithelial cell adhesion molecule
chr4_-_57301643 1.157 NM_002703
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr3_-_13008959 1.151 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr19_+_7701976 1.150 NM_001127396
NM_006949
STXBP2

syntaxin binding protein 2

chr5_-_150603649 1.148 NM_015621
CCDC69
coiled-coil domain containing 69
chr2_-_198364560 1.148 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr6_+_7541837 1.143 DSP
desmoplakin
chr6_-_53409507 1.141 GCLC
glutamate-cysteine ligase, catalytic subunit
chr22_+_22988781 1.136 NM_199127
GGTLC2
gamma-glutamyltransferase light chain 2
chr3_+_53880590 1.133 IL17RB
interleukin 17 receptor B
chr14_-_24657986 1.128 IPO4
importin 4
chr1_-_160990862 1.127 F11R
F11 receptor
chr7_-_23509972 1.126 NM_006547
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr1_-_27816542 1.124 WASF2
WAS protein family, member 2
chr12_-_103311053 1.106 PAH
phenylalanine hydroxylase
chr11_+_7535000 1.105 NM_003621
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr20_+_61273786 1.104 NM_016354
SLCO4A1
solute carrier organic anion transporter family, member 4A1
chr5_-_133706717 1.101 CDKL3
cyclin-dependent kinase-like 3
chr8_+_95653272 1.095 ESRP1
epithelial splicing regulatory protein 1
chr8_+_123793894 1.094 NM_014943
ZHX2
zinc fingers and homeoboxes 2
chr17_-_7137580 1.093 DVL2
dishevelled, dsh homolog 2 (Drosophila)
chr3_-_4508939 1.093 SUMF1
sulfatase modifying factor 1
chr20_+_48552935 1.091 RNF114
ring finger protein 114
chr20_-_17949067 1.086 NM_014426
SNX5
sorting nexin 5
chr17_-_2614926 1.077 NM_015229
KIAA0664
KIAA0664
chr7_-_95951268 1.077 NM_001160210
NM_014251
SLC25A13

solute carrier family 25, member 13 (citrin)

chr1_-_21995793 1.075 NM_001145657
NM_002885
RAP1GAP

RAP1 GTPase activating protein

chrX_+_105937067 1.071 NM_024539
RNF128
ring finger protein 128
chr17_+_72744794 1.068 SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr6_+_31949800 1.052 NM_001242823
NM_001252204
NM_007293
NM_001002029
LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr8_-_145638929 1.047 SLC39A4
solute carrier family 39 (zinc transporter), member 4
chr5_-_131132642 1.045 FNIP1
folliculin interacting protein 1
chr17_+_53342356 1.041 HLF
hepatic leukemia factor
chr1_+_11333244 1.041 NM_013319
UBIAD1
UbiA prenyltransferase domain containing 1
chr2_+_17721806 1.040 NM_003385
VSNL1
visinin-like 1
chr12_-_122750954 1.030 VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr17_+_72744746 1.028 NM_004252
SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr8_+_95653340 1.024 NM_001034915
NM_001122825
NM_001122826
NM_001122827
NM_017697
ESRP1




epithelial splicing regulatory protein 1




chr2_+_17721983 1.021 VSNL1
visinin-like 1
chr4_-_103266577 1.021 NM_001135146
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr9_+_6757919 1.020 KDM4C
lysine (K)-specific demethylase 4C
chrX_-_39956655 1.017 NM_001123385
NM_017745
BCOR

BCL6 corepressor

chr6_+_7541892 1.016 DSP
desmoplakin
chr17_-_79885544 1.009 NM_002359
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr19_+_797390 1.008 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr2_+_29117503 1.004 NM_015131
WDR43
WD repeat domain 43
chr20_-_17949384 1.003 NM_152227
SNX5
sorting nexin 5
chr2_-_220042731 0.997 CNPPD1
cyclin Pas1/PHO80 domain containing 1
chr14_-_24658010 0.997 NM_024658
IPO4
importin 4
chr9_-_112083005 0.997 NM_018424
NM_019114
EPB41L4B

erythrocyte membrane protein band 4.1 like 4B

chr1_+_116916029 0.996 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr11_+_34127208 0.996 NAT10
N-acetyltransferase 10 (GCN5-related)
chr2_+_64681270 0.994 NM_014181
LGALSL
lectin, galactoside-binding-like
chr7_+_26403944 0.994 NM_001199838
SNX10
sorting nexin 10
chr3_+_50654589 0.992 MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr8_-_80993009 0.991 NM_001025252
TPD52
tumor protein D52
chr13_-_46742678 0.986 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_5021141 0.985 BHLHE40
basic helix-loop-helix family, member e40
chr6_-_35696359 0.983 NM_001145775
FKBP5
FK506 binding protein 5
chr17_+_72744775 0.974 SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
chr11_+_61560401 0.973 FEN1
flap structure-specific endonuclease 1
chr11_+_118958696 0.970 NM_001024382
HMBS
hydroxymethylbilane synthase
chr6_-_53409795 0.967 GCLC
glutamate-cysteine ligase, catalytic subunit
chr11_-_119252267 0.965 USP2
ubiquitin specific peptidase 2
chr14_-_94789641 0.962 NM_001756
SERPINA6
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
chr1_+_154193294 0.942 NM_014847
UBAP2L
ubiquitin associated protein 2-like
chrX_+_115567746 0.938 NM_007231
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_-_100662905 0.938 NM_000169
GLA
galactosidase, alpha
chr7_-_103629962 0.937 NM_005045
NM_173054
RELN

reelin

chr12_-_122751044 0.937 NM_022916
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr16_+_2570322 0.937 NM_001145815
NM_015944
AMDHD2

amidohydrolase domain containing 2

chr5_+_137801178 0.934 NM_001964
EGR1
early growth response 1
chr9_-_6645564 0.934 NM_000170
GLDC
glycine dehydrogenase (decarboxylating)
chr15_-_70390226 0.932 TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chrX_-_100603956 0.931 NM_004085
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr1_+_116915938 0.930 ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr2_-_148778262 0.927 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr16_-_5083933 0.927 NM_016256
NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr6_-_35888937 0.923 NM_003137
SRPK1
SRSF protein kinase 1
chr3_+_5021096 0.921 NM_003670
BHLHE40
basic helix-loop-helix family, member e40
chr15_+_45315301 0.920 NM_003104
SORD
sorbitol dehydrogenase
chr19_+_35773409 0.919 NM_021175
HAMP
hepcidin antimicrobial peptide
chr19_+_7702020 0.918 STXBP2
syntaxin binding protein 2
chr8_+_22224786 0.908 SLC39A14
solute carrier family 39 (zinc transporter), member 14
chr5_-_73937248 0.905 NM_003633
ENC1
ectodermal-neural cortex 1 (with BTB-like domain)
chr17_+_27370155 0.904 PIPOX
pipecolic acid oxidase
chr11_+_34127110 0.904 NM_001144030
NM_024662
NAT10

N-acetyltransferase 10 (GCN5-related)

chr11_-_118972784 0.903 NM_001382
DPAGT1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
chr19_+_10812111 0.902 NM_031209
QTRT1
queuine tRNA-ribosyltransferase 1
chr3_+_53880563 0.900 NM_018725
IL17RB
interleukin 17 receptor B
chr12_+_56473944 0.900 ERBB3
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
chr12_-_103311380 0.897 NM_000277
PAH
phenylalanine hydroxylase
chr17_-_39093671 0.893 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr17_+_55162530 0.893 NM_003488
AKAP1
A kinase (PRKA) anchor protein 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.