Motif ID: HSF1,2.p2

Z-value: 2.257


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HSF2chr6_+_122720685-0.684.1e-03Click!
HSF1chr8_+_145515244,
chr8_+_145515279
-0.312.4e-01Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_224903324 7.704 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr9_-_88715024 6.163 NM_177937
GOLM1
golgi membrane protein 1
chr11_-_119294242 4.922 NM_006288
THY1
Thy-1 cell surface antigen
chr6_+_29913400 4.556


chr7_+_134464417 4.363 CALD1
caldesmon 1
chr7_+_134464161 4.090 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr16_+_70502824 3.916 FUK
fucokinase
chr14_-_52535737 3.882 NID2
nidogen 2 (osteonidogen)
chr3_-_123411185 3.789 MYLK
myosin light chain kinase
chr14_-_52535945 3.660 NM_007361
NID2
nidogen 2 (osteonidogen)
chr14_-_52535765 3.370 NID2
nidogen 2 (osteonidogen)
chr14_-_52535711 3.303 NID2
nidogen 2 (osteonidogen)
chr12_+_119616594 3.282 NM_014365
HSPB8
heat shock 22kDa protein 8
chr20_+_19870209 3.257 NM_018993
RIN2
Ras and Rab interactor 2
chr3_+_158787040 3.251 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr6_+_151646634 3.191 NM_144497
AKAP12
A kinase (PRKA) anchor protein 12
chr2_-_106055229 3.169 NM_201557
FHL2
four and a half LIM domains 2
chr7_-_80548322 2.751 SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr7_-_80548666 2.646 NM_006379
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr11_-_111782447 2.642 NM_001885
CRYAB
crystallin, alpha B
chr12_+_75874512 2.460 NM_006851
GLIPR1
GLI pathogenesis-related 1
chr6_+_146864827 2.392 NM_006834
RAB32
RAB32, member RAS oncogene family
chrX_+_135278912 2.374 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr2_-_190044330 2.361 NM_000393
COL5A2
collagen, type V, alpha 2
chrX_+_135230736 2.318 NM_001159700
FHL1
four and a half LIM domains 1
chr9_-_88714395 2.283 GOLM1
golgi membrane protein 1
chrX_-_106243442 2.250 NM_001085354
NM_024657
MORC4

MORC family CW-type zinc finger 4

chr11_-_6341708 2.248 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr22_-_36681757 2.217 MYH9
myosin, heavy chain 9, non-muscle
chr11_+_69467210 2.203 CCND1
cyclin D1
chrX_-_10535476 2.150 NM_001193278
NM_001193279
NM_001193280
NM_001193281
MID1



midline 1 (Opitz/BBB syndrome)



chr6_+_146864965 2.134 RAB32
RAB32, member RAS oncogene family
chr2_-_158731622 2.129 NM_001105
ACVR1
activin A receptor, type I
chr7_+_130126035 2.076 NM_177524
MEST
mesoderm specific transcript homolog (mouse)
chr8_-_12973752 2.076 NM_001164271
DLC1
deleted in liver cancer 1
chr9_-_88714460 2.023 GOLM1
golgi membrane protein 1
chr20_+_9198036 2.018 NM_182797
PLCB4
phospholipase C, beta 4
chr5_+_17217781 2.012 BASP1
brain abundant, membrane attached signal protein 1
chr10_+_124220990 1.978 NM_002775
HTRA1
HtrA serine peptidase 1
chr10_-_75410778 1.808 NM_024875
SYNPO2L
synaptopodin 2-like
chr21_+_30452872 1.792 NM_020152
C21orf7
chromosome 21 open reading frame 7
chr2_-_188419185 1.773 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr20_+_4666796 1.759 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr1_+_150480486 1.756 NM_001202858
NM_004425
NM_022664
ECM1


extracellular matrix protein 1


chr9_-_88714486 1.671 NM_016548
GOLM1
golgi membrane protein 1
chr1_+_158979681 1.666 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr12_+_13349601 1.660 NM_001423
EMP1
epithelial membrane protein 1
chr1_+_150480584 1.626 ECM1
extracellular matrix protein 1
chr10_+_75673346 1.620 PLAU
plasminogen activator, urokinase
chr7_+_134464372 1.608 CALD1
caldesmon 1
chrX_+_135251795 1.590 NM_001167819
FHL1
four and a half LIM domains 1
chrX_+_135251454 1.526 NM_001159704
FHL1
four and a half LIM domains 1
chr1_+_114522029 1.515 NM_020190
OLFML3
olfactomedin-like 3
chr7_+_130131921 1.499 NM_002402
MEST
mesoderm specific transcript homolog (mouse)
chr19_+_15218141 1.497 NM_033025
SYDE1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr7_+_94024201 1.465 COL1A2
collagen, type I, alpha 2
chr3_+_135741576 1.439 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr10_+_54074037 1.437 NM_012242
DKK1
dickkopf 1 homolog (Xenopus laevis)
chr11_+_12695851 1.422 NM_021961
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr13_+_111134933 1.400 COL4A2
collagen, type IV, alpha 2
chr6_-_105627857 1.387 NM_022361
POPDC3
popeye domain containing 3
chr3_+_45067750 1.375 NM_003278
CLEC3B
C-type lectin domain family 3, member B
chr2_-_188419049 1.330 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_151344145 1.310 NM_005168
RND3
Rho family GTPase 3
chr4_+_41258895 1.299 NM_004181
UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr16_+_56659679 1.273 MT1E
metallothionein 1E
chr6_+_129204285 1.271 NM_000426
NM_001079823
LAMA2

laminin, alpha 2

chr14_-_70883680 1.269 NM_001202547
NM_001202548
NM_001202549
NM_018373
SYNJ2BP-COX16


SYNJ2BP
SYNJ2BP-COX16 readthrough


synaptojanin 2 binding protein
chr5_-_131562934 1.245 NM_001017973
NM_004199
P4HA2

prolyl 4-hydroxylase, alpha polypeptide II

chr1_-_201390845 1.243 NM_003281
TNNI1
troponin I type 1 (skeletal, slow)
chr12_-_120687956 1.226 NM_025157
PXN
paxillin
chr4_+_41258909 1.217 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr21_-_27512668 1.215 NM_001136016
APP
amyloid beta (A4) precursor protein
chr17_-_7297826 1.214 PLSCR3
phospholipid scramblase 3
chr4_+_41258941 1.211 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr15_+_25101697 1.207 NM_022805
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr12_-_8815266 1.194 MFAP5
microfibrillar associated protein 5
chr6_-_134496833 1.178 SGK1
serum/glucocorticoid regulated kinase 1
chr7_+_102553343 1.178 NM_001031692
NM_005824
LRRC17

leucine rich repeat containing 17

chr7_+_134576187 1.171 CALD1
caldesmon 1
chr2_-_163099877 1.117 NM_004460
FAP
fibroblast activation protein, alpha
chr3_+_159557745 1.115 SCHIP1
schwannomin interacting protein 1
chr10_-_126849066 1.059 NM_001329
CTBP2
C-terminal binding protein 2
chr12_-_50595303 1.050 NM_001243775
LIMA1
LIM domain and actin binding 1
chr16_+_29831755 1.038 MVP
major vault protein
chr3_+_159557649 1.022 NM_001197109
SCHIP1
schwannomin interacting protein 1
chrX_-_51239295 1.017 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr13_-_33760215 1.008 NM_001243466
NM_178007
STARD13

StAR-related lipid transfer (START) domain containing 13

chr9_+_504661 0.997 NM_015158
KANK1
KN motif and ankyrin repeat domains 1
chr16_+_29831714 0.986 NM_005115
NM_017458
MVP

major vault protein

chr12_+_1726221 0.976 NM_030775
WNT5B
wingless-type MMTV integration site family, member 5B
chrX_-_51239426 0.975 NM_018159
NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chrX_-_21776158 0.965 NM_014332
SMPX
small muscle protein, X-linked
chr20_+_9458460 0.965 PLCB4
phospholipase C, beta 4
chr1_-_108735362 0.960 NM_213651
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr10_-_116444112 0.949 ABLIM1
actin binding LIM protein 1
chr1_-_173176314 0.940 NM_003326
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr8_+_70378858 0.938 NM_001128204
NM_015170
SULF1

sulfatase 1

chr12_-_53012332 0.928 NM_175068
KRT73
keratin 73
chr2_-_211168315 0.919 NM_079422
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr2_-_158732341 0.912 NM_001111067
ACVR1
activin A receptor, type I
chr2_+_189839078 0.912 NM_000090
COL3A1
collagen, type III, alpha 1
chr11_-_27681195 0.911 NM_001143816
NM_170735
BDNF

brain-derived neurotrophic factor

chr9_-_75567915 0.904 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr3_-_123339423 0.903 NM_053031
NM_053032
MYLK

myosin light chain kinase

chr15_-_56209305 0.901 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr16_+_56716378 0.899 NM_005952
MT1X
metallothionein 1X
chr1_-_149908098 0.892 NM_181873
MTMR11
myotubularin related protein 11
chr7_+_134576150 0.886 NM_033139
NM_033140
CALD1

caldesmon 1

chr2_-_217560247 0.880 NM_000599
IGFBP5
insulin-like growth factor binding protein 5
chr1_-_149908759 0.875 NM_001145862
MTMR11
myotubularin related protein 11
chr5_+_36608430 0.873 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chrX_-_10645726 0.868 NM_001098624
MID1
midline 1 (Opitz/BBB syndrome)
chr6_-_134497069 0.865 NM_001143678
SGK1
serum/glucocorticoid regulated kinase 1
chr5_-_72744351 0.860 NM_004472
FOXD1
forkhead box D1
chr12_-_52967608 0.850 NM_175053
KRT74
keratin 74
chr11_-_27743604 0.845 NM_170731
BDNF
brain-derived neurotrophic factor
chr18_+_3451589 0.845 NM_170695
NM_173210
TGIF1

TGFB-induced factor homeobox 1

chr3_+_187943192 0.843 NM_001167671
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_-_33168356 0.839 NM_001161708
NM_030786
SYNC

syncoilin, intermediate filament protein

chr9_-_35689902 0.832 NM_003289
NM_213674
TPM2

tropomyosin 2 (beta)

chr6_+_83072922 0.832 NM_006670
TPBG
trophoblast glycoprotein
chr3_-_8811263 0.832 NM_000916
OXTR
oxytocin receptor
chr9_-_35689799 0.825 TPM2
tropomyosin 2 (beta)
chrX_-_106960268 0.816 NM_004089
TSC22D3
TSC22 domain family, member 3
chr2_+_28616346 0.811 FOSL2
FOS-like antigen 2
chr5_-_146833150 0.800 NM_001387
DPYSL3
dihydropyrimidinase-like 3
chr9_-_75568232 0.796 NM_000689
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr2_-_192711651 0.792 SDPR
serum deprivation response
chr1_+_78444922 0.784 DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_-_114102488 0.783 NM_001164342
ZBTB20
zinc finger and BTB domain containing 20
chr11_-_27741192 0.783 NM_001143807
BDNF
brain-derived neurotrophic factor
chr10_+_121411042 0.779 BAG3
BCL2-associated athanogene 3
chr10_-_116444374 0.764 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chrX_+_114795176 0.763 NM_005032
PLS3
plastin 3
chr8_-_110620220 0.762 SYBU
syntabulin (syntaxin-interacting)
chr13_+_48807492 0.760 ITM2B
integral membrane protein 2B
chr8_-_18541441 0.741 PSD3
pleckstrin and Sec7 domain containing 3
chr12_+_53693454 0.736 NM_021640
C12orf10
chromosome 12 open reading frame 10
chr7_+_143079354 0.735 ZYX
zyxin
chr11_-_104839263 0.731 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_-_50616425 0.730 NM_001113547
LIMA1
LIM domain and actin binding 1
chr9_-_13279562 0.726 MPDZ
multiple PDZ domain protein
chr11_-_119293848 0.724 THY1
Thy-1 cell surface antigen
chr8_-_18666295 0.713 NM_206909
PSD3
pleckstrin and Sec7 domain containing 3
chr17_-_10452939 0.712 NM_001100112
NM_017534
MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr5_+_140797243 0.711 NM_018927
PCDHGB7
protocadherin gamma subfamily B, 7
chr14_-_53417808 0.710 NM_001134999
NM_001135000
NM_006832
FERMT2


fermitin family member 2


chr6_-_134498973 0.710 NM_001143677
SGK1
serum/glucocorticoid regulated kinase 1
chr6_-_6320875 0.709 F13A1
coagulation factor XIII, A1 polypeptide
chr12_-_69357019 0.708 NM_001874
CPM
carboxypeptidase M
chr1_+_101185195 0.693 NM_001078
NM_001199834
NM_080682
VCAM1


vascular cell adhesion molecule 1


chr11_-_63381907 0.686 NM_007069
PLA2G16
phospholipase A2, group XVI
chr2_+_69240137 0.684 NM_018153
NM_032208
NM_053034
ANTXR1


anthrax toxin receptor 1


chr11_+_101983170 0.684 NM_001195045
YAP1
Yes-associated protein 1
chr2_-_224903933 0.684 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr5_-_122372413 0.679 NM_000943
PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr6_-_6320897 0.678 NM_000129
F13A1
coagulation factor XIII, A1 polypeptide
chr5_+_140864626 0.677 NM_018928
NM_032406
PCDHGC4

protocadherin gamma subfamily C, 4

chr9_+_124086842 0.671 GSN
gelsolin
chr7_+_98923495 0.665 NM_001190996
NM_006409
ARPC1A

actin related protein 2/3 complex, subunit 1A, 41kDa

chr11_-_63381840 0.663 PLA2G16
phospholipase A2, group XVI
chr2_-_113542970 0.658 NM_000575
IL1A
interleukin 1, alpha
chr13_+_48807250 0.656 NM_021999
ITM2B
integral membrane protein 2B
chr5_-_131563481 0.649 NM_001017974
NM_001142598
NM_001142599
P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr19_+_35607218 0.646 FXYD3
FXYD domain containing ion transport regulator 3
chr2_+_66662692 0.644 MEIS1
Meis homeobox 1
chr1_-_149908721 0.644 MTMR11
myotubularin related protein 11
chr10_+_121410751 0.642 NM_004281
BAG3
BCL2-associated athanogene 3
chr2_+_28615695 0.639 FOSL2
FOS-like antigen 2
chr1_+_162602198 0.635 NM_001014796
NM_006182
DDR2

discoidin domain receptor tyrosine kinase 2

chr10_+_121411071 0.632 BAG3
BCL2-associated athanogene 3
chr17_+_9745847 0.625 GLP2R
glucagon-like peptide 2 receptor
chr15_+_68924326 0.624 NM_001190457
CORO2B
coronin, actin binding protein, 2B
chr16_+_3115312 0.620 NM_001012631
NM_001012633
NM_001012718
NM_004221
IL32



interleukin 32



chr16_+_3115638 0.618 NM_001012634
IL32
interleukin 32
chr4_-_186877413 0.616 SORBS2
sorbin and SH3 domain containing 2
chr5_-_122372320 0.611 PPIC
peptidylprolyl isomerase C (cyclophilin C)
chr4_-_187644983 0.611 NM_005245
FAT1
FAT tumor suppressor homolog 1 (Drosophila)
chr11_+_75273100 0.606 NM_001207014
NM_001235
SERPINH1

serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)

chr2_-_230135954 0.601 NM_001100818
NM_017933
PID1

phosphotyrosine interaction domain containing 1

chr10_+_86131546 0.599 FAM190B
family with sequence similarity 190, member B
chr10_+_121485638 0.599 INPP5F
inositol polyphosphate-5-phosphatase F
chr1_+_162602308 0.599 DDR2
discoidin domain receptor tyrosine kinase 2
chr6_-_84140854 0.599 NM_002395
ME1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr12_+_49208615 0.594 CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr10_+_123748688 0.593 NM_206861
NM_206862
TACC2

transforming, acidic coiled-coil containing protein 2

chr12_-_6451156 0.582 NM_001065
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr9_+_79115548 0.581 NM_001097636
GCNT1
glucosaminyl (N-acetyl) transferase 1, core 2
chr16_+_3115611 0.581 NM_001012635
IL32
interleukin 32
chr19_+_3122560 0.580


chr11_-_63381485 0.577 PLA2G16
phospholipase A2, group XVI
chr21_+_30517897 0.576 C21orf7
chromosome 21 open reading frame 7
chr12_-_52914080 0.571 NM_000424
KRT5
keratin 5
chr14_+_85996454 0.568 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_-_203144910 0.559 NM_004997
MYBPH
myosin binding protein H
chr11_-_101454658 0.556 NM_004621
TRPC6
transient receptor potential cation channel, subfamily C, member 6
chr7_+_32996961 0.556 NM_007270
FKBP9
FK506 binding protein 9, 63 kDa
chr10_+_123754141 0.554 TACC2
transforming, acidic coiled-coil containing protein 2
chrX_+_80457597 0.551 SH3BGRL
SH3 domain binding glutamic acid-rich protein like

Gene Ontology Analysis

Gene overrepresentation in process category:

Enrichment   P-value GO Accession GO Term
3.80 1.30e-02 GO:0009888 tissue development

Gene overrepresentation in compartment category:

Enrichment   P-value GO Accession GO Term
11.93 1.05e-03 GO:0044420 extracellular matrix part
3.50 1.54e-03 GO:0044421 extracellular region part
5.93 1.83e-03 GO:0031012 extracellular matrix
2.47 1.99e-02 GO:0005576 extracellular region
5.57 2.48e-02 GO:0005578 proteinaceous extracellular matrix
22.47 3.14e-02 GO:0031594 neuromuscular junction

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
1.48 1.75e-02 GO:0005515 protein binding
3.41 2.75e-02 GO:0042802 identical protein binding
11.46 3.53e-02 GO:0005201 extracellular matrix structural constituent