• All motifs sorted by activity significance
• All samples sorted alphabetically

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)

Motif ID: FOXO1,3,4.p2

Z-value: 2.085

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr3_-_149086884	10.235		TM4SF1	transmembrane 4 L six family member 1
chr1_-_57044980	4.919		PPAP2B	phosphatidic acid phosphatase type 2B
chr1_-_57045235	4.771	NM_003713	PPAP2B	phosphatidic acid phosphatase type 2B
chr9_+_75766794	4.450		ANXA1	annexin A1
chr1_-_57045129	3.702		PPAP2B	phosphatidic acid phosphatase type 2B
chr16_+_55512801	3.520	NM_004530	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr9_+_706744	3.476	NM_153186	KANK1	KN motif and ankyrin repeat domains 1
chr18_-_21852189	2.723	NM_018030	OSBPL1A	oxysterol binding protein-like 1A
chr8_-_13134028	2.716		DLC1	deleted in liver cancer 1
chr22_+_33196801	2.529	NM_000362	TIMP3	TIMP metallopeptidase inhibitor 3
chr12_+_53491417	2.509	NM_002178	IGFBP6	insulin-like growth factor binding protein 6
chr7_-_95064213	2.433	NM_000305 NM_001018161	PON2	paraoxonase 2
chr1_-_57045214	2.419		PPAP2B	phosphatidic acid phosphatase type 2B
chr5_-_42811959	2.417	NM_001085486 NM_001093726 NM_005410	SEPP1	selenoprotein P, plasma, 1
chr12_+_13043955	2.385	NM_003979	GPRC5A	G protein-coupled receptor, family C, group 5, member A
chr9_+_75766777	2.364	NM_000700	ANXA1	annexin A1
chr4_-_80994183	2.246
chr6_+_121756744	2.192	NM_000165	GJA1	gap junction protein, alpha 1, 43kDa
chr12_+_53491448	2.152		IGFBP6	insulin-like growth factor binding protein 6
chr7_+_134464417	2.064		CALD1	caldesmon 1
chr14_-_69354900	1.996		ACTN1	actinin, alpha 1
chr17_+_1665233	1.971	NM_002615	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr11_+_844111	1.959		TSPAN4	tetraspanin 4
chr1_-_103496768	1.926		COL11A1	collagen, type XI, alpha 1
chr16_+_55515468	1.869	NM_001127891	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
chr12_-_9268440	1.864		A2M	alpha-2-macroglobulin
chr17_+_1665306	1.850		SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_+_123754141	1.839		TACC2	transforming, acidic coiled-coil containing protein 2
chr12_-_9268513	1.833		A2M	alpha-2-macroglobulin
chr11_+_844445	1.806	NM_001025237	TSPAN4	tetraspanin 4
chr8_+_70405080	1.785		SULF1	sulfatase 1
chr13_-_38172862	1.768	NM_001135934 NM_001135935 NM_001135936 NM_006475	POSTN	periostin, osteoblast specific factor
chr12_-_9268522	1.759	NM_000014	A2M	alpha-2-macroglobulin
chr10_+_123923104	1.721	NM_006997 NM_206860	TACC2	transforming, acidic coiled-coil containing protein 2
chr3_+_154797910	1.705	NM_007288	MME	membrane metallo-endopeptidase
chr5_-_125930604	1.705	NM_001182 NM_001201377 NM_001202404	ALDH7A1	aldehyde dehydrogenase 7 family, member A1
chr14_+_94577078	1.703	NM_001130080 NM_005532	IFI27	interferon, alpha-inducible protein 27
chr5_+_125800786	1.679	NM_001146322	GRAMD3	GRAM domain containing 3
chr20_+_45338125	1.665	NM_030777	SLC2A10	solute carrier family 2 (facilitated glucose transporter), member 10
chr11_+_844062	1.658	NM_001025234	TSPAN4	tetraspanin 4
chr4_+_55095263	1.632	NM_006206	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide
chr10_+_123922940	1.582		TACC2	transforming, acidic coiled-coil containing protein 2
chr2_-_217540722	1.582		IGFBP5	insulin-like growth factor binding protein 5
chr15_+_32933869	1.560	NM_001144757 NM_003020	SCG5	secretogranin V (7B2 protein)
chr6_+_123110345	1.544		SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A
chr11_+_129979330	1.540		APLP2	amyloid beta (A4) precursor-like protein 2
chr2_-_163099877	1.535	NM_004460	FAP	fibroblast activation protein, alpha
chrX_-_38079980	1.507	NM_001170750 NM_001170751 NM_001170752 NM_006307	SRPX	sushi-repeat containing protein, X-linked
chr2_+_189839113	1.504		COL3A1	collagen, type III, alpha 1
chr13_-_45048436	1.498	NM_001243798	TSC22D1	TSC22 domain family, member 1
chr3_-_149421059	1.497	NM_001168278	WWTR1	WW domain containing transcription regulator 1
chr2_-_188419185	1.475	NM_001032281 NM_006287	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr20_+_19915716	1.463		RIN2	Ras and Rab interactor 2
chrX_+_102611379	1.458	NM_001006612 NM_001006613 NM_001006614 NM_016303	WBP5	WW domain binding protein 5
chr12_-_8815479	1.421		MFAP5	microfibrillar associated protein 5
chr17_+_1665281	1.413		SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr22_+_38599026	1.410	NM_001161573	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)
chrX_-_10645726	1.410	NM_001098624	MID1	midline 1 (Opitz/BBB syndrome)
chr8_-_134309448	1.406	NM_001135242 NM_006096	NDRG1	N-myc downstream regulated 1
chr5_+_125758818	1.395	NM_001146320 NM_001146321 NM_023927	GRAMD3	GRAM domain containing 3
chr8_+_31497267	1.395	NM_013962	NRG1	neuregulin 1
chr15_+_99191671	1.385		IGF1R	insulin-like growth factor 1 receptor
chr17_+_1665342	1.384		SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_-_105627857	1.375	NM_022361	POPDC3	popeye domain containing 3
chr8_-_62602285	1.359	NM_001164750 NM_001164751 NM_001164752 NM_001164753 NM_020164 NM_032467 NM_032468	ASPH	aspartate beta-hydroxylase
chr2_-_151344145	1.339	NM_005168	RND3	Rho family GTPase 3
chr11_-_8739398	1.331		ST5	suppression of tumorigenicity 5
chr8_-_125579395	1.328		MTSS1	metastasis suppressor 1
chr9_-_16727887	1.314		BNC2	basonuclin 2
chr7_-_124405029	1.309		GPR37	G protein-coupled receptor 37 (endothelin receptor type B-like)
chr3_+_138066489	1.275	NM_001252091 NM_012219	MRAS	muscle RAS oncogene homolog
chr2_-_219157207	1.272	NM_022152	TMBIM1	transmembrane BAX inhibitor motif containing 1
chr12_-_8815266	1.270		MFAP5	microfibrillar associated protein 5
chr2_+_189839078	1.263	NM_000090	COL3A1	collagen, type III, alpha 1
chr2_-_190044330	1.257	NM_000393	COL5A2	collagen, type V, alpha 2
chr6_-_134498973	1.256	NM_001143677	SGK1	serum/glucocorticoid regulated kinase 1
chr5_-_39394423	1.244		DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr3_+_187943192	1.234	NM_001167671	LPP	LIM domain containing preferred translocation partner in lipoma
chr8_+_70405027	1.231	NM_001128205 NM_001128206	SULF1	sulfatase 1
chr2_-_217560247	1.225	NM_000599	IGFBP5	insulin-like growth factor binding protein 5
chr8_-_18541441	1.192		PSD3	pleckstrin and Sec7 domain containing 3
chr2_-_238322840	1.184	NM_004369 NM_057164 NM_057165 NM_057166 NM_057167	COL6A3	collagen, type VI, alpha 3
chr1_-_168106810	1.181		GPR161	G protein-coupled receptor 161
chr3_+_154798078	1.172	NM_007289	MME	membrane metallo-endopeptidase
chr7_+_76054251	1.171	NM_001110354	ZP3	zona pellucida glycoprotein 3 (sperm receptor)
chr9_+_124043719	1.166		GSN	gelsolin
chr16_-_28621279	1.157	NM_001055 NM_177529	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr11_-_102668892	1.129	NM_001145938 NM_002421	MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr5_+_125759076	1.126		GRAMD3	GRAM domain containing 3
chr1_-_168106727	1.101		GPR161	G protein-coupled receptor 161
chr4_-_186697065	1.100	NM_001145673	SORBS2	sorbin and SH3 domain containing 2
chr1_+_226016428	1.078		EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)
chrX_-_114252132	1.077	NM_000640	IL13RA2	interleukin 13 receptor, alpha 2
chr2_-_192711923	1.069	NM_004657	SDPR	serum deprivation response
chr12_-_9268475	1.059		A2M	alpha-2-macroglobulin
chr11_-_27681195	1.054	NM_001143816 NM_170735	BDNF	brain-derived neurotrophic factor
chr4_+_41614911	1.053	NM_001112719 NM_001112720	LIMCH1	LIM and calponin homology domains 1
chr1_-_201465700	1.051	NM_001193572	CSRP1	cysteine and glycine-rich protein 1
chr1_-_93342706	1.047	NM_001252271	FAM69A	family with sequence similarity 69, member A
chr1_+_145524989	1.042	NM_003637	ITGA10	integrin, alpha 10
chr21_+_37507209	1.040	NM_001236	CBR3	carbonyl reductase 3
chr2_-_192711651	1.031		SDPR	serum deprivation response
chr7_+_12250818	1.022	NM_001134232 NM_018374	TMEM106B	transmembrane protein 106B
chr3_-_150920946	1.010	NM_013308	GPR171	G protein-coupled receptor 171
chr20_+_44035203	1.005	NM_001048223 NM_001048224	DBNDD2	dysbindin (dystrobrevin binding protein 1) domain containing 2
chr21_+_30452872	1.004	NM_020152	C21orf7	chromosome 21 open reading frame 7
chr5_+_36608430	1.004	NM_001166695	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_189839132	1.000		COL3A1	collagen, type III, alpha 1
chr17_-_8424217	0.987		MYH10	myosin, heavy chain 10, non-muscle
chr1_+_162602308	0.984		DDR2	discoidin domain receptor tyrosine kinase 2
chr8_-_27941387	0.980	NM_001010906	C8orf80	chromosome 8 open reading frame 80
chr9_-_14086901	0.967		NFIB	nuclear factor I/B
chr4_-_111119752	0.967	NM_001130721 NM_024090	ELOVL6	ELOVL fatty acid elongase 6
chr5_-_151066445	0.963		SPARC	secreted protein, acidic, cysteine-rich (osteonectin)
chr9_+_97521930	0.954	NM_001193329	C9orf3	chromosome 9 open reading frame 3
chr12_-_8815370	0.939	NM_003480	MFAP5	microfibrillar associated protein 5
chr6_+_36644236	0.929	NM_001220777 NM_078467	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr1_-_168106535	0.921		GPR161	G protein-coupled receptor 161
chr21_+_30517897	0.918		C21orf7	chromosome 21 open reading frame 7
chr11_+_101983170	0.916	NM_001195045	YAP1	Yes-associated protein 1
chr11_-_102668822	0.900		MMP1	matrix metallopeptidase 1 (interstitial collagenase)
chr15_-_72501017	0.882		PKM2	pyruvate kinase, muscle
chr1_+_163041694	0.868	NM_001113380	RGS4	regulator of G-protein signaling 4
chr3_-_58522873	0.854	NM_003500	ACOX2	acyl-CoA oxidase 2, branched chain
chr3_-_185826748	0.846	NM_004454	ETV5	ets variant 5
chr1_+_162602198	0.845	NM_001014796 NM_006182	DDR2	discoidin domain receptor tyrosine kinase 2
chr17_+_26662547	0.833	NM_021137	TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr12_-_76425375	0.832	NM_007350	PHLDA1	pleckstrin homology-like domain, family A, member 1
chr15_+_99192696	0.824	NM_000875	IGF1R	insulin-like growth factor 1 receptor
chr5_+_34684611	0.818	NM_001145521 NM_001145525	RAI14	retinoic acid induced 14
chr8_+_19170999	0.814	NM_001174160 NM_022071 NM_001174159	SH2D4A	SH2 domain containing 4A
chr10_-_90750955	0.808	NM_001141945	ACTA2	actin, alpha 2, smooth muscle, aorta
chr2_-_238322770	0.807		COL6A3	collagen, type VI, alpha 3
chr4_+_124320664	0.797	NM_005841	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr19_+_50031232	0.797		RCN3	reticulocalbin 3, EF-hand calcium binding domain
chr12_+_56915587	0.796	NM_002898	RBMS2	RNA binding motif, single stranded interacting protein 2
chr6_+_139456240	0.792	NM_016217	HECA	headcase homolog (Drosophila)
chr1_-_203154304	0.784		CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)
chr7_-_50772997	0.779	NM_001001550	GRB10	growth factor receptor-bound protein 10
chr21_+_35190586	0.779		ITSN1	intersectin 1 (SH3 domain protein)
chr2_+_138721807	0.759	NM_001024074 NM_001024075 NM_006895	HNMT	histamine N-methyltransferase
chr19_+_36239261	0.753	NM_019104	LIN37	lin-37 homolog (C. elegans)
chr1_+_86889768	0.751	NM_006536	CLCA2	chloride channel accessory 2
chr4_+_154074269	0.748	NM_001130067	TRIM2	tripartite motif containing 2
chr2_-_238322815	0.745		COL6A3	collagen, type VI, alpha 3
chr10_+_124145584	0.735	NM_001195608	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr10_-_118680978	0.734		KIAA1598	KIAA1598
chr6_-_112575880	0.733		LAMA4	laminin, alpha 4
chr1_-_203155910	0.732	NM_001276	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)
chrX_+_106045880	0.729	NM_017752 NM_198881	TBC1D8B	TBC1 domain family, member 8B (with GRAM domain)
chr1_-_203155827	0.719		CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)
chrX_-_100914816	0.713	NM_014782 NM_177949	ARMCX2	armadillo repeat containing, X-linked 2
chr9_-_95298251	0.713	NM_001197295 NM_001197296 NM_001393	ECM2	extracellular matrix protein 2, female organ and adipocyte specific
chr1_+_35246789	0.711	NM_024009	GJB3	gap junction protein, beta 3, 31kDa
chr9_-_75567915	0.710		ALDH1A1	aldehyde dehydrogenase 1 family, member A1
chr10_+_63808968	0.708	NM_001244638	ARID5B	AT rich interactive domain 5B (MRF1-like)
chr6_-_131321868	0.708	NM_001252660	EPB41L2	erythrocyte membrane protein band 4.1-like 2
chr13_-_110802708	0.707		COL4A1	collagen, type IV, alpha 1
chr2_+_201450730	0.702	NM_001159	AOX1	aldehyde oxidase 1
chr11_-_17191287	0.701	NM_002645	PIK3C2A	phosphoinositide-3-kinase, class 2, alpha polypeptide
chr11_-_27743604	0.701	NM_170731	BDNF	brain-derived neurotrophic factor
chr14_-_51411118	0.701	NM_001163940 NM_002863	PYGL	phosphorylase, glycogen, liver
chr1_+_171154387	0.698	NM_001460	FMO2	flavin containing monooxygenase 2 (non-functional)
chr1_-_240775448	0.697	NM_022469	GREM2	gremlin 2
chr9_+_115913266	0.696		SLC31A2	solute carrier family 31 (copper transporters), member 2
chr18_+_47088400	0.692	NM_006033	LIPG	lipase, endothelial
chr11_+_19372270	0.691	NM_001111018	NAV2	neuron navigator 2
chr1_-_203155745	0.686		CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)
chr5_+_73109342	0.679	NM_001244364	RGNEF	190 kDa guanine nucleotide exchange factor
chr6_-_46889620	0.670	NM_001098518	GPR116	G protein-coupled receptor 116
chr9_+_120466625	0.670		TLR4	toll-like receptor 4
chr3_+_138067678	0.667	NM_001252092	MRAS	muscle RAS oncogene homolog
chr5_+_79703792	0.664	NM_001105251 NM_014733	ZFYVE16	zinc finger, FYVE domain containing 16
chr5_-_16742336	0.663		MYO10	myosin X
chr1_+_20915440	0.662	NM_001785	CDA	cytidine deaminase
chr19_-_58662144	0.660	NM_024620	ZNF329	zinc finger protein 329
chrX_-_119603136	0.658		LAMP2	lysosomal-associated membrane protein 2
chr3_+_62305395	0.656	NM_020685	C3orf14	chromosome 3 open reading frame 14
chr17_-_15554809	0.652		TRIM16	tripartite motif containing 16
chr12_+_79439432	0.648	NM_001135806	SYT1	synaptotagmin I
chr1_-_203155867	0.641		CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)
chr9_+_115913227	0.641	NM_001860	SLC31A2	solute carrier family 31 (copper transporters), member 2
chr20_-_34543280	0.639	NM_016558	SCAND1	SCAN domain containing 1
chr3_+_132316080	0.635	NM_016557	CCRL1	chemokine (C-C motif) receptor-like 1
chr13_-_33760215	0.634	NM_001243466 NM_178007	STARD13	StAR-related lipid transfer (START) domain containing 13
chr7_+_134464372	0.634		CALD1	caldesmon 1
chr5_+_102201713	0.624		PAM	peptidylglycine alpha-amidating monooxygenase
chr1_+_204913353	0.624	NM_001160331	NFASC	neurofascin
chr3_-_52488030	0.623	NM_003280	TNNC1	troponin C type 1 (slow)
chr1_-_31845818	0.619	NM_004102	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr10_-_98336445	0.619		TM9SF3	transmembrane 9 superfamily member 3
chr1_-_161207879	0.612	NM_001077469 NM_001077470 NM_001077471 NM_001077472 NM_001077473 NM_001077474 NM_001077475 NM_001077476 NM_001077477 NM_001077478 NM_001077479 NM_001077480 NM_001077481 NM_001077482 NM_005122	NR1I3	nuclear receptor subfamily 1, group I, member 3
chr9_+_120466453	0.607	NM_138554	TLR4	toll-like receptor 4
chr19_-_36523540	0.606	NM_001199570	CLIP3	CAP-GLY domain containing linker protein 3
chr18_+_72922725	0.602	NM_005786	TSHZ1	teashirt zinc finger homeobox 1
chr6_-_112575766	0.601	NM_001105206 NM_001105207 NM_001105208 NM_001105209 NM_002290	LAMA4	laminin, alpha 4
chr22_-_31686707	0.600		PIK3IP1	phosphoinositide-3-kinase interacting protein 1
chr18_-_500583	0.598	NM_130386	COLEC12	collectin sub-family member 12
chr15_-_30114536	0.597	NM_003257 NM_175610	TJP1	tight junction protein 1 (zona occludens 1)
chr17_-_65362667	0.593	NM_002816 NM_174871	PSMD12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
11.18	7.75e-03	GO:0030198	extracellular matrix organization

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
3.04	5.49e-06	GO:0005576	extracellular region
3.84	1.27e-05	GO:0044421	extracellular region part
6.50	2.74e-05	GO:0031012	extracellular matrix
7.20	3.29e-05	GO:0005578	proteinaceous extracellular matrix
11.45	2.56e-04	GO:0044420	extracellular matrix part
43.68	3.93e-03	GO:0005583	fibrillar collagen
19.42	5.27e-03	GO:0005581	collagen
3.14	2.25e-02	GO:0005615	extracellular space

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
80.06	5.01e-04	GO:0031994	insulin-like growth factor I binding
9.52	4.14e-03	GO:0019838	growth factor binding
12.92	4.39e-03	GO:0004867	serine-type endopeptidase inhibitor activity
5.78	7.52e-03	GO:0004857	enzyme inhibitor activity
8.51	7.77e-03	GO:0004866	endopeptidase inhibitor activity
8.37	8.57e-03	GO:0030414	peptidase inhibitor activity
8.15	9.89e-03	GO:0061135	endopeptidase regulator activity
24.03	2.68e-02	GO:0005520	insulin-like growth factor binding
6.73	2.84e-02	GO:0061134	peptidase regulator activity