Motif ID: BACH2.p2

Z-value: 1.801


Transcription factors associated with BACH2.p2:

Gene SymbolEntrez IDGene Name
BACH2 60468 BTB and CNC homology 1, basic leucine zipper transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BACH2chr6_-_910065800.136.3e-01Click!


Activity profile for motif BACH2.p2.

activity profile for motif BACH2.p2


Sorted Z-values histogram for motif BACH2.p2

Sorted Z-values for motif BACH2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of BACH2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_21452981 10.890 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_153003677 8.018 NM_003125
SPRR1B
small proline-rich protein 1B
chr1_+_223889253 7.441 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr17_-_39768939 6.478 NM_005557
KRT16
keratin 16
chr18_+_61144143 5.125 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr1_-_209824641 4.650 NM_001017402
LAMB3
laminin, beta 3
chr1_-_152009440 4.372 S100A11
S100 calcium binding protein A11
chr18_+_61442611 4.324 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr1_-_152009406 4.207 S100A11
S100 calcium binding protein A11
chr19_+_39279849 3.890 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr19_-_39264144 3.800 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr11_-_2950593 3.642 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr11_-_6341708 3.377 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr11_-_102668822 3.238 MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr11_-_102668892 3.230 NM_001145938
NM_002421
MMP1

matrix metallopeptidase 1 (interstitial collagenase)

chr1_+_183155393 3.180 LAMC2
laminin, gamma 2
chr1_+_223900061 3.175 NM_001748
CAPN2
calpain 2, (m/II) large subunit
chr1_+_223900226 3.109 CAPN2
calpain 2, (m/II) large subunit
chr17_-_39743085 3.020 NM_000526
KRT14
keratin 14
chr3_-_151034514 2.973 NM_023915
GPR87
G protein-coupled receptor 87
chr10_+_17270257 2.939 NM_003380
VIM
vimentin
chr10_+_17270469 2.892 VIM
vimentin
chr1_-_152009490 2.704 NM_005620
S100A11
S100 calcium binding protein A11
chr1_+_152956563 2.674 NM_001199828
NM_005987
SPRR1A

small proline-rich protein 1A

chr1_-_95007139 2.538 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr13_-_45048436 2.525 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr1_+_183155361 2.435 LAMC2
laminin, gamma 2
chr10_+_121410751 2.388 NM_004281
BAG3
BCL2-associated athanogene 3
chr10_+_121411042 2.328 BAG3
BCL2-associated athanogene 3
chr16_+_56642477 2.304 NM_005953
MT2A
metallothionein 2A
chr10_+_121411086 2.294 BAG3
BCL2-associated athanogene 3
chr11_-_65667858 2.256 FOSL1
FOS-like antigen 1
chr11_-_118134986 2.255 MPZL2
myelin protein zero-like 2
chr11_-_118134956 2.251 MPZL2
myelin protein zero-like 2
chr11_+_67351065 2.231 NM_000852
GSTP1
glutathione S-transferase pi 1
chr19_-_51523272 2.222 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr11_-_118135197 2.167 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr5_-_175843531 2.166 NM_001834
NM_007097
CLTB

clathrin, light chain B

chr6_-_84140758 2.155 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr19_-_43969723 2.131 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr6_-_84140854 2.111 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr7_+_48128225 2.100 NM_181597
UPP1
uridine phosphorylase 1
chr12_-_106533810 2.051 NM_014840
NUAK1
NUAK family, SNF1-like kinase, 1
chr17_+_73717515 2.024 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr10_+_121411071 2.011 BAG3
BCL2-associated athanogene 3
chr6_-_84140744 1.996 ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr1_+_150480584 1.923 ECM1
extracellular matrix protein 1
chr11_-_65667809 1.922 FOSL1
FOS-like antigen 1
chr16_+_56685810 1.855 NM_005947
MT1B
metallothionein 1B
chr16_+_57662301 1.832 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr1_+_150480486 1.807 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr1_+_223900212 1.734 CAPN2
calpain 2, (m/II) large subunit
chr1_+_156084541 1.723 LMNA
lamin A/C
chr10_+_121410891 1.721 BAG3
BCL2-associated athanogene 3
chr1_+_32043745 1.701 NM_001204415
TINAGL1
tubulointerstitial nephritis antigen-like 1
chr1_+_26606621 1.695 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr5_-_175843360 1.678 CLTB
clathrin, light chain B
chr1_+_36621751 1.629 NM_018067
MAP7D1
MAP7 domain containing 1
chr1_+_27189628 1.578 NM_006142
SFN
stratifin
chr1_+_183155173 1.578 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr1_+_35246789 1.560 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr3_-_12800739 1.544 NM_018306
TMEM40
transmembrane protein 40
chr1_+_26606586 1.540 SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr1_+_36621457 1.534 MAP7D1
MAP7 domain containing 1
chr6_-_134496833 1.506 SGK1
serum/glucocorticoid regulated kinase 1
chr6_+_30852756 1.487 NM_001202523
DDR1
discoidin domain receptor tyrosine kinase 1
chr18_+_61637262 1.478 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr2_-_85641128 1.477 CAPG
capping protein (actin filament), gelsolin-like
chr3_-_48632592 1.466 NM_000094
COL7A1
collagen, type VII, alpha 1
chr6_-_138428477 1.412 NM_022121
PERP
PERP, TP53 apoptosis effector
chr7_+_116312412 1.410 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr19_-_44174497 1.404 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr15_-_60690115 1.390 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr11_+_101983170 1.318 NM_001195045
YAP1
Yes-associated protein 1
chr1_+_156084565 1.317 LMNA
lamin A/C
chr20_+_4666796 1.278 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chrX_-_10851808 1.277 NM_033290
MID1
midline 1 (Opitz/BBB syndrome)
chr1_-_152009467 1.267 S100A11
S100 calcium binding protein A11
chr2_+_47596286 1.245 NM_002354
EPCAM
epithelial cell adhesion molecule
chr7_-_1498961 1.206 MICALL2
MICAL-like 2
chr17_+_18625335 1.163 NM_001037330
TRIM16L
tripartite motif containing 16-like
chrX_+_12993224 1.155 NM_021109
TMSB4X
thymosin beta 4, X-linked
chr1_+_156084579 1.142 LMNA
lamin A/C
chr11_-_65667860 1.131 NM_005438
FOSL1
FOS-like antigen 1
chr8_-_42065193 1.131 NM_000930
NM_033011
PLAT

plasminogen activator, tissue

chr3_+_184016985 1.107 NM_002808
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr2_+_47596447 1.083 EPCAM
epithelial cell adhesion molecule
chr11_-_33744497 1.047 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr11_-_8739398 1.013 ST5
suppression of tumorigenicity 5
chr5_-_141061798 1.011 NM_022481
ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr16_-_122573 1.010 NM_022450
RHBDF1
rhomboid 5 homolog 1 (Drosophila)
chr1_-_153521717 0.984 NM_002960
S100A3
S100 calcium binding protein A3
chr7_-_93519990 0.980 NM_006528
TFPI2
tissue factor pathway inhibitor 2
chr10_+_71075609 0.975 NM_033496
HK1
hexokinase 1
chr7_-_107643330 0.969 NM_002291
LAMB1
laminin, beta 1
chr19_-_44174271 0.944 PLAUR
plasminogen activator, urokinase receptor
chr21_-_36421630 0.934 RUNX1
runt-related transcription factor 1
chr6_-_111927473 0.924 NM_001164281
NM_147686
TRAF3IP2

TRAF3 interacting protein 2

chr19_-_51472816 0.893 NM_002774
KLK6
kallikrein-related peptidase 6
chr20_+_44035203 0.870 NM_001048223
NM_001048224
DBNDD2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr3_+_184017038 0.863 PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr4_+_169753105 0.853 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr4_+_74606222 0.853 NM_000584
IL8
interleukin 8
chr19_-_44285012 0.848 KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr5_-_141061749 0.835 ARAP3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr1_+_156084458 0.831 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr8_+_26150731 0.830 NM_001177591
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr16_+_89988416 0.827 NM_001197181
TUBB3
tubulin, beta 3 class III
chr2_-_85641153 0.823 CAPG
capping protein (actin filament), gelsolin-like
chr1_-_154943001 0.818 NM_001130040
NM_183001
SHC1

SHC (Src homology 2 domain containing) transforming protein 1

chr1_-_17308072 0.816 NM_001135247
NM_017459
MFAP2

microfibrillar-associated protein 2

chr1_-_6662898 0.795 NM_014851
KLHL21
kelch-like 21 (Drosophila)
chr11_+_394199 0.790 NM_007183
PKP3
plakophilin 3
chrX_-_48937457 0.752 WDR45
WD repeat domain 45
chr6_-_111927059 0.731 TRAF3IP2
TRAF3 interacting protein 2
chr17_+_79651035 0.721 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr6_+_30856462 0.706 NM_001202521
NM_001202522
NM_013994
DDR1


discoidin domain receptor tyrosine kinase 1


chr19_-_44285407 0.694 NM_002250
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr12_-_56122840 0.689 NM_001040034
NM_001780
CD63

CD63 molecule

chr17_+_79651072 0.686 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr15_+_52121807 0.685 NM_014547
TMOD3
tropomodulin 3 (ubiquitous)
chr6_+_150070856 0.679 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr17_+_79651042 0.677 HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr17_-_767287 0.669 NM_001205319
NXN
nucleoredoxin
chrX_-_48937560 0.662 NM_001029896
WDR45
WD repeat domain 45
chr20_+_44034632 0.662 NM_001197139
NM_001048221
NM_001048222
NM_001197140
NM_018478
DBNDD2




dysbindin (dystrobrevin binding protein 1) domain containing 2




chr2_-_31352489 0.652 NM_001253827
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr3_+_187930720 0.646 NM_005578
LPP
LIM domain containing preferred translocation partner in lipoma
chr17_+_79650961 0.645 NM_004712
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr3_-_49395697 0.641 GPX1
glutathione peroxidase 1
chr17_+_74381419 0.634 SPHK1
sphingosine kinase 1
chr22_-_44708730 0.618 NM_001099294
KIAA1644
KIAA1644
chr7_+_143078444 0.618 ZYX
zyxin
chr6_-_159239254 0.616 EZR
ezrin
chr7_+_143078457 0.613 ZYX
zyxin
chr12_-_56122792 0.612 CD63
CD63 molecule
chr7_+_143078447 0.607 ZYX
zyxin
chr17_-_7493389 0.599 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr19_+_36630999 0.586 CAPNS1
calpain, small subunit 1
chr19_+_36631001 0.585 CAPNS1
calpain, small subunit 1
chr5_+_35856990 0.585 NM_002185
IL7R
interleukin 7 receptor
chr17_-_65362667 0.576 NM_002816
NM_174871
PSMD12

proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

chr6_-_150346599 0.567 NM_130900
RAET1L
retinoic acid early transcript 1L
chr20_+_44637539 0.560 NM_004994
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr17_+_74381186 0.544 NM_001142602
SPHK1
sphingosine kinase 1
chr12_-_56122800 0.541 CD63
CD63 molecule
chr3_+_169940246 0.540 PRKCI
protein kinase C, iota
chr6_+_150070844 0.537 PCMT1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr11_+_67351276 0.535 GSTP1
glutathione S-transferase pi 1
chr8_-_42065037 0.525 PLAT
plasminogen activator, tissue
chr7_+_143078399 0.522 ZYX
zyxin
chr8_-_25315791 0.522 KCTD9
potassium channel tetramerisation domain containing 9
chr3_+_100238063 0.514 TMEM45A
transmembrane protein 45A
chr14_-_75643309 0.514 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chrX_+_49028183 0.492 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr12_-_56122748 0.491 CD63
CD63 molecule
chr16_-_84538219 0.488 NM_020947
KIAA1609
KIAA1609
chr6_-_134497069 0.487 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr19_+_41725098 0.486 NM_001699
NM_021913
AXL

AXL receptor tyrosine kinase

chr3_+_128445024 0.485 RAB7A
RAB7A, member RAS oncogene family
chr17_+_74380943 0.484 SPHK1
sphingosine kinase 1
chr19_+_36630846 0.484 NM_001003962
NM_001749
CAPNS1

calpain, small subunit 1

chr22_+_45072936 0.481 PRR5
proline rich 5 (renal)
chr16_+_15596122 0.480 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr6_-_159239198 0.478 EZR
ezrin
chr1_-_6662681 0.478 KLHL21
kelch-like 21 (Drosophila)
chr22_+_31478845 0.478 NM_001207017
SMTN
smoothelin
chr6_-_159239269 0.476 NM_003379
EZR
ezrin
chr17_-_39538635 0.475 NM_021013
KRT34
keratin 34
chr17_-_18161869 0.469 FLII
flightless I homolog (Drosophila)
chr11_+_2924504 0.465 SLC22A18
solute carrier family 22, member 18
chr2_-_55277672 0.460 RTN4
reticulon 4
chr18_+_61254533 0.459 NM_012397
SERPINB13
serpin peptidase inhibitor, clade B (ovalbumin), member 13
chrX_-_15511358 0.457 PIR
pirin (iron-binding nuclear protein)
chr12_-_15114495 0.456 NM_001175
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_-_55277653 0.456 RTN4
reticulon 4
chr15_+_22892683 0.449 NM_014608
CYFIP1
cytoplasmic FMR1 interacting protein 1
chr17_-_27467395 0.447 MYO18A
myosin XVIIIA
chr3_-_49395751 0.443 NM_000581
NM_201397
GPX1

glutathione peroxidase 1

chr14_-_75643333 0.441 TMED10
transmembrane emp24-like trafficking protein 10 (yeast)
chr2_+_113875469 0.438 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr7_+_143078358 0.436 NM_001010972
NM_003461
ZYX

zyxin

chr3_+_169940214 0.433 NM_002740
PRKCI
protein kinase C, iota
chr7_+_143078395 0.432 ZYX
zyxin
chr11_+_62649160 0.432 SLC3A2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr15_-_71184611 0.428 NM_020147
THAP10
THAP domain containing 10
chr8_-_24814028 0.427 NM_006158
NEFL
neurofilament, light polypeptide
chr15_+_22892517 0.426 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr3_+_169940223 0.417 PRKCI
protein kinase C, iota
chr15_+_22892699 0.410 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr2_-_73316782 0.407 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr19_+_38755097 0.406 NM_001166103
NM_021102
SPINT2

serine peptidase inhibitor, Kunitz type, 2

chr15_+_22892723 0.406 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr7_-_137028275 0.405 PTN
pleiotrophin
chr2_-_55277620 0.405 RTN4
reticulon 4
chr12_-_53343607 0.400 KRT8
keratin 8
chr15_+_22892714 0.397 CYFIP1
cytoplasmic FMR1 interacting protein 1
chr5_+_73981055 0.394 HEXB
hexosaminidase B (beta polypeptide)
chr21_+_30517897 0.393 C21orf7
chromosome 21 open reading frame 7
chr17_-_18162018 0.391 FLII
flightless I homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
94.26 2.89e-07 GO:0031581 hemidesmosome assembly
13.31 8.12e-07 GO:0008544 epidermis development
37.04 5.78e-05 GO:0007044 cell-substrate junction assembly
4.05 3.44e-03 GO:0009888 tissue development
21.84 9.55e-03 GO:0030193 regulation of blood coagulation
44.45 1.15e-02 GO:0042730 fibrinolysis
20.25 1.30e-02 GO:0050818 regulation of coagulation
17.66 2.24e-02 GO:0061041 regulation of wound healing
32.75 3.00e-02 GO:0045103 intermediate filament-based process

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
17.89 6.14e-04 GO:0005604 basement membrane
69.13 6.82e-04 GO:0043256 laminin complex
6.32 7.49e-04 GO:0031012 extracellular matrix
207.36 1.82e-03 GO:0005610 laminin-5 complex
41.49 3.62e-03 GO:0005605 basal lamina
10.60 7.89e-03 GO:0044420 extracellular matrix part
5.94 1.20e-02 GO:0005578 proteinaceous extracellular matrix
2.49 1.75e-02 GO:0005576 extracellular region
69.13 2.70e-02 GO:0031233 intrinsic to external side of plasma membrane
2.99 3.65e-02 GO:0044421 extracellular region part
10.38 4.48e-02 GO:0005882 intermediate filament

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
4.11 8.69e-03 GO:0005198 structural molecule activity
13.39 1.58e-02 GO:0004867 serine-type endopeptidase inhibitor activity