Motif ID: HES1.p2

Z-value: 2.993


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HES1chr3_+_1938539300.107.2e-01Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_58358120 3.679 NM_001206897
NM_003888
NM_170696
ALDH1A2


aldehyde dehydrogenase 1 family, member A2


chr16_+_29817810 2.813 NM_001042539
NM_002383
MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr15_-_58357848 2.729 ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr7_+_155089614 2.673 INSIG1
insulin induced gene 1
chr3_-_47823419 2.545 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr7_+_106685007 2.536 NM_002736
PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
chr7_-_148581379 2.229 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr21_-_46962281 2.153 NM_001205206
NM_194255
SLC19A1

solute carrier family 19 (folate transporter), member 1

chr1_-_32801606 2.051 NM_023009
MARCKSL1
MARCKS-like 1
chr21_+_35445808 2.034 NM_032476
NM_006933
MRPS6
SLC5A3
mitochondrial ribosomal protein S6
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
chr2_-_96811138 1.991 NM_004418
DUSP2
dual specificity phosphatase 2
chr7_+_155089483 1.960 NM_005542
NM_198336
NM_198337
INSIG1


insulin induced gene 1


chr5_+_612404 1.872 NM_018140
CEP72
centrosomal protein 72kDa
chr5_+_612454 1.757 CEP72
centrosomal protein 72kDa
chr15_+_50474357 1.744 NM_001159629
NM_003645
SLC27A2

solute carrier family 27 (fatty acid transporter), member 2

chr10_-_23003443 1.676 NM_005028
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr5_+_131630065 1.643 NM_003059
SLC22A4
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
chr22_+_19711065 1.643 NM_000407
GP1BB
glycoprotein Ib (platelet), beta polypeptide
chr6_+_135502477 1.642 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_-_38273852 1.598 NM_024640
YRDC
yrdC domain containing (E. coli)
chr19_+_30302861 1.594 NM_001238
CCNE1
cyclin E1
chr3_-_47823368 1.585 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chrX_-_154033729 1.565 NM_001166460
NM_001166461
NM_001166462
NM_002436
MPP1



membrane protein, palmitoylated 1, 55kDa



chr6_-_13711643 1.510 NM_005493
RANBP9
RAN binding protein 9
chr7_-_148581297 1.491 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_148581403 1.478 NM_001203247
NM_001203248
NM_004456
NM_152998
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr3_-_47823337 1.470 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr6_+_57037333 1.468 BAG2
BCL2-associated athanogene 2
chr6_-_13711484 1.437 RANBP9
RAN binding protein 9
chr5_+_75699003 1.419 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr7_-_100230676 1.415 TFR2
transferrin receptor 2
chr21_-_44495894 1.403 NM_000071
CBS
cystathionine-beta-synthase
chr7_-_148581377 1.393 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr16_+_222845 1.387 NM_000517
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chrX_-_109561314 1.375 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr19_-_1652327 1.364 NM_003200
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr16_+_84733606 1.357 USP10
ubiquitin specific peptidase 10
chr6_+_37137882 1.347 NM_001243186
NM_002648
PIM1

pim-1 oncogene

chr19_+_35759880 1.343 NM_003367
NM_207291
USF2

upstream transcription factor 2, c-fos interacting

chr9_+_131451519 1.331 SET
SET nuclear oncogene
chr16_+_30194730 1.321 NM_001193333
NM_007074
CORO1A

coronin, actin binding protein, 1A

chr19_+_1071208 1.313 HMHA1
histocompatibility (minor) HA-1
chr14_+_103243813 1.309 NM_001199427
NM_003300
NM_145725
NM_145726
TRAF3



TNF receptor-associated factor 3



chr18_+_12948010 1.290 SEH1L
SEH1-like (S. cerevisiae)
chr1_-_11120081 1.274 NM_003132
SRM
spermidine synthase
chr16_+_84733596 1.270 USP10
ubiquitin specific peptidase 10
chr1_-_38273846 1.266 YRDC
yrdC domain containing (E. coli)
chr6_+_157802479 1.265 NM_024630
NM_153746
ZDHHC14

zinc finger, DHHC-type containing 14

chr7_+_100027404 1.252 MEPCE
methylphosphate capping enzyme
chr6_-_13814546 1.248 NM_001031713
CCDC90A
coiled-coil domain containing 90A
chr1_+_46713385 1.243 RAD54L
RAD54-like (S. cerevisiae)
chr7_+_100027253 1.238 NM_019606
MEPCE
methylphosphate capping enzyme
chr14_+_101193190 1.236 NM_003836
DLK1
delta-like 1 homolog (Drosophila)
chr16_+_84733611 1.227 USP10
ubiquitin specific peptidase 10
chr1_+_167189948 1.222 NM_001198786
NM_002697
POU2F1

POU class 2 homeobox 1

chr17_-_76124767 1.194 TMC6
transmembrane channel-like 6
chr16_+_2039945 1.173 NM_004209
SYNGR3
synaptogyrin 3
chr16_+_84733554 1.169 NM_005153
USP10
ubiquitin specific peptidase 10
chr14_+_101193275 1.169 DLK1
delta-like 1 homolog (Drosophila)
chr21_+_45285026 1.169 AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr19_+_35759967 1.160 USF2
upstream transcription factor 2, c-fos interacting
chr17_+_79989485 1.158 NM_005052
RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
chr22_-_22221937 1.151 MAPK1
mitogen-activated protein kinase 1
chr10_-_99094427 1.148 NM_012083
FRAT2
frequently rearranged in advanced T-cell lymphomas 2
chr3_-_47823275 1.148 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr4_+_57774035 1.144 NM_005612
REST
RE1-silencing transcription factor
chr6_-_13711952 1.136 RANBP9
RAN binding protein 9
chr17_-_40428311 1.132 STAT5B
signal transducer and activator of transcription 5B
chr1_-_53793743 1.132 NM_001018054
NM_004631
NM_017522
NM_033300
LRP8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr16_-_88717395 1.131 NM_000101
CYBA
cytochrome b-245, alpha polypeptide
chr17_+_30813928 1.127 NM_003885
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr19_+_49622480 1.123 NM_003660
PPFIA3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr3_-_47823377 1.120 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr3_-_47823343 1.117 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr1_+_2985730 1.113 NM_022114
NM_199454
PRDM16

PR domain containing 16

chr7_-_87505640 1.103 SLC25A40
solute carrier family 25, member 40
chr17_+_40440481 1.099 STAT5A
signal transducer and activator of transcription 5A
chrX_-_154033647 1.099 MPP1
membrane protein, palmitoylated 1, 55kDa
chr19_+_4402658 1.099 NM_005483
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chr16_+_226678 1.095 NM_000558
HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr11_+_65029312 1.085 NM_002689
POLA2
polymerase (DNA directed), alpha 2 (70kD subunit)
chr11_+_14665268 1.075 NM_000922
PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr3_-_47823333 1.064 SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr7_+_75677402 1.063 MDH2
malate dehydrogenase 2, NAD (mitochondrial)
chr3_-_47823386 1.061 NM_003074
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chrX_-_109561298 1.054 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr2_-_101034049 1.042 NM_004854
CHST10
carbohydrate sulfotransferase 10
chr4_+_57774090 1.038 REST
RE1-silencing transcription factor
chr3_-_13008959 1.037 NM_014869
IQSEC1
IQ motif and Sec7 domain 1
chr22_+_29876180 1.035 NM_021076
NEFH
neurofilament, heavy polypeptide
chr1_+_23345928 1.035 NM_001009999
NM_015013
KDM1A

lysine (K)-specific demethylase 1A

chr1_-_39338976 1.033 NM_012333
MYCBP
c-myc binding protein
chr12_-_6716475 1.032 CHD4
chromodomain helicase DNA binding protein 4
chr7_+_87505543 1.024 NM_006716
DBF4
DBF4 homolog (S. cerevisiae)
chr14_+_103243832 1.014 TRAF3
TNF receptor-associated factor 3
chrX_+_102470003 1.007 NM_001080425
NM_001127688
BEX4

brain expressed, X-linked 4

chr1_+_212458867 1.004 NM_006243
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr6_+_135502521 1.001 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_+_65991357 0.999 NM_001198687
NM_001198688
NM_001198689
LEPR


leptin receptor


chr21_+_45285101 0.996 NM_020132
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr5_+_118691549 0.996 NM_014350
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chrX_-_48776282 0.995 NM_006875
PIM2
pim-2 oncogene
chr16_+_85646923 0.985 NM_014615
KIAA0182
KIAA0182
chr1_+_65991390 0.983 LEPR
leptin receptor
chrX_-_3631654 0.980 NM_005044
PRKX
protein kinase, X-linked
chr16_+_15489586 0.975 NM_001128423
NM_173803
MPV17L

MPV17 mitochondrial membrane protein-like

chr1_+_227127937 0.974 NM_020247
ADCK3
aarF domain containing kinase 3
chr6_+_36410800 0.973 KCTD20
potassium channel tetramerisation domain containing 20
chr19_-_10613767 0.973 NM_203500
KEAP1
kelch-like ECH-associated protein 1
chrX_-_154033696 0.972 MPP1
membrane protein, palmitoylated 1, 55kDa
chr3_-_50649080 0.967 CISH
cytokine inducible SH2-containing protein
chr5_-_79950783 0.967 NM_000791
DHFR
dihydrofolate reductase
chr1_+_23345985 0.966 KDM1A
lysine (K)-specific demethylase 1A
chr3_-_50540853 0.958 NM_001005505
NM_001174051
NM_006030
CACNA2D2


calcium channel, voltage-dependent, alpha 2/delta subunit 2


chr15_+_41786055 0.953 NM_002220
ITPKA
inositol-trisphosphate 3-kinase A
chr21_+_33031932 0.943 NM_000454
SOD1
superoxide dismutase 1, soluble
chr19_-_55972935 0.941 ISOC2
isochorismatase domain containing 2
chr8_+_61591239 0.939 NM_017780
CHD7
chromodomain helicase DNA binding protein 7
chr19_+_33072087 0.937 NM_004708
PDCD5
programmed cell death 5
chr1_+_25757381 0.933 NM_018202
TMEM57
transmembrane protein 57
chr7_-_994259 0.931 NM_006869
ADAP1
ArfGAP with dual PH domains 1
chr5_+_149546340 0.928 NM_001804
CDX1
caudal type homeobox 1
chr2_-_10588451 0.928 NM_002539
ODC1
ornithine decarboxylase 1
chr19_-_13068008 0.926 GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr8_+_56792399 0.924 LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr1_+_10092990 0.924 NM_001105562
NM_006048
UBE4B

ubiquitination factor E4B

chr17_-_3867585 0.923 NM_005173
NM_174953
NM_174954
NM_174955
NM_174956
NM_174957
NM_174958
ATP2A3






ATPase, Ca++ transporting, ubiquitous






chr19_-_13068033 0.922 NM_052850
GADD45GIP1
growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr9_+_131451847 0.913 SET
SET nuclear oncogene
chr1_+_227127959 0.913 ADCK3
aarF domain containing kinase 3
chr17_-_79980685 0.912 NM_144998
STRA13
stimulated by retinoic acid 13 homolog (mouse)
chr5_+_68665123 0.908 NM_133343
RAD17
RAD17 homolog (S. pombe)
chr22_+_21771661 0.908 NM_015094
HIC2
hypermethylated in cancer 2
chr5_+_95067511 0.906


chr18_-_12377248 0.906 NM_006796
AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr9_+_135545389 0.901 GTF3C4
general transcription factor IIIC, polypeptide 4, 90kDa
chr1_+_91966653 0.895 NM_001134420
CDC7
cell division cycle 7 homolog (S. cerevisiae)
chrX_-_137793826 0.879 NM_004114
FGF13
fibroblast growth factor 13
chr15_-_38856830 0.879 NM_001128602
NM_005739
RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)

chr16_-_4401265 0.879 NM_016069
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr1_+_91966365 0.879 NM_001134419
NM_003503
CDC7

cell division cycle 7 homolog (S. cerevisiae)

chr10_-_23003036 0.879 PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr20_+_55966440 0.874 NM_017495
NM_183425
RBM38

RNA binding motif protein 38

chr12_-_108954952 0.873 SART3
squamous cell carcinoma antigen recognized by T cells 3
chr10_-_43892697 0.873 NM_001098207
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr16_+_81040515 0.872 CENPN
centromere protein N
chr5_+_70883179 0.872 MCCC2
methylcrotonoyl-CoA carboxylase 2 (beta)
chr16_+_15489619 0.872 MPV17L
MPV17 mitochondrial membrane protein-like
chr22_-_20104428 0.868 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr20_-_30795346 0.867 NM_002657
PLAGL2
pleiomorphic adenoma gene-like 2
chr6_+_36410543 0.864 NM_173562
KCTD20
potassium channel tetramerisation domain containing 20
chr9_+_4985082 0.864 JAK2
Janus kinase 2
chr1_+_227127993 0.860 ADCK3
aarF domain containing kinase 3
chr3_-_38071030 0.856 NM_006225
PLCD1
phospholipase C, delta 1
chr22_+_19701968 0.856 NM_002688
SEPT5
septin 5
chr19_-_9731883 0.851 NM_152289
ZNF561
zinc finger protein 561
chr12_-_108954942 0.844 SART3
squamous cell carcinoma antigen recognized by T cells 3
chr12_+_93771607 0.837 NM_019094
NM_199040
NUDT4

NUDT4P1
nudix (nucleoside diphosphate linked moiety X)-type motif 4

nudix (nucleoside diphosphate linked moiety X)-type motif 4 pseudogene 1
chr7_+_99775346 0.836 STAG3
stromal antigen 3
chr1_-_53793583 0.835 LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr6_+_135502445 0.832 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr12_-_6716550 0.831 NM_001273
CHD4
chromodomain helicase DNA binding protein 4
chr1_+_182808481 0.826 DHX9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
chr2_-_172750724 0.824 NM_003705
SLC25A12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr7_-_65447233 0.820 NM_000181
GUSB
glucuronidase, beta
chr1_-_161147209 0.819 B4GALT3
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr18_-_23670533 0.812 NM_001007559
NM_005637
SS18

synovial sarcoma translocation, chromosome 18

chr17_+_73257992 0.812 MRPS7
mitochondrial ribosomal protein S7
chr1_-_11120047 0.812 SRM
spermidine synthase
chr2_-_27435014 0.811 NM_021095
SLC5A6
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
chr17_+_73257944 0.807 MRPS7
mitochondrial ribosomal protein S7
chr11_-_32452358 0.805 NM_001198551
NM_001198552
WT1

Wilms tumor 1

chr1_-_220101925 0.805 NM_018713
SLC30A10
solute carrier family 30, member 10
chr10_+_30722856 0.804 NM_001244134
NM_005204
MAP3K8

mitogen-activated protein kinase kinase kinase 8

chr17_+_73257745 0.800 NM_015971
MRPS7
mitochondrial ribosomal protein S7
chr18_+_2655885 0.800 NM_015295
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr19_-_8373157 0.798 NM_001165895
NM_016579
CD320

CD320 molecule

chr7_-_87505667 0.797 NM_018843
SLC25A40
solute carrier family 25, member 40
chr7_-_99698278 0.796 NM_182776
MCM7
minichromosome maintenance complex component 7
chr1_+_227127999 0.796 ADCK3
aarF domain containing kinase 3
chr7_-_148581359 0.795 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr9_-_131790434 0.794 NM_020145
SH3GLB2
SH3-domain GRB2-like endophilin B2
chr5_+_118691692 0.794 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr12_-_108954929 0.793 SART3
squamous cell carcinoma antigen recognized by T cells 3
chr3_-_13461802 0.792 NM_024923
NUP210
nucleoporin 210kDa
chr6_+_20404033 0.788 NM_001243076
E2F3
E2F transcription factor 3
chr6_+_57037058 0.785 NM_004282
BAG2
BCL2-associated athanogene 2
chr1_-_38273683 0.785 YRDC
yrdC domain containing (E. coli)
chr10_+_16478941 0.783 NM_001001484
NM_030664
PTER

phosphotriesterase related

chr1_+_11751778 0.782 NM_198545
C1orf187
chromosome 1 open reading frame 187
chr6_+_10747991 0.782 NM_001127711
NM_030969
TMEM14B

transmembrane protein 14B

chr4_+_108910869 0.778 NM_001184705
NM_005327
HADH

hydroxyacyl-CoA dehydrogenase

chrX_+_49326599 0.778 NM_001098405
GAGE12F
GAGE4
GAGE5
GAGE7
GAGE12E
G antigen 12F
G antigen 4
G antigen 5
G antigen 7
G antigen 12E
chr1_+_12040475 0.777 MFN2
mitofusin 2
chr4_-_2965147 0.776 NOP14
NOP14 nucleolar protein homolog (yeast)
chr16_-_47007567 0.775 NM_005880
DNAJA2
DnaJ (Hsp40) homolog, subfamily A, member 2
chr9_-_139981102 0.775 LOC100289341
uncharacterized LOC100289341
chr18_-_12377168 0.774 AFG3L2
AFG3 ATPase family gene 3-like 2 (S. cerevisiae)
chr11_+_747428 0.772 NM_006755
TALDO1
transaldolase 1
chr19_+_10982244 0.771 NM_199141
CARM1
coactivator-associated arginine methyltransferase 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
4.61 4.50e-03 GO:0050878 regulation of body fluid levels
186.01 1.69e-02 GO:0046544 development of secondary male sexual characteristics
37.21 3.74e-02 GO:0043029 T cell homeostasis

Nothing significant found in compartment category.

Nothing significant found in function category.